|
Fly 211 KSQLPNHISNPIKSSFEDFRGTTRSSD-ELALLLIQLLTRCVDAEQESQLSVTVHNFALGHLCSS 274
:|..|..:.:.::..|.:::..|..|. |....|:.||...:.|.:.| :|.:|
Human 76 QSSSPTALWDMLERKFLEYQQLTHKSPIERQKSLLSLLPLFLKAWEHS----------VGIIC-- 128
Fly 275 SEQDASGNNDELIKFELLQLIAHCVNNFYVLEQQQPNV----HDFNSNFGQLLYALTANRRSPLL 335
|..||.:|..|::....:.|:..| .......||||:......:...|
Human 129 --------------FPSLQRLAEDVSDQLAQQLQKALVGKPAEQARLAAGQLLWWKGDVDQDGYL 179
Fly 336 AHGVLYIMFG----TLHNLVDNGVRELNQIDVRNFDACFEVLQ-------------EAAKSTNFS 383
....:|::.| ||..:.::|:..| :|| |..:|.
Human 180 LLKSVYVLTGTDSETLGRVAESGLPAL-------------LLQCLYLFFVFPLDKDELLESD--- 228
Fly 384 TAIFLHIYKMLLRLTDNLSSQEQHLQSLMESSASTAMPKQQQHPRHKRQRSSQLHCLGATSLSCY 448
|.:.||.:::..|:.|..|.|:.|:..|...:: |.|| :|
Human 229 ----LQVQKMFVQMLLNICSDSQGLEGLLSGSELQSL-------------------LIAT--TC- 267
Fly 449 FQGKLYHLLPSLEAELQEHSVRSLLRTGSCCCHYNVRNYATCLQLATQLSSSYQKCAYKFLHYNV 513
|:||| ||.:....: |:..| :|.:......::|.
Human 268 ---------------LREHS----------CCFWKEPTF--CVLRA--ISKAQNLSIIQYLQ--- 300
Fly 514 LHTIFVKRNPQGCPGCEDKLKSPVFHMD---LLNIYKDNYKALLNTPAMLLFLKHLKHIAY---- 571
.|..|:.:.|......|.|.:|..... :|...||:|.. :..|||:......|
Human 301 -ATDCVRLSLQNLSRLTDTLPAPEVSEAVSLILGFVKDSYPV-----SSALFLEFENSEGYPLLL 359
Fly 572 --LLPYDLASGILAEVALPIFRRYKELI----ESGESKRKI-SKVTPLQLPS----------KLE 619
||.|| |:......|.......|: ..|.|:.|: ..:|..||.. .::
Human 360 KVLLRYD---GLTQSEVDPHLEELLGLVVWLTTCGRSELKVFDSITYPQLEGFKFHHEASGVTVK 421
Fly 620 NYRALHECLSIF---------VMYLSDIRLVKAFYNEENIRYMQ--------------------- 654
|.:|.....::| :..||.||.:.| :|..|...::
Human 422 NLQAFQVLQNVFHKASDSVLCIQVLSVIRTMWA-WNARNFFLLEWTLQPISQFVEIMPLKPAPVQ 485
Fly 655 ------------DLLIIP-ELQRGVCDLIKVGIDNIAFLGENSQEQITLSRRLIQLQLNSSD--- 703
:|..:| |:.|.|..||| |:.....||......|.:...|
Human 486 EHFFQLLEALVFELHYVPHEILRKVQHLIK----------ESPGPSCTLMALQSILSIAGGDPLF 540
Fly 704 ----RASQLFQALLYKCSKHSRAKFWL---DESSTPAKLEGHKPADI----LYITALQWTL-NFE 756
|.|.|...||.:..| :||... ::.|||...:..:.... :.:|.|:.:: |..
Human 541 TDIFRDSGLLGLLLAQLRK--QAKIMRKSGNKVSTPGVQDPERELTCVMLRIVVTLLKGSVRNAV 603
Fly 757 LLKTSQLFYNEFAKIYSIPVEMLDDEDEDEVETPTSELL--------------------PGEKKL 801
:||...:. .|.||: ||||...|......|.| .||.:|
Human 604 VLKDHGMV--PFIKIF------LDDECYREASLSILEQLSAINAEEYMSIIVGALCSSTQGELQL 660
Fly 802 RHGDKNIFDILKLNYNALGCFLMLPKATMGPTTSSTATTPTAGICGSSSLETLVSQL-------P 859
: .|:|| :|...|:.||.......|| |.:.|.:|:|.| |
Human 661 K------LDLLK----SLLRILVTPKGRAAFRVSS----------GFNGLLSLLSDLEGSLQEPP 705
Fly 860 LAGSTSVS---------VTTAASSDYADSTLDYASVIGN-------YDSYSRDMATPSFLQQLLA 908
|....:|| .|..|.| :.|.:..|.|. ::..:.|:. ||.
