DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ACXD and ADCY2

DIOPT Version :9

Sequence 1:NP_620469.2 Gene:ACXD / 38284 FlyBaseID:FBgn0040507 Length:1162 Species:Drosophila melanogaster
Sequence 2:NP_065433.2 Gene:ADCY2 / 108 HGNCID:233 Length:1091 Species:Homo sapiens


Alignment Length:1189 Identity:328/1189 - (27%)
Similarity:526/1189 - (44%) Gaps:281/1189 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 LFIFIHVAVTV-IHTLLLLTTPEIKYVYVDMVAYMC-----------SGLVIWVVLGVNFRSELV 119
            |.:|..:.:.| .|...|:|.|....::..:...:|           ..||||:.|         
Human    62 LAVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSLVIWICL--------- 117

  Fly   120 SKHGWVVYATSWLAVCVMVLMDIGLNVYHATSHNDILNPIYDAYTLYAIYMFMPVPYLLQPF--- 181
                   .|..:|.:|                ....::| :|..:.:...:|  |.|.:.||   
Human   118 -------VAMGYLFMC----------------FGGTVSP-WDQVSFFLFIIF--VVYTMLPFNMR 156

  Fly   182 --VLGSAVT-FCYIINYSFVITAKDDNQMH---SILNEAIYLSCVNLLGIFFRLMRDIALRTTFL 240
              ::.|.:| ..:.|..|..::|....:.|   .||...|...|.||.|.:.:.:.::||:.|:.
Human   157 DAIIASVLTSSSHTIVLSVCLSATPGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQ 221

  Fly   241 DRRQYVEENLLLRYARDQERSLLLSILPAQIADRLQEDVKNRIERSKQQHQQQSQVDLRRSADSQ 305
            |....::..:.|.:.:.|:..||||:|||.||..::.::..|::..|....:.:.          
Human   222 DTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTN---------- 276

  Fly   306 TLKRWRQPDHGTLFIEPHEDVTVLYADVVNYTHLTTTLDVKKLVEALHDLFVRFDIASEEYNVLR 370
                    :...|:::.|.:|::||||:|.:|.|.:.....:||..|::||.:||..::|...:|
Human   277 --------NFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMR 333

  Fly   371 IKFLGDCYYCVAGLANPNADHAKCCVDLGLRMIKDIRDVREKRHLNIDMRIGVHSGDVLSGVIGA 435
            ||.||||||||:||.....:|||.||.:||.|.:.|:.||:...::|:||:|||||:||.||||.
Human   334 IKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGL 398

  Fly   436 AKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLDGEYFFEDGTEKAREDPVLQKHGIRTFL 500
            .|||:|:||.||.:||.:||.|..||||:|..||..|:|.|..|:|....| ||.|::|.::|:.
Human   399 QKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIR-DPYLKQHLVKTYF 462

  Fly   501 IKSLRAPMHDPRRRMRERQVKKLSEASKANFMHNSTLHQYNQVRNQAKLEMCREL---------- 555
            :.:.:.....|:...|.|                   |..:..:.:|.:.|.|.|          
Human   463 VINPKGERRSPQHLFRPR-------------------HTLDGAKMRASVRMTRYLESWGAAKPFA 508

  Fly   556 -----DKMPI--GRIQLTKV------FRRSTRLTQDE---IEEETFRRNISSCCLFFRIRNWEFQ 604
                 |.|..  |:|..|.|      |:..|..|:.:   .|||...|.|.:....    |.:.|
Human   509 HLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNERMIQAIDGI----NAQKQ 569

  Fly   605 YIKEPDVM----------------------LKYSIALAWVIYMGLLTIQLLSKDARYHYWYIDGT 647
            ::|..|:.                      .||.:..|.:|:..:..:|:|............|.
Human   570 WLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGISFGA 634

