DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oseg2 and ift172

DIOPT Version :9

Sequence 1:	NP_647700.2	Gene:	Oseg2 / 38282	FlyBaseID:	FBgn0035317	Length:	1754	Species:	Drosophila melanogaster
Sequence 2:	NP_001002312.1	Gene:	ift172 / 432389	ZFINID:	ZDB-GENE-040827-1	Length:	1745	Species:	Danio rerio

Alignment Length:	1769	Identity:	806/1769 - (45%)
Similarity:	1196/1769 - (67%)	Gaps:	39/1769 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQLKYLRTLLEGQEQIQRIAGLAWSPNQQRLAIATADRHILLYDDAGERRDKFSTKPANPANGKN 65
            |||||::|||..|:...::..:||:||..:.|:.|.||.::|||:.||:||:|:||||:|..||.
Zfish     1 MQLKYMKTLLTPQDGAAKVTCMAWAPNNAKFAVCTIDRVVILYDEQGEKRDRFTTKPADPKYGKK 65

  Fly    66 SYVIRGLAFSPDSTKLAVGQSDSIVYVYKLGESWNDKKVICNKFPQASAVTALIWLTSGSIIAGL 130
            :||::.:||||||||:||.|:|:|::|||:||.|.|||||||||.|.||||:|:|.:..:||.||
Zfish    66 TYVVKSMAFSPDSTKIAVAQTDNIIFVYKIGEEWGDKKVICNKFIQTSAVTSLVWPSEHAIIFGL 130

  Fly   131 EDGKVRALHSKSNKSQSLYGGDSICISLAANTKGTGFLSGHNDGTIIRYFMTDEAT-EPLGRVVQ 194
            .:||||..::|::||.::||.||..:||.:|..|.|.||||.|||::|||:.||.: |..|:::.
Zfish   131 AEGKVRQANTKTSKSSTIYGTDSYVVSLTSNVSGKGILSGHADGTVVRYFIDDEGSGESQGKLLT 195

  Fly   195 HPVPPFALAWPQGGFCAGGCDQRIVFYDSMGRQLRTFDHSRTEGEREFTVAACSPNGQAVAFGSF 259
            |..||:||||........|||::||.|...|..::|||:||...|:||||||.||:||::..|||
Zfish   196 HACPPYALAWGTNSIIVAGCDKKIVAYGKEGNVIQTFDYSRDRAEKEFTVAASSPSGQSIVVGSF 260

  Fly   260 DRIRIFAWSPRQGAWSESATKEVACLYTLSSLLWRRDGARLALGSVSGAVLLFESVLRRTVWQDK 324
            ||:|:|.||||:|.|.||:.||:..|||:::|.|::||:||::|::.|.|.:|:..|||:::::|
Zfish   261 DRLRVFNWSPRKGTWDESSPKEIPNLYTITALSWKKDGSRLSVGTLCGGVEMFDCCLRRSIYKNK 325

  Fly   325 FELIFVAPSQLLVRSLTEPSQALTIESQLGLEIDDVRIMGRDNYLVARTEESLILCDLTRNLSSE 389
            ||:.:|..||::||:|:..:: :.::||.|.|||:|::||:|.||||.|.::|:|.||..|..||
Zfish   326 FEMTYVGLSQVIVRNLSTGTR-VVLKSQYGYEIDEVKVMGKDQYLVAHTSDTLLLGDLVSNKLSE 389

  Fly   390 VPWTASGHHERFYFENPTVCLIFNVGELSLVEYGENSILGSVRTEFVNPHVISVRLNER--GNAK 452
            |.|..||.:|:|:|||.|||:|||.|||:|||||.|.|||||||||:|||:||||||||  ...:
Zfish   390 VAWQGSGGNEKFFFENETVCMIFNAGELALVEYGSNDILGSVRTEFINPHLISVRLNERRQRGVE 454

  Fly   453 ENKKLAFLLDAKTICVVDLISRMTSGQISHETKIDWLELSETAHKLLFRDKKLRLILVDNYTGKK 517
            :|||||:|:|.|||.:|||:.....|.|||::|||||||:||..|||||||||||.|.|..:..|
Zfish   455 DNKKLAYLIDIKTIAIVDLVGGYNLGTISHDSKIDWLELNETGRKLLFRDKKLRLHLYDIESSVK 519

