Protein Alignment ACXD and ADCY3

DIOPT Version :9

• Sequence 1: NP_620469.2
• Gene: ACXD / 38284
• FlyBaseID: FBgn0040507
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: XP_011530791.1
• Gene: ADCY3 / 109
• HGNCID: 234
• Length: 1186
• Species: Homo sapiens
• Alignment Length: 1296
• Identity: 344/1296 - (26%)
• Similarity: 547/1296 - (42%)
• Gaps: 366/1296 - (28%)

  Fly    49 LEDSYDLYMRRLR---VGYLSLFIFIHVAVTVIHTLLLLTTPEIKYVYVDMVAYMCSGLVIWVVL 110
            ||:.|..|.:|.|   :..|.:|..:.....|:...::.::.::..:.|..:     |||:.::|
Human    62 LENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLASLAVAGI-----GLVLDIIL 121

  Fly   111 GVNFRSEL----VSKHGWVVYATSWLAVCVMVLMDIGLNVYHATSHNDILNPIYDAYTLYAIYMF 171
            .|..:..|    |::.  |:....||.:...:...:|||...|.:.:|.:.  :..:.:::  .|
Human   122 FVLCKKGLLPDRVTRR--VLPYVLWLLITAQIFSYLGLNFARAHAASDTVG--WQVFFVFS--FF 180

  Fly   172 MPVPYLLQPFVLGSAVTFCYIINYSFVITAKDDNQ--------MHSIL-NEAIYLSCVNLLGIFF 227
            :.:|..|.|.|:.|.|: |.:......:|.....|        :..|| |..:|| |...:||..
Human   181 ITLPLSLSPIVIISVVS-CVVHTLVLGVTVAQQQQEELKGMQLLREILANVFLYL-CAIAVGIMS 243

  Fly   228 RLMRDIALRTTFLDRRQYVEENLLLRYARDQERSLLLSILPAQIADRLQEDVKNRIERSKQQHQQ 292
            ..|.|...|..||:.||.:|..:.|.....|:.:|:|||||..:||.:.:|:|          :.
Human   244 YYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMK----------KD 298

  Fly   293 QSQVDLRRSADSQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNYTHLTTTLDVKKLVEALHDLFV 357
            :||.|              |....|:::..||:|::|:||:|.:|.|::....::||:.|::||.
Human   299 ESQKD--------------QQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFA 349

  Fly   358 RFDIASEEYNVLRIKFLGDCYYCVAGLANPNADHAKCCVDLGLRMIKDIRDVREKRHLNIDMRIG 422
            |||..:.:|:.||||.|||||||:.||.:...|||.|.:.:||.|::.|..||||....:|||:|
Human   350 RFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVG 414

  Fly   423 VHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATG----------------------RVHVS 465
            ||:|.||.||:|..:||:|:||.||.:||::||.|..|                      |||:|
Human   415 VHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGGSKIEERLYSCVVAPTLRLRWERVHIS 479

  Fly   466 QKTLSLLDGEYFFEDGTEKAREDPVLQKHGIRTFLI----------------------------- 501
            |.|:..|.||:..|.|...:|.| .|::.||.|:||
Human   480 QSTMDCLKGEFDVEPGDGGSRCD-YLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASS 543

  Fly   502 ----------KSLRAPMH-----------------------------------------DPRRRM 515
                      |......|                                         :||||:
Human   544 KSSSPALIETKEPNGSAHSSGSTSEKPEEQDAQLFPTTLSHLPHSRCLPGSQADNPSFPNPRRRL 608

  Fly   516 RERQV-KKLSEASKANFMHNSTLHQYNQVRNQAKLEMCRELDKMPIGRIQLTKVFRRSTRL---- 575
            |.:.: .::.:||:..       |:.||:.|:|.||  ||..::    ::....|..|.|.
Human   609 RLQDLADRVVDASEDE-------HELNQLLNEALLE--RESAQV----VKKRNTFLLSMRFMDPE 660

