DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCOT and Oxct2b

DIOPT Version :9

Sequence 1:	NP_647683.1	Gene:	SCOT / 38261	FlyBaseID:	FBgn0035298	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_862907.2	Gene:	Oxct2b / 353371	MGIID:	2664115	Length:	520	Species:	Mus musculus

Alignment Length:	485	Identity:	289/485 - (59%)
Similarity:	366/485 - (75%)	Gaps:	6/485 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 RNGKI--YESAIDAVADVQDGAQILFGGFGICGIPEKMINALKQKGVKNITGVSNNGGVDDTGLG 94
            |:|.:  |...:.||..|:||:.::.||||:|||||.:|.|||.||||::..||:|.||||.|||
Mouse    36 RSGSVHFYTDPVKAVEGVKDGSTVMLGGFGLCGIPENLIGALKTKGVKDLKIVSSNVGVDDFGLG 100

  Fly    95 VLIKQKQVSKVIGSYVGENTELVRQYLEGELAVELTPQGTLAEKIRAGGAGIPAFYTPTGYATLV 159
            :|:..|||.:|:.||:|||....:.||.|||.:|:||||||||:|||||.|:|||||||||.|||
Mouse   101 ILLASKQVRRVVCSYLGENALCEKLYLAGELELEMTPQGTLAERIRAGGTGVPAFYTPTGYGTLV 165

  Fly   160 QEGGAPIKYSKDGKVEISSEKKPVKEFNGKNYVMEESIFADFAFVKAQKADPLGNLVFNKAARNF 224
            ||||:||:|:.||.:...||.:.|:||.|:.|::|.:|.||||.:|..|||..||::|..:||||
Mouse   166 QEGGSPIRYAPDGHLITLSEPREVREFQGRFYLLEHAIRADFALIKGWKADRSGNVIFRGSARNF 230

  Fly   225 NAPMCRAAKITVAEVEEIVPIGALSPDEIHVPGIYINRIFKGTNYNKRVERLRITEPKDPSKPAP 289
            |.|||:||.|:|.||||||.:|..:|::||:|.||::|:.||..:.||:|||...:    |||||
Mouse   231 NVPMCKAADISVVEVEEIVDVGTFAPEDIHIPNIYVDRVIKGPKFEKRIERLTTRD----SKPAP 291

  Fly   290 PPNPAQVLRERIARRVALEFHDGMYANLGIGIPVLSSNYIPKGMNVMLQSENGILGLGPFPTKDK 354
            ........|.||.:|.||||.||||||||||||||:||||...|.|.|.||||||||||||.|::
Mouse   292 GSKDNDPSRTRIIKRAALEFQDGMYANLGIGIPVLASNYISPKMTVYLHSENGILGLGPFPLKNE 356

  Fly   355 VDPDLINAGKESVTVVPGASYFGSDDSFAMIRGGHVDITILGAMEVSATGDLANWMIPGKLVKGM 419
            ||.|:|||||::||||||..:|.||||||||||||:.:|:||||:||..|||||||:|||.||||
Mouse   357 VDADVINAGKQTVTVVPGGCFFASDDSFAMIRGGHLQLTMLGAMQVSQYGDLANWMVPGKKVKGM 421

  Fly   420 GGAMDLVAAPGTKVIITMEHNARDGSPKILDTCSLPLTGKGVIDMIISEKAVFTVEKGVGLTLIE 484
            |||||||::..|:|::||||..:...||||..|::|||||..:|:||:|||||.|....||||:|
Mouse   422 GGAMDLVSSKKTRVVVTMEHCTKTKQPKILKKCTMPLTGKRCVDLIITEKAVFEVNHSKGLTLVE 486

  Fly   485 VAEGYTVDDIIASTGAKFTVSPNLKKMGQI 514
            :.||.:||||.|:|...|.||||||.|.||
Mouse   487 LWEGSSVDDIKATTACSFAVSPNLKPMQQI 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCOT	NP_647683.1	AtoD	35..268	CDD:224702	132/234 (56%)
SCOT	NP_647683.1	pcaJ_scoB_fam	298..504	CDD:188219	136/205 (66%)
Oxct2b	NP_862907.2	YdiF	49..515	CDD:227016	284/469 (61%)
		AtoD	49..274	CDD:224702	131/224 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..299		8/22 (36%)
		SugarP_isomerase	299..506	CDD:294243	136/206 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850248
Domainoid	1	1.000	305	1.000	Domainoid score	I1357
eggNOG	1	0.900	-	-		E1_COG2057
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	624	1.000	Inparanoid score	I869
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60825
OrthoDB	1	1.010	-	-		D332119at33208
OrthoFinder	1	1.000	-	-		FOG0002929
OrthoInspector	1	1.000	-	-		otm42669
orthoMCL	1	0.900	-	-		OOG6_100924
Panther	1	1.100	-	-	O	PTHR13707
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1930
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770