Protein Alignment ACXD and Adcy6

DIOPT Version :10

• Sequence 1: NP_620469.2
• Gene: ACXD / 38284
• FlyBaseID: FBgn0040507
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: XP_006520366.3
• Gene: Adcy6 / 11512
• MGIID: 87917
• Length: 1254
• Species: Mus musculus
• Alignment Length: 1231
• Identity: 332/1231 - (26%)
• Similarity: 548/1231 - (44%)
• Gaps: 312/1231 - (25%)

  Fly    37 WSYLV-----RKCRNLELEDSYDLYMRRLRVGYLSLFIFIHVAVTVIHTLLLLT------TPEIK 90
            |..||     ::.|:.:||..|..|..::....|:|.    :||.|:...:|||      .|:..
Mouse   205 WHRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLL----MAVLVLLMAVLLTFHAAPAQPQPA 265

  Fly    91 YVYVDMVAYMCSGLVIWVVLGV-----NFRSELVSKHGWVVYATSWLAVCVMVLMDIGLNVYHAT 150
            |     ||.:....|::|||.|     :||.:.:    |||   |::.:.::..:.:|..:
Mouse   266 Y-----VALLTCASVLFVVLMVVCNRHSFRQDSM----WVV---SYVVLGILAAVQVGGAL---- 314

  Fly   151 SHNDILNPIYDAYTLYAIYMFMPVPYLLQPFVLGSAVTFCYIINYSFVITAKDDNQMHSIL---- 211
                ..||...:..|:....|:.:.|.|.|..:.:||.....::...:|.|...|.....|
Mouse   315 ----AANPHSPSAGLWCPVFFVYITYTLLPIRMRAAVLSGLGLSTLHLILAWQLNSSDPFLWKQL 375

  Fly   212 --NEAIYLSCVNLLGIFFRLMRDIALRTTFLDRRQYVEENLLLRYARDQERSLLLSILPAQIADR 274
              |..::| |.|.:|:......:::.|..|.:.|.|::..|.|::...|:..||||:||..:|..
Mouse   376 GANVVLFL-CTNAIGVCTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAME 439

  Fly   275 LQEDVKNRIERSKQQHQQQSQVDLRRSADSQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNYTHL 339
            ::||:..:.|                  |....|         ::|:.|::|::|:||:..:|.|
Mouse   440 MKEDINTKKE------------------DMMFHK---------IYIQKHDNVSILFADIEGFTSL 477

  Fly   340 TTTLDVKKLVEALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNADHAKCCVDLGLRMIK 404
            .:....::||..|::||.|||..:.|.:.||||.||||||||:||....||||.|||::|:.||:
Mouse   478 ASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIE 542

  Fly   405 DIRDVREKRHLNIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTL 469
            .|..|||...:|::||:|:|||.|..||:|..|||||:||.||.:||.:||.|..||:|:::.||
Mouse   543 AISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATL 607

  Fly   470 SLLDGEYFFEDGTEKAREDPVLQKHGIRTFLIKSLRAPMHDPRRRMRERQVKKLSEASKANFMHN 534
            ..|:|:|..|.|....| :..|::..|.||||      :...::|..|:.:....:.::||.|..
Mouse   608 QYLNGDYEVEPGRGGER-NAYLKEQCIETFLI------LGASQKRKEEKAMLAKLQRTRANSMEG 665

  Fly   535 STLHQYNQVRNQAKLEMCRELDKMPIGRIQLTKVFR--------RSTRLTQ------DEIEE--- 582
            .               |.|.:......|.:.:|.||        :..|..|      ||::|
Mouse   666 L---------------MPRWVPDRAFSRTKDSKAFRQMGIDDSSKDNRGAQDALNPEDEVDEFLG 715

  Fly   583 --------ETFRR-NISSCCLFFRIRNWEFQYIKEPDVMLKYSIALAWVIYMGLLTIQLLSKDAR 638
                    :..|: ::....|.|:..:.|.:|.::.|......:|.|.:::..:..||||.
Mouse   716 RAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLV---- 776

