Protein Alignment mv and LRBA

DIOPT Version :10

• Sequence 1: NP_647681.2
• Gene: mv / 38259
• FlyBaseID: FBgn0288310
• Length: 3535
• Species: Drosophila melanogaster
• Sequence 2: NP_001427359.1
• Gene: LRBA / 987
• HGNCID: 1742
• Length: 2868
• Species: Homo sapiens
• Alignment Length: 3197
• Identity: 662/3197 - (20%)
• Similarity: 1049/3197 - (32%)
• Gaps: 1152/3197 - (36%)

  Fly   992 CKKLLLKLFEATMAICIKGFQ-NEEVEKMQKHLRKLRAIILSHATDNWSEHGEQHARDNAVIQTL 1055
            |:..:..:|.|.:...|:..| ..||..::|.|.|:..:                  ||.:...|
Human   106 CQAEVWSMFTAILKKSIRNLQVCTEVGLVEKVLGKIEKV------------------DNMIADLL 152

  Fly  1056 QTLLKI-AELSSTHQEPTGVVNSPSGDSQQPRPRARS-----------------FN-----SGSV 1097
            ..:|.: |..:.|.:|.....:...||..:..|.|..                 ||     :.::
Human   153 VDMLGVLASYNLTVRELKLFFSKLQGDKGRWPPHAGKLLSVLKHMPQKYGPDAFFNFPGKSAAAI 217

  Fly  1098 ELPRLQTVKLPAKNSLATPPTPRRRPNSSEANAGVDADYFSTRASLSCAADSELELSENEHEFYL 1162
            .||.:  .|.|.:|........|..|.:   |..||.|    :..|.|              |..
Human   218 ALPPI--AKWPYQNGFTFHTWLRMDPVN---NINVDKD----KPYLYC--------------FRT 259

  Fly  1163 TADEGYEADGEIADLSESECELNGGVLAANESTWTPFQPSSRYRSHIMHQGLSQLVVQMLAELSL 1227
            :...||.|            ...||.|..     |..:...:...|
Human   260 SKGLGYSA------------HFVGGCLIV-----TSIKSKGKGFQH------------------- 288

  Fly  1228 LCIK---QPNGW-TESLTQLANRL--FVIRDYLGGPLCLLKGFAPILSCSDP------------- 1273
             |:|   :|..| ..::..:.||.  ..:|.|:.|.|.........::.||.
Human   289 -CVKFDFKPQKWYMVTIVHIYNRWKNSELRCYVNGELASYGEITWFVNTSDTFDKCFLGSSETAD 352

  Fly  1274 --RLRELQQSILELVTH-LNTPEVLQCYYSILASK-----QPPVDLLMRHMHH---ISSGSLRKA 1327
              |:...|.:.:.|.:. ||..::...|...|..|     :...||.:.. ||   :..|.|..|
Human   353 ANRVFCGQMTAVYLFSEALNAAQIFAIYQLGLGYKGTFKFKAESDLFLAE-HHKLLLYDGKLSSA 416

  Fly  1328 QPCMELDF---PIITDGKIVVTSEP-------------LVSEQIERVRLHHQQCQTNTLFTRAAC 1376
                 :.|   |..||.::.:.|.|             |:.:.::.|..|..|...::: .....
Human   417 -----IAFTYNPRATDAQLCLESSPKDNPSIFVHSPHALMLQDVKAVLTHSIQSAMHSI-GGVQV 475

  Fly  1377 IFPVTQTRLWQPDGLTLSLWLELRGQQMHRSSMQFNDDETRYSGEDLTKLHLLSLGTNQAMVSIY 1441
            :||             |...|:.|         |:..||.     |||                .
Human   476 LFP-------------LFAQLDYR---------QYLSDEI-----DLT----------------I 497

  Fly  1442 ISNNMQLIFELVKPNEQLAPVRVEEQIEANADTASVISANTQAANGGTIRQALKQTKLA----LL 1502
            .|..:..|.||:|.:     :.::||:.| .....||..:.:.::...:.:|:.:..||    |.
Human   498 CSTLLAFIMELLKNS-----IAMQEQMLA-CKGFLVIGYSLEKSSKSHVSRAVLELCLAFSKYLS 556