Human 706 LQAWGAVSPRQTLELVLYTLCAVS----AALHWDPVNGYFFRRNGLFEKLAEDLC-------LLG 759
Fly 909 C---EPDESTVLFDIRGSQSSKDNPSNSLILPSEEEGATADGIINKLFSIVGSLFGGSPGS---- 966
| ..:|..:| |....:|..|...|:..:.....:....|.....|:|.|...:.|:
Human 760 CFGALEEEGNLL---RSWVDTKARPFADLLGTAFSSSGSLPPRIQSCLQILGFLDSMASGTLHLR 821
Fly 967 -------------------GGSANSPTR---------ANIDADFFCLYEPNGEC--KKLLLKLFE 1001
|.:.:.|.| ..:|.....:..|...| .:||.:|:.
Human 822 GDLKESLRTKQGPVVDVQKGETGSDPQRNFKQWPDLEERMDEGDAAIMHPGVVCIMVRLLPRLYH 886
Fly 1002 ATMAICIKGFQNEEVE-KMQKHLRKL------------------------RAIILSHATDN---- 1037
...... :||:: .:..|::.| ||::.|.:..:
Human 887 EDHPQL-----SEEIQCSLASHIQSLVKSEKNRQVMCEAGLLGTLMASCHRALVTSGSPLHSRLI 946
Fly 1038 --WSEHGEQHARDNAVIQ--------TLQTLLKIAELSSTH---------QEPTGVVNSP----- 1078
:.:...|....:.:.| :|....||.:.|.|| |...|:...|
Human 947 RIFEKLASQAIEPDVLRQFLGLGIPSSLSATTKILDSSHTHRGNPGCSGSQTAQGLAEGPWPAAP 1011
Fly 1079 -----SGDSQQPRPRARSFNS----------------------------------------GSVE 1098
.|.:|.|:|...|.:| |.:.
Human 1012 DAGLHPGVTQAPQPLGESQDSTTALQTALSLISMTSPRNLQPQRAALAPSFVEFDMSVEGYGCLF 1076
Fly 1099 LPRLQTVK--------------------------------LPAKNSLATPPTPRRRPNSSEANAG 1131
:|.|.||. |.:::..||...|.|........|.
Human 1077 IPTLSTVMGTSTEYSVSGGIGTGATRPFPPPGGLTFSCWFLISRHGAATEGHPLRFLTLVRHLAR 1141
Fly 1132 VDADYFSTRASLSCAADSELELSENEHEFYLTADEGYEADGEIADLSESE--------CELN--- 1185
.:..:.....|| |..|..|.:|..|.|| :..|:.|.| |:|.
Human 1142 TEQPFVCFSVSL-CPDDLSLVVSTEEKEF------------QPLDVMEPEDDSEPSAGCQLQVRC 1193
Fly 1186 GGVLAANESTWTPFQPSSRYRSHIMHQGLSQLVVQMLAELSLLCIKQPNGWTESLTQLANRLFV- 1249
|.:||..:........:...:.|.... :.|..|::....:|.|:...|...|:...| ||
Human 1194 GQLLACGQWHHLAVVVTKEMKRHCTVS--TCLDGQVIGSAKMLYIQALPGPFLSMDPSA---FVD 1253
Fly 1250 IRDYLGGPLCLLKGFAPILSCSDPRLRE--LQQSILELVTHLN---------------------T 1291
:..|:..|....:..:.|.......|.| :....||::..|. |
Human 1254 VYGYIATPRVWKQKSSLIWRLGPTYLFEEAISMETLEVINKLGPRYCGNFQAVHVQGEDLDSEAT 1318
Fly 1292 P----------------------EVLQCYYSI---LASKQ---------PPVDLLMRHMHHISSG 1322
| ::...|..: |.:|: .||.||.....|: ||
Human 1319 PFVAEERVSFGLHIASSSITSVADIRNAYNEVDSRLIAKEMNISSRDNAMPVFLLRNCAGHL-SG 1382
Fly 1323 SLRKAQPCMELDFPIITDGKIVVTSEPLVSEQIERVRLHHQQCQTNTL-FTRAACIFPVTQTRLW 1386
||| |.|.:.| .|: .||:.|.....::| |.....|..
