DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oseg2 and Ift172

DIOPT Version :9

Sequence 1:	NP_647700.2	Gene:	Oseg2 / 38282	FlyBaseID:	FBgn0035317	Length:	1754	Species:	Drosophila melanogaster
Sequence 2:	NP_080574.5	Gene:	Ift172 / 67661	MGIID:	2682064	Length:	1749	Species:	Mus musculus

Alignment Length:	1761	Identity:	829/1761 - (47%)
Similarity:	1198/1761 - (68%)	Gaps:	36/1761 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQLKYLRTLLEGQEQIQRIAGLAWSPNQQRLAIATADRHILLYDDAGERRDKFSTKPANPANGKN 65
            ||||:|||||..|:...::..:|||.|..:.|:.|.||.:||||:.||||||||||||:...|:.
Mouse     1 MQLKHLRTLLSPQDGAAKVTCMAWSQNNAKFAVCTVDRVVLLYDEHGERRDKFSTKPADMKYGRK 65

  Fly    66 SYVIRGLAFSPDSTKLAVGQSDSIVYVYKLGESWNDKKVICNKFPQASAVTALIWLTSGSIIAGL 130
            ||:::|:||||||||:|:||:|:|:||||:||.|.|||||||||.|.||||.|.|.....|:.||
Mouse    66 SYMVKGMAFSPDSTKIAIGQTDNIIYVYKIGEDWGDKKVICNKFIQTSAVTCLQWPAEYVIVFGL 130

  Fly   131 EDGKVRALHSKSNKSQSLYGGDSICISLAANTKGTGFLSGHNDGTIIRYFMTDEAT-EPLGRVVQ 194
            .:||||..::|:|||.::||.:|..::|..|..|.|.||||.||||:|||..||.: |..|::|.
Mouse   131 AEGKVRLANTKTNKSSTIYGTESYVVALTTNCSGKGILSGHADGTIVRYFFDDEGSGESQGKLVN 195

  Fly   195 HPVPPFALAWPQGGFCAGGCDQRIVFYDSMGRQLRTFDHSRTEGEREFTVAACSPNGQAVAFGSF 259
            ||.||:||||......|.|||:|||.|...|..|:|||:||...|||||.||.||.||:|..||:
Mouse   196 HPCPPYALAWATNSIVAAGCDRRIVAYGKEGHVLQTFDYSRDPQEREFTTAAASPGGQSVVLGSY 260

  Fly   260 DRIRIFAWSPRQGAWSESATKEVACLYTLSSLLWRRDGARLALGSVSGAVLLFESVLRRTVWQDK 324
            ||:|:|.||||:..|.|:..||:|.|||:::|.|:|||:||..|::.|.|..|:..|||:::::|
Mouse   261 DRLRVFNWSPRRSIWEEAKPKEIANLYTVTALAWKRDGSRLCAGTLCGGVEQFDCCLRRSIYKNK 325

  Fly   325 FELIFVAPSQLLVRSLTEPSQALTIESQLGLEIDDVRIMGRDNYLVARTEESLILCDLTRNLSSE 389
            |||.:|.|||::|::|:..:: :.::|..|.|:::|:|:|::.||||.|.::|:|.||..|..||
Mouse   326 FELTYVGPSQVIVKNLSSGTR-VVLKSHYGYEVEEVKILGKERYLVAHTSDTLLLGDLNTNRLSE 389

  Fly   390 VPWTASGHHERFYFENPTVCLIFNVGELSLVEYGENSILGSVRTEFVNPHVISVRLNER--GNAK 452
            :.|..||.:|:::|||..||:|||.|||:|||||.|..||||||||:|||:||||:|||  ...:
Mouse   390 IAWQGSGGNEKYFFENENVCMIFNAGELTLVEYGSNDSLGSVRTEFMNPHLISVRINERCQRGME 454

  Fly   453 ENKKLAFLLDAKTICVVDLISRMTSGQISHETKIDWLELSETAHKLLFRDKKLRLILVDNYTGKK 517
            :|||||:|:|.|||.:||||.....|.||||:::|||||:||.|||||||:||||.|.|..:..|
Mouse   455 DNKKLAYLVDIKTIAIVDLIGGYNIGTISHESRVDWLELNETGHKLLFRDRKLRLHLYDIESCSK 519

