|
Fly 4 MEVKEKEEQLLLDTLIGLWSQYLQASELEDASVKDHWLWLLLYNLQFLDDKNLQDAWLNSHFNLM 68
|..||:||:| ::.|.::|..| .|:..|.|
Mouse 42 MTQKEQEEKL--------------------------YMMLPVFNRVF----------GNAPPNTM 70
Fly 69 PEELCSYLLEQVYQI----ISEAKRSQESSPTHEPEQQDKCIKQLRKQHNLAQLILSTPSDCNKI 129
.|:. |.||:...|: ::|.:|...:..| |...:.|.|. |.::...:.::
Mouse 71 TEKF-SDLLQFTTQVSRLMVTEIRRRASNKST---EAASRAIVQF--------LEINQSEEASR- 122
Fly 130 LALRTFLTDKLGHHLLTFLLRVDIKLIAS--QKSL-CHL----------CINLF------PNCKW 175
|..||| .|.|:|| ||:: |.. |:.|| |....
Mouse 123 -----------GWMLLT-----TINLLASSGQKTVDCMTTMSVPSTLVKCLYLFFDLPHVPEAGG 171
Fly 176 SASNEQLIPMTSIAQFIGSFYLNSQSKKLRRQQQPKSQLPNHISNPIKSSFEDFRGTTRSSDELA 240
.|.|| :|:......:...::.. ..||.....|..:| ...|:|.
Mouse 172 GAQNE--LPLAERRGLLQKAFVQI-LVKLCSFVSPAEEL-------------------AQKDDLQ 214
Fly 241 LLLIQLLTRCV-------DAEQESQLSVTVHNFALGHL-------CSSSEQDASGNNDELIKFEL 291
||...:.:.|. .:..|..::::.|..::..: |.|:.......:|:|...|:
Mouse 215 LLFSAITSWCPPYNLPWRKSAGEVLMTISRHGLSVNVVKYIHEKECLSTCVQNMQQSDDLSPLEI 279
Fly 292 LQLIA--HCVNNFYVLEQ---QQPNVHDF----NSNF-GQLLYALTANRRSPLLAHGVLYIMFGT 346
:::.| .| ::.:. .|..:.|| ..|| ..||..|...:.:. ....|..:...
Mouse 280 VEMFAGLSC----FLKDSSDVSQTLLDDFRIWQGYNFLCDLLLRLEQGKEAE--CRDALKDLVSL 338
Fly 347 LHNLVDNGVRELNQI-----------------------DVRNFDACFEVLQEA---AKSTNFSTA 385
:.:|...||.||... .|||..| |.|||.| || |||...
Mouse 339 VTSLTTYGVSELKPAGVTTGAPFLLPGFAVPQPAGKGHSVRNIQA-FAVLQNAFLKAK-TNFLAQ 401
Fly 386 IFL----HIYKMLLRLTDNLS---SQEQHLQSLMESSASTAMPKQQQHPRHKRQRSSQLHCLGAT 443
|.| :|| :.||.: .:.||..|......| .:|:.|..
Mouse 402 IILDAITNIY-----MADNANYFILESQHTLSQFAEKIS-KLPEVQNK----------------- 443
Fly 444 SLSCYFQGKLYHLLPSLEAELQEHSVRSLLRTGSCCCHYNVRNYATCLQLAT-----QLSSSY-- 501
|| |:.|..|.|| ||..|.:|.: :.||||
Mouse 444 ----YF-------------EMLEFVVFSL-------------NYIPCKELISVSILLKSSSSYHC 478
Fly 502 ----QKCAYKFLHYNVLHTIFVKRNPQGCPGCEDKLKSPVF-HMDLLNIYKD---NYKALLNTPA 558
.|...||..: |.:...|| .:.||.:..: .|.|||..||
Mouse 479 SIIAMKTLLKFTRH-------------------DYIFKDVFREVGLLEVMVNLLHKYAALLKDPA 524
Fly 559 MLL----------FLKHLKHIAYLLPYDLA---------SGILAE----------VALPIFRRY- 593
..| .::..||:|.|:...|. :||..| |..|..|::
Mouse 525 QALNEQGDSRNNSSVEDQKHLALLVMEALTVLLQGSNTNAGIFREFGGARCAHNIVKYPQCRQHA 589
Fly 594 ----KELIES--GESKR-----KISKVTPLQLPSKLENYRAL-------HECLSIFVMYLSDIRL 640
::|:.| ||... .:....|.:|..|.:..||| |...::| |.
