Protein Alignment acs and SLC36A3

DIOPT Version :10

• Sequence 1: NP_647686.1
• Gene: acs / 38264
• FlyBaseID: FBgn0035300
• Length: 451
• Species: Drosophila melanogaster
• Sequence 2: NP_001138489.1
• Gene: SLC36A3 / 285641
• HGNCID: 19659
• Length: 511
• Species: Homo sapiens
• Alignment Length: 487
• Identity: 151/487 - (31%)
• Similarity: 251/487 - (51%)
• Gaps: 71/487 - (14%)

  Fly    19 TPTKSANG-SNDDYDPHQHRELKNPTTNFQTFAHFLKASVGTGVLAMPSAFAHAGYVNGTLLTLI 82
            :|::|::. ::::..|.....|    :..||..|.||.::|||:|.:|.|..:||.:.|.:..|.
Human    21 SPSESSSSITSENVHPAGEAGL----SMMQTLIHLLKCNIGTGLLGLPLAIKNAGLLVGPVSLLA 81

  Fly    83 IGSLALYCLHILIKCMYILCKRQRVPYVSFSQAMNLGLKQGP-PWLR-----------------C 129
            ||.|.::|:.||:.|...|.:|.:..:|::.:|...||:..| .|||                 |
Human    82 IGVLTVHCMVILLNCAQHLSQRLQKTFVNYGEATMYGLETCPNTWLRAHAVWGRWNLALSPRLEC 146

  Fly   130 LAPIAV---PFVDG---------------------FLAFYHFGICCVYVVFIAESIKQLVDEYLV 170
            ...|:.   |.:.|                     .|.....|.|.||.:|:|::::|:|::..|
Human   147 SGKISAHCNPHLQGSSNSPAQASRVAGIYRYTVSFLLVITQLGFCSVYFMFMADNLQQMVEKAHV 211

  Fly   171 ---------------VWDVRIHMCIIIVPLLLIYSIKNLKLLAPFSSAANLLLLVGFGIILYYIF 220
                           :.|:|.:|.||:..|:|:..|:|||:|:.||:.||:..|....:|..||.
Human   212 TSNICQPREILTLTPILDIRFYMLIILPFLILLVFIQNLKVLSVFSTLANITTLGSMALIFEYIM 276

  Fly   221 EELPPLSERDPFVAAGK-LPTFFGTVLFALEAVGVILAIEENMATPKSFVGPCGILNSGMSIVLG 284
            |.:|..|.. |.:|..| ...||||.:|..|.||::|.::..|..|:.|   ..:|..|||||:.
Human   277 EGIPYPSNL-PLMANWKTFLLFFGTAIFTFEGVGMVLPLKNQMKHPQQF---SFVLYLGMSIVII 337

  Fly   285 LYVLLGFFGYWKYGNESEGSITLNIPQSEIPAQVVKVFFAITTWISYALQGYVTAHILWDKYLAK 349
            ||:|||..||.|:|::::.|||||:|...: .|.||:.::|..:.:||||.:|.|.|: ..:...
Human   338 LYILLGTLGYMKFGSDTQASITLNLPNCWL-YQSVKLMYSIGIFFTYALQFHVPAEII-IPFAIS 400

  Fly   350 RFKETRQTFYELIFRAIIVLLTFGCAVAIPDLSVFLSLVGSFCLSILGLIFPVLLQICVQYTEGY 414
            :..|:...|.:|..|:.:|.||...|:.||.|.:.:|||||...|.|.||.|.||:|.:.|:|..
Human   401 QVSESWALFVDLSVRSALVCLTCVSAILIPRLDLVISLVGSVSSSALALIIPALLEIVIFYSEDM 465

  Fly   415 GPFRIKLIINLLLLCFGIFGGVVGTYVSILDI 446
            .  .:.:..::::...|:.|.:.|||.::.::
Human   466 S--CVTIAKDIMISIVGLLGCIFGTYQALYEL 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
acs	NP_647686.1	SLC5-6-like_sbd	42..444	CDD:444915	147/459 (32%)
SLC36A3	NP_001138489.1	SLC5-6-like_sbd	41..492	CDD:444915	148/462 (32%)