  Fly   518 QTLLSNISFVQWVPQSDVVVAQSNSNLAIWYNIDLPEHVTMQSVRGEAIEVLRENGRTVVRSQDG 582
            ..:|:..|:|||||.|||:|||:.::|.:||||:.||.|||.|:||:.:.:.|..|:|.|...:|
Mouse   520 TMILNFCSYVQWVPGSDVLVAQNRNSLCVWYNIEAPERVTMSSIRGDVVGLERGGGKTEVMVTEG 584

  Fly   583 PSEHNYQLDEGLVEFGTAVNDSDFGRAVHFLESLGDKPAAKAMWHNLALIALEDGNLRVAQRCYA 647
            .:...|.|||||:|||||::|.::.||..|||:|...|..:|||..|:.:|||...|..|:||::
Mouse   585 VTTVAYTLDEGLIEFGTAIDDGNYTRATAFLETLEMTPETEAMWKTLSKLALEARQLHTAERCFS 649

  Fly   648 ALGNVSKAYYLAGMIQQADEFEESSGSPGILCPEVRAKLALLGSDLRTAERIYLEQGDIESALKM 712
            |||:|:||.:|....:.||:.....|..|....:|||:||:|..:.:.||.|:|||..:|.|:.|
Mouse   650 ALGHVAKARFLHETNEIADQVSREYGGEGTDFYQVRARLAMLEKNYKLAEMIFLEQNAVEEAMDM 714

  Fly   713 YQQLGMWDEAVALAERRGYNRIAELKQQHMDYLLSSEQQEKAGQVLEEQGDLQQAMSLYMKANKP 777
            ||:|..|:|.:|:||.:|:..:.:|::.:..:|:.::|:|:||::.|.|||...|:|||:||..|
Mouse   715 YQELHRWEECIAVAEAKGHPALEKLRRDYYQWLMDTQQEERAGELQESQGDGLAAISLYLKAGLP 779

  Fly   778 ARAARLALKTPHILQDEQVMLQVTEGLVRSELYELAGDIAHRLSRPEAALALYRKGGAYARALEI 842
            |:||||.|....:|.:.:::..:|..|::.||||.|||:..::..|:.||..|.||.|:.:|:|:
Mouse   780 AKAARLVLTREELLANTELVEHITTALIKGELYERAGDLFEKIRNPQRALECYCKGNAFMKAVEL 844

  Fly   843 GRVVAPQEVTALEEEWGDWLVSRKQLDASINHYIEAGATQKALEAAVGAKQWRKAVQIAKVLDEP 907
            .|:..|.||..|||.|||.||.:|||||:|||||||..:.||:|||:||:||:||:.|..:.|.
Mouse   845 ARLAFPVEVVRLEEAWGDHLVQQKQLDAAINHYIEARCSIKAIEAALGARQWKKAIYILDLQDR- 908

  Fly   908 ELIQRYAVDLAKHLAFAGDLDGAEDMLVRANLHKDAIELLNRHGKWERAYLIGEKHLKAEQVREL 972
            ....:|...:|:|.|...:.:.||::..:.:..||||::..:.|:||:|:.:..|.::.|.|..|
Mouse   909 NTASKYYPRVAQHYASLQEYEIAEELYTKGDRTKDAIDMYTQAGRWEQAHKLAMKCMRPEDVSVL 973

  Fly   973 FVQLAGTLEEQGKFRDAEKVLIAVNEPDLAIAMYKRRELYDSMIRLVERYHKDLLDSTHLHLARQ 1037
            ::..|..:|:|||:|:||::.:.|.||||||.|:|:.:|||.|||||.::|.|||..|||||.::
Mouse   974 YITQAQEMEKQGKYREAERLYVTVEEPDLAITMFKKHKLYDDMIRLVGKHHPDLLSDTHLHLGKE 1038

  Fly  1038 LESRGKLKNAEMHFVASGDWKSAVHMYCSSGRWEDGYRVAKLKGTEGASQQVAYMWAKSMPTEGA 1102
            ||:.|:|:.||.|::.:.:||:.|:||.|||.||:.|||||..|...|.:.|||:||||:..|.|
Mouse  1039 LEAEGRLQEAEYHYLEAQEWKATVNMYRSSGLWEEAYRVAKAHGGANAHKHVAYLWAKSLGGEAA 1103