Mouse 590 LMTIQQLVLSPNGEDDMGTLLGLMHSAPPTELQLKTDILRALLSVLRESHRSRTVF-------RK 647
Fly 641 VKAFYNEENIRYMQDLLIIPELQRGVCDLIKVGIDNIAFLGENSQEQITLSRRLIQLQLNSSDRA 705
|..|. |:..||: .::|.:....|.|.:.: ||.|:......:...|.:
Mouse 648 VGGFV------YITSLLV--AMERSLSSPPKNGWEKV------SQSQVLELLHTVFCTLTA---- 694
Fly 706 SQLFQALLYKCSKHSRAKFWLDESSTPAKLEGHKPADILYITALQWTLNFELLKTSQLF---YNE 767
||.|: ||.....| |.:| :|.|..:..| :::
Mouse 695 -----ALRYE----------------PANSHFFK-------TEIQ----YEKLADAVRFLGCFSD 727
Fly 768 FAKIYSI--------PVEMLDDEDEDEVE--TPTSELLPGEKKLRHGDKNIFDILKLNYNALG-- 820
..||.:: |.:.|.:|....|: :|| |||..|....:.|:..::..
Mouse 728 LRKISAVNVFPSNTQPFQRLLEEGAVSVDSVSPT---------LRHCSKLFIYLYKVATDSFDSH 783
Fly 821 ------CFL---MLPKATMGPTTS-------STATTPTAGICGSSSLETLVSQLPLAGSTSVSVT 869
|.. .||.....|..| ..:|.|.......:.|:..|:..||..|.:|.:.
Mouse 784 AEQIPPCLTSESSLPSPWGTPALSRKRHAFHCVSTPPVYPAKNVTDLKLQVTSSPLQSSDAVIIH 848
Fly 870 TAASSDYADSTLDYASVIGNYDSYSRDMATPSFLQQLLACEPDESTVLFDIRGSQSSKDNPSNSL 934
..|.....|......||.....:....:|..:.||.|:..|.::..:.
Mouse 849 PGAMLAMLDLLASVGSVTQPEHALDLQLAVANILQSLVHTERNQQVMC----------------- 896
Fly 935 ILPSEEEGATADGIINKLFSIVGSLFGGSPGSGGSANSPTRANIDADFFCLYEPNGECKKLLLKL 999
|.|..| :|....|: |..|.| ..|:.| |.::
Mouse 897 -----EAGLHA-----RLLQRCGA-----------------ALADED-HSLHPP-------LQRM 926
Fly 1000 FEATMAICIKGFQNEEVEKMQKHLRKLRAIILSHATDNWSEHGEQHARDNAVIQTLQTLLKIAEL 1064
||. ..::.:|.| .|:..|::|
Mouse 927 FER--------LASQALEPM----------------------------------VLREFLRLA-- 947
Fly 1065 SSTHQEPTGVVNSPSGDSQQPRPRARSFNSGSVELPRLQTVKLPAKNSLATPPTPRRRPNSSEAN 1129
|| .|.|:.:...|:..::...:||:..|
Mouse 948 ------------SP-------------LNCGAWDKKLLKQYRVHKPSSLSFEP------------ 975
Fly 1130 AGVDADYFSTRASLSCAADSELELSENEHEFYLTADEGYEADGEIADLSESECELNGGVLAANES 1194
..|:|: :|:.||..:| .|.:::|
Mouse 976 --------EMRSSV------------------ITSLEGLGSD---------------NVFSSHE- 998
Fly 1195 TWTPFQPSSRYRSHIMHQGLSQLVVQMLAELSLLCIKQPNGWTESLTQLANRLFVIRDYLGGPLC 1259
.:.|| :|...:|...|.|..||::. |
Mouse 999 -------DNHYR------------------ISKSLVKSAEGSTVPLTRVK--------------C 1024
Fly 1260 LLKGFAPILSCSDPRLR--ELQQSILELVTHLNTPEVLQC-YYSILASKQPPVDLLMRHMHHISS 1321
