DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXD and ADCY8

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_001106.1	Gene:	ADCY8 / 114	HGNCID:	239	Length:	1251	Species:	Homo sapiens

Alignment Length:	1201	Identity:	346/1201 - (28%)
Similarity:	546/1201 - (45%)	Gaps:	266/1201 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 NWEWSY-------LVRKCRNLELEDSYDLYM----RRLRVGYLSLFIFIHVAVTVIHTLLLLTTP 87
            |..:||       |....::.:||..|..|.    |:..|....|.:...:.:.|:| |.|.:.|
Human   144 NGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLH-LSLASAP 207

  Fly    88 --EIKYVYVDMVAYMCSGLVIWVVLGVNFRSELVSKHGWVVYA--TSWLAVCVMVL---MDIGLN 145
              .:|.:.:...    :|:.:.:...|..|.:..| |.::.|:  .:|:|:...:|   :..||
Human   208 MDPLKGILLGFF----TGIEVVICALVVVRKDTTS-HTYLQYSGVVTWVAMTTQILAAGLGYGL- 266

  Fly   146 VYHATSHNDILNPIYDAYTLYAIYMFMPVPYLLQPFVLGSAVTFCYIINYSFVITAKDDNQMHSI 210
                  ..|.:.  |..:||:|.|..:|:| |....:.|...:...:| ...||.......::.:
Human   267 ------LGDGIG--YVLFTLFATYSMLPLP-LTWAILAGLGTSLLQVI-LQVVIPRLAVISINQV 321

  Fly   211 LNEAIYLSCVNLLGIFFRLMRDIALRTTFLDRRQYVEENLLLRYARDQERSLLLSILPAQIADRL 275
            :.:|:...|:|..|||...:.|.|.|..||:.|:.||..|.|.....::..|:||:||..:...:
Human   322 VAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEM 386

  Fly   276 QEDVKNRIERSKQQHQQQSQVDLRRSADSQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNYTHLT 340
            ..|:.| :|....|||                       ...::|..:|:|::|:|||..:|:|:
Human   387 INDMTN-VEDEHLQHQ-----------------------FHRIYIHRYENVSILFADVKGFTNLS 427

  Fly   341 TTLDVKKLVEALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNADHAKCCVDLGLRMIKD 405
            |||..::||..|::||.|||..:.|::.||||.||||||||:||..|..|||.|||::||.|||.
Human   428 TTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKT 492

  Fly   406 IRDVREKRHLNIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLS 470
            ||.||.:...::|||||:|||.||.||:|..|||||:||.||||||:||:.|..||:|:|:.||.
Human   493 IRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLD 557

  Fly   471 LLDGEYFFEDGTEKAREDPVLQKHGIRTFLIKSLRAPMHDPRRRMRERQVKKLSEAS-------- 527
            .|:|:|..|:|..|.|.: .|:||.|.|:|||.    ..|....:.|..||:...:|
Human   558 CLNGDYNVEEGHGKERNE-FLRKHNIETYLIKQ----PEDSLLSLPEDIVKESVSSSDRRNSGAT 617

  Fly   528 -----------------KANFMHNSTLHQYNQVRNQAKLEM-----CRELDKMPIGRIQLTKVFR 570
                             |.|.:...|.:..|.:.|.....:     ..|::|    ||:.|...|
Human   618 FTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINK----RIEHTIDLR 678

  Fly   571 RSTRLTQDEIEEETFRRNISSCCLFFRIRNWEFQYIKEPDVMLKYSIALAWVIYMGLLTIQLLSK 635
            ...:|.         |.:|....|.|:..:.|.:|.:..|.:.|.::..|:::.:.:..||.|..
Human   679 SGDKLR---------REHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLP 734

  Fly   636 DARYHYWYIDGTTIILLTMLLIV----SWYKKL---------WI--MYMSDADVSSPNGRLSGFL 685
            .:|.....|..:.:|:|...|::    ..||.|         ||  .|::
Human   735 SSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETYLA--------------- 784

  Fly   686 FRMSDEMQRNVVIRVVMYFLIIFSYCAVAIMQVVGCSSDEDYADLDPTYDERVQ----CFHP--W 744
                    |||:|    :..|:.::.. ||:.::.|..|:.....:.|::....    |.:|  :
Human   785 --------RNVII----FASILINFLG-AILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYF 836

  Fly   745 ILTNCMTLVIGMSFLFTRIPFIIKSCFSALIMIGYAVLVVSEFNFI---YANSPSTNVNF--NAK 804
            :.|..:.:|....||  |:..::|.....:::..||:|..:.:..:   |.|...:..:|  ..:
Human   837 VFTGVLAMVTCAVFL--RLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKE 899

  Fly   805 YSHILLMIITFGIFHLMERQTEFIAKVDYNWKRQLIKKQEDALITNDTIKVLLTNILPTHVADFY 869
            .|.:|:.:....:|: ..:|.|:.|::|:.|:.|..::..:.....:..:.:|.||||:|||..:
Human   900 VSLLLMAMFLLAVFY-HGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHF 963

  Fly   870 LSNQLQN-ELYYEEYDNVAVMFASIKNF-------DTDKIG---LRVLNEIICDFDDVLNKYSQS 923
            |.....| |||.:.||.|.||||||..|       :.:..|   ||:|||||.|||::|.: .:.
Human   964 LEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGE-DRF 1027

  Fly   924 LRVEKIKVANWTYMAACGLDVSRSEQVNAPQMKFRNVSLMPNGRRSRYDGARSSNADGVQRVPYG 988
            ..:||||....||||..||         :|
Human  1028 QDIEKIKTIGSTYMAVSGL---------SP----------------------------------- 1048

  Fly   989 NGSNIALDLDLERGQYE---GNVITSGPRISSTHNGSSSNEVVRVMAEFALDLMRTMRRFNTENM 1050
                       |:.|.|   |::.                    .:|:|:|.|..:::..|..:.
Human  1049 -----------EKQQCEDKWGHLC--------------------ALADFSLALTESIQEINKHSF 1082

  Fly  1051 QTEYEGSTDYGMLRIGISHGRAMAGVVGISKPHYDIWGNPVNMASRMDSTGVPGQIQVTENTALK 1115
             ..:|       ||||||||..:|||:|..||.|||||..||:|||||||||.|:|||.|.|.|.
Human  1083 -NNFE-------LRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLI 1139

  Fly  1116 LREFNIQCNYRGMTFVKG----RGNIPTYII 1142
            |::.....:|||..:|||    .|.|.||.:
Human  1140 LKDQGFAFDYRGEIYVKGISEQEGKIKTYFL 1170

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	60/252 (24%)
		CYCc	254..476	CDD:214485	99/221 (45%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	99/181 (55%)
		CYCc	856..1117	CDD:214485	93/274 (34%)
		Nucleotidyl_cyc_III	878..1142	CDD:299850	93/280 (33%)
ADCY8	NP_001106.1	Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1..182		9/37 (24%)
		Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1..109
		Essential for CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	38..40
		Essential for CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	49..51
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..92
		AC_N	<161..400	CDD:292831	61/256 (24%)
		CYCc	366..564	CDD:214485	99/221 (45%)
		Guanylate_cyc	405..589	CDD:278633	100/184 (54%)
		DUF1053	617..711	CDD:283888	19/106 (18%)
		CYCc	944..1148	CDD:214485	94/287 (33%)
		Guanylate_cyc	973..1172	CDD:278633	93/282 (33%)
		Involved in CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1109..1251		33/62 (53%)
		Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250\|UniProtKB:P40146	1200..1215
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1223..1251
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810