DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXD and gucy1a2

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	XP_009290254.2	Gene:	gucy1a2 / 100330875	ZFINID:	ZDB-GENE-121023-3	Length:	608	Species:	Danio rerio

Alignment Length:	423	Identity:	105/423 - (24%)
Similarity:	184/423 - (43%)	Gaps:	84/423 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 TFCYIINYSFVI---------------TAKDD-------NQMHSILNEAIYLSCVNLLGIFFRLM 230
            |||....:..|:               .||.|       :....:::..|..|..|:|   .||.
Zfish   197 TFCRAFPFHLVLGSNMEVLQVGEGLRKQAKTDPHRTLTFSNSFELVSPRIPCSFQNIL---LRLS 258

  Fly   231 RDIALRT----TFLDRRQYV-----------EENLLL-----RYARDQE---RSLLLSILPAQIA 272
            ....:||    :.||.|:.|           |.|.::     |..|.:|   |.|.||.:|...|
Zfish   259 TPFTIRTRPDGSSLDCREKVMELKGQMLHLPESNSIMFLGSPRVDRLEELMGRGLHLSDIPIHDA 323

  Fly   273 DR----------LQEDVKNRIERSK---QQHQQQSQVDLRRSAD----------SQTLKRWR-QP 313
            .|          .|:.:|.|:::.|   ::..|..:.:.||:.|          :|.|  |: .|
Zfish   324 TRDVILVGEQAKAQDGLKKRMDKLKATLEKTHQALEEEKRRTVDLLYSIFPGDVAQRL--WQGLP 386

  Fly   314 DHGTLFIEPHEDVTVLYADVVNYTHLTTTLDVKKLVEALHDLFVRFDIASEEYNVLRIKFLGDCY 378
            .....|    :|||:|::|:|.:|.:.......:::..|::|:.|||......:|.:|:.:||.
Zfish   387 VQAKKF----DDVTMLFSDIVGFTAVCAQCTPMQVISMLNELYTRFDYQCGILDVYKIETIGDA- 446

  Fly   379 YCVAGLANPNAD-HAKCCVDLGLRMIKDIRDVREKRHLNIDMRIGVHSGDVLSGVIGAAKWQFDI 442
            |||||..:...| |||....:.|:|::...:|.......|.:|||:|||.||:||:|....::.:
Zfish   447 YCVAGGLHRKIDSHAKPIALMALKMMELSEEVLTPDGKPIKLRIGIHSGSVLAGVVGVMMPRYCL 511

  Fly   443 WSKDVDIANRLEATGATGRVHVSQKTLSLL--DGEYFFEDGTEKAREDPVLQK-HGIRTFLIKSL 504
            :..:|.:|::.|:......::||..|..||  |..:.|...:.:...|...:: .||..|| ::.
Zfish   512 FGNNVTLASKFESGSHPRCINVSPTTYQLLRDDRSFTFIPRSRQELPDNFPKEIPGICYFL-EAG 575

  Fly   505 RAPMHDPRRRMRERQVKKLSEASKANFMHNSTL 537
            ::..|......|...::|:|......|:..::|
Zfish   576 KSQSHASLTSTRSAPIRKVSYNIGTMFLRETSL 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	34/150 (23%)
		CYCc	254..476	CDD:214485	71/251 (28%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	55/185 (30%)
		CYCc	856..1117	CDD:214485
		Nucleotidyl_cyc_III	878..1142	CDD:299850
gucy1a2	XP_009290254.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900