Human 1383 SLR-------------TIGAVAV-------GQL-GVRVFHSSPAASSLDFIGGPAILL------- 1419
Fly 1387 QPDGLTLSLWLELRGQQMHRSSMQFNDDETRYSGEDLTKLHLLSLGTNQAMVSIYISN--NMQLI 1449
|| :|| ..||.|.|:. :..|| |:.|:.||....:.: ..|::
Human 1420 ---GL-ISL---------------ATDDHTMYAA--VKVLH--SVLTSNAMCDFLMQHICGYQIM 1461
Fly 1450 FELVKPNEQLAPVRVEEQIEANADTASVISANTQAANGGTIRQALKQTKLALLNSFGQMHLLNGH 1514
..|::....|...|:.:.|.:.|.|..: |.
Human 1462 AFLLRKKASLLNHRIFQLILSVAGTVEL-----------------------------------GF 1491
Fly 1515 QASADSTGGYFESSAVQLQHLRLPRHKWMHLVFGLQQQADSVEISIFLDGLEQHTMRLPFRNLRQ 1579
::||.:..|.| ||:......||: .||::|:|:|...|| .::.|....|.
Human 1492 RSSAITNTGVF-------QHILCNFELWMN-------TADNLELSLFSHLLE--ILQSPREGPRN 1540
Fly 1580 LTRVHSFQLLALGEGQPTGRSPGSSSSSRSTLDGSTPRYALSNVILFKRRLVDPLLMMN--LTAM 1642
....|..||: |:. :.||. :|.|:.: .|.:
Human 1541 AEAAHQAQLI--------------------------PKL----IFLFN----EPSLIPSKISTII 1571
Fly 1643 GPDFTEFTQCQVANWKPNYGFVSLGKLSSSNFGNHLDCMRQLRQARVLVYTAQQPDLV----MSY 1703
| ...||:. .|......||....:|||. :|..| :..
Human 1572 G-----ILACQLR--------------------GHFSTQDLLRIGLFVVYTL-KPSSVNERQICM 1610
Fly 1704 DASQELDMACYGQPHGHMLYGELQQHQAQTLQAATS-----LSGGLSTLLYL------FARIVEL 1757
|.:.:..:....|..|..:: |:....:.|.:..| ||......::| |..:::.
Human 1611 DGALDPSLPAGSQTSGKTIW--LRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQG 1673
Fly 1758 TGNASTQALALDLLLQVAHSDAQLYTEFQRQDYLSLIGYVIKSEKCSKDVQLLRSIVNNACSQVL 1822
..:|||..|||.|||....|.: |.|.| :|.|....:| |:.::.|.: :::|..||..
Human 1674 HLHASTTVLALKLLLYFLASPS-LRTRF--RDGLCAGSWV---ERSTEGVDI---VMDNLKSQSP 1729
Fly 1823 ITRKGDSI----NVNDNTMATLVY-PRLML--------TVLQRYSDWHRSGATHSDVLDMLFRCI 1874
:..:...: .|.::.:|..|: |.:.| |.|....|..: |.||.:.:.:
Human 1730 LPEQSPCLLPGFRVLNDFLAHHVHIPEVYLIVSTFFLQTPLTELMDGPK------DSLDAMLQWL 1788
Fly 1875 LALTRDKHPQRDFNMEQLQKCGLL--GALLNLCKVYVIESPSPVQISPYA-------AECFVQIL 1930
| .:|.| |::.:.||. |||| ::|........|.| |:.|
Human 1789 L----QRHHQ-----EEVLQAGLCTEGALL------LLEMLKATMSQPLAGSEDGAWAQTF---- 1834
Fly 1931 AVFSGSPPDSSMLDEIMKLLLLLHKPSDCYVTHDRTHFYFLLTAQQPTKERSLVAANLSRVTTSL 1995
|.| :::.|.|:|:
Human 1835 -------PAS-----VLQFLSLVHR---------------------------------------- 1847
Fly 1996 RRQLHPQPQELDPE-RAERIKKLRRLHASTSGYRKAVNEFEEHLDQMADCSNLNKSALRLLSPVE 2059
.:|| ||. ||....:...:.|...|.:|.|. .|
Human 1848 ---TYPQ----DPAWRAPEFLQTLAIAAFPLGAQKGVG-------------------------AE 1880
Fly 2060 ATRWRLKFKRRHPTSANSPKRSPLKIARRRIHPHLHLGKIWQPSGHSTPSSGQS---SLPNRKTD 2121
:|| :.:||:.: ..|.||....|: :.|.|:
Human 1881 STR-----------NTSSPEAA--------------------AEGDSTVEGLQAPTKAHPARR-- 1912
Fly 2122 FYDQLGIIRLQQRLLILLKDFLCLLPDSSVDVVTRHYVKLELLLVLANQRSCAVRQAIIQLVDVL 2186
:|::...:||::. ||..|| .:.::.||:||..:...:.:.::...|
Human 1913 --------KLREFTQLLLREL--LLGASS----PKQWLPLEVLLEASPDHATSQQKRDFQ----- 1958
Fly 2187 TKRLPSGELNAATKLMHPLHLANQLTIHGCDVGMFEACLAWINGMHCSLTDIQSCDAPVRIRQRF 2251
|..|.:|.:|.| ...|.|..||.