  Fly   648 TIILLTMLLIVSWYKKL------------WIMYMSDADVSSPNGRLSGFLFRMSDEMQRNVVIRV 700
            ..:||..:|.|.:..:|            |::..|....:.|..|:|..:...:      :::.:
Human   635 AFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTA------IILMM 693

  Fly   701 VMYFLIIFSYCAVAIMQVVGCSSDEDYADLDPTYDERVQ--CFHPWILTNCMTLVIGMSFLFTRI 763
            .::.:...|.....|......::....|..:.....|.|  .|.|:.:.:|:..:|..| :|.|:
Human   694 AVFNMFFLSDSEETIPPTANTTNTSFSASNNQVAILRAQNLFFLPYFIYSCILGLISCS-VFLRV 757

  Fly   764 PFIIKSCFSALIMIGYAVLVVSEFNFIYANSPSTNVNFNAKYSHIL------------LMIITFG 816
            .:.:|.....:.::||..:::           .|:.:....||.:|            :..::..
Human   758 NYELKMLIMMVALVGYNTILL-----------HTHAHVLGDYSQVLFERPGIWKDLKTMGSVSLS 811

  Fly   817 IFHL----MERQTEFIAKVDYNWKRQLIKKQEDALITNDTIKVLLTNILPTHVADFYLSNQLQN- 876
            ||.:    :.||.|:..::|:.||.:..|::|:.....:..:|||.|:||.|||:.:|:..|:| 
Human   812 IFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNE 876

  Fly   877 ELYYEEYDNVAVMFASIKNF-------DTDKIG---LRVLNEIICDFDDVLNKYSQSLRVEKIKV 931
            |||::.||.|.||||||.:|       |.:|.|   ||:|||||.||||:|:|...| .|||||.
Human   877 ELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFS-GVEKIKT 940

  Fly   932 ANWTYMAACGLDVSRSEQVNAPQMKFRNVSLMPNGRRSRYDGARSSNADGVQRVPYGNGSNIALD 996
            ...|||||.||                  |.:|:...|:                          
Human   941 IGSTYMAATGL------------------SAVPSQEHSQ-------------------------- 961

  Fly   997 LDLERGQYEGNVITSGPRISSTHNGSSSNEVVRVMAEFALDLMRTMRRFNTENMQTEYEGSTDYG 1061
             :.|| ||             .|.|:        |.|||..|:..:...|..:.       .|: 
Human   962 -EPER-QY-------------MHIGT--------MVEFAFALVGKLDAINKHSF-------NDF- 995

  Fly  1062 MLRIGISHGRAMAGVVGISKPHYDIWGNPVNMASRMDSTGVPGQIQVTENTALKLREFNIQCNYR 1126
            .||:||:||..:|||:|..||.||||||.||:|||||||||..:|||||.|:|.|:.....|..|
Human   996 KLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCR 1060

  Fly  1127 GMTFVKGRGNIPTYIIGID 1145
            |:..|||:|::.||.:..:
Human  1061 GIINVKGKGDLKTYFVNTE 1079

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACXDNP_620469.2 AC_N <42..284 CDD:292831 52/237 (22%)
CYCc 254..476 CDD:214485 90/221 (41%)
Nucleotidyl_cyc_III 321..503 CDD:299850 86/181 (48%)
CYCc 856..1117 CDD:214485 105/271 (39%)
Nucleotidyl_cyc_III 878..1142 CDD:299850 103/273 (38%)
ADCY2NP_065433.2 AC_N <33..260 CDD:292831 51/232 (22%)
CYCc 236..439 CDD:214485 90/220 (41%)
Guanylate_cyc 281..465 CDD:278633 87/184 (47%)
DUF1053 495..599 CDD:283888 20/107 (19%)
CYCc 848..1056 CDD:214485 107/283 (38%)
Guanylate_cyc 878..1077 CDD:278633 103/274 (38%)
Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769 905..922 9/16 (56%)
Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769 990..993 0/9 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D181177at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45627
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
54.880

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