  Fly  1503 NSFGQMHLLNGHQASADSTGGYFESSAVQL-QHLRLPRHKWMHLVFGLQQQADSVEISIFLDGLE 1566
            |....|.||.                  || .|:.|....|:|....:|....:...:.|:.
Human   557 NLQNGMPLLK------------------QLCDHVLLNPAIWIHTPAKVQLMLYTYLSTEFIG--- 600

  Fly  1567 QHTMRLPFRNLRQLTRV----HS--FQLLALGEGQPTGRSPGSSSSSRSTLDGSTP--RYALS-- 1621
              |:.: :..:|::..|    |:  :...|:.....:|.:|       ..|||..|  :..||
Human   601 --TVNI-YNTIRRVGTVLLIMHTLKYYYWAVNPQDRSGITP-------KGLDGPRPNQKEMLSLR 655

  Fly  1622 -NVILFKRRLV-----------------------DPLLMMNLTAMGPDFTEFTQCQVANWKPNYG 1662
             .:::|.::||                       |..||..|..:....:|.....:..:....|
Human   656 AFLLMFIKQLVMKDSGVKEDELQAILNYLLTMHEDDNLMDVLQLLVALMSEHPNSMIPAFDQRNG 720

  Fly  1663 FVSLGKLSSSN-----------FGNHLDCMRQLRQARVLVYTAQQPDLVMSYDASQELDMACYGQ 1716
            ...:.||.:|.           .|..|..:...|:|.|::
Human   721 LRVIYKLLASKSEGIRVQALKAMGYFLKHLAPKRKAEVML------------------------- 760

  Fly  1717 PHGHMLYGELQQHQAQTLQAATSLSGGLSTLLYLFARIVELTGNASTQALALDLLLQVAHSDAQL 1781
              ||.|:..|    |:.|...|:|. .::|...||..::|..|   ||      ::...|.|...
Human   761 --GHGLFSLL----AERLMLQTNLI-TMTTYNVLFEILIEQIG---TQ------VIHKQHPDPDS 809

  Fly  1782 YTEFQRQDYLSLIGYVIK-SEKCSKDVQLLRS-------IVNNA---------CS----QVLITR 1825
            ..:.|....|.:|..::: |.:|.:.:::.|:       :.||:         ||    .:|...
Human   810 SVKIQNPQILKVIATLLRNSPQCPESMEVRRAFLSDMIKLFNNSRENRRSLLQCSVWQEWMLSLC 874

  Fly  1826 KGDSINVNDNTMATLVYP--RLML--TVLQRYSDWH----RSGATHSDVLDMLFRCILALTRDKH 1882
            ..:..|.::..:..:||.  |::|  .|...:..|.    ....|||.|           |.:.|
Human   875 YFNPKNSDEQKITEMVYAIFRILLYHAVKYEWGGWRVWVDTLSITHSKV-----------TFEIH 928

  Fly  1883 PQRDFNMEQLQKCGLLGALLNLC------------------------------------------ 1905
            .:...|:.:.|: |.:...:.||
Human   929 KENLANIFREQQ-GKVDEEIGLCSSTSVQAASGIRRDINVSVGSQQPDTKDSPVCPHFTTNGNEN 992

  Fly  1906 ----KVYVIESPSPVQIS----------------------------------------------- 1919
                |...:||.|.:::.
Human   993 SSIEKTSSLESASNIELQTTNTSYEEMKAEQENQELPDEGTLEETLTNETRNADDLEVSSDIIEA 1057

  Fly  1920 -PYAAECFV----------QILA-VFSGSPPDSSMLDEIMKLLLLLHKPSDCYVTHDRTHFYFLL 1972
             ..::..|:          ::.| :.|.|..|:|.:.|.:...::..:..|.||.        |.
Human  1058 VAISSNSFITTGKDSMTVSEVTASISSPSEEDASEMPEFLDKSIVEEEEDDDYVE--------LK 1114

  Fly  1973 TAQQPTKERSLVAANLSRVTTSLRRQLHPQPQELDPERAERIKKL-------------------- 2017
            ....||:|     |||   .|.|      |...|.|..:|..:||
Human  1115 VEGSPTEE-----ANL---PTEL------QDNSLSPAASEAGEKLDMFGNDDKLIFQEGKPVTEK 1165