Human 1959 -----SEVLLSAMELFH--------MTSGGDAAMFR----------------------------- 1981
Fly 2252 GLPSLLAIAEGTEPQWVFKALLRLYLQNPDDQTCLIEAGLLQC-SVKALYKIYSLRVGQSNADES 2315
:|.|||...:|.....|.| :.| :.|.:.|:|| |..:||..
Human 1982 ---------DGKEPQPSAEAAAAPSLAN------------ISCFTQKLVEKLYS---GMFSADPR 2022
Fly 2316 -----VVELLATIGERAMRSVGQI-NLVWDILNLLSFYQDKQPQLIMRSFRTAQAQLQLEWLTKF 2374
::|.:..:.|.|......: :.::..||.:..|...:|| ::....|.|..:..|
Human 2023 HILLFILEHIMVVIETASSQRDTVLSTLYSSLNKVILYCLSKPQ------QSLSECLGLLSILGF 2081
Fly 2375 FEPNSFRVAVTNDSSLSHSELRTRVELLIDRCTQFFTVGVGQTTGPNYVASSQELALFQLLVSYG 2439
.:.:...|..|.:|::|. || |.....:.:.:.:.|. .:|
Human 2082 LQEHWDVVFATYNSNISF--------LL---CLMHCLLLLNERSYPE---------------GFG 2120
Fly 2440 ISSNQRCNNFIAWGLQPS-----RPRDLRSY---------IVDALWRSQQDEFQRAIICDAKMIK 2490
:....|.:.:....|.|: :..||.|. .|..||:....:.|:.:. ||..|.
Human 2121 LEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQLVAQRQQTLE-DAFKID 2184
Fly 2491 ALLWLSLLEDMPE-PIENLKPLCDALGIKENDSSWN--LVHELDRLDQNRNNMAAKQK-TLLEKT 2551
||:.....| .||.:.||.:...:| :|. |..|...| .:|:|:|...| ||...:
Human 2185 ----LSVKPGEREVKIEEVTPLWEETMLK----AWQHYLASEKKSL-ASRSNVAHHSKVTLWSGS 2240
Fly 2552 VYRFEPLV--QQCVESSMVTTRKVAELQNAERKALMCHMKVYDDTYTYTK---------WLEIIR 2605
:.....|: :|..:....|...|:.::|..|:....:..:|.|.....| |..|..
Human 2241 LSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQRRKCGNIKAANAWARIQE 2305
Fly 2606 RMTHEGAPWHSAERAE-CS-WELDDTEGPSRVHTRLRRC-------------------HLDIDRR 2649
::..|...|...|..: || ||||..|||:|:..|::|. |:.....
Human 2306 QLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLEALSSGRHKESQDKNDHISQTNA 2370
Fly 2650 FFMNE--YRPGQGHREDLEPYVRPLDYLIASYDQQLNISLNSQ-----------ILYNFAAK--- 2698
...:| .|..:| ||....:|....::...|:.||:|: ||.....|
Human 2371 ENQDELTLREAEG-----EPDEVGVDCTQLTFFPALHESLHSEDFLELCRERQVILQELLDKEKV 2430
Fly 2699 -----FLPVDGEI--EGEIIITDLKLYF------------LATYRC------------------- 2725
.:.|.|.: ||.::......|. ..|..|
Human 2431 TQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTGDVYCTRHCLSNISDPFIFNLCSKDRST 2495
Fly 2726 RYFNVNC-DIANITEIWLKRYQHQETAFEILLDTNKSLFFSLQNADDWKIMREVFCD-----KIV 2784
.:::..| ..|::.|:...|:..|:.|.||......|.|....|.|..|..:. ||. |..
Human 2496 DHYSCQCHSYADMRELRQARFLLQDIALEIFFHNGYSKFLVFYNNDRSKAFKS-FCSFQPSLKGK 2559
Fly 2785 AT----------PDQSKVIAITQQWREGLLTNWEYLMTLNQISGRTYNDLMQYPVFPWVLANYNS 2839
|| |...:: :.|:|::..::|:||||.||..:|||.||.|||||||||||:|.|
Human 2560 ATSEDTLNLRRYPGSDRI--MLQKWQKRDISNFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTS 2622
Fly 2840 EVLDLREGHNFRRLGRPIAVQVEENEKHYISNYTYIDSTNTTMGSLILKPYHYSSHYSNSGTVLH 2904
|.|:|.....||.|.:|:..|.:|.:..:|..:..::.|. |.:.:: .||.:|||::..|..
