Protein Alignment mv and CG43367

DIOPT Version :10

• Sequence 1: NP_647681.2
• Gene: mv / 38259
• FlyBaseID: FBgn0288310
• Length: 3535
• Species: Drosophila melanogaster
• Sequence 2: NP_001189048.2
• Gene: CG43367 / 38505
• FlyBaseID: FBgn0263110
• Length: 2754
• Species: Drosophila melanogaster
• Alignment Length: 3297
• Identity: 676/3297 - (20%)
• Similarity: 1126/3297 - (34%)
• Gaps: 1132/3297 - (34%)

  Fly   612 LQLPSKLENYRALHE------------------CLSIFVMYLSDIRLVKAFYNE---ENIRYMQD 655
            |||..:.||....||                  .:..|::...|:...:....|   |.:..:.|
  Fly    38 LQLDFQAENCPMWHEVQPDSGPHLGRLPDELLPAIGKFIIVARDVCETEGKLEEQAIEEVAILVD 102

  Fly   656 LLIIPELQRGVCDLIKVGIDNIAFL--GENSQEQITLSRRLIQLQL---NSSDRASQLFQALLYK 715
            .|:|      ||.    ..|||..:  .|.....|.:..|:.:.|:   .|....|.||
  Fly   103 CLVI------VCR----HFDNILSIIKYEYKPNLIAILSRVFKQQMELPQSVPAISHLF------ 151

  Fly   716 CSKHSRAKFWLDESSTPAKLEGHKPADILYITALQWT--LNFELLKTSQLFYNEFAKIYSIPVEM 778
                         ||..|.||      ::|...|.|.  :..:....|:|.|    |.:|:.||:
  Fly   152 -------------SSFSAFLE------VMYDPYLTWRSFVRGQSADYSRLSY----KPHSVHVEI 193

  Fly   779 LDDEDEDEVETP-TSELLPGEKKLRHGDKNIFDILKLNYNALGCFLMLPKATMGPTTSSTATTPT 842
            :          | ..:....||.:|:.     :|.:...|.||
  Fly   194 V----------PFIYDCFQEEKLIRYA-----EIGESLLNILG---------------------- 221

  Fly   843 AGICGSSSLETLVSQLPLAGSTSVSVTTAASSDYADSTLDYASVIGNYDSYSRDMATPSFLQQLL 907
            |.|||        |||.|....|::.|:..::             .|.::.:.....|.....||
  Fly   222 AVICG--------SQLQLKVQKSLNSTSTLTN-------------RNTNALTTSSLAPCSGDGLL 265

  Fly   908 ACEPDESTVLFDIRGSQSSKDNPSNSLILPSEEEGATADGIINKLFSIVGSLFGGSPGSGGSANS 972
            .|                  ||..|                                  |..|..
  Fly   266 DC------------------DNLRN----------------------------------GMKAIC 278

  Fly   973 PTRANIDADFFCLYEPNGECKKLLLKLFEATMAICIKGFQNEE-----VEKMQKHLRKLRAIILS 1032
            |...:|.......:|.....:::.|:.: |.|.|.::....||     |..:|.:...|:.::.:
  Fly   279 PATVSITMSILRQWESANNLRRVALQCY-ALMVIVLQKSSPEERQIDLVTLVQLYCDALQELLAT 342

  Fly  1033 HATDNWSEHGE--QHARDNAVIQTLQTLLKIAELSSTHQEPTGVVNSPSGDSQQPRPRARSFNSG 1095
            ...|:...:.:  ..|..:..|.       :|.||||.......|...:|.|:...      :|.
  Fly   343 KHFDSGDANFDITSDADQDVAID-------MAALSSTVAAVKFFVTGDAGVSEAVS------DSN 394

  Fly  1096 SVE----LPRLQTVKLPAKNSLATPPTPRRRPNSSEANAGVDADYFSTRASLSCAADSELELSEN 1156
            .:|    ||:|  :|            |....:||...:.::|.....|.|...|  |:|...|.
  Fly   395 LLELLTNLPKL--IK------------PWHISHSSSLCSTMEALAILARHSPQSA--SQLRQGER 443

  Fly  1157 EHEFYLTADEGYEADGEIAD------LSESECELNGGVLAANESTWTPFQPSSRYRSHIMHQGLS 1215
            ....:.:..|......|:.|      ..|||..|....:......|.| ....|.:.|:     :
  Fly   444 IERLFTSLQEYGSPTVELLDTCFMLGYDESEHFLLLPEVMLRLLNWVP-TLQEREQLHV-----T 502

  Fly  1216 QLVVQMLAELSLLCIKQPNGWTES--LTQLANRLFVIRDYLGGPLCLLKGFAPILSCSDPRLREL 1278
            .||::              |.|::  ...:|....:|:...|   |||...:...:|
  Fly   503 SLVLK--------------GCTDNYRTKTVACGSHIIKAVCG---CLLTAESLAENC-------- 542