|:....| .|.||. .:..:.:|..|.| |...| :...||....|.: :.:::
Mouse 1025 LVSMTTP----HDIRLHGSSVTPAFVEFDTSL---EGFGCLFLPSLAPHNAPTN------NTVTT 1076
Fly 1322 GSLRKAQPCMELDFPIITDGKIVVTSEPLVSEQIERVRLHHQQCQTNTLFTRAACIFPVTQTRLW 1386
| :|||.:| |.....|: .||
Mouse 1077 G---------------LTDGAVV--SGMGSGER----------------------FFP------- 1095
Fly 1387 QPDGLTLSLWLELRGQQMHRSSMQFNDDETRYSGEDLTKLHLLSLGTNQAMVSIYISNNMQLIFE 1451
.|.||:.|.|..:. |.||
Mouse 1096 PPSGLSYSCWFCIE----HFSS------------------------------------------- 1113
Fly 1452 LVKPNEQLAPVRVEEQI-EANAD------TASVISANTQAANGGTIRQALKQTKLALLNSFGQMH 1509
.||.. |||:...: .||:. .|.|:||.. |..:..||..||.::
Mouse 1114 --PPNNH--PVRLLTVVRRANSSEQHYVCLAIVLSAKD--------RSLIVSTKEELLQNY---- 1162
Fly 1510 LLNGHQASADSTGGYFESSAVQLQHLRLP------------RHKWMHLVF----GLQQQADSVEI 1558
.|.... |||..:: || ..:|.||.. |:.:.:.:
Mouse 1163 --------VDDFSE--ESSFYEI----LPCCARFRCGELVVEGQWHHLALLMSRGMLKNSTA--- 1210
Fly 1559 SIFLDGLEQHTMRLPFRNLRQLTRVHSFQLLALGEGQPTGRSPGSSSSSR----STL---DGSTP 1616
:::|||....|::|.: ||| :||.|.|:. ||: .|:.|
Mouse 1211 ALYLDGQLVSTVKLHY--------VHS--------------TPGGSGSANPPVLSTVYAYVGTPP 1253
Fly 1617 -RYALSNVIL------FKRRLVDPLLMMNLTAMGPDFTEFTQ-----CQ--------------VA 1655
:..:::::. |...::.|..:..:..:||::....| |: ||
Mouse 1254 AQRQIASLVWRLGPTHFLEEVLPPSSVTTIYELGPNYVGSFQAVCVPCKDAKSEGVTPSPVSLVA 1318
Fly 1656 NWKPNYGFVSLGKLSSSNFG------NHLDCMRQLRQARVLVYTAQQPDLVMSYDASQELDMACY 1714
..|.::|..:| .:||.... |.||.....:|..:..:....| :.:.::|:..|:..
Mouse 1319 EEKVSFGLYAL-SVSSLTVARIRKVYNKLDSKAIAKQLGISSHENATP-VKLVHNAAGHLNGP-- 1379
Fly 1715 GQPHGHMLYGELQQHQAQTLQAATSLS--GGLSTLLYLFARIVELTG-NASTQALA--------- 1767
.:..|..|.|.|..........||:|. ||.:.:|.|.|...::.| .|:.:||.
Mouse 1380 ARTIGAALIGYLGVRTFVPKPVATTLQYIGGAAAILGLVAMASDVEGLYAAVKALVCVVKSNPLA 1444
Fly 1768 ------------LDLLLQVAHS-------------------------------------DAQLYT 1783
|.:||:...| |.:::.
Mouse 1445 SKEMERIKGYQLLAMLLKKKRSLLNSHILHLTFSLVGTVDSGHETSIIPNSTAFQDLLCDFEVWL 1509
Fly 1784 EFQRQDYLSLIGYVI----KSEKCSKDVQLLRSIVNNACSQVLITRKGDSINVNDNTMATLVYPR 1844
....:.:|||..:.| :|.:.||:.:|:|.. ....::|:|.: .::::..|:|.: ..
