Protein Alignment ACXD and Adcy7

DIOPT Version :10

• Sequence 1: NP_620469.2
• Gene: ACXD / 38284
• FlyBaseID: FBgn0040507
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: XP_006530643.1
• Gene: Adcy7 / 11513
• MGIID: 102891
• Length: 1146
• Species: Mus musculus
• Alignment Length: 1195
• Identity: 327/1195 - (27%)
• Similarity: 526/1195 - (44%)
• Gaps: 239/1195 - (20%)

  Fly    53 YDLYMRRLRVGYLSLFIFIHVAVTVIHTLLLLTTPEIKYVYVDM--------VAYMCSGLVIWVV 109
            |:.|......|.|.|.:.:..|.|.|..:      .|.:.:.|:        .|::.  |.::|.
Mouse    22 YEKYRLTSLHGPLLLLLLLVAAATCIALI------SIAFSHEDLRRHQVVLGTAFLM--LTLFVA 78

  Fly   110 LGVNFRSE-LVSKHGWVVYATSWLAVCVMVLMDIGL-----NVYHATSHNDILNPIYDAYTLYAI 168
            |.|....| ||.:....:...:|  .|:|||..:.:     |..||...    .|.: .:.::.:
Mouse    79 LYVLVYVECLVQRWLRALALLTW--ACLMVLGSVLMWDSLENEAHAWEQ----VPFF-LFVVFVV 136

  Fly   169 YMFMPVPYLLQPFVLGSAVTFCYIINYSFVI----TAKDDNQMH-SILNEAIYLSCVNLLGIFFR 228
            |..:|:. .....|.|...|..:::.:..|.    |:....|:. .:|..|:.|...|..|.|.:
Mouse   137 YALLPLS-RRAAIVAGVTSTVSHLLVFGAVTRAFQTSMSSTQLGLQLLANAVILLGGNFTGAFHK 200

  Fly   229 LMRDIALRTTFLDRRQYVEENLLLRYARDQERSLLLSILPAQIADRLQEDVKNRIERSKQQHQQQ 293
            .....|.|..|:...:.::....||..:.|:.:||||:|||.|:..::..:..|::....:|.
Mouse   201 HQLQDASRDLFIYTVKCIQIRRKLRVEKRQQENLLLSVLPAHISMGMKLAIIERLKEGGDRHY-- 263

  Fly   294 SQVDLRRSADSQTLKRWRQPDHG--TLFIEPHEDVTVLYADVVNYTHLTTTLDVKKLVEALHDLF 356
                              .||:.  :|:::.|::|::||||:|.:|.|.:....|:||..|::||
Mouse   264 ------------------MPDNNFHSLYVKRHQNVSILYADIVGFTRLASDCSPKELVVVLNELF 310

  Fly   357 VRFDIASEEYNVLRIKFLGDCYYCVAGLANPNADHAKCCVDLGLRMIKDIRDVREKRHLNIDMRI 421
            .:||..::....:|||.||||||||:||......||:.||.:||.:.:.|:.|||...::|.||:
Mouse   311 GKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDICEAIKQVREATGVDISMRV 375

  Fly   422 GVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLDGEYFFEDGTEKAR 486
            |:|||:||.||||..|||:|:||.||.:|||:||.|..||||:::.||:.||..|..|||..:.|
Mouse   376 GIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLNHLDKAYEVEDGHGEQR 440

  Fly   487 EDPVLQKHGIRTFLIKSLRA-----PMH-------DPRRRMRE--RQVKKLSEASKAN-FMHNST 536
             ||.|::..|||:|:...|:     |.|       |...:||.  |..:.|.....|. |.|.:
Mouse   441 -DPYLKEMNIRTYLVIDPRSQQPPPPSHHLSKPKGDATLKMRASVRVTRYLESWGAARPFAHLN- 503

  Fly   537 LHQYNQVRNQAKLEMCRELDKMPIGRIQLTKVFRRSTRLTQDEIEEETFR--RNISS---CCL-- 594
             |:.:...::..:...|....:|:.|.:............:|:.::|...  ..:||   ||.
Mouse   504 -HRESVSSSETPISNGRRQKAIPLRRHRAPDRSASPKGRLEDDCDDEMLSAIEGLSSTRPCCSKS 567

