DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1139 and SLC36A2

DIOPT Version :9

Sequence 1:	NP_647686.1	Gene:	CG1139 / 38264	FlyBaseID:	FBgn0035300	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_861441.2	Gene:	SLC36A2 / 153201	HGNCID:	18762	Length:	483	Species:	Homo sapiens

Alignment Length:	459	Identity:	160/459 - (34%)
Similarity:	252/459 - (54%)	Gaps:	35/459 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LELTTPTKSANGSND------DYDPHQHRELKNP--TTNFQTFAHFLKASVGTGVLAMPSAFAHA 71
            |:|.:|.:||....:      |..|.:...||..  .|.||...|.:|.::|||:|.:|.|..:|
Human    18 LDLMSPPESAKKLENKDSTFLDESPSESAGLKKTKGITVFQALIHLVKGNMGTGILGLPLAVKNA 82

  Fly    72 GYVNGTLLTLIIGSLALYCLHILIKCMYILCKRQRVPYVSFSQAMNLGLKQGP-PWLRCLAPIAV 135
            |.:.|.|..|::|.:|.:|:|||:||....|||...|::.:...:..||:..| .||:..|....
Human    83 GILMGPLSLLVMGFIACHCMHILVKCAQRFCKRLNKPFMDYGDTVMHGLEANPNAWLQNHAHWGR 147

  Fly   136 PFVDGFLAFYHFGICCVYVVFIAESIKQLVD------------EYLVV---WDVRIHMCIIIVPL 185
            ..|..||.....|.||||:||:|:::||:|:            |.:::   .|.|::|...:..|
Human   148 HIVSFFLIITQLGFCCVYIVFLADNLKQVVEAVNSTTNNCYSNETVILTPTMDSRLYMLSFLPFL 212

  Fly   186 LLIYSIKNLKLLAPFSSAANLLLLVGFGIILYYIFEELPPLSERDPFVAAGK-LPTFFGTVLFAL 249
            :|:..|:||::|..||..||:.:||...||:.||.:|:|..| |.|.||:.| .|.||||.:|:.
Human   213 VLLVLIRNLRILTIFSMLANISMLVSLVIIIQYITQEIPDPS-RLPLVASWKTYPLFFGTAIFSF 276

  Fly   250 EAVGVILAIEENMATPKSFVGPCGILNSGMSIVLGLYVLLGFFGYWKYGNESEGSITLNIPQSEI 314
            |::||:|.:|..|...:.|.   .||:.|||||..||:.:...||.::|::.:.||:||:|...:
Human   277 ESIGVVLPLENKMKNARHFP---AILSLGMSIVTSLYIGMAALGYLRFGDDIKASISLNLPNCWL 338

  Fly   315 PAQVVKVFFAITTWISYALQGYVTAHILWDKYLAKRFKETRQTF-YELIFRAIIVLLTFGCAVAI 378
             .|.||:.:......:||||.||.|.|:....:::  ..||... .:|..|.::|.||...|:.|
Human   339 -YQSVKLLYIAGILCTYALQFYVPAEIIIPFAISR--VSTRWALPLDLSIRLVMVCLTCLLAILI 400

  Fly   379 PDLSVFLSLVGSFCLSILGLIFPVLLQICVQYTEGYGPFRIKLIINLLLLCFGIFGGVVGTYVSI 443
            |.|.:.:|||||...:.|.||.|.||::...|:||..|  :.:..:.|:...|..|.|||||.::
Human   401 PRLDLVISLVGSVSGTALALIIPPLLEVTTFYSEGMSP--LTIFKDALISILGFVGFVVGTYQAL 463

  Fly   444 LDII 447
            .:::
Human   464 DELL 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1139	NP_647686.1	SdaC	36..404	CDD:223884	139/387 (36%)
CG1139	NP_647686.1	SLC5-6-like_sbd	42..444	CDD:294310	151/421 (36%)
SLC36A2	NP_861441.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..46		4/19 (21%)
SLC36A2	NP_861441.2	SLC5-6-like_sbd	52..463	CDD:320982	151/419 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158607
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	1	1.010	-	-		D284074at33208
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X121
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.860