DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15879 and ABHD8

DIOPT Version :9

Sequence 1:	NP_647694.1	Gene:	CG15879 / 38274	FlyBaseID:	FBgn0035309	Length:	342	Species:	Drosophila melanogaster
Sequence 2:	NP_078803.4	Gene:	ABHD8 / 79575	HGNCID:	23759	Length:	439	Species:	Homo sapiens

Alignment Length:	314	Identity:	70/314 - (22%)
Similarity:	111/314 - (35%)	Gaps:	92/314 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 GNRTERPILAIHG-------WLDNLGTFDRLIPLLPDYIGVLCIDLPGHGRSAHIQPGMHYAVND 81
            |.:.:..:..|||       |.:.|..|.||     .| .|:..||.|||.|:..|....|....
Human   171 GAQADVVLFFIHGVGGSLAIWKEQLDFFVRL-----GY-EVVAPDLAGHGASSAPQVAAAYTFYA 229

  Fly    82 YVLIIPRVMKEYGWSKVSLMGHSLGGIISFVYTSLA---PDTVDMVISLDILLPLSKDPK----- 138
            ....:..:.|.|...:..|:|||.|  :||. |.||   ||.|..||.::...|.:.:|.
Human   230 LAEDMRAIFKRYAKKRNVLIGHSYG--VSFC-TFLAHEYPDLVHKVIMINGGGPTALEPSFCSIF 291

  Fly   139 ----TVIKYLNHSLDKHLVE--------EERQV--EGNLHEPPSYTLAQLTQVLAKGSDNSVTPE 189
                .|:..|:..|....::        :|:|:  |||.....|:.|
Human   292 NMPTCVLHCLSPCLAWSFLKAGFARQGAKEKQLLKEGNAFNVSSFVL------------------ 338

  Fly   190 FAQHLLHRQVSKSQLYPDRFFFSRDGRVKYYSHLQMEPEFGEALVKRIRRIPCLIIKGSKSDFVE 254
                   |.:...|.:|       :|...|::.|               .:|.|::.|....||.
Human   339 -------RAMMSGQYWP-------EGDEVYHAEL---------------TVPVLLVHGMHDKFVP 374

  Fly   255 ARTEKAVA-ILRQNNPHFEFYE-VEGGTHHVHLHAAEECARYIVPFIRHHRPPA 306
            ...::.:| ||.     ..|.: ::.|:|.|.|...|.....:..|:.....|:
Human   375 VEEDQRMAEILL-----LAFLKLIDEGSHMVMLECPETVNTLLHEFLLWEPEPS 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15879	NP_647694.1	MhpC	29..302	CDD:223669	68/303 (22%)
CG15879	NP_647694.1	Abhydrolase	47..>109	CDD:304388	18/61 (30%)
ABHD8	NP_078803.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..70
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..156
		MhpC	156..416	CDD:223669	68/305 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142111
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840