  Fly  1279 QQSILELVTHLN----TPEVLQCYYSIL--ASKQPPVDLLMRHMHHISSGSLRKAQPCME---LD 1334
            .|::::|:..|:    .|..|:|.:|:|  .:|.|....|.:.:..|:..|||.:..|.|   ::
  Fly   543 VQNLIKLIEELSKLSIVPAELKCIFSLLRQGTKFPQFKQLQQTLVVIALQSLRGSNSCAEFFSIE 607

  Fly  1335 FPIITDGKIVVTSEPLVSEQIER--------------VRLHHQQCQTN------TLFTRAACIFP 1379
            .|  |||.:|        ..|..              ||.:..:.|:|      ||.|.:...|.
  Fly   608 QP--TDGILV--------PDIRNWTISGSYGFIFHILVRFNQLKEQSNSRRMLLTLQTASGSGFE 662

  Fly  1380 VTQTRLWQPDG------LTLSLWL-------ELRGQQMHRSSMQFNDDETRYSGEDLTKLHLLSL 1431
            |    ..||:|      ||...:|       .|...|.|..::.....:..:|
  Fly   663 V----FVQPNGNVVVAALTRREYLTSSTATKTLMDGQWHYLTVAITPPKRPFS------------ 711

  Fly  1432 GTNQAMVSIYISNNMQL-----------------IFELVKPNEQ--------------------- 1458
               .:.::||:....:|                 |..:|.|.:.
  Fly   712 ---YSQINIYVDFVQKLSATLKVQAVNEPFTVCSIGAVVAPPQPGEVAKTGNMPRSSSQESGSSG 773

  Fly  1459 ---LAPVRVEEQIEANADTASVISANTQAANGGTIRQ---ALKQTKLALLNSFGQMHLLNGHQAS 1517
               :.|..:|..:.||......:...||.|....::.   .::.|      .||:...||||...
  Fly   774 YKGMLPSLLERTLSANVSNYFTLPMRTQTAFDPNVKNFPIGMQDT------VFGEQTCLNGHLGG 832

  Fly  1518 ---ADST---------GGYFESSAVQLQHLRLPRHKWMHLVFGLQQQADSVEIS-----IFLDGL 1565
               ||.|         |..|.|                  :|  .|..|.:|::     .:..|.
  Fly   833 VLLADPTTSLKTIFDAGANFSS------------------IF--SQDNDLLELNSRFVFCYAPGA 877

  Fly  1566 EQHTMRLPFRNLRQLTRVHSFQLLALGEGQ---PTGRSPGSSSSSR----------STLDGSTPR 1617
            ..|                       |..|   |.|:.||..::..          :::.|
  Fly   878 IWH-----------------------GTCQDLIPGGKYPGRINAQHCKIVKIQETINSIGG---- 915

  Fly  1618 YALSNVILFKRRLV--DPLLMMNLTAMG---------PDFTEFTQCQV------ANWK----PNY 1661
              :|.::....||:  |....:::.::.         |...|||..::      ..||    |..
  Fly   916 --ISAILPMLHRLITLDQTTDISIGSVSEESLSCAPTPSAEEFTDWEMLSSNSYTEWKMLQHPLA 978

  Fly  1662 GFVSLGKLSSSNFGNHLDCMRQLRQARVL--VYTAQQ--PDLVMSYDASQELDMACYGQPHGHML 1722
            .|:.|.:..:.   .|.....||..:..|  |.|..|  |..:...:|.    ||.      |:|
  Fly   979 SFLCLLRYLTH---EHETNQEQLLSSECLAIVGTMLQRCPPSLFDVNAL----MAT------HLL 1030

  Fly  1723 YGELQQHQAQTLQAATSLSGGLSTLLYLFARIV-----------ELT-GNASTQA---------- 1765
            ...||.|:|:        :|| ..|..|:|.||           ::| |:|...:
  Fly  1031 MESLQGHKAE--------AGG-QLLDALYAHIVFDFAIWSRLQFQITLGHAQYLSAMIKNDRKFF 1086

  Fly  1766 -------LALDLLLQ-------VAHSDAQ---------------------------LYTEFQRQD 1789
                   ..||::.|       ::..||:                           .:....|||
  Fly  1087 RKRYGVQFVLDVVRQYYSTPDSISDDDAKTIRATLFGIIKFYLQKDVNIKEVNSMITFLASVRQD 1151

  Fly  1790 -----YLSLIGYVIKSEKCSKDVQLLRSIVNNACSQVLITRKGDSINVNDNTMATLVYPRLMLTV 1849
                 :|.::.:.::.:.| ||            ..||:..:..|.|:..|......|...:...
  Fly  1152 VVLVEFLEMMTFYVRGKNC-KD------------QMVLLLHEPQSANLLYNFFVDKSYSNEIQEA 1203