  Fly   518 QTLLSNISFVQWVPQSDVVVAQSNSNLAIWYNIDLPEHVTMQSVRGEAIEVLRENGRTVVRSQDG 582
            .|:||...:|||||.|||||||:..||.:||.||.||.|||..::|:.:::.|.||:|.|...:|
Zfish   520 STMLSFCPYVQWVPGSDVVVAQNRGNLCVWYTIDSPERVTMFPLKGDIVDLERSNGKTEVIVNEG 584

  Fly   583 PSEHNYQLDEGLVEFGTAVNDSDFGRAVHFLESLGDKPAAKAMWHNLALIALEDGNLRVAQRCYA 647
            .:..:|.|||||:|||||::|.|:.||..|||:|......:|||..|:.::||...|.:|:||:|
Zfish   585 VNSISYTLDEGLIEFGTAIDDGDYYRATAFLETLEMSAETEAMWKTLSKLSLEAQQLHIAERCFA 649

  Fly   648 ALGNVSKAYYLAGMIQQADEFEESSGSPGILCPEVRAKLALLGSDLRTAERIYLEQGDIESALKM 712
            |||:||||.:|....:.||...:.....|....:|:|:||:|..:.:.||..|:||..::..::|
Zfish   650 ALGDVSKARFLNETNKIADAVAKEYDGDGTDHYQVKARLAMLDKNFKLAEMYYMEQNAVDEVMEM 714

  Fly   713 YQQLGMWDEAVALAERRGYNRIAELKQQHMDYLLSSEQQEKAGQVLEEQGDLQQAMSLYMKANKP 777
            ||:|.||||.:|:||.:|:..:..|::.:..||:.:.|.|||.:|.|.:||...|::||:||..|
Zfish   715 YQELHMWDECIAVAEGKGHPELDNLRRSYYSYLMETNQNEKAAEVKENEGDFTGAVNLYLKAGLP 779

  Fly   778 ARAARLALKTPHILQDEQVMLQVTEGLVRSELYELAGDIAHRLSRPEAALALYRKGGAYARALEI 842
            |:||.||:....:|..:.::.::|..|::.|.||.|||:..|....:.||..||||.|:.:|:::
Zfish   780 AKAAWLAMSKDELLSSQDIISRITAALIKGEFYERAGDLFERTRNNQRALECYRKGNAFKKAVDL 844

  Fly   843 GRVVAPQEVTALEEEWGDWLVSRKQLDASINHYIEAGATQKALEAAVGAKQWRKAVQIAKVLDEP 907
            .||..|.||..|||.|||:||.:||:||:||||||||.:.||:|||:.|:||:||:.|.: |.|.
Zfish   845 ARVAFPAEVVKLEEVWGDYLVQQKQMDAAINHYIEAGRSTKAIEAAIAARQWKKALHILE-LQED 908

  Fly   908 ELIQRYAVDLAKHLAFAGDLDGAEDMLVRANLHKDAIELLNRHGKWERAYLIGEKHLKAEQVREL 972
            ....:|.:.:|:|.|...:.:.||.:.|:.:..||||::..:.|:||:|:.:..|.:..|.|..|
Zfish   909 RTAAKYYLKIAQHYASLQEFEVAERLFVKGDHIKDAIDMYTQAGRWEQAHKLAVKCMTQEDVSVL 973

  Fly   973 FVQLAGTLEEQGKFRDAEKVLIAVNEPDLAIAMYKRRELYDSMIRLVERYHKDLLDSTHLHLARQ 1037
            :|..|..||::||:::||::...|:||||||.|||:.::||.|||||..:|||||..||:|||::
Zfish   974 YVSRAQELEKEGKYKEAERLFTTVDEPDLAITMYKKNKMYDDMIRLVAVHHKDLLQETHIHLAKE 1038

  Fly  1038 LESRGKLKNAEMHFVASGDWKSAVHMYCSSGRWEDGYRVAKLKGTEGASQQVAYMWAKSMPTEGA 1102
            ||:..:.:.||.|::...|||:||:||..:..||:.||:||..|...|.:||||:||||:..|.|
Zfish  1039 LEAESRFQEAEYHYLEGQDWKAAVNMYRVNDMWEEAYRIAKTHGGANAHKQVAYLWAKSLGGEAA 1103