  Fly  1103 VRLLSKLGLLDTAVGFACDSGQFEFAMELCKFAGK-PTDEVHLKIAMSLEDEGKFEAAEAEFLKA 1166
            ||||:|||||:..:..|.|:..||||.||.:.|.| ...|:|||.||.||||||||.|||||::|
Mouse  1104 VRLLNKLGLLEATIDHAADNCSFEFAFELSRLAFKHKAPEIHLKYAMYLEDEGKFEEAEAEFIRA 1168

  Fly  1167 NKPREAILMYQHAGDWQAALNVAENHLPDAVGEVLIGQASAALETSNYKDYEALLLRAHRPDLII 1231
            .||:||:||:.|..||:||..|||.|.||:|.|||:|||..|||..:::..|.|||||.||.|.:
Mouse  1169 GKPKEAVLMFVHNQDWEAAQRVAEAHDPDSVAEVLVGQARGALEEKDFQKAEGLLLRAQRPGLAL 1233

  Fly  1232 EHYKQESLYEDALRIAEEHYPSALNDLRRLQAQLQRGQAQAQAGEDAASISRSYLQKAAEFAKKE 1296
            .:||:..|:.|||||.:::.|   ..|..||.:.:| :|..:.|.....:    :::|.::.:..
Mouse  1234 NYYKEAGLWSDALRICKDYVP---GQLEALQEEYER-EATKKGGRGVEGL----VEQARQWEQAG 1290

  Fly  1297 QFRKAAECLMQIDSSNAEDASTLERALLRAAEICNQFLEGQDAQELAQSLGPRLLAIKQIGPAAQ 1361
            ::.:|.:|.:::..|.:  :..:|:..::|||:..:||..|.:.|:.:.:||:|:.|.:...||:
Mouse  1291 EYSRAVDCYLKVRDSGS--SGLMEKCWMKAAELSIKFLPPQRSLEVVRVVGPQLIGIGKHSAAAE 1353

  Fly  1362 LYLAADMPKQAVDVFIKTEQWSKARRLAKEIDPDLQLLAYVEQQQKASLKHEGNIEQLADIDIVS 1426
            |||..|:.|:|:|.||:.|:|:||:|:|||:||..:  .||:|..|..||::|.::.|..:|:|:
Mouse  1354 LYLNLDLVKEAIDAFIEGEEWNKAKRVAKELDPRYE--DYVDQHYKEFLKNQGKVDSLVGVDVVA 1416

  Fly  1427 ALDLLAEHGEWQRCLEKAKGLNPALLQKYVAVYAAQLIREGNCTTALGLYLSYGAPPIEAHFNIY 1491
            ||||..|.|:|.:|:|.|...|..:|.||||:||..|||||....||.||:.:|||....:||||
Mouse  1417 ALDLYVEQGQWDKCIETATKQNYKILHKYVALYATHLIREGGYAQALALYVQHGAPANPQNFNIY 1481

  Fly  1492 TRIALDCLAL-REEQTERGTTWRQLRDFLFRLLQSL-KATPAQSQTKFAASMEQF---LLIAHYY 1551
            .||..|.::. .....|...:|..|||.||.|.::| |::.|.|     |:.|:|   |||:|||
Mouse  1482 KRIFTDMVSSPGTNNAEAYHSWADLRDVLFNLCENLVKSSEANS-----AAHEEFEMMLLISHYY 1541

  Fly  1552 ATRAACKEVQALQPVALRLSLALLRHTDLLPVDKGFYEAGMDLRQAGREAEAFVMLNHYLDVCEA 1616
            |||:|.:.::.|:.||.|||::|||||.|||.||.|||||...::.|.|..||:.||.:||:.:|
Mouse  1542 ATRSAAQSIKQLETVAARLSVSLLRHTQLLPADKAFYEAGTAAKEVGWENMAFIFLNRFLDLTDA 1606