  Fly   639 YHYWYIDGTTIIL-----LTMLLIVSWYKKLWIMYMSDADVSSPNGRLSGFLFRMSDEMQRNVV- 697
            :.|     :|:||     :.:||:|:      ::..:.....|       |..:....:.||:|
Mouse   777 FPY-----STLILGIYAAIFLLLLVT------VLICAVCSCGS-------FFPKALQRLSRNIVR 823

  Fly   698 -------IRVVMYFLIIFS--------------YCAVAIM-----QVVGCSSDE-DYA-DLD--- 731
                   :.:....|:..|              .||..::     .|..|...: :|: .||
Mouse   824 SRVHSTAVGIFSVLLVFISAIANMFTCNHTPIRTCAARMLNLTPADVTACHLQQLNYSLGLDAPL 888

  Fly   732 -----PTYDERVQCFHPWILTNCMTLVIGMSFLFTRI--------PFIIKSCFSALIMIGYAVLV 783
                 ||      |..|......:.|.:..|.:|..|        .||:...:..|:::|....:
Mouse   889 CEGTAPT------CSFPEYFVGNVLLSLLASSVFLHISSIGKLAMTFILGFTYLVLLLLGPPAAI 947

  Fly   784 VSEFNFIYA--NSPSTNVNFNA-----------KY-SHILLMIITFGIFHLMERQTEFIAKVDYN 834
            ...::.:..  ...|:|..|:.           || :.::|::....:: |..:|.|..|::|:.
Mouse   948 FDNYDLLLGVHGLASSNETFDGLDCPAVGRVALKYMTPVILLVFALALY-LHAQQVESTARLDFL 1011

  Fly   835 WKRQLIKKQEDALITNDTIKVLLTNILPTHVADFYLSNQLQN-ELYYEEYDNVAVMFASIKNF-- 896
            ||.|...::|:........:.||.||||..||..:|:.:.:| ||||:..:.||||||||.||
Mouse  1012 WKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSE 1076

  Fly   897 -----DTDKIG---LRVLNEIICDFDDVLNKYSQSLRVEKIKVANWTYMAACGLDVSRSEQVNAP 953
                 :.:..|   ||:|||||.|||::::: .:..::||||....|||||.||:.|..:||
Mouse  1077 FYVELEANNEGVECLRLLNEIIADFDEIISE-ERFRQLEKIKTIGSTYMAASGLNASTYDQV--- 1137

  Fly   954 QMKFRNVSLMPNGRRSRYDGARSSNADGVQRVPYGNGSNIALDLDLERGQYEGNVITSGPRISST 1018
                        ||                                                  :
Mouse  1138 ------------GR--------------------------------------------------S 1140

  Fly  1019 HNGSSSNEVVRVMAEFALDLMRTMRRFNTENMQTEYEGSTDYGMLRIGISHGRAMAGVVGISKPH 1083
            |        :..:|::|:.||..|:..|        |.|.:...::||::.|..:|||:|..||.
Mouse  1141 H--------ITALADYAMRLMEQMKHIN--------EHSFNNFQMKIGLNMGPVVAGVIGARKPQ 1189

  Fly  1084 YDIWGNPVNMASRMDSTGVPGQIQVTEN--TALKLREFNIQCNYRGMTFVKGRGNIPTYII 1142
            ||||||.||::|||||||||.:||||.:  ..|..:.:.::|  ||:..|||:|.:.||.:
Mouse  1190 YDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLEC--RGVVKVKGKGEMTTYFL 1248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:318454	63/258 (24%)
		Nucleotidyl_cyc_III	321..503	CDD:448371	86/181 (48%)
		Nucleotidyl_cyc_III	878..1142	CDD:448371	89/275 (32%)
Adcy6	XP_006520366.3	AC_N	83..454	CDD:318454	68/291 (23%)
		Guanylate_cyc	456..640	CDD:425528	87/190 (46%)
		Adcy_cons_dom	668..755	CDD:461877	16/86 (19%)
		Guanylate_cyc	1056..1250	CDD:425528	89/277 (32%)