  Fly  1103 VRLLSKLGLLDTAVGFACDSGQFEFAMELCKFAGK-PTDEVHLKIAMSLEDEGKFEAAEAEFLKA 1166
            |:||:|.|||:||:.||.|:..|:||.||.:.:.| ...::|||.||.|||:|.|..||.||:||
Zfish  1104 VKLLNKFGLLETAIDFAADNYTFDFAFELARLSMKQKIPDIHLKNAMFLEDQGNFNEAEIEFIKA 1168

  Fly  1167 NKPREAILMYQHAGDWQAALNVAENHLPDAVGEVLIGQASAALETSNYKDYEALLLRAHRPDLII 1231
            .||:||:||:.|..||..|..|||.|.|::|.::|:.||....:...::..||.||||.||:|.|
Zfish  1169 GKPKEAVLMHVHNKDWSNAQRVAEAHDPESVADILVSQAKFCFDQKEFQKAEAFLLRAQRPELAI 1233

  Fly  1232 EHYKQESLYEDALRIAEEHYPSALNDLRRLQAQLQRGQAQAQAGEDAASISRSYLQKAAEFAKKE 1296
            ::||...::.||:||.:::.||.|:.|::      ..:::...|.:      ..:::|.|:.:..
Zfish  1234 KYYKDAGMWTDAMRICKDYLPSKLSVLQK------EYESEGNWGVE------GMIEQAQEWEQTG 1286

  Fly  1297 QFRKAAECLMQI-DSSNAEDASTLERALLRAAEICNQFLEGQDAQELAQSLGPRLLAIKQIGPAA 1360
            .:.:|.:|.::: ||||.:   .|.:..::|||:..:||....|.:::|.:||||:.:::...||
Zfish  1287 DYSRAVDCYLKVKDSSNLD---LLLKCWMKAAELAIKFLSHDKAVDVSQIVGPRLIQLRKYNEAA 1348

  Fly  1361 QLYLAADMPKQAVDVFIKTEQWSKARRLAKEIDPDLQLLAYVEQQQKASLKHEGNIEQLADIDIV 1425
            :|||..|:.|.|:|.||:.|:|:||:|:|||:||.|:  .||:::.|..||::|.::.|..:|:|
Zfish  1349 ELYLNLDLIKNAIDAFIEGEEWNKAKRVAKELDPRLE--EYVDKRYKEHLKNQGKVDSLVGVDVV 1411

  Fly  1426 SALDLLAEHGEWQRCLEKAKGLNPALLQKYVAVYAAQLIREGNCTTALGLYLSYGAPPIEAHFNI 1490
            :|||:.||.|:|::|::.|...|..:|.||:|:||..||:||.....|.||:.:|.|....:|||
Zfish  1412 AALDMYAERGQWEKCIDTASKQNFKVLHKYIALYATHLIKEGEVEKVLSLYIQHGVPAYSQNFNI 1476

  Fly  1491 YTRIALDCLALREEQ-TERGTTWRQLRDFLFRLLQSL-KATPAQSQTKFAASMEQFLLIAHYYAT 1553
            |.|:..:.:.||:.. .|....|..|||.|..|.::| |::.|.|...  ...||.||:||||||
Zfish  1477 YKRMFQELVNLRDRDCAEAFRMWSDLRDVLLLLCENLTKSSEANSPAH--EEFEQMLLVAHYYAT 1539

  Fly  1554 RAACKEVQALQPVALRLSLALLRHTDLLPVDKGFYEAGMDLRQAGREAEAFVMLNHYLDVCEAIE 1618
            |:|.|.:..|..||.:||::|||||:|:|.||.|||||:..:..|.|..||:.||.:||:.:.|:
Zfish  1540 RSAAKGIDQLSSVAAKLSISLLRHTELIPADKAFYEAGLAAKAVGWENMAFIFLNRFLDLADGID 1604

  Fly  1619 EGSGQLVDHSDLASTDFPSSVPLPEDIHLKNDPSLHEEVREWVLAVSMDQQVDQQLPTDDRGLYE 1683
            ||:...:||:|...||.|..||:|..:|:..:.  .||:|||||.|||||:|:|.||.|:||.||
Zfish  1605 EGTLDALDHTDFQDTDIPFEVPVPSRLHVTVEK--REEIREWVLTVSMDQRVEQVLPKDERGTYE 1667

