DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15879 and EPHX2

DIOPT Version :9

Sequence 1:	NP_647694.1	Gene:	CG15879 / 38274	FlyBaseID:	FBgn0035309	Length:	342	Species:	Drosophila melanogaster
Sequence 2:	NP_001970.2	Gene:	EPHX2 / 2053	HGNCID:	3402	Length:	555	Species:	Homo sapiens

Alignment Length:	315	Identity:	70/315 - (22%)
Similarity:	123/315 - (39%)	Gaps:	60/315 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 WYGNRTERPILAIHGWLDNLGTFDRLIPLLPDYIGVLCIDLPGHGRSAHIQPGMHYAVNDYVLII 86
            ||..|.:.|.||..|:                  .||.:|:.|:|.|:.......|.:......:
Human   271 WYSWRYQIPALAQAGY------------------RVLAMDMKGYGESSAPPEIEEYCMEVLCKEM 317

  Fly    87 PRVMKEYGWSKVSLMGHSLGGIISFVYTSLAPDTVDMVISLDI-LLPLSKD--PKTVIKYLNHSL 148
            ...:.:.|.|:...:||..||::.:......|:.|..|.||:. .:|.:.:  |...|| .|...
Human   318 VTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIK-ANPVF 381

  Fly   149 DKHLVEEERQV-EGNLHEPPSYTLAQLTQVLAKGSDNSV---------------TPEFAQHLLHR 197
            |..|..:|..| |..|.:    .|::..:.|.:.||.||               :||  :..|.|
Human   382 DYQLYFQEPGVAEAELEQ----NLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPE--EPSLSR 440

  Fly   198 QVSKS--QLYPDRFFFSR-DGRVKYYSHLQMEPEFGEALVKRIRRIPCLIIKGSKSDFVEARTEK 259
            .|::.  |.|..:|..|. .|.:.:|.:::...::....:.|...||.|::...| |||
Human   441 MVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEK-DFV------ 498

  Fly   260 AVAILRQNN----PHFEFYEVEGGTHHVHLHAAEECARYIVPFIRH--HRPPALT 308
            .|..:.|:.    ||.:...:|...|...:....|..:.::.::..  ..||.::
Human   499 LVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARNPPVVS 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15879	NP_647694.1	MhpC	29..302	CDD:223669	65/300 (22%)
CG15879	NP_647694.1	Abhydrolase	47..>109	CDD:304388	13/61 (21%)
EPHX2	NP_001970.2	Phosphatase	1..224
		HAD_sEH-N_like	3..214	CDD:319790
		Phosphate binding. /evidence=ECO:0000269\|PubMed:15096040	123..124
		Epoxide hydrolase	235..555		70/315 (22%)
		Abhydrolase_1	259..531	CDD:395444	67/291 (23%)
		Microbody targeting signal. /evidence=ECO:0000255	553..555		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142141
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840