Protein Alignment ACXD and Adcy4

DIOPT Version :9

• Sequence 1: NP_620469.2
• Gene: ACXD / 38284
• FlyBaseID: FBgn0040507
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: NP_001348533.1
• Gene: Adcy4 / 104110
• MGIID: 99674
• Length: 1077
• Species: Mus musculus
• Alignment Length: 1156
• Identity: 309/1156 - (26%)
• Similarity: 499/1156 - (43%)
• Gaps: 293/1156 - (25%)

  Fly   102 SGLVIWVVL-----GVNFRSELVSKHGWVVYATSWLAVCVMVLMDIGLNVYHATSHNDILNPIYD 161
            ||| |||.|     |..|...:||         :|..|...:
Mouse    93 SGL-IWVALLALGYGFLFTGGVVS---------AWDQVSFFL----------------------- 124

  Fly   162 AYTLYAIYMFMPVPYLLQPFVLGSAVTFCYIINYSFVITAKDDNQ---MHSILNEAIYLSCVNLL 223
             :.::.:|..:|:. :......|...:..:::.....:..:.::|   :..:...|:...|.|::
Mouse   125 -FIIFTVYAMLPLG-MRDAAAAGVISSLSHLLVLGLYLGWQPESQRALLPQLAANAVLFLCGNVV 187

  Fly   224 GIFFRLMRDIALRTTFLDRRQYVEENLLLRYARDQERSLLLSILPAQIADRLQEDVKNRIERSKQ 288
            |.:.:.:.:.|||.||.:....:.....|...:..:..||||||||.:|..::.::..|::..::
Mouse   188 GAYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQR 252

  Fly   289 QHQQQSQVDLRRSADSQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNYTHLTTTLDVKKLVEALH 353
            ...:.:.                  :..:|:::.|:.|:|||||:|.:|.|.:....|:||..|:
Mouse   253 SRPENTN------------------NFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLN 299

  Fly   354 DLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNADHAKCCVDLGLRMIKDIRDVREKRHLNID 418
            :||.:||..::|:..:|||.||||||||:||.....|||..||.:||.|.:.||.:|....::|:
Mouse   300 ELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRVATGVDIN 364

  Fly   419 MRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLDGEYFFEDGTE 483
            ||:|||||.||.||||..|||:|:||.||.:||.:||.|..||||::..||:||.|.|..|....
Mouse   365 MRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVERADT 429

  Fly   484 KAREDPVLQKHGIRTFLIKSLRAPMHDPR------------RRMR-----ERQVKKLSEASKANF 531
            :.| ||.|::.|..|:|:...||...|.:            ..||     .|.::....|..  |
Mouse   430 EHR-DPYLRELGEPTYLVIDPRAEEEDEKGTAKGLLSSLEGHTMRPSLLMTRYLESWGAAKP--F 491

  Fly   532 MHNSTLH----------------QYNQVRNQAKLEMCRELDKMPIGRIQLTKVFRRSTRLTQDEI 580
            .|.|.|.                |::..|::....:..|||...      .|.|:...:|...:.
Mouse   492 AHLSHLDSPVSTSTPLPEKAFSPQWSLDRSRTPRGLDDELDTGD------AKFFQVIEQLNSQKQ 550

  Fly   581 EEETFRRNISSCCLFFRIRNWEFQYIKEPDVMLKYSIALAWVIYMGLLTIQLL------------ 633
            .:::  ::.:...|:||.:..|.||........||..|..:::::...|||:|
Mouse   551 WKQS--KDFNLLTLYFREKEMEKQYRLSALPAFKYYAACTFLVFLSNFTIQMLVTTRPPALIITY 613

  Fly   634 -----------------------SKDARYHYW---------------YIDGTTIILLTMLLIVSW 660
                                   .|..:..:|               ...||..|||...:.::
Mouse   614 SITFLLFFLLLFVCFSEHLTKCVQKGPKMLHWLPALSVLVATRPGFRVALGTATILLVFTMAIA- 677

  Fly   661 YKKLWIMYMSDADVSSPNGRLSGFLFRMSDEMQRNVVIRVVMYFLIIFS-YCAVAIMQVVGCSSD 724
             ..|::...||....:.|  :|...|..|.||..::.:..:....|.:| :|.|  :..:.||
Mouse   678 -SLLFLPVSSDCLFLASN--VSSVTFNASWEMPGSLPLISIPLISIPYSMHCCV--LGFLSCS-- 735

  Fly   725 EDYADLDPTYDERVQCFHPWILTNCMTLVIGMSF---LFTRIPFIIKSCFSALIMIGYAVLVVSE 786
                                       |.:.|||   |...:.:::.||  :|.:..:|.|....
Mouse   736 ---------------------------LFLHMSFELKLLLLLLWLVASC--SLFLHSHAWLSDCL 771

  Fly   787 FNFIYANSPSTN---VNFNAKYSHILLMIITFGIFHLMERQTEFIAKVDYNWKRQLIKKQEDALI 848
            ...:| .|||.:   |....|....:...|.|....::.||.|:..::|:.||::|.:::|:...
Mouse   772 IARLY-QSPSDSRPGVLKEPKLMGAIYFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETET 835

  Fly   849 TNDTIKVLLTNILPTHVADFYLSNQLQNE-LYYEEYDNVAVMFASIKNF-------DTDKIG--- 902
            ..:..::||.|:||.|||..::....:|| ||::.|:.|.|:|||:.:|       :.:..|
Mouse   836 MENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLEC 900

  Fly   903 LRVLNEIICDFDDVLNKYSQSLRVEKIKVANWTYMAACGLDVSRSEQVNAPQMKFRNVSLMPNGR 967
            ||:|||||.|||::|:|...| .|||||....|||||.||:.:                   :|:
Mouse   901 LRLLNEIIADFDELLSKPKFS-GVEKIKTIGSTYMAATGLNAT-------------------SGQ 945

  Fly   968 RSRYDGARSSNADGVQRVPYGNGSNIALDLDLERGQYEGNVITSGPRISSTHNGSSSNEVVRVMA 1032
            .::.|..|                                        |.:|.|:        |.
Mouse   946 DTQQDSER----------------------------------------SCSHLGT--------MV 962

  Fly  1033 EFALDL---MRTMRRFNTENMQTEYEGSTDYGMLRIGISHGRAMAGVVGISKPHYDIWGNPVNMA 1094
            |||:.|   :..:.:.:..|.:           ||:|::||..:|||:|..||.||||||.||:|
Mouse   963 EFAVALGSKLGVINKHSFNNFR-----------LRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVA 1016

  Fly  1095 SRMDSTGVPGQIQVTENTALKLREFNIQCNYRGMTFVKGRGNIPTYIIGID 1145
            |||:||||.|:|||||.||..|:.....|..||...|||:|.:.||.:..|
Mouse  1017 SRMESTGVLGKIQVTEETARALQSLGYTCYSRGSIKVKGKGELCTYFLNTD 1067

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	37/189 (20%)
		CYCc	254..476	CDD:214485	90/221 (41%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	88/181 (49%)
		CYCc	856..1117	CDD:214485	92/274 (34%)
		Nucleotidyl_cyc_III	878..1142	CDD:299850	92/276 (33%)
Adcy4	NP_001348533.1	AC_N	<115..246	CDD:318454	26/164 (16%)
		Guanylate_cyc	264..418	CDD:306677	77/153 (50%)
		DUF1053	479..580	CDD:368844	20/110 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	502..524		2/21 (10%)
		Guanylate_cyc	866..1065	CDD:306677	92/277 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.880