  Fly   576 --TQDEIEEETFRRNISSCCLFFRIRNWEFQYIKEPDVMLKYSIALAWVIYMGLLTIQLLS---- 634
              |:..:|:|.......||.....:.....:.:.:|.:|..|...:...|.:.:|||..|:
Human   661 METRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAIFP 725

  Fly   635 -----KDARYHYWYIDGTTIILLTMLLIVSWYKKLWIMYMSDADVSSPNGRLSGFLFRMSDEMQR 694
                 |...:..| ||.|           .|.:..|.|             |:.|:..|:
Human   726 RAFPKKLVAFSTW-IDRT-----------RWARNTWAM-------------LAIFILVMA----- 760

  Fly   695 NVV--IRVVMYFLIIFSYCAVAIMQVVGCSSDEDYADLDPTYDERVQCFHPWILTNCMTLVIGMS 757
            |||  :..:.|:....:  |.|.|:..|...:      :|.|...|.     :|:...|:::
Human   761 NVVDMLSCLQYYTGPSN--ATAGMETEGSCLE------NPKYYNYVA-----VLSLIATIML--- 809

  Fly   758 FLFTRIPFIIKSCFSALIMIGYAVLVVSEFNFIYANSP------------------------STN 798
               .::..::|  .:.::::..||..::    :||..|                        ..|
Human   810 ---VQVSHMVK--LTLMLLVAGAVATIN----LYAWRPVFDEYDHKRFREHDLPMVALEQMQGFN 865

  Fly   799 VNFN----------AKYSHILLMIITFGIFHLMERQTEFIAKVDYNWKRQLIKKQEDALITNDTI 853
            ...|          :|||..:::.:....|:...|..|.:|:..:.||.::..::|.........
Human   866 PGLNGTDSRLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWN 930

  Fly   854 KVLLTNILPTHVADFYL-SNQLQNELYYEEYDNVAVMFASIKNF----DTDKIG------LRVLN 907
            :.|:||:||.|||..:| |.:...|||.:.||.:.|||||:.||    ..:.|.      ||.||
Human   931 EALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLN 995

  Fly   908 EIICDFDDVLNKYSQSLRV-EKIKVANWTYMAACGLDVSRSEQVNAPQMKFRNVSLMPNGRRSRY 971
            |||.|||.:|:  :...|| .|||....|||||.|:    :..||.
Human   996 EIISDFDSLLD--NPKFRVITKIKTIGSTYMAASGV----TPDVNT------------------- 1035

  Fly   972 DGARSSNADGVQRVPYGNGSNIALDLDLERGQYEGNVITSGPRISSTHNGSSSNEVVRVMAEFAL 1036
            :|..|||.:...              :.||.|:..:                       :|:|||
Human  1036 NGFASSNKEDKS--------------ERERWQHLAD-----------------------LADFAL 1063

  Fly  1037 DLMRTMRRFNTENMQTEYEGSTDYGMLRIGISHGRAMAGVVGISKPHYDIWGNPVNMASRMDSTG 1101
            .:..|:...|.:        |.:..|||||::.|..:|||:|..|||||||||.||:||||:|||
Human  1064 AMKDTLTNINNQ--------SFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTG 1120

  Fly  1102 VPGQIQVTENTALKLREFNIQCNYRGMTFVKGRGNIPTYII-GIDSEYQF-------LPHR 1154
            |.|.|||.|.|.:.|||:..:...||..||||:|.:.|:.: |.|....|       |||:
Human  1121 VMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDKLATFPNGPSVTLPHQ 1181

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	63/250 (25%)
		CYCc	254..476	CDD:214485	92/243 (38%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	87/242 (36%)
		CYCc	856..1117	CDD:214485	96/272 (35%)
		Nucleotidyl_cyc_III	878..1142	CDD:299850	96/274 (35%)
ADCY3	XP_011530791.1	AC_N	<44..303	CDD:292831	65/263 (25%)
		CYCc	273..490	CDD:214485	92/240 (38%)
		Guanylate_cyc	310..516	CDD:278633	87/206 (42%)
		CYCc	925..1143	CDD:214485	99/287 (34%)
		Guanylate_cyc	956..1163	CDD:278633	96/276 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810