Protein Alignment ACXD and adcy9

DIOPT Version :10

• Sequence 1: NP_620469.2
• Gene: ACXD / 38284
• FlyBaseID: FBgn0040507
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: XP_031748711.1
• Gene: adcy9 / 100126441
• XenbaseID: XB-GENE-999257
• Length: 1369
• Species: Xenopus tropicalis
• Alignment Length: 1328
• Identity: 299/1328 - (22%)
• Similarity: 504/1328 - (37%)
• Gaps: 414/1328 - (31%)

  Fly    46 NLE---LEDSYDLYMRRLRVG--YL-------SLFIFIHVAVTVIHTL------LLLTTPEIKYV 92
            |||   :|..:....||.|..  ||       |::..:|:...::..|      |::......:.
 Frog   151 NLEEACVERCFPQTQRRFRYALMYLSVAGLLWSIYFSVHMKSKLVSHLAPTLCFLIVCLGFFSFT 215

  Fly    93 YVDMVAYMCSGLVIWVVLGVNFRSELVSKHGWVVYATSWLAVCVMVLMD-------IGLNVYHAT 150
            :....|..|:.:.:.|.|              :|:|.: ||....||..       :.|....||
 Frog   216 FTKSYARHCTAISLLVTL--------------LVFALT-LASQFQVLSPGLVSDSLLNLTSSTAT 265

  Fly   151 SHNDILNPIYD----AYTLYAIYMFMPVPYLLQPFVLGSAVTFCY-IINYSFVITAKDD------ 204
            ..:..|:.:..    ...|..:|..|.:|..|.. .||.|.:..: ...|.|    :|:
 Frog   266 DFSSCLSQVGSFSICVEVLLLLYTVMHLPLYLSA-CLGVAYSILFETFGYHF----RDERCFGPL 325

  Fly   205 --NQMH-SILNEAIYLSCVNLLGIFFRLMRDIALRTTFLDRRQYVEENLLLRYARDQERSLLLSI 266
              ...| .:|::|:...|::.:|:...:|.::..|:|||...|.:.....|...:..:..::.|:
 Frog   326 VGRMAHWELLSKALLHICIHAIGVHLFIMSEVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSV 390

  Fly   267 LPAQIADRLQEDVKNRIERSKQQHQQQSQVDLRRSADSQTLKRWRQPDHGTLFIEPH-----EDV 326
            :|..|||.|.:...:..|.|.::|...|....::.:..|     :.|    :...|.     |.|
 Frog   391 MPRIIADDLMKQGDDESENSVKRHSASSPKSRKKKSSIQ-----KTP----IIFRPFKMQRIEQV 446

  Fly   327 TVLYADVVNYTHLTTTLDVKKLVEALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNADH 391
            ::|:||:|.:|.::.......||..|:|||.|||...||....:|..||||||||||...|..||
 Frog   447 SILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRPDH 511

  Fly   392 AKCCVDLGLRMIKDIRDVREKRHLNIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEAT 456
            |.||:::||.||:.|....:::...::||:|||:|.||.|::|..:::||:||.||::||.:|..
 Frog   512 AYCCIEMGLGMIEAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQL 576

  Fly   457 GATGRVHVSQKTLSLLDGEYFFEDGTEKAREDPVL---QKHGIRTFLIKSLR------------- 505
            |..|:||:|:||...||..|..||.....|...::   |..|::||||...|
 Frog   577 GVAGKVHISEKTARYLDDRYLMEDSMVVERLGQIVAADQLKGLKTFLISGRRPRVPSCSCSQTLL 641

  Fly   506 -------------------APMH-----DPRRRMRERQV-------------------------- 520
                               ||..     ||.....:.::
 Frog   642 PIQEGADLSSPALAPHGQTAPSETSAASDPLPNCTQPEILKSCPSCGETAARDGPEEGVSTANGG 706

  Fly   521 ----------------------KKLSEASKANFMHNSTLHQYNQVRNQAK--------------- 548
                                  ::..|.|..:.:.||....|:.::.:.:
 Frog   707 GSEEWKGGATRPPSIAXSLKDPERSPEPSSEDTLTNSQASLYDMLQEKGRWCGVSMDQSALLPLR 771