  Fly  2018 --------------RRLHASTSGY---RKAVNEF--EEHLDQMA-----------------DC-- 2044
                          :.:.||.|..   ...|::.  |..|.||.                 ||
Human  1166 QTDTETQDSKDSGIQTMTASGSSAMSPETTVSQIAVESDLGQMLEEGKKATNLTRETKLINDCHG 1230

  Fly  2045 -----SNLNKSALRLLSPVEATRWRLKFKRRHPTSANSPKRSPLKIARRRIHPHLHLGKIWQPSG 2104
                 |:..|.|...:|.|.....||:.|......|..|.|..|:|:|:
Human  1231 SVSEASSEQKIAKLDVSNVATDTERLELKASPNVEAPQPHRHVLEISRQ---------------- 1279

  Fly  2105 HSTPSSGQSSLP---------NRKTDF-YDQLGIIRLQQRLLI-------------------LLK 2140
            |..|  ||...|         :|.|.| ..:....::.||||.                   .:.
Human  1280 HEQP--GQGIAPDAVNGQRRDSRSTVFRIPEFNWSQMHQRLLTDLLFSIETDIQMWRSHSTKTVM 1342

  Fly  2141 DFLCLLPDSSVDVV----TRHYVK-------------LELLLV----------------LANQRS 2172
            ||:    :||.:|:    |.|.:.             |.||..                |:.:.|
Human  1343 DFV----NSSDNVIFVHNTIHLISQVMDNMVMACGGILPLLSAATSATHELENIEPTQGLSIEAS 1403

  Fly  2173 CAVRQAIIQLVDVL-------------TKRLPSGELNAATKLMHPLHLANQLTIHGCDVGMFEAC 2224
            ....|.:|.|||||             .|.:.||.:     |...|.|...:.:..|......:.
Human  1404 VTFLQRLISLVDVLIFASSLGFTEIEAEKSMSSGGI-----LRQCLRLVCAVAVRNCLECQQHSQ 1463

  Fly  2225 LAW-----INGMHCSLTDI--QSCDAPV--------------RIRQRFGLPSLLAIA----EGTE 2264
            |..     :..|| ||..:  .:..:||              |:.|...:..|.|:.    |.::
Human  1464 LKTRGDKALKPMH-SLIPLGKSAAKSPVDIVTGGISPVRDLDRLLQDMDINRLRAVVFRDIEDSK 1527

  Fly  2265 PQWVFKALLRLYL---------------QNPDDQTCLIEAG-------LLQCSVKALYKIYSLRV 2307
             |..|.||..:|.               ||........|.|       |.:.:..|...:.:..|
Human  1528 -QAQFLALAVVYFISVLMVSKYRDILEPQNERHSQSCTETGSENENVSLSEITPAAFSTLTTASV 1591

  Fly  2308 GQSNADESVVELLATIGERAMRSVGQ----------------INLVWDILNLLSFYQDKQPQL-- 2354
            .:|.:..|.....:.|||.....:|.                .:.:.::|:.||...:|.|:.
Human  1592 EESESTSSARRRDSGIGEETATGLGSHVEVTPHTAPPGVSAGPDAISEVLSTLSLEVNKSPETKN 1656

  Fly  2355 ------------------------IMRSFRT-------------------AQAQLQLEWLTKFFE 2376
                                    |:||...                   |...|.:|      :
Human  1657 DRGNDLDTKATPSVSVSKNVNVKDILRSLVNIPADGVTVDPALLPPACLGALGDLSVE------Q 1715

  Fly  2377 PNSFR------VAVTNDSSLSHSELRTRVELLIDRCTQFFTVGVGQTTGPNYVASSQELALFQLL 2435
            |..||      :.....|::|.|...|.:                 .|....|.||.:.|  |..
Human  1716 PVQFRSFDRSVIVAAKKSAVSPSTFNTSI-----------------PTNAVSVVSSVDSA--QAS 1761

  Fly  2436 VSYGISSNQRCNNFIAWGLQPSRPRDLRSYIVDALWRSQQDEFQRAIICDAKMIKALLWLSLLED 2500
            ...|.|...|.:|    ...||.|      .||::   .||....              :|:.|.
Human  1762 DMGGESPGSRSSN----AKLPSVP------TVDSV---SQDPVSN--------------MSITER 1799

