DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXD and gucy1b1

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	XP_004911214.1	Gene:	gucy1b1 / 100379900	XenbaseID:	XB-GENE-950986	Length:	618	Species:	Xenopus tropicalis

Alignment Length:	409	Identity:	89/409 - (21%)
Similarity:	176/409 - (43%)	Gaps:	109/409 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 VSKHGWVVYATSWLAVCVMVLMDIGLNVYHATSHNDILNPIYDAYTLYAIYMFMP----VPYLLQ 179
            :|.||.:.:..:   |.|:...:..|:|..:.|.:::.........|....:::|    :.:|..
Frog   263 ISFHGILSHINT---VFVLRSKEGLLDVEKSESEDELTGTEISCLRLKGQMIYLPEADNILFLCS 324

  Fly   180 PFVLGSAVTFCYIINYSFVITAKDDNQMHSILNEAIYLSCVN---------LLGIFFR----LMR 231
            |.|:                      .:..:....:|||.:.         |||..||    |.:
Frog   325 PSVM----------------------NLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQ 367

  Fly   232 DIALRTTFLDRRQYVEENLLLRYARDQER---SLLLSILPAQIADRLQEDVKNRIERSKQQHQQQ 293
            ::.:.|   ||.|:.     ||...|:::   :||.|:||..:|:.|             :|::
Frog   368 ELEILT---DRLQHT-----LRALEDEKKKTDTLLYSVLPPSVANEL-------------RHKR- 410

  Fly   294 SQVDLRRSADSQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNYT-----HLTTTLDVKKLVEALH 353
             .|..:|                      :::||:|::.:|.:.     |.:.. ...|:|..|:
Frog   411 -PVPAKR----------------------YDNVTILFSGIVGFNTFCSKHASGE-GAMKIVNLLN 451

  Fly   354 DLFVRFDIASEEYN---VLRIKFLGDCYYCVAGLANPNADHAKCCVDLGLRMIKDIRDVREKRHL 415
            |::.||||.::..|   |.:::.:||.|..|:|:..|...||:....|.|.|::....|:....
Frog   452 DIYTRFDILTDSRNNPYVYKVETVGDKYMTVSGIPEPCVHHARSICHLALDMMEIAGQVQVDGE- 515

  Fly   416 NIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLL------DG 474
            ::.:.||:|:|:|::||||....::.::...|::.:|.|.||..|:::||:.|...|      |.
Frog   516 SVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDP 580

  Fly   475 EYFFE---DGTEKAREDPV 490
            ::..:   ..:.|.:.||:
Frog   581 QFHLQYRGPVSMKGKTDPM 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	36/184 (20%)
		CYCc	254..476	CDD:214485	58/238 (24%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	50/187 (27%)
		CYCc	856..1117	CDD:214485
		Nucleotidyl_cyc_III	878..1142	CDD:299850
gucy1b1	XP_004911214.1	HNOB	2..166	CDD:377902
		HNOBA	207..406	CDD:369471	35/175 (20%)
		Guanylate_cyc	412..605	CDD:306677	52/212 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910