DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCOT and oxct1a

DIOPT Version :9

Sequence 1:	NP_647683.1	Gene:	SCOT / 38261	FlyBaseID:	FBgn0035298	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001007292.1	Gene:	oxct1a / 442923	ZFINID:	ZDB-GENE-040723-3	Length:	525	Species:	Danio rerio

Alignment Length:	511	Identity:	313/511 - (61%)
Similarity:	396/511 - (77%)	Gaps:	12/511 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RYTASI----------KAIACYSTSGKQRNGKIYESAIDAVADVQDGAQILFGGFGICGIPEKMI 68
            :.||:|          |...||.::..||:.:.|...:|||.|:.:||.:|.||||:|||||.:|
Zfish    17 KVTATIKTNIPRFSVGKTCGCYFSTSSQRSAQFYSDPLDAVKDIPNGATVLVGGFGLCGIPENLI 81

  Fly    69 NALKQKGVKNITGVSNNGGVDDTGLGVLIKQKQVSKVIGSYVGENTELVRQYLEGELAVELTPQG 133
            |:|.:.|||::|.||||.||||.|||:|::.||:.::|.||||||.|..||||.|||.|||||||
Zfish    82 NSLLKTGVKSLTAVSNNAGVDDFGLGLLLRTKQIKRMISSYVGENVEFERQYLSGELEVELTPQG 146

  Fly   134 TLAEKIRAGGAGIPAFYTPTGYATLVQEGGAPIKYSKDGKVEISSEKKPVKEFNGKNYVMEESIF 198
            ||||:|||||||:|||:|.|||.||:||||:||||:|||.:.|:||.:.|:||||::|:||:||.
Zfish   147 TLAERIRAGGAGVPAFFTATGYGTLIQEGGSPIKYNKDGTIAIASEPREVREFNGRHYIMEKSIT 211

  Fly   199 ADFAFVKAQKADPLGNLVFNKAARNFNAPMCRAAKITVAEVEEIVPIGALSPDEIHVPGIYINRI 263
            .|||.:||.|||..||::|.|.|||||.|||:|||.|:.||||||.:|..:.::||:|.||::||
Zfish   212 GDFALIKAWKADKAGNIIFRKTARNFNQPMCKAAKTTIVEVEEIVDVGTFASEDIHIPSIYVHRI 276

  Fly   264 FKGTNYNKRVERLRITEPKDPSKPAPPPNPAQVLRERIARRVALEFHDGMYANLGIGIPVLSSNY 328
            ..|.:|.||:||.  |..|..::...|...:.::||||.||.||||.||||||||||||:|:||:
Zfish   277 VNGDHYEKRIERR--TVKKAQAENPKPKKDSDIVRERIIRRAALEFEDGMYANLGIGIPMLASNF 339

  Fly   329 IPKGMNVMLQSENGILGLGPFPTKDKVDPDLINAGKESVTVVPGASYFGSDDSFAMIRGGHVDIT 393
            |...:.|.||||||||||||:||:|.||.||||||||:||::|||:||.||:|||||||||:::|
Zfish   340 IKPDITVHLQSENGILGLGPYPTEDAVDADLINAGKETVTILPGAAYFSSDESFAMIRGGHINLT 404

  Fly   394 ILGAMEVSATGDLANWMIPGKLVKGMGGAMDLVAAPGTKVIITMEHNARDGSPKILDTCSLPLTG 458
            :||||:||..|||||||||||:||||||||||||:.||||::||||:|:.|..||::.|:|||||
Zfish   405 MLGAMQVSKYGDLANWMIPGKMVKGMGGAMDLVASAGTKVVVTMEHSAKGGKHKIMEKCNLPLTG 469

  Fly   459 KGVIDMIISEKAVFTVEKGVGLTLIEVAEGYTVDDIIASTGAKFTVSPNLKKMGQI 514
            |..:|.||:|||||.|:|..|||||||.||.|.|||...||..|.||||||.|.||
Zfish   470 KQCVDRIITEKAVFDVDKDKGLTLIEVWEGLTPDDIKKCTGTPFEVSPNLKPMQQI 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCOT	NP_647683.1	AtoD	35..268	CDD:224702	143/232 (62%)
SCOT	NP_647683.1	pcaJ_scoB_fam	298..504	CDD:188219	145/205 (71%)
oxct1a	NP_001007292.1	YdiF	55..524	CDD:227016	302/470 (64%)
		AtoD	55..277	CDD:224702	140/221 (63%)
		SugarP_isomerase	308..515	CDD:294243	145/206 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596141
Domainoid	1	1.000	312	1.000	Domainoid score	I1276
eggNOG	1	0.900	-	-		E1_COG2057
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H377
Inparanoid	1	1.050	636	1.000	Inparanoid score	I805
OMA	1	1.010	-	-		QHG60825
OrthoDB	1	1.010	-	-		D332119at33208
OrthoFinder	1	1.000	-	-		FOG0002929
OrthoInspector	1	1.000	-	-		otm24433
orthoMCL	1	0.900	-	-		OOG6_100924
Panther	1	1.100	-	-	LDO	PTHR13707
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2787
SonicParanoid	1	1.000	-	-		X1930
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800