  Fly  1684 SSL-----GPNDLPCMLSGFPVRGRQPVTFQGSSNQVNRDVWSKFSVALKMSPGSGIADIISFTE 1743
            :||     |...|||:::|:||. |..:.|:......|:|.|:||.:|.|.:......|::.|..
Zfish  1668 ASLVAASTGIRSLPCVITGYPVL-RNKIEFKRPGMAANKDDWNKFLMATKTTHSPECQDVLKFIT 1731

  Fly  1744 KWQG---AANYVMH 1754
            :|.|   :|.|..|
Zfish  1732 QWCGGLPSAGYSFH 1745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oseg2	NP_647700.2	WD40	18..313	CDD:295369	153/295 (52%)
		WD40	19..>325	CDD:225201	157/306 (51%)
		WD40 repeat	19..63	CDD:293791	21/43 (49%)
		WD40 repeat	70..106	CDD:293791	23/35 (66%)
		WD40 repeat	115..150	CDD:293791	15/34 (44%)
		WD40 repeat	156..194	CDD:293791	19/38 (50%)
		WD40 repeat	199..232	CDD:293791	13/32 (41%)
		WD40 repeat	244..281	CDD:293791	22/36 (61%)
		WD40 repeat	288..312	CDD:293791	9/23 (39%)
		PRK12798	<1212..1393	CDD:237211	60/181 (33%)
ift172	NP_001002312.1	WD 1	14..53		15/38 (39%)
		WD40	17..408	CDD:225201	197/391 (50%)
		WD40	17..318	CDD:295369	154/300 (51%)
		WD40 repeat	20..64	CDD:293791	21/43 (49%)
		WD 2	64..103		23/38 (61%)
		WD40 repeat	69..110	CDD:293791	27/40 (68%)
		WD 3	110..148		18/37 (49%)
		WD40 repeat	116..148	CDD:293791	14/31 (45%)
		WD 4	150..190		21/39 (54%)
		WD40 repeat	155..194	CDD:293791	19/38 (50%)
		WD 5	195..233		15/37 (41%)
		WD40 repeat	200..233	CDD:293791	13/32 (41%)
		WD 6	238..278		24/39 (62%)
		WD40 repeat	242..266	CDD:293791	16/23 (70%)
		WD 7	284..323		16/38 (42%)
		WD 8	483..521		25/37 (68%)
		WD 9	522..559		22/36 (61%)
		WD 10	680..725		18/44 (41%)
		TPR 1	691..725		14/33 (42%)
		TPR 2	750..784		16/33 (48%)
		SNAP	808..>997	CDD:305195	80/189 (42%)
		TPR 3	809..842		14/32 (44%)
		TPR repeat	811..866	CDD:276937	26/54 (48%)
		TPR 4	854..887		21/32 (66%)
		TPR repeat	870..905	CDD:276937	21/35 (60%)
		TPR repeat	908..954	CDD:276937	12/45 (27%)
		TPR 5	912..945		9/32 (28%)
		TPR 6	947..971		6/23 (26%)
		TPR repeat	958..997	CDD:276937	12/38 (32%)
		TPR 7	972..1004		14/31 (45%)
		TPR 8	1042..1075		12/32 (38%)
		TPR 9	1272..1305		8/38 (21%)
		TPR 10	1328..1361		12/32 (38%)
		TPR 11	1407..1441		13/33 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580876
Domainoid	1	1.000	1543	1.000	Domainoid score	I6
eggNOG	1	0.900	-	-		E1_KOG3616
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15202
Inparanoid	1	1.050	1594	1.000	Inparanoid score	I78
OMA	1	1.010	-	-		QHG56342
OrthoDB	1	1.010	-	-		D21469at33208
OrthoFinder	1	1.000	-	-		FOG0006527
OrthoInspector	1	1.000	-	-		oto40991
orthoMCL	1	0.900	-	-		OOG6_104287
Panther	1	1.100	-	-	LDO	PTHR15722
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2702
SonicParanoid	1	1.000	-	-		X5503
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800