DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15879 and Serhl

DIOPT Version :9

Sequence 1:	NP_647694.1	Gene:	CG15879 / 38274	FlyBaseID:	FBgn0035309	Length:	342	Species:	Drosophila melanogaster
Sequence 2:	NP_075964.1	Gene:	Serhl / 68607	MGIID:	1890404	Length:	311	Species:	Mus musculus

Alignment Length:	326	Identity:	90/326 - (27%)
Similarity:	146/326 - (44%)	Gaps:	63/326 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EVRIPAPWGHISGRWYGNRTERPILAIHGWLDNLGTFDRLIPLLPDYIGVLCIDLPGHGRSAHIQ 72
            |:::..|||||:.:.:|::...|:|.:||||||..:|||||||||.....:.:|..|||.|:|..
Mouse     6 ELKLAVPWGHIALKVWGSQKNPPVLCLHGWLDNANSFDRLIPLLPQDFCYMAMDFGGHGLSSHYN 70

  Fly    73 PGMHYAVNDYVLIIPRVMKEYGWSKVSLMGHSLGGIISFVYTSLAPDTVDMVISLDILLPL---S 134
            ||:.|...::|..:.||...:.|::.:|:|||.||.:...:..:.|:.||.:|.|| ..|.   |
Mouse    71 PGLPYYQQNFVSEVRRVATAFKWNQFTLLGHSFGGCVGGTFACMFPEMVDKLILLD-STPFFLDS 134

  Fly   135 KDPKTVIKYLNHSLDKHLVEEERQVEGNLHEPPSYTLAQLTQVLAKGSDNSVTPE-----FAQHL 194
            .:.:.::.|...:     :|...|||.:                .|.|..:|:||     |..:.
Mouse   135 NEMENILTYRRRN-----IEHTLQVEAS----------------QKKSLRAVSPEEMLQGFLNNN 178

  Fly   195 LHRQVSKSQLYPDR--------FFFSRDGRVKYYSHLQMEPEFG------EALVKRIRRIPC--L 243
            .|......:|...|        ...:||.|:.:       ||..      |..|...:.:..  |
Mouse   179 SHLDKDCGELILQRGTTKVDAGLVLNRDRRISW-------PENSFDFVSKEMFVHSAKSLQASVL 236

  Fly   244 IIKGSKSDFVEARTEKA--------VAILRQN-NPHFEFYEVEGGTHHVHLHAAEECARYIVPFI 299
            :||..:..:...|...|        |..||.. ...|:|.||. |.|::|::..:..|..:.||:
Mouse   237 MIKALQGYYDVRRANDADKAPMHFMVDTLRSTLKERFQFVEVP-GNHYIHMNKPQVVAGVVGPFL 300

  Fly   300 R 300
            :
Mouse   301 Q 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15879	NP_647694.1	MhpC	29..302	CDD:223669	83/305 (27%)
CG15879	NP_647694.1	Abhydrolase	47..>109	CDD:304388	25/61 (41%)
Serhl	NP_075964.1	MhpC	15..303	CDD:223669	86/317 (27%)
Serhl	NP_075964.1	Abhydrolase_5	28..>129	CDD:289465	42/101 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832186
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1454
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	142	1.000	Inparanoid score	I4450
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51866
OrthoDB	1	1.010	-	-		D1285824at2759
OrthoFinder	1	1.000	-	-		FOG0001238
OrthoInspector	1	1.000	-	-		otm42436
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43329
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4622
SonicParanoid	1	1.000	-	-		X774
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.900