Protein Alignment ACXD and ADCY1

DIOPT Version :10

• Sequence 1: NP_620469.2
• Gene: ACXD / 38284
• FlyBaseID: FBgn0040507
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: NP_066939.1
• Gene: ADCY1 / 107
• HGNCID: 232
• Length: 1119
• Species: Homo sapiens
• Alignment Length: 1074
• Identity: 301/1074 - (28%)
• Similarity: 476/1074 - (44%)
• Gaps: 256/1074 - (23%)

  Fly   149 ATSHNDILNPIYDAYTLYAIYMFMPVPYLLQPFVLGSAVTFCYIINYSFVITAKDDNQMHSILNE 213
            ||:...:...:...:..||:   :||..|| ....|..|...:::..:.::.||......::...
Human   157 ATAEQGVWQLLLVTFVSYAL---LPVRSLL-AIGFGLVVAASHLLVTATLVPAKRPRLWRTLGAN 217

  Fly   214 AIYLSCVNLLGIFFRLMRDIALRTTFLDRRQYVEENLLLRYARDQERSLLLSILPAQIADRLQED 278
            |:....||:.|:|.|::.:.:.|..||..|..:|:.|.|....:::..||:|:||..:|..::||
Human   218 ALLFVGVNMYGVFVRILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKED 282

  Fly   279 VKNRIERSKQQHQQQSQVDLRRSADSQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNYTHLTTTL 343
            .....||...:                            ::|:.|::|::|:||:|.:|.|.:..
Human   283 FLKPPERIFHK----------------------------IYIQRHDNVSILFADIVGFTGLASQC 319

  Fly   344 DVKKLVEALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNADHAKCCVDLGLRMIKDIRD 408
            ..::||:.|::||.:||..:.|.:..|||.||||||||:||..|..|||.|||::||.||..|..
Human   320 TAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITS 384

  Fly   409 VREKRHLNIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLD 473
            |.|...::::||:|:|:|.||.||:|..|||:|:||.||.:||.:||.|..|:||:::.||:.|:
Human   385 VAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLN 449

  Fly   474 GEYFFEDGTEKAREDPVLQKHGIRTFLIKSLRAPMHDPRRRMRERQVKKLSEASKANFMHNST-- 536
            |:|..|.|....| :..|:.|.|.||.|    .|.|  ||::....:  ||:...|..|...|
Human   450 GDYEVEPGYGHER-NSFLKTHNIETFFI----VPSH--RRKIFPGLI--LSDIKPAKRMKFKTVC 505

  Fly   537 --LHQYNQVRNQAKLEM-------CRELDKMPIGRIQLTKVFRRSTRLTQDEI-EEETFRRNISS 591
              |.|....|...|.|:       |.:.||            ||:.|...::: ...:|..|:..
Human   506 YLLVQLMHCRKMFKAEIPFSNVMTCEDDDK------------RRALRTASEKLRNRSSFSTNVVY 558

  Fly   592 CCLFFRIRNWEFQYIKEPDVMLKYSIALAWVIYMGLLTIQL--LSKDARYH-------------- 640
            .....|:..:..:.::.....|:       :..:...|::.  :.::.:||
Human   559 TTPGTRVNRYISRLLEARQTELE-------MADLNFFTLKYKHVEREQKYHQLQDEYFTSAVVLT 616

  Fly   641 ----------YWYIDGTTIILLTMLLIVSWYKKLWIMYMSDADVSSPNGRLSGFLFRMSDEMQRN 695
                      |..|...::::|.:|:....:....::|:....|....|.|:
Human   617 LILAALFGLVYLLIFPQSVVVLLLLVFCICFLVACVLYLHITRVQCFPGCLT------------- 668

  Fly   696 VVIRVVMYFLIIFSYCAVAIMQVVGC----------------SSDEDYADLDPTYDERVQCFHPW 744
            :.||.|:...|:....:||...||||                ||......| ||..  .:..|..
Human   669 IQIRTVLCIFIVVLIYSVAQGCVVGCLPWAWSSKPNSSLVVLSSGGQRTAL-PTLP--CESTHHA 730

  Fly   745 ILTNCM--TLVIGMSFLFTRIPFIIKSCFSALIMIGYAVLVVSEFNFIYANSPSTNVNFNAKYSH 807
            :|. |:  ||.:.:.|..:.:|.:|  ..|.|......||.:|.:......:.|     ...|..
Human   731 LLC-CLVGTLPLAIFFRVSSLPKMI--LLSGLTTSYILVLELSGYTRTGGGAVS-----GRSYEP 787

  Fly   808 ILLMIITFGIFHLMERQTEFIAKVDYNWKRQLIKKQEDALITNDTIKV----LLTNILPTHVAD- 867
            |:.:::......|..||.:...::||.|..|..:::||.    :.:|:    :|.|:||.|||.
Human   788 IVAILLFSCALALHARQVDIRLRLDYLWAAQAEEEREDM----EKVKLDNRRILFNLLPAHVAQH 848

  Fly   868 FYLSNQLQNELYYEEYDNVAVMFASIKNF-------DTDKIG---LRVLNEIICDFDDVLNK--Y 920
            |.:||....:|||:.|..|.||||||.||       |.:.:|   ||:|||||.|||:::.|  |
Human   849 FLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFY 913

  Fly   921 SQSLRVEKIKVANWTYMAACGLDVSRSEQVNAPQMKFRNVSLMPNGRRSRYDGARSSNADGVQRV 985
            ..   :||||....|||||.||         ||
Human   914 KD---IEKIKTIGSTYMAAVGL---------AP-------------------------------- 934

  Fly   986 PYGNGSNIALDLDLERGQYEGNVITSGPRIS---STHNGSSSNEVVRVMAEFALDLMRTMRRFNT 1047
                                    |||.:..   |:|        :..:|:||:::...:...|
Human   935 ------------------------TSGTKAKKSISSH--------LSTLADFAIEMFDVLDEIN- 966

  Fly  1048 ENMQTEYEGSTDYGMLRIGISHGRAMAGVVGISKPHYDIWGNPVNMASRMDSTGVPGQIQVTENT 1112
                  |:...|: :||:||:.|..:|||:|..:|.||||||.||:|||||||||.|:|||||..
Human   967 ------YQSYNDF-VLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEV 1024

  Fly  1113 ALKLREFNIQCNY----RGMTFVKGRGNIPTYII 1142
            ...||    :|.|    ||...|||:|.:.||.:
Human  1025 HRLLR----RCPYHFVCRGKVSVKGKGEMLTYFL 1054

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:318454	33/134 (25%)
		Nucleotidyl_cyc_III	321..503	CDD:448371	83/181 (46%)
		Nucleotidyl_cyc_III	878..1142	CDD:448371	96/282 (34%)
ADCY1	NP_066939.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28
		AcyC	100..456	CDD:441717	110/330 (33%)
		Guanylate_cyc	294..476	CDD:425528	83/182 (46%)
		Interaction with calmodulin. /evidence=ECO:0000250	493..520		6/26 (23%)
		Guanylate_cyc	859..1056	CDD:425528	96/284 (34%)
		Interaction with calmodulin. /evidence=ECO:0000250	1024..1047		9/26 (35%)