DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1139 and Slc38a4

DIOPT Version :9

Sequence 1:	NP_647686.1	Gene:	CG1139 / 38264	FlyBaseID:	FBgn0035300	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_001344987.1	Gene:	Slc38a4 / 69354	MGIID:	1916604	Length:	547	Species:	Mus musculus

Alignment Length:	539	Identity:	99/539 - (18%)
Similarity:	179/539 - (33%)	Gaps:	186/539 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 DYDPHQHRELKNPTTNF-QTFAHFLKASVGTGVLAMPSAFAHAGYVNGTLLTLIIGSLALYCLHI 93
            ||....|..:    |:| .:..:...|.:|:|:|.:..|.|:.|.:...::.|.:..|:||.:|:
Mouse    65 DYADEHHPGM----TSFGMSSFNLSNAIMGSGILGLSYAMANTGIILFIIMLLTVAILSLYSVHL 125

  Fly    94 LIK-------CMYILCKRQRVPYVSFSQAMNLGLKQGPPWLRCLAPIAVPFVDGFLAFYHFGICC 151
            |:|       .:|     :::...:|.....:|                .|:.  :...:.|...
Mouse   126 LLKTAKEGGSLIY-----EKLGEKAFGWPGKIG----------------AFIS--ITMQNIGAMS 167

  Fly   152 VYVVFIAESIKQLVDEYLVV------WDVRIHMCI------IIVPLLLIYSIKNLKLLAPFSSAA 204
            .|:..|...:.:::..::.:      |.:..:..:      ||:||.|   :|||..|. ::|..
Mouse   168 SYLFIIKYELPEVIRAFMGLEENTGEWYLNGNYLVLFVSVGIILPLSL---LKNLGYLG-YTSGF 228

  Fly   205 NLLLLVGF-GIILYYIFE---ELPPLSERDPFVAAGKLPTFFGTV---LFAL----EAVGVILAI 258
            :|..:|.| .:::|..|:   .||.|...:     |.| ||..|:   :.:|    |:.||...:
Mouse   229 SLSCMVFFVSVVIYKKFQIPCPLPALDHNN-----GNL-TFNNTLPIHMISLPNDSESSGVNFMM 287

  Fly   259 EENMATP-----KSFVGP---------------------------------------C------- 272
            :.....|     |...||                                       |
Mouse   288 DYAHHNPAGLDEKQVAGPLHSNGVEYEAQGAEKCQPKYFVFNSRTAYAIPILAFAFVCHPEVLPI 352

  Fly   273 -------------GILNSGMSIVLGLYVLLGFFGYWKYGNESEG--------------------- 303
                         .:.|..:|.:|.:|:|...|||..:..:.|.
Mouse   353 YSELKDRSRRKMQTVSNISISGMLVMYLLAALFGYLSFYGDVEDELLHAYSKVYTFDTALLMVRL 417

  Fly   304 ----SITLNIPQSEIPAQVVKVFFAITTWISYALQGYVTAHILWDKYLAKRFKETRQTFYELIFR 364
                ::||.:|         .|.|.|.|.:...|  :......|.|:..              ..
Mouse   418 AVLVAVTLTVP---------IVLFPIRTSVITLL--FPRKPFSWLKHFG--------------IA 457

  Fly   365 AIIVLLTFGCAVAIPDLSVFLSLVGSFCLSILGLIFPVLLQICVQYTEGYGPFRIKLIIN-LLLL 428
            |||:.|.....:.:|.:......:|:...::|..|.|....:.:...|   |.|....|. |:.|
Mouse   458 AIIIALNNILVILVPTIKYIFGFIGASSATMLIFILPAAFYLKLVKKE---PLRSPQKIGALVFL 519

  Fly   429 CFGIFGGVVGTYVSILDII 447
            ..||...:....:.|||.|
Mouse   520 VTGIIFMMGSMALIILDWI 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1139	NP_647686.1	SdaC	36..404	CDD:223884	85/487 (17%)
CG1139	NP_647686.1	SLC5-6-like_sbd	42..444	CDD:294310	92/522 (18%)
Slc38a4	NP_001344987.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
Slc38a4	NP_001344987.1	SLC5-6-like_sbd	75..535	CDD:382020	92/520 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849024
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840