  Fly   549 ------------LEMCRE-------LDKMPIGRIQLTKVFRRSTRLTQDEIEEETFR----RNIS 590
                        :|:.:|       ..|.||..:.|..:.:......:...:||..|    :..:
 Frog   772 FKNIREKTDAHFVEVIKEDSLMKDYFFKPPINPLSLNFLDKELETSYRGSYQEEVLRMAPVKTFA 836

  Fly   591 SC----------CLFFRIRNWEFQYIKE-PDVMLKYSIALAWVIYMGLLTIQLLSKDARYHYWYI 644
            |.          |.|..|......::|. .|.:...::||..:...|||....|....|..: |:
 Frog   837 SAKFSSLLDVLLCFFIFILLSVACFLKPGTDPVSPPTLALVLLSVCGLLGFLSLLVSVRMTF-YL 900

  Fly   645 DGTTIILLTMLLIVS-WYKKLWIMYMSDADVSSPNGRLSGFLFRMSDEMQRNVVIRVVMYFLIIF 708
            :...:....:|.|:| |..:.:|                             ..:.|.:...::|
 Frog   901 EDMLLCTRRLLEIISGWLPRHFI-----------------------------GTVLVCLPAAVVF 936

  Fly   709 SYCAVAIMQVVGCSSDEDYADLDPTYDERVQCFHPWILTNCMTLVIGM----------SFLFTRI 763
            ||.           |.:.|.::..|            :..|..|:|.|          |:|.:.:
 Frog   937 SYL-----------SSDFYTNIHYT------------MFLCSALLIPMVQYCNFCQLSSWLRSSL 978

  Fly   764 PFIIKSCFSALIMIGYAVLVVSEFNF-----IYANSPSTNVNFNAK-----------------YS 806
            ..|..:....|:   |..|...:...     |..|..::|.:|.|:                 .:
 Frog   979 ATIAGATMLTLL---YLPLCPEKLRLAPETDIEGNMSTSNSSFEAEDNARTEFPFTLLGQEIAVA 1040

  Fly   807 HILLMIITFGIFHLMERQTEFIAKVDYN---------WKRQLIKKQEDALITNDTIKVLLTNILP 862
            :.||:::.:    .:.|:.|...::.|:         .|.|.::.|.|         .||.||:|
 Frog  1041 YFLLLLLVW----FLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQAD---------WLLRNIIP 1092

  Fly   863 THVADFYLSNQLQ-NELYYEEYDNVAVMFASI--------KNFDTDKIGLRVLNEIICDFDDVLN 918
            .|||:     ||: ::.|.:.:|:..|:||||        :|::..|...|||||:|.|||::|:
 Frog  1093 YHVAE-----QLKVSQSYSKNHDDAGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLS 1152

  Fly   919 KYSQSLRVEKIKVANWTYMAACGLDVSRSEQVNAPQMKFRNVSLMPNGRRSRYDGARSSNADGVQ 983
            |...|. :||||....|||||.||:.|:.:..:.|
 Frog  1153 KPHYSC-IEKIKTIGATYMAASGLNPSQCQDSSQP------------------------------ 1186

  Fly   984 RVPYGNGSNIALDLDLERGQYEGNVITSGPRISSTHNGSSSNEVVRVMAEFALDLMRTMRRFNTE 1048
                                                     :..::.:.|||.::|..:..||..
 Frog  1187 -----------------------------------------HRHLQTLFEFAKEMMSVVDDFNNN 1210

  Fly  1049 NMQTEYEGSTDYGMLRIGISHGRAMAGVVGISKPHYDIWGNPVNMASRMDSTGVPGQIQVTENTA 1113
            .:...::       ||||.:||...|||:|.:|..|||||:.||:|||||:|||..:||.:|.:.
 Frog  1211 MLWFNFK-------LRIGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQASEESY 1268

  Fly  1114 LKLREFNIQCNYRGMTFVKGRGNIPTYI 1141
            ..|.:.....:|||...|||:|.:.||:
 Frog  1269 RVLVKMGYDFDYRGTVNVKGKGQMKTYL 1296

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:318454	56/276 (20%)
		Nucleotidyl_cyc_III	321..503	CDD:448371	79/189 (42%)
		Nucleotidyl_cyc_III	878..1142	CDD:448371	79/272 (29%)
adcy9	XP_031748711.1	AcyC	226..631	CDD:441717	127/433 (29%)
		Guanylate_cyc	438..626	CDD:425528	78/187 (42%)
		Guanylate_cyc	1105..1297	CDD:425528	79/271 (29%)