  Fly  1617 IEEGSGQLVDHSDLASTDFPSSVPLPEDIHLKNDPSLHEEVREWVLAVSMDQQVDQQLPTDDRGL 1681
            ||||:...:||||...||.|..||||...|:..  :..||||:|||.|||||:::|.||.|:||:
Mouse  1607 IEEGTLDALDHSDFQDTDIPFEVPLPAKQHVPE--AQREEVRDWVLTVSMDQRLEQVLPRDERGV 1669

  Fly  1682 YESSL-----GPNDLPCMLSGFPVRGRQPVTFQGSSNQVNRDVWSKFSVALKMSPGSGIADIISF 1741
            ||:||     |...|||:::|:|:. |..:.|:......|:|.|:||.:|:|.|......|::.|
Mouse  1670 YEASLVAASTGVRALPCLITGYPIL-RNKIEFKRPGKAANKDNWNKFLMAIKTSHSPVCQDVLKF 1733

  Fly  1742 TEKWQG 1747
            ..:|.|
Mouse  1734 ISQWCG 1739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oseg2	NP_647700.2	WD40	18..313	CDD:295369	161/295 (55%)
		WD40	19..>325	CDD:225201	165/306 (54%)
		WD40 repeat	19..63	CDD:293791	24/43 (56%)
		WD40 repeat	70..106	CDD:293791	25/35 (71%)
		WD40 repeat	115..150	CDD:293791	15/34 (44%)
		WD40 repeat	156..194	CDD:293791	19/38 (50%)
		WD40 repeat	199..232	CDD:293791	16/32 (50%)
		WD40 repeat	244..281	CDD:293791	19/36 (53%)
		WD40 repeat	288..312	CDD:293791	10/23 (43%)
		PRK12798	<1212..1393	CDD:237211	59/180 (33%)
Ift172	NP_080574.5	WD 1	14..53		17/38 (45%)
		WD40	17..388	CDD:225201	191/371 (51%)
		WD40	17..318	CDD:295369	162/300 (54%)
		WD40 repeat	20..64	CDD:293791	24/43 (56%)
		WD 2	64..103		24/38 (63%)
		WD40 repeat	69..110	CDD:293791	29/40 (73%)
		WD 3	110..148		18/37 (49%)
		WD40 repeat	116..148	CDD:293791	14/31 (45%)
		WD 4	150..191		20/40 (50%)
		WD40 repeat	155..194	CDD:293791	19/38 (50%)
		WD 5	195..233		19/37 (51%)
		WD40 repeat	200..248	CDD:293791	26/47 (55%)
		WD 6	238..278		23/39 (59%)
		WD 7	284..323		18/38 (47%)
		WD 8	483..520		23/36 (64%)
		WD 9	521..559		20/37 (54%)
		TPR 1	593..624		17/30 (57%)
		TPR 2	692..725		14/32 (44%)
		TPR 3	809..842		14/32 (44%)
		SNAP	810..>994	CDD:305195	79/184 (43%)
		TPR repeat	810..866	CDD:276937	27/55 (49%)
		TPR 4	854..887		21/32 (66%)
		TPR repeat	870..906	CDD:276937	22/35 (63%)
		TPR repeat	909..954	CDD:276937	11/44 (25%)
		TPR 5	912..945		8/32 (25%)
		TPR 6	947..970		6/22 (27%)
		TPR 7	971..1004		14/32 (44%)
		TPR 8	1042..1075		15/32 (47%)
		TPR 9	1142..1175		23/32 (72%)
		TPR 10	1276..1309		4/38 (11%)
		TPR 11	1345..1378		15/32 (47%)
		TPR 12	1411..1445		14/33 (42%)
		TPR 13	1447..1477		15/29 (52%)
		TPR 14	1574..1607		15/32 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837273
Domainoid	1	1.000	1546	1.000	Domainoid score	I5
eggNOG	1	0.900	-	-		E1_KOG3616
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15202
Inparanoid	1	1.050	1629	1.000	Inparanoid score	I82
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56342
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006527
OrthoInspector	1	1.000	-	-		oto94903
orthoMCL	1	0.900	-	-		OOG6_104287
Panther	1	1.100	-	-	LDO	PTHR15722
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2702
SonicParanoid	1	1.000	-	-		X5503
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790