DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXD and ADCY9

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	XP_005255136.1	Gene:	ADCY9 / 115	HGNCID:	240	Length:	1372	Species:	Homo sapiens

Alignment Length:	1320	Identity:	311/1320 - (23%)
Similarity:	534/1320 - (40%)	Gaps:	360/1320 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 NLE---LEDSYDLYMRRLR-----VGYLSLFIFIHVAVTVIHTLLLLTTPEIKYVYVDMVAYMCS 102
            |||   ||..:....||.|     :|:..|...|:.||.:...|:::..|.:.::.|      |.
Human    99 NLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLV------CV 157

  Fly   103 GLVIWVVLGVNFRSELVSKHGWVVYATSWLAVCVMVLMDIGLNVYHATSHNDILNPIYD------ 161
            |..::..      ::|.::|    ||.:.||:.::|.      .....:...:|.|:..
Human   158 GFFLFTF------TKLYARH----YAWTSLALTLLVF------ALTLAAQFQVLTPVSGRGDSSN 206

  Fly   162 ---------------------AYTLYAIYMFMPVPYLLQPFVLGSAV-----TFCYIINYSFVIT 200
                                 ...|:.:|..|.:|..|. ..||.|.     ||.|.........
Human   207 LTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLS-LCLGVAYSVLFETFGYHFRDEACFP 270

  Fly   201 AKDDNQMH-SILNEAIYLSCVNLLGIFFRLMRDIALRTTFLDRRQYVEENLLLRYARDQERSLLL 264
            :.....:| .:|:..:...|::.:|:...:|..:..|:|||...|.:.....|...:..:..::.
Human   271 SPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIH 335

  Fly   265 SILPAQIADRLQEDVKNRIERSKQQHQQQSQVDLRRSADSQTLKRWRQPDHGTLFIEPHEDVTVL 329
            |::|..|||.|.:......|.|.::|...|..:.::.:..|......:|    ..::..|:|::|
Human   336 SVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRP----FKMQQIEEVSIL 396

  Fly   330 YADVVNYTHLTTTLDVKKLVEALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNADHAKC 394
            :||:|.:|.::.......||..|:|||.|||...||....:|..||||||||||...|.||||.|
Human   397 FADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYC 461

  Fly   395 CVDLGLRMIKDIRDVREKRHLNIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGAT 459
            |:::||.|||.|....:::...::||:|||:|.||.|::|..:::||:||.||::||.:|..|..
Human   462 CIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVA 526

  Fly   460 GRVHVSQKTLSLLDGEYFFEDG--TEKAREDPVL-QKHGIRTFLIKSLRAPMHDPRRRMRE---- 517
            |:||:|:.|...||..|..|||  .|:..:..|. |..|::|:||...||  .:.|....|
Human   527 GKVHISEATAKYLDDRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQRA--KESRCSCAEALLS 589

  Fly   518 -------RQV----KKLSEASKANFMHNSTLHQYNQVRNQAKLEMCRE-----LDKMPIG----- 561
                   .||    :....||..|.   |.|.|  .|:....|:.|..     ..|...|
Human   590 GFEVIDGSQVSSGPRGQGTASSGNV---SDLAQ--TVKTFDNLKTCPSCGITFAPKSEAGAEGGA 649

  Fly   562 -RIQLTKVFRRSTRLTQDEI------------------------------EEETFRRNISSCCLF 595
             :.......:.||::|...:                              :||....:.:|.|..
Human   650 PQNGCQDEHKNSTKVTSSWLLFLSVPLLAHPPKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEI 714

  Fly   596 FRIR-NW-------------EFQYIKEP------DVMLKYSIALAWVIY--MGLLTIQLLSKDAR 638
            .:.: .|             .|:.|:|.      ||:.:.|:...:...  :...::..|.::..
Human   715 LQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELE 779