Mouse 1510 HAPYELHLSLFEHFIELLTESSEASKNAKLMREF--QLIPKLLLTLR--DMSLSQPTIAAI--SN 1568
Fly 1845 LMLTVLQRY---SDWHRSGATHSDVLDMLFRC----ILALTRDKHP----QRDFNMEQLQKCGLL 1898
::..:||.: :|..|.|...|..|.....| ::.:..::.| :.:|. ||:
Mouse 1569 VLSFLLQGFPNSNDLLRFGQFISSTLPTFAVCEKFVVMEINNEEKPDPGAEEEFG-------GLV 1626
Fly 1899 GA--------LLNLCKVYVIESPSPVQISPYAAECFVQILA-----VFSGSPPDSSMLDEIMKLL 1950
.| ||::....|..|.....|:..|.|..|:.|. :|.......:.:...|::|
Mouse 1627 SANLILLRNRLLDILLKLVYTSKEKTNINLQACEELVRTLGFDWIMMFMEEHLHPTTVTAAMRIL 1691
Fly 1951 LLL-------------------HKPSDCYVTH-------------------------DRTHF--- 1968
::| .:.:|..:|: |..||
Mouse 1692 VVLLSNQSILIKFKEGLSGGGWLEQTDSVLTNKIGTVLGFNVGRSAGGRSTVREINRDACHFPGF 1756
Fly 1969 ----------------YFLLTA---QQPTKERSLVAANLSRVTTSLRRQLHPQPQELD---PERA 2011
||||.| |||..| .|:.|. |..:
Mouse 1757 LVLQSFLPKHTNVPALYFLLMALFLQQPVSE---------------------LPENLQVSVPVTS 1800
Fly 2012 ERIKK------------LRRLHASTSGYRKAVNEFEEHLDQMADCSNLNKSALRLLSPVEATRWR 2064
.|.|: :..:.||:.....:::.. |: :||..||..:.
Mouse 1801 SRCKQGCQFDLDSIWTFIFGVPASSGTVVSSIHNV---------CT---ESAFLLLGMLR----- 1848
Fly 2065 LKFKRRHPTSANSPKRSPLKIARRRIHPHLHLGKIWQPSGHSTPSSGQSSLPNRKTDFYDQLGII 2129
:..|||.:|..:.:..|.:| :.|.:.::...|:.|....
Mouse 1849 --------SMLNSPWQSEEEGSWLREYP-VTLMQFFRYLYHNVPDLAS----------------- 1887
Fly 2130 RLQQRLLILLKDFLCLLPDSSVDVVTRHYVKLELLLVLANQRSCAVRQAIIQLVDVLTKRLPSGE 2194
:.|..||||.|..:......|.| .|::..|.::......:......|....|..|..
Mouse 1888 ------MWLSPDFLCALAATVFPFNIRPY--SEMVTDLDDEVGSPAEEFKAFAADTGMNRSQSEY 1944
Fly 2195 LNAATKLMHPLHLANQLTIHGCDVGMFEACLAWINGMHC--------SLTDI---QSCDAPVRIR 2248
.|..|| ..||.|.....:|:.....|....| .|.|: .|.:...|.:
Mouse 1945 CNVGTK--------TYLTNHPAKKFVFDFMRVLIIDNLCLTPASKQTPLIDLLLEASPERSTRTQ 2001
Fly 2249 QR-FGLPSLLAIAEGTEPQWVFKALLRLYLQNPDDQTCLIEAGLLQCSVKALYKIYSLRV----- 2307
|: |....|.::.: ..|....|...|....:...|..|..|..:: .::.||
Mouse 2002 QKEFQTHVLDSVMD--------HLLAADVLLGEDASLPITSGGSYQVLVNNVF-YFTQRVVDKLW 2057
Fly 2308 -GQSNAD-----ESVVELLATIGERAMRSVG-QINLVWDILNLLSFYQDKQPQLIMRSFRTAQAQ 2365
|..|.: :.:::|:| :...||.| .::.|:..||....|| ..|:.:|...|
Mouse 2058 QGMFNKESKLLIDFIIQLIA---QSKRRSQGLSLDAVYHCLNRTILYQ------FSRAHKTVPQQ 2113