  Fly  2501 MPEPIENLKPLC-------------DALG---------------IKENDSSWNLV-----HELDR 2532
            :...:|...||.             ..||               :|.:.|...||     .|...
Human  1800 LEHALEKAAPLLREIFVDFAPFLSRTLLGSHGQELLIEGTSLVCMKSSSSVVELVMLLCSQEWQN 1864

  Fly  2533 LDQNRNNMA----AKQKTLLEKTVYRFEPLVQQCVESSMVTTRKVAE--LQNAERKAL------- 2584
            ..|....:|    ..:..||.:|:.  :.||:...|:..:.:|:.||  .::||.::|
Human  1865 SIQKNAGLAFIELVNEGRLLSQTMK--DHLVRVANEAEFILSRQRAEDIHRHAEFESLCAQYSAD 1927

  Fly  2585 ------MCHMKV----YDDTYTYTKWLE-IIRRMTHEGAPW--HSAERAECSWELDDTEGPSRVH 2636
                  ||...:    |.|..|.|:.:: ||..:|.:...|  .:..|....|.||..|...|
Human  1928 KREDEKMCDHLIRAAKYRDHVTATQLIQKIINILTDKHGAWGNSAVSRPLEFWRLDYWEDDLR-- 1990

  Fly  2637 TRLRRCHLDIDRRFFMNEYRPGQGHRE-DLEPYVRPL---------------------------- 2672
               ||      |||..|..  |..|.| .|:..|..:
Human  1991 ---RR------RRFVRNPL--GSTHPEATLKTAVEHVCIFKLRENSKATDEDILAKGKQSIRSQA 2044

  Fly  2673 --------DYLIASYDQQLNISLNSQILYNFA--------AKFLPVDGEIEGEIIITDLKLYFLA 2721
                    :.|:...|..|: |::.:.|.|.|        |:.:.....::|.:.:|..:|||..
Human  2045 LGNQNSENEILLEGDDDTLS-SVDEKDLENLAGPVSLSTPAQLVAPSVVVKGTLSVTSSELYFEV 2108

  Fly  2722 TYRCRYF-NVNCDIANITE-------------IWLKRYQHQETAFEILLDTNKSLFFSLQNADDW 2772
            ......| .::..|...||             |:.:||..|.||.||.:....::.|   |..|.
Human  2109 DEEDPNFKKIDPKILAYTEGLHGKWLFTEIRSIFSRRYLLQNTALEIFMANRVAVMF---NFPDP 2170

  Fly  2773 KIMREV--FCDKI---------------VATPDQ-SKVIAITQQWREGLLTNWEYLMTLNQISGR 2819
            ..:::|  :..::               :|:|.| .|...:||:|:...::|:||||.||.|:||
Human  2171 ATVKKVVNYLPRVGVGTSFGLPQTRRISLASPRQLFKASNMTQRWQHREISNFEYLMFLNTIAGR 2235

  Fly  2820 TYNDLMQYPVFPWVLANYNSEVLDLREGHNFRRLGRPIAVQVEENEKHYISNYTYIDSTNTTMGS 2884
            :||||.||||||||:.||.||.|||....|||.|.:||.....:....:...|...:...
Human  2236 SYNDLNQYPVFPWVITNYESEELDLTLPTNFRDLSKPIGALNPKRAAFFAERYESWEDDQ----- 2295

  Fly  2885 LILKPYHYSSHYSNSGTVLHFLVRVPPFTSYFLRYQDNDFDLPDRTFHALNTTWLLASRDSPTDV 2949
              :..:||.:|||.:..||.:|:|:.|||:|||..|...||..||||.:::..|..:.||: :|:
Human  2296 --VPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSISRAWRNSQRDT-SDI 2357

  Fly  2950 KELIPEFFCLPEMFENFERFKFGCRQNGERVEDVSLPPWSQRDSRLFVLIHRQALESELVRNQIH 3014
            |||||||:.|||||.||..:..|...:|..|.||.||||: :.|..||.|:|.|||||.|..|:|
Human  2358 KELIPEFYYLPEMFVNFNNYNLGVMDDGTVVSDVELPPWA-KTSEEFVHINRLALESEFVSCQLH 2421