  Fly   639 YHY---------------WYIDGTTIILLTMLLIVSWYKKL----WIMYMSDADVSSPNGRLSGF 684
            ..|               .:...|...||.:.|..:.:..|    ::.|.: |.|..|...|:.|
Human   780 RSYRTSYQEEVIKNSPVKTFASPTFSSLLDVFLSTTVFLTLSTTCFLKYEA-ATVPPPPAALAVF 843

  Fly   685 LFRMSDE-MQRNVVIRVVMYFLIIFS---------------YCAVAIMQVVGCSSDEDYADLDPT 733
            ...:..| :...|.||:|.:...:.:               :|..||:  |...:...|:.:...
Human   844 SAALLLEVLSLAVSIRMVFFLEDVMACTKRLLEWIAGWLPRHCIGAIL--VSLPALAVYSHVTSE 906

  Fly   734 YDERVQCFHPWILTNCMTLVIGMSFL-FTRIPFIIKSCFSALIMIGYAVLVVSEFNFIYAN-SPS 796
            |:..:   |..:.|....|:..:.:. |.::...::|..:.::..|..:|       :|.: .|.
Human   907 YETNI---HFPVFTGSAALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLL-------LYVSLCPD 961

  Fly   797 TNV---------NFNAKYS-------------------------HILLMIITFGIFHLMERQTEF 827
            ::|         ||:::.:                         .:||:::.|     :.|:.|.
Human   962 SSVLTSPLDAVQNFSSERNPCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVWF-----LNREFEV 1021

  Fly   828 IAKVDYN---------WKRQLIKKQEDALITNDTIKVLLTNILPTHVADFYLSNQLQ-NELYYEE 882
            ..::.|:         .|.|.::.|.|         .||.||:|.|||:     ||: ::.|.:.
Human  1022 SYRLHYHGDVEADLHRTKIQSMRDQAD---------WLLRNIIPYHVAE-----QLKVSQTYSKN 1072

  Fly   883 YDNVAVMFASI--------KNFDTDKIGLRVLNEIICDFDDVLNK--YSQSLRVEKIKVANWTYM 937
            :|:..|:||||        :|::..|...|||||:|.|||::|:|  ||.   :||||....|||
Human  1073 HDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSS---IEKIKTIGATYM 1134

  Fly   938 AACGLDVSRSEQVNAPQMKFRNVSLMPNGRRSRYDGARSSNADGVQRVPYGNGSNIALDLDLERG 1002
            ||.||:.::::
Human  1135 AASGLNTAQAQ------------------------------------------------------ 1145

  Fly  1003 QYEGNVITSGPRISSTHNGSSSNEVVRVMAEFALDLMRTMRRFNTENMQTEYEGSTDYGMLRIGI 1067
                             :||...|.::::.|||.::||.:..||...:...::       ||:|.
Human  1146 -----------------DGSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFK-------LRVGF 1186

  Fly  1068 SHGRAMAGVVGISKPHYDIWGNPVNMASRMDSTGVPGQIQVTENTALKLREFNIQCNYRGMTFVK 1132
            :||...|||:|.:|..|||||:.||:|||||:|||..:|||:|.:...|.:.....:|||...||
Human  1187 NHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVK 1251

  Fly  1133 GRGNIPTYIIGIDSEYQFLP 1152
            |:|.:.||:....::::.:|
Human  1252 GKGQMKTYLYPKCTDHRVIP 1271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	55/278 (20%)
		CYCc	254..476	CDD:214485	81/221 (37%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	80/184 (43%)
		CYCc	856..1117	CDD:214485	82/271 (30%)
		Nucleotidyl_cyc_III	878..1142	CDD:299850	82/273 (30%)
ADCY9	XP_005255136.1	DUF2339	<118..>301	CDD:287113	34/205 (17%)
		CYCc	326..544	CDD:214485	81/221 (37%)
		Guanylate_cyc	385..573	CDD:278633	80/187 (43%)
		CYCc	1043..1243	CDD:214485	85/294 (29%)
		Guanylate_cyc	1069..1260	CDD:278633	81/271 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6595
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.760