Protein Alignment CG15822 and sestd1

DIOPT Version :10

• Sequence 1: NP_001137872.2
• Gene: CG15822 / 38273
• FlyBaseID: FBgn0035308
• Length: 1267
• Species: Drosophila melanogaster
• Sequence 2: NP_878301.2
• Gene: sestd1 / 360133
• ZFINID: ZDB-GENE-030801-1
• Length: 714
• Species: Danio rerio
• Alignment Length: 804
• Identity: 198/804 - (24%)
• Similarity: 348/804 - (43%)
• Gaps: 125/804 - (15%)

  Fly     5 VLNALQTRSAYLSGGFDRQKRIVFVVNAFNDLQLWNRRYLQVTLDYLKRSLSASVLQNGVSVVVN 69
            :|..|:.:.|:||||.||:..::..:....:..  :...|..|||||....|......|.:|:|:
Zfish     6 ILPVLKKKLAFLSGGKDRRSGLILTIPLCTEQT--SMEELSTTLDYLLGIPSEKCKARGFTVIVD 68

  Fly    70 AQESSSRISRQQVRQIYALFGGDINVDLYLVRAEGFWEKHVEP-C---TKSQVKGEPLVLSKARL 130
            .::|...|.:..|..:..:...:::: :.:|:.:.||:|.|.. |   .|.::..|.:::|..:|
Zfish    69 GRKSQWNIVKTVVLMLQNVIPAEVSL-VCVVKPDEFWDKKVTHFCFWKEKDRLGFEVILVSANKL 132

  Fly   131 FKFIEPQNLPEELGGTLQFNYDLWLQQRKSIDEFTKSHVQTLASMEKLLALLREHKSLRPAEADV 195
            .::|||..|.:|.||:|.:::..|:.:|...::|||.....|..    |.::.|::....||.|
Zfish   133 TRYIEPCQLTDEFGGSLLYDHLDWVNKRLVFEKFTKESTSLLDE----LIVINENEKGSQAEKD- 192

  Fly   196 ELKKCAQMHAGVQNDIETAIDLGNAILA-----RFNEVYETHSPPPQAVAPASESPAGPPPIAAH 255
               :.::.:.....|.||.:..|:.:|:     |||               .||...|
Zfish   193 ---RSSESNILPSFDPETVLQTGHELLSELQQRRFN---------------GSEGGGG------- 232

  Fly   256 SASAGSPQKPLLPPDLACERTRIELRLNEIEKKQTAIR---TAWLELLRSLREARELSTLEDGVS 317
            ..:|.||....|            |...::.|...::|   |.:.|:.|...:..:|..::..|.
Zfish   233 GGTAWSPMDDEL------------LAQPQVMKLLDSLREQYTKYQEVCRQRSKRSQLEEIQTKVM 285

  Fly   318 FVTNWILQEAELLLSRQRSVAGDVRGCEALRSAHDQLELECRETYGCYAELLYKIEKFAAERQAS 382
            .|.||:.......|..|..:...:|..:||:..|:::|.:..|.:..|.||..:|...     .|
Zfish   286 QVVNWLEGPGTDQLRTQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAAL-----LS 345

  Fly   383 SKDMDRCQDLLSQRDFMQFVCRSFAKRLERRRNVLMTALRFHR----LLDQFEDLLATGNHVVEV 443
            :.|.:...:|...:..:..||...|.:||.|:|||.:|..||.    |..|.:.||.    ::..
Zfish   346 AGDEEDLMELKGLQQQLSDVCYRQASQLEFRQNVLQSAYEFHMTAQDLSQQLDGLLG----MLCA 406

  Fly   444 DSRSLDWPEAEQLLMQLNKNQEMLGHVEREL--VRE-GEKLSDMLAMPVKDALGRDLQLDYSAEI 505
            |....|....:|.|..|   :|.|..||..|  :|| |:.|.|.::.....:.|:::.::....|
Zfish   407 DVAPADGAAIQQTLKHL---EEKLKSVESALQTLREKGQALLDQMSNQTSFSYGKEVGVENKENI 468

  Fly   506 AQLRRQIDESRRRRQVCGHRLALQRLTLEQVTHIHAYEEDARRARDWLQELYAVLLRCHSHVGCN 570
            ..:...:::.:.|:|.|...:.::||.:.|:..:...||||.:|.:||.||...||:.|..:|.:
Zfish   469 DHIHSVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDASQAVEWLGELLDALLKTHIRLGDD 533

  Fly   571 IHEIQLQKDELQGFEETGRSIYHYGCQLLEASQTLRLCCKLEPSSFRSQSNSSQGFISDELQHTW 635
            ..|.::..::.:.|.:..:|.|.||.|||:|  |:.||     .|.|..:.|| |.....|...|
Zfish   534 SQETKVLLEKHKKFVDVAQSTYDYGRQLLQA--TVVLC-----QSLRCTTRSS-GDTLPRLNRVW 590

  Fly   636 HSLQSVAQEQMTRLRVSAVFHRSVEAYYRQLRELRPLLTKELSAQLQQQQRQQHNRSSSGIGSDA 700
            ......:.|:..||.:::.||.:.|...|:..||..||                          .
Zfish   591 KQFTVTSDERQHRLEMASAFHTAAEKIVRESPELAELL--------------------------V 629

  Fly   701 EAELESELSPLGE-MPPRLQRHLV---AREQLLVEVGRMVRLGRLLKKRLKEPFVLDALTGKRFR 761
            :.|...|:..||: :..||...::   ..||.....|.|......:::|:|      .:..|||.
Zfish   630 DVEAYEEVETLGKGLLDRLTVPVIFPDGSEQFFGSPGDMASSAESIRERMK------LVEEKRFL 688

  Fly   762 NLFAKSKGDEEVEQ-----EVGPR 780
            ...|:.:.:||.|:     ||.||
Zfish   689 QEEAEQRLEEEEEEEEAALEVEPR 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15822	NP_001137872.2	CRAL_TRIO_2	25..152	CDD:463965	31/130 (24%)
		SPEC	298..526	CDD:413338	58/234 (25%)
		SPEC	420..649	CDD:413338	64/235 (27%)
sestd1	NP_878301.2	CRAL_TRIO_2	33..153	CDD:463965	31/122 (25%)
		COG4913	242..>438	CDD:443941	53/219 (24%)
		Spectrin 1	275..381		28/110 (25%)
		SPEC	383..607	CDD:413338	66/238 (28%)
		Spectrin 2	384..497		28/119 (24%)
		Spectrin 3	503..605		35/109 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	691..714		8/22 (36%)