DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1139 and SLC38A10

DIOPT Version :9

Sequence 1:	NP_647686.1	Gene:	CG1139 / 38264	FlyBaseID:	FBgn0035300	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	XP_011522590.1	Gene:	SLC38A10 / 124565	HGNCID:	28237	Length:	1134	Species:	Homo sapiens

Alignment Length:	443	Identity:	87/443 - (19%)
Similarity:	175/443 - (39%)	Gaps:	90/443 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 TNFQTFAHFLKASVGTGVLAMPSAFAHAGYVNGTLLTLIIGSLALYCLHILIK-CMYI-----LC 102
            :|:....:.:.:.||..||.||..|...|.|.|.|       |.::|..:..: ||::     |.
Human     7 SNWGLITNIVNSIVGVSVLTMPFCFKQCGIVLGAL-------LLVFCSWMTHQSCMFLVKSASLS 64

  Fly   103 KRQRVPYVSFSQAMNLGLKQGPPWLRCLAPIAVPFVDGFLAFYHFGICCVYVVFIAESIKQLVDE 167
            ||:  .|....:|                    |....|.|:...|...|....|...:...:..
Human    65 KRR--TYAGLGEA--------------------PSPQAFHAYGKAGKMLVETSMIGLMLGTCIAF 107

  Fly   168 YLVVWDVRIHMCIII--------VPLLLIYSIKNLKLLAPFSSAANLLLLV----GFGIILYYIF 220
            |:|:.|:..:....:        ..:.|:::: :|.::.|.|...|::..:    ...::.|.:|
Human   108 YVVIGDLGSNFFARLFGFQVGGTFRMFLLFAV-SLCIVLPLSLQRNMMASIQSFSAMALLFYTVF 171

  Fly   221 EELPPLSERDPFVAAGK----------------LPTFFGTVLFALEAVGVILAIEENMATPKSFV 269
            ..:..||.....:.:|:                :|.|  .:.||.::  .:|...:::..| |..
Human   172 MFVIVLSSLKHGLFSGQWLRRVSYVRWEGVFRCIPIF--GMSFACQS--QVLPTYDSLDEP-SVK 231

  Fly   270 GPCGILNSGMSIVLGLYVLLGFFGYWKYGNESEGSITLNIPQSEIPAQVVKVFFAITTWISYALQ 334
            ....|..|.:::|...||::|||||..:...:.|::.::.| |.:..::::|.|.::..:.:.:.
Human   232 TMSSIFASSLNVVTTFYVMVGFFGYVSFTEATAGNVLMHFP-SNLVTEMLRVGFMMSVAVGFPMM 295

  Fly   335 GYVTAHILWDKYLAKRFKETRQTFY------ELIFRAIIVLLTFGCAVA---IPDLSVFLSLVGS 390
            .......|......::.|:  .||.      .|.|:|:.:.:.||..|.   ||::...|.|.|:
Human   296 ILPCRQALSTLLCEQQQKD--GTFAAGGYMPPLRFKALTLSVVFGTMVGGILIPNVETILGLTGA 358

  Fly   391 FCLSILGLIFPVLLQICVQYTEGYGPFRIKLIINLLLLCFGIFGGVVGTYVSI 443
            ...|::..|.|.|:         |.......:.:.::|..|:...||.|..::
Human   359 TMGSLICFICPALI---------YKKIHKNALSSQVVLWVGLGVLVVSTVTTL 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1139	NP_647686.1	SdaC	36..404	CDD:223884	80/402 (20%)
CG1139	NP_647686.1	SLC5-6-like_sbd	42..444	CDD:294310	87/443 (20%)
SLC38A10	XP_011522590.1	SLC5-6-like_sbd	6..388	CDD:294310	82/427 (19%)
		SdaC	14..404	CDD:223884	86/436 (20%)
		BASP1	488..690	CDD:283191
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810