DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SCOT and OXCT2

DIOPT Version :9

Sequence 1:	NP_647683.1	Gene:	SCOT / 38261	FlyBaseID:	FBgn0035298	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_071403.1	Gene:	OXCT2 / 64064	HGNCID:	18606	Length:	517	Species:	Homo sapiens

Alignment Length:	491	Identity:	291/491 - (59%)
Similarity:	373/491 - (75%)	Gaps:	6/491 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 CYSTSGKQRNGKIYESAIDAVADVQDGAQILFGGFGICGIPEKMINALKQKGVKNITGVSNNGGV 88
            |::||.:.| .|.|...::.|.|:.|||.::.||||:|||||.:|.||.:..||::..||:|.||
Human    31 CFATSPRLR-AKFYADPVEMVKDISDGATVMIGGFGLCGIPENLIAALLRTRVKDLQVVSSNVGV 94

  Fly    89 DDTGLGVLIKQKQVSKVIGSYVGENTELVRQYLEGELAVELTPQGTLAEKIRAGGAGIPAFYTPT 153
            :|.|||:|:..:||.:::.|||||||....|||.|||.:||||||||||:|||||||:|||||||
Human    95 EDFGLGLLLAARQVRRIVCSYVGENTLCESQYLAGELELELTPQGTLAERIRAGGAGVPAFYTPT 159

  Fly   154 GYATLVQEGGAPIKYSKDGKVEISSEKKPVKEFNGKNYVMEESIFADFAFVKAQKADPLGNLVFN 218
            ||.||||||||||:|:.||.:.:.|:.:.|:||||.::::|.:|.||||.||..|||..||:||.
Human   160 GYGTLVQEGGAPIRYTPDGHLALMSQPREVREFNGDHFLLERAIRADFALVKGWKADRAGNVVFR 224

  Fly   219 KAARNFNAPMCRAAKITVAEVEEIVPIGALSPDEIHVPGIYINRIFKGTNYNKRVERLRITEPKD 283
            ::|||||.|||:||.:|..||||||.:||..|::||||.||::|:.||..|.||:|||.|.:.:|
Human   225 RSARNFNVPMCKAADVTAVEVEEIVEVGAFPPEDIHVPNIYVDRVIKGQKYEKRIERLTILKEED 289

  Fly   284 PSKPAPPPNPAQVLRERIARRVALEFHDGMYANLGIGIPVLSSNYIPKGMNVMLQSENGILGLGP 348
            ..     ....:..|.||.||.||||.||||||||||||:|:||:|...|.|.|.||||||||||
Human   290 GD-----AGKEEDARTRIIRRAALEFEDGMYANLGIGIPLLASNFISPSMTVHLHSENGILGLGP 349

  Fly   349 FPTKDKVDPDLINAGKESVTVVPGASYFGSDDSFAMIRGGHVDITILGAMEVSATGDLANWMIPG 413
            |||:|:||.|||||||::|||:||..:|.||||||||||||:.:|:||||:||..||||||||||
Human   350 FPTEDEVDADLINAGKQTVTVLPGGCFFASDDSFAMIRGGHIQLTMLGAMQVSKYGDLANWMIPG 414

  Fly   414 KLVKGMGGAMDLVAAPGTKVIITMEHNARDGSPKILDTCSLPLTGKGVIDMIISEKAVFTVEKGV 478
            |.|||||||||||::..|:|::||:|..:|.:|||::.|::|||||..:|.||:|||||.|.:..
Human   415 KKVKGMGGAMDLVSSQKTRVVVTMQHCTKDNTPKIMEKCTMPLTGKRCVDRIITEKAVFDVHRKK 479

  Fly   479 GLTLIEVAEGYTVDDIIASTGAKFTVSPNLKKMGQI 514
            .|||.|:.||.|||||..|||..|.|||||:.|.|:
Human   480 ELTLRELWEGLTVDDIKKSTGCAFAVSPNLRPMQQV 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCOT	NP_647683.1	AtoD	35..268	CDD:224702	135/232 (58%)
SCOT	NP_647683.1	pcaJ_scoB_fam	298..504	CDD:188219	137/205 (67%)
OXCT2	NP_071403.1	YdiF	48..514	CDD:227016	284/470 (60%)
		AtoD	48..274	CDD:224702	133/225 (59%)
		SugarP_isomerase	297..505	CDD:294243	137/207 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159881
Domainoid	1	1.000	314	1.000	Domainoid score	I1287
eggNOG	1	0.900	-	-		E1_COG2057
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	631	1.000	Inparanoid score	I846
Isobase	1	0.950	-	0	Normalized mean entropy	S2149
OMA	1	1.010	-	-		QHG60825
OrthoDB	1	1.010	-	-		D332119at33208
OrthoFinder	1	1.000	-	-		FOG0002929
OrthoInspector	1	1.000	-	-		otm40593
orthoMCL	1	0.900	-	-		OOG6_100924
Panther	1	1.100	-	-	O	PTHR13707
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1930
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.720