  Fly   595 --------FFRIRNWEFQYIKEPDVMLKYSIALAWVIYMGLLTIQLLSKDARYHYWYIDGTTIIL 651
                    .|..:.:|.:|...|....:|..|.|.::::.:|.:.||............|....|
Mouse   568 DDFHTFGPIFLEKGFEREYRLVPIPRARYDFACASLVFVCILLVHLLVMPRMATLGVSFGLVACL 632

  Fly   652 LTMLLIVSWYKKLWIMYMSDADVSSPNGRLSGFLFRMSDEMQRNVVIRVVMYFLIIFSYCAVAIM 716
            |.::|...:..:....:.|.:.:.:           :|:.::...::|:|:..|.:.|...|||:
Mouse   633 LGLVLSFCFATEFSRCFPSRSTLQA-----------ISESVETQPLVRLVLVVLTVGSLLTVAII 686

  Fly   717 QV-----VGCSSDEDYADLDPTYDERV--QC-FHPWILTNCMTLVIGMSFLFTRIPFIIKSCFSA 773
            .:     .|.....|..........||  .| ..|:...:|:...|..| :|.|:...:|:....
Mouse   687 NMPLTLNPGPEQPGDNKTSPLAAQNRVGTPCELLPYYTCSCILGFIACS-VFLRMSLELKAMLLT 750

  Fly   774 LIMIGYAVLVVSEFNF-----IYANSPSTNVNFNAKY---------SHIL--------------- 809
            :.::.|.:|    ||.     :..||..||.....:.         ||.|
Mouse   751 VALVAYLLL----FNLSPCWHVSGNSTETNGTQRTRLLLSDAQSMPSHTLAPGARETAPSPSYLE 811

  Fly   810 ---------LMIITFGIFHLMERQTEFIAKVDYNWKRQLIKKQEDALITNDTIKVLLTNILPTHV 865
                     .:|:.:....|:.||.::..::|..||::..|:.|:.....:..::||.|:||.||
Mouse   812 RDLKIMVNFYLILFYATLILLSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHV 876

  Fly   866 ADFYLSNQLQNELYYEEYDNVAVMFASIKNF-------DTDKIG---LRVLNEIICDFDDVLNKY 920
            |..::.::...:.|::.||.|.|||||:.:|       |.:|.|   ||:|||||.|||::|.|.
Mouse   877 AAHFIGDKAAEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKP 941

  Fly   921 SQSLRVEKIKVANWTYMAACGLDVSRSEQVNAPQMKFRNVSLMPNGRRSRYDGARSSNADGVQRV 985
            ..| .|||||....|||||.||..                   |:|..::
Mouse   942 KFS-GVEKIKTIGSTYMAAAGLSA-------------------PSGHENQ--------------- 971

  Fly   986 PYGNGSNIALDLDLERGQYEGNVITSGPRISSTHNGSSSNEVVRVMAEFALDLMRTMRRFNTENM 1050
                        ||||              ...|.|        |:.||::.||..:...|..:.
Mouse   972 ------------DLER--------------KHVHIG--------VLVEFSMALMSKLDGINRHSF 1002

  Fly  1051 QTEYEGSTDYGMLRIGISHGRAMAGVVGISKPHYDIWGNPVNMASRMDSTGVPGQIQVTENTALK 1115
            .:        ..||:||:||..:|||:|..||.||||||.||:||||:|||..|:|||||.|...
Mouse  1003 NS--------FRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTI 1059

  Fly  1116 LREFNIQCNYRGMTFVKGRGNIPTY 1140
            |:.....|..||:..|||:|.:.||
Mouse  1060 LQGLGYSCECRGLINVKGKGELRTY 1084

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:318454	56/249 (22%)
		Nucleotidyl_cyc_III	321..503	CDD:448371	87/181 (48%)
		Nucleotidyl_cyc_III	878..1142	CDD:448371	96/273 (35%)
Adcy7	XP_006530643.1	AcyC	48..456	CDD:441717	139/444 (31%)
		Guanylate_cyc	272..422	CDD:425528	72/149 (48%)
		Adcy_cons_dom	487..594	CDD:461877	18/108 (17%)
		Guanylate_cyc	890..1085	CDD:425528	96/272 (35%)