Fly 2366 LQLEWLTKFFEPNSFRVAVTNDSSL----SHSELRTRVELLIDRCTQFFTVGVGQTTGPNYVASS 2426
:.| .:|.||...|.:.: :|.: |.: .|.....:.: :..||
Mouse 2114 VAL--------LDSLRVLTVNRNLILGPGNHDQ-----EFI--SCLAHCLINL-------HAGSS 2156
Fly 2427 QELALFQLLVSYGISSNQRCNNFIAWGLQPSRPRDLRSYIVDALWRSQQDEFQRAIICDAKMIKA 2491
.| .:|:.:..| ...|.:. .|.|:.. |..:.....|.::. :|||
Mouse 2157 VE--------GFGLEAEAR---MTTWHIM--IPSDIEP---DGGYSQDISEGRQL------LIKA 2199
Fly 2492 L--LWLSLLEDMPEPIENL------------------KPLCDALGIKENDSSW--NLVHE----- 2529
: :|..|:....:.:|.| :||.:..|:| .| :|.||
Mouse 2200 VNRVWTELIHSKKQVLEELFKVSLPVNDRGHVDIALARPLIEEAGLK----CWQNHLAHEKKCIS 2260
Fly 2530 ------------LDRLDQ--NRNNMAAKQKTLLEKTVYRFEPLVQQ---------CVESSMVTTR 2571
|.|:.. ..:.:...::...|..:::..|..|: .|...:|.|
Mouse 2261 RGEALVPTTQSKLSRVSSGFGLSKLTGSRRNRKESGLHKHSPSPQEISQWMFTHIAVVRDLVDT- 2324
Fly 2572 KVAELQNAERKALMCHMKVYDDTYTYTKWLEIIRRMTHEGAPWHSAERAEC-SWELDDTEGPSRV 2635
:..|.|..::.|| .|...:|.:|...:..|...|.....:.. .|.|:.||||.|:
Mouse 2325 QYKEYQERQQNAL---------KYVTEEWCQIECELLRERGLWGPPIGSHLDKWMLEMTEGPCRM 2380
Fly 2636 HTRLRRCHLDIDRRFFMNEYRPGQGHREDLEPYV------------------RPLDYLIA----- 2677
..::.| ...|.|.| ||| .|.|.:||
Mouse 2381 RKKMVR------NDMFYNHY-----------PYVPETEQEASVGSEIPSKQPEPPDDVIAQKKPA 2428
Fly 2678 ------SYDQQ---LNISLNSQILYNFA----------------------------------AKF 2699
|||.: |.::..:..:...| ::.
Mouse 2429 RYRRAISYDSKEYYLRLASGNPAIVQDAIVESSEGEATQQEPEHGEDTIAKVKGLVKPPLKRSRS 2493
Fly 2700 LPVDGEIEGEIIITD-------------------LKLY-----FLATYRC--------------- 2725
.|..|:.|.:..:.| |:|. ....|||
Mouse 2494 APDGGDEETQEQLQDQIAESGSIEEEEKTDNATLLRLLEEGEKIQHMYRCARVQGLDTSEGLLLF 2558
Fly 2726 --RYFNV----------------------------------------NCDI---ANITEIWLKRY 2745
.:|.| .|.| .:|.|:..:||
Mouse 2559 GKEHFYVIDGFTMTATREIRDIETLPPNMHEPIIPRGARQGPSQLKRTCSIFAYEDIKEVHKRRY 2623
Fly 2746 QHQETAFEILLDTNKSLFFSLQNADDWKIMREVFCDKIVATPDQSKVI----------------- 2793
..|..|.|:.....::...:.|.....|:.:. |...:.:..|.|:.:
Mouse 2624 LLQPIAVEVFSGDGRNYLLAFQKGIRNKVYQR-FLAVVPSLTDSSESVSGQRPNTSVEQGSGLLS 2687
Fly 2794 ------AITQQWREGLLTNWEYLMTLNQISGRTYNDLMQYPVFPWVLANYNSEVLDLREGHNFRR 2852
::||:|..|.::|::|||.||.::||:||||||||||||:|::|:||.:||.....||.
