Protein Alignment acs and Slc38a9

DIOPT Version :10

• Sequence 1: NP_647686.1
• Gene: acs / 38264
• FlyBaseID: FBgn0035300
• Length: 451
• Species: Drosophila melanogaster
• Sequence 2: NP_848861.1
• Gene: Slc38a9 / 268706
• MGIID: 1918839
• Length: 560
• Species: Mus musculus
• Alignment Length: 554
• Identity: 109/554 - (19%)
• Similarity: 180/554 - (32%)
• Gaps: 173/554 - (31%)

  Fly     1 MNDDIKTVTVYPTTL--------ELTTPTKSANGSNDDYDPHQHR-----------ELKNPT--- 43
            :||.|:.|:.:...:        .||||...|..:.|...|....           :||:.|
Mouse    49 VNDVIQRVSDHAAAMNKRIHYYSRLTTPADKALIAPDHVVPAPEECYVYSPLGSAYKLKSYTEGY 113

  Fly    44 ---TNFQTFAHFLKASVGTGVLAMPSAFAHAGYVNGTLLTLIIGSLALYCLHILIKCMYIL---- 101
               |:..|........:||.:|::|.....||:..|..:.:::|.|.|||.:.::|....:
Mouse   114 GKNTSLVTIFMIWNTMMGTSILSIPWGIKQAGFTTGMCVIVLMGLLTLYCCYRVVKSRSTISTSD 178

  Fly   102 ---------CKRQRVPYVSFSQAMNLGLKQGPPWLRCLAPIAVPFVDGFLAFYHFGICCVYVV-- 155
                     ||..   :.||.|           |...|          |......|...||.|
Mouse   179 TSTWEYPDVCKHY---FGSFGQ-----------WSSLL----------FSLVSLIGAMIVYWVLM 219

  Fly   156 ---------FIAESIKQLVDEYLVV---------------------------------------W 172
                     ||...|..:.|...|:                                       |
Mouse   220 SNFLFNTGKFIFNFIHHINDTDTVLSTNNSNPVICPNAGSGGRPDNSSMIFYNNNTEVQLFEKWW 284

  Fly   173 D----VRIHMCIIIVPLLLIYSIKNLKLLAP-FSSAANLLLLVGFGIILYYI------------- 219
            |    |..::..:::|||      |.|  :| |.|..|:|   |...:||.|
Mouse   285 DKSRTVPFYLIGLLLPLL------NFK--SPSFFSKFNIL---GTVSVLYLIFVVTLKAVRLGFH 338

  Fly   220 --FEELPPLSERDPFVAAGKLPTFFGTVLFALEAVGVILAIEENMATPKSFVGPCGILNSGMSIV 282
              |....|.....|.:.| :.|...|.:..|......|:.:.:|....::.|....|   ...:|
Mouse   339 LEFHWFVPTEFFVPEIRA-QFPQLMGVLTLAFFIHNCIITLLKNNKNQENNVRDLCI---AYMLV 399

  Fly   283 LGLYVLLGFFGYWKYGNES------EGSITLNIPQSEIPAQVVKVFFAITTWISYALQGYVT--- 338
            ...|:.:|...:..:.:..      |.:...|.|.|:|.:.:.::|........|.|.||:.
Mouse   400 TLTYLYIGILVFASFPSPPLPKDCIEQNFLDNFPSSDILSFIARIFLLFQMMTVYPLLGYLARVQ 464

  Fly   339 --AHILWDKYLAKRFKETRQTFYELIFRAIIVLLTFGCAVAIPDLSVFLSLVGSFCLSILGLIFP 401
              .||..|.|        ...|:.||...:||......|...|::...:...|:.|......|:|
Mouse   465 LLGHIFGDIY--------PSIFHVLILNLVIVGAGVTMACFYPNIGGIIRYSGAACGLAFVFIYP 521

  Fly   402 VLLQICVQYTEGYGPFRI---KLIINLLLLCFGI 432
            .|:.|...:.|.    |:   ||:.:::::..|:
Mouse   522 SLIYIISLHQEE----RLTWPKLVFHVIIIILGL 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
acs	NP_647686.1	SLC5-6-like_sbd	42..444	CDD:444915	96/494 (19%)
Slc38a9	NP_848861.1	SLC5-6-like_sbd	114..556	CDD:444915	95/489 (19%)
		Important for arginine binding and amino acid transport. /evidence=ECO:0000250|UniProtKB:Q08BA4	128..133		1/4 (25%)
		CARC motif. /evidence=ECO:0000250|UniProtKB:Q8NBW4	443..453		1/9 (11%)
		CRAC motif. /evidence=ECO:0000250|UniProtKB:Q8NBW4	456..462		3/5 (60%)