  Fly  3015 NWIDLIFGYKQSGESAVEAINVFHPATY--AVFLDSEISDPIEREAVKTMVKTYGQMPRQLFKSP 3077
            .||||||||||.|..||.|:|||:..||  ||.|:| |:||:.||||:..::::||.|.||...|
Human  2422 QWIDLIFGYKQQGPEAVRALNVFYYLTYEGAVNLNS-ITDPVLREAVEAQIRSFGQTPSQLLIEP 2485

  Fly  3078 HP--ASKPLDYSLVGKPIVSTVRGLRWGVYVGSPQLKAPSWANIHKIPGTEHLVSFCNTNVVYAL 3140
            ||  .|....|.|:..|::.|.:..:..:.|    ||.||     ..|.| |:.:  ||....|.
Human  2486 HPPRGSAMQVYLLLQSPLMFTDKAQQDVIMV----LKFPS-----NSPVT-HVAA--NTQPGLAT 2538

  Fly  3141 PGRASVMQGAEPDTYNVISWGYDDRIVRIQPLNKPQAKPKNLLHNGT-----------FDDITAC 3194
            |...:|       |.|           |:..:||....|   .|.|.           .|.:.|.
Human  2539 PAVITV-------TAN-----------RLFAVNKWHNLP---AHQGAVQDQPYQLPVEIDPLIAS 2582

  Fly  3195 GCDVNSNQLWFGHKSGRISVYKCTGGLDSQQRA-------SAKSRQSYARGFSLSYNSAFRKMTN 3252
            ...::..|:              |..||...:.       ::.:|.....||   ::.:||..:.
Human  2583 NTGMHRRQI--------------TDLLDQSIQVHSQCFVITSDNRYILVCGF---WDKSFRVYST 2630

  Fly  3253 KGIGGGGSERVDEAGNL------HPTSSASSVNSSSISSGGDAF----QRDGADLNW-------- 3299
                        :.|.|      |.........|.|. .||:.:    .||...|.|
Human  2631 ------------DTGRLIQVVFGHWDVVTCLARSESY-IGGNCYILSGSRDATLLLWYWNGKCSG 2682

  Fly  3300 LGP----------TLLVRHTDEITCITLSVEFKIAVTAGRDGIAVIWDLNDWSYVRTIARPAEIH 3354
            :|.          .:|..|..|:||..:..|..:.::..::|..:|..:|. ..:||:..|..
Human  2683 IGDNPGSETAAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMNG-DLLRTLEGPEN-- 2744

  Fly  3355 QSPITHVAISPTL------GDIVTVHTLPQSCNTSTDPKPTAVATRPNSLNVADECFEVTEENLD 3413
                   .:.|.|      |..|..:.....|..|.:.|                 .:.|.|..|
Human  2745 -------CLKPKLIQASREGHCVIFYENGLFCTFSVNGK-----------------LQATMETDD 2785

  Fly  3414 DFVNVNVNPNGKSILR---LHSVNARYVQHLVH-------EDRILAVCYSYIKEGVGVNVIATAV 3468
            :...:.::.:|:.:|.   ...|..|.|..|..       :..|.|:..||.:.    .:|:...
Human  2786 NIRAIQLSRDGQYLLTGGDRGVVVVRQVSDLKQLFAYPGCDAGIRAMALSYDQR----CIISGMA 2846

  Fly  3469 EGGFVRFWSSWN 3480
            .|..|.|::.:|
Human  2847 SGSIVLFYNDFN 2858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mv	NP_647681.2	PH-like	2704..2785	CDD:473070	21/111 (19%)
		Beach	2796..3080	CDD:214982	139/287 (48%)
		WD40	<3302..>3518	CDD:441893	37/205 (18%)
LRBA	NP_001427359.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..35
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	969..1005		3/35 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1018..1039		0/20 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1161..1193		3/31 (10%)
		WD 1	1301..1343		6/41 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1586..1668		12/81 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1759..1789		10/42 (24%)
		WD 2	2596..2638		8/56 (14%)
		WD 3	2641..2684		9/43 (21%)
		WD 4	2700..2740		10/40 (25%)
		WD 5	2782..2821		8/38 (21%)
		WD 6	2824..2863		9/39 (23%)