Mouse 2688 TLVGEKSVTQRWERGEISNFQYLMHLNTLAGRSYNDLMQYPVFPWILSDYDSEEVDLTNPKTFRN 2752
Fly 2853 LGRPIAVQVEENEKHYISNYTYIDSTNTTMGSLILKPYHYSSHYSNSGTVLHFLVRVPPFTSYFL 2917
|.:|:..|.:|....|...|...:..|....: |||.:|||::..|..:|||:.|||..||
Mouse 2753 LAKPMGAQTDERLAQYKKRYKDWEDPNGETPA-----YHYGTHYSSAMIVASYLVRMEPFTQIFL 2812
Fly 2918 RYQDNDFDLPDRTFHALNTTWLLASRDSPTDVKELIPEFFCLPEMFENFERFKFGCRQNGERVED 2982
|.|...|||.||.||::...|..||:.:..||||||||||.|||...|...|..||:|||.::.|
Mouse 2813 RLQGGHFDLADRMFHSVREAWYSASKHNMADVKELIPEFFYLPEFLFNSNNFDLGCKQNGTKLGD 2877
Fly 2983 VSLPPWSQRDSRLFVLIHRQALESELVRNQIHNWIDLIFGYKQSGESAVEAINVFHPATYAVFLD 3047
|.||||::.|.|.|:.:||:|||.:.|...:|.||||||||||.|.:||||:||||...|...:|
Mouse 2878 VILPPWAKGDPREFIRVHREALECDYVSAHLHEWIDLIFGYKQQGPAAVEAVNVFHHLFYEGQVD 2942
Fly 3048 -SEISDPIEREAVKTMVKTYGQMPRQLFKSPHPASKPLDYSLVGKPIVSTVRGLRWGVYVGSPQL 3111
..|:||::..|....:..:||:|:||||.|||. |.:.|.:.|...|:.|
Mouse 2943 IYNINDPLKETATIGFINNFGQIPKQLFKKPHPP----------KRVRSRLNGDNIGISV----- 2992
Fly 3112 KAPSWANIHKIPGTEHLVSF------------------CNTNVVYALPGRASVMQGAEPDTYN-V 3157
|..|...|| ...||.:. |....:.|:.....:: |..:| .
Mouse 2993 --PPGATSDKI-FFHHLDNLRPSLTPVKELKEPVGQIVCTDKGILAVEQNKVLI----PPAWNKT 3050
Fly 3158 ISWGYDDRIVRIQPLNKPQAKPKNLLHNGTFDDITACGCDVNSNQLWFGHKSGRISVYKCTGGLD 3222
.:|||.|...|: ||::...| ::||:|
Mouse 3051 FAWGYADLSCRL----------------GTYESDKA------------------VTVYEC----- 3076
Fly 3223 SQQRASAKSRQSYARGFSLSYNSAFRKMTNKGIGGGGSERVDEAGNLHPTSSASSVNSSSISSGG 3287
:.|.|.: ..|...|...:.:||
Mouse 3077 ----------------------------------------LSEWGQI---LCAVCPNPKLVITGG 3098
Fly 3288 DA----FQRDGADLNWLGP-TL---LVRHTDEITCITLSVEFKIAVTAGRDGIAVIWDLNDWSYV 3344
.: ....|.......| || |:.|||.:||.|.|:.:.|.|:..||...:|||||..|::
Mouse 3099 TSTVVCVWEMGTSKEKAKPLTLKQALLGHTDTVTCATASLAYHIIVSGSRDRTCIIWDLNKLSFL 3163
Fly 3345 RTIARPAEIHQSPITHVAISPTLGDIVTVHTLPQSCNTSTDPKPTAVATRPNSLNVADECFEVTE 3409
..:.. |::|::.:.|:...|||| ||
Mouse 3164 TQLRG----HRAPVSALCINELTGDIV-------SC----------------------------- 3188
Fly 3410 ENLDDFVNVNVNPNGKSILRLHSVNARYVQHLVHEDRILAVCYSYIKEGVGVNVIATAVEGGFVR 3474
...:::| .:.||..|:.:::...| ..:|:..|.|.:.|....|||.|....|.||
Mouse 3189 --AGTYIHV-WSINGNPIVSVNTFTGR-------SQQIVCCCMSEMNEWDTQNVIVTGHSDGVVR 3243
Fly 3475 FW 3476
||
Mouse 3244 FW 3245
| 