Human 2623 ETLNLANPKIFRDLSKPMGAQTKERKLKFIQRFKEVEKTE---GDMTVQ-CHYYTHYSSAIIVAS 2683
Fly 2905 FLVRVPPFTSYFLRYQDNDFDLPDRTFHALNTTWLLASRDSPTDVKELIPEFFCLPEMFENFERF 2969
:|||:||||..|...|...||:.||.||::.:||..|||::.:||:||.||||.|||...|....
Human 2684 YLVRMPPFTQAFCALQGGSFDVADRMFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGV 2748
Fly 2970 KFGCRQNGERVEDVSLPPWSQRDSRLFVLIHRQALESELVRNQIHNWIDLIFGYKQSGESAVEAI 3034
:|||.|:|..:.||.||||:..|.|.|:.:||:||||:.|...:|:||||||||||.|.:||:|:
Human 2749 EFGCMQDGTVLGDVQLPPWADGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAV 2813
Fly 3035 NVFHPATYAVFLD-SEISDPIEREAVKTMVKTYGQMPRQLFKSPHP----ASKPL-------DYS 3087
|:|||..|...:| |.|:||:.:..:...|..:||:|:|||..||| |.||| ..|
Human 2814 NIFHPYFYGDRMDLSSITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVS 2878
Fly 3088 LVG--KPIVSTVRGLR------WGVYVGSPQLKAPSWANIHKIPGTEHLVSFCNTNVVYALPGRA 3144
|.| :|...:::.|| ..:|:.|...::|..| |..|..||..:.....|.|..
Human 2879 LPGHPQPFFYSLQSLRPSQVTVKDMYLFSLGSESPKGA-IGHIVSTEKTILAVERNKVLL----- 2937
Fly 3145 SVMQGAEPDTYN-VISWGYDDRIVRIQPLNKPQAKPKNLLHNGTFDDITACGCDVNSNQLWFGHK 3208
|..:| ..|||:||
Human 2938 -------PPLWNRTFSWGFDD-------------------------------------------- 2951
Fly 3209 SGRISVYKCTGGLDSQQRASAKSRQSYARGFSLSYNSAFRKMTNKGIGGGGSERVDEAGNLHPTS 3273
:.|..| ||.|....||.:.:...| |...|....||:
Human 2952 ------FSCCLG---------------------SYGSDKVLMTFENLAAWG--RCLCAVCPSPTT 2987
Fly 3274 SASSVNSS-------SISSGGDAFQRDGADLNWLGPTLLVRHTDEITCITLSVEFKIAVTAGRDG 3331
..:|..|: |::.| :..|..|. ..|..||..:||:..||.|.:.|:..:|.
Human 2988 IVTSGTSTVVCVWELSMTKG----RPRGLRLR----QALYGHTQAVTCLAASVTFSLLVSGSQDC 3044
Fly 3332 IAVIWDLNDWSYVRTIARPAEIHQSPITHVAISPTLGDIVTVHTLPQSCNTSTDPKPTAVATRPN 3396
..::|||:..::|..: || |:..|:.:.||...|.|| || |....
Human 3045 TCILWDLDHLTHVTRL--PA--HREGISAITISDVSGTIV-------SC-----------AGAHL 3087
Fly 3397 SLNVADECFEVTEENLDDFVNVNVNPNGKSILRLHSVNARYVQHLVHEDRILAVCYSYIKEGVG- 3460
|| .|||..| |.|:...:.. |..|...| :.||..
Human 3088 SL-----------------WNVNGQP-------LASITTAWGP----EGAITCCC---LMEGPAW 3121
Fly 3461 --VNVIATAVEGGFVRFWSS---------------------------W--NLSFVSEL-----TT 3489
..:|.|..:.|.||.|.: | ||:...|| .|
Human 3122 DTSQIIITGSQDGMVRVWKTEDVKMSVPGRPAGEEPLAQPPSPRGHKWEKNLALSRELDVSIALT 3186
Fly 3490 G----TSP-IRSICYS-THQHLVVLTRESHIQVWESEG 3521
| ||| :.::..| .|..|:|......|..|.::|
Human 3187 GKPSKTSPAVTALAVSRNHTKLLVGDERGRIFCWSADG 3224
| 