  Fly  1850 LQRYSDWHRSGATHSDVLDMLFRCILALTRDKHPQRDFNMEQLQKCGLLG-----ALLNLCKVYV 1909
            ..|:.    ||...:..:...::.:|.|       .|...||....|...     :|.:....::
  Fly  1204 AIRFI----SGLLATSRVHQKYKQVLRL-------YDQTTEQSMFPGFFSFITPLSLSSTILFHL 1257

  Fly  1910 IESPSPVQISPYAAECFVQILAVFSGSPPDSSMLDEIMKLL------------------------ 1950
            ::....:| ..||...|:    |:..|..|..:..||.|.|
  Fly  1258 VDEMLGLQ-PDYAGLIFL----VYHVSSCDLPVKLEIAKRLLQTTFVKQQSTVAMAKQTGWQESI 1317

  Fly  1951 --LLLHKPSDCYVTHDRTHFYFLLTAQQPTKER---------------SLVAANLSRVTTSLRR- 1997
              ||:.||               :|:..|.:|:               |...|....:|.|.:.
  Fly  1318 ARLLIRKP---------------ITSSPPDEEKRRSFGINLDVLLEDNSNFLAQADLITFSEQEI 1367

  Fly  1998 ---QLHPQPQELDPERAERIKKLRRLHASTSGYRKAVNEFEEHLDQMADCSN--LNKSALRLLSP 2057
               ||..|.||   |.::....|..:.||.:   :|....|..:.::|:..:  :.::|..|.|.
  Fly  1368 GLAQLQQQQQE---ELSDSGLILNEIQASVT---EAATVIESEIKELAESVSGAVVENANSLFSV 1426

  Fly  2058 VEATRWRLK----------------------FKRRHPTSANSPKRSPLKIARRRIHPHLHLGKIW 2100
            :..|...|:                      .:|....|:::..:||
  Fly  1427 IRQTTHDLQDTFESLTQGSSTDTADGSQTPSIQREESLSSDTSSQSP------------------ 1473

  Fly  2101 QPSGHSTPSSGQSSLPNRKTDFYDQLGIIRLQQRLLILLKDFL---------------------- 2143
                |..|....|.......||... |.:..:::|:.|:.:.|
  Fly  1474 ----HGPPKKSDSLESTSAFDFVAD-GDVDTEEQLVYLVSNTLFNIFWRGIPNDHPQCWQERGQV 1533

  Fly  2144 --CL-LPDSSVDVVTRHY-VKLELLLVLANQRSCAVRQAIIQLVDVLTKRLPSGELNAATKLMHP 2204
              |: |...:.:::|.|. ::|.:|       ..||:.::..|.:..::.|.:.| ||:    |.
  Fly  1534 LGCINLLALNNELITSHLSLRLRIL-------EMAVQASLFDLSEHGSQTLVNQE-NAS----HI 1586

  Fly  2205 LHLANQLTIHG--------CDVGMFEACLAWINGMHCSLTDIQSCDAPVRIRQRFGLPSLLAIAE 2261
            |.:..:|.:.|        |...:.:..||.                         |.:|:...:
  Fly  1587 LRMVYELVVLGSNEDESKKCSTKLLDGVLAL-------------------------LDALMIFQQ 1626

  Fly  2262 GTEPQWVFKALLRLYLQNPDDQTCLIEAGLLQCS--------VKALYKIYSLRVGQSNADESVVE 2318
            |:...|  ..::||         ||  ..||:||        ..|..|::::...:|..|.:.:.
  Fly  1627 GSSDDW--SDMIRL---------CL--GLLLKCSHHPNPGIVAMATAKLHAILQSRSTEDPAELS 1678

  Fly  2319 LLATIGERAMRSVGQINLVWDILNLLSFYQDKQPQLIMRSFRTAQAQLQLEWLTKFFEPNSFRVA 2383
            .|.....||:.:..::.               .|                       |..||.:.
  Fly  1679 YLLYSINRALDNAIEVG---------------NP-----------------------EEYSFLMP 1705

  Fly  2384 VTNDSSLSHSELRTRVELLIDRCTQFFTVGVGQTTGPNYVASSQELALFQLLVSYGISSNQRCNN 2448
            |              ::.|:::|...|.:   .:|.|:..::|.....|.....|  |::::..|
  Fly  1706 V--------------MKALLEKCRVAFNL---DSTLPDLPSTSSGPVFFNDFQMY--STSKKWRN 1751

  Fly  2449 FIAWGLQPSRPRDLRSYIVDALWRSQQDEFQRAIICDAKMIKALLWLSLLEDMPEPIENLKPLCD 2513
            ||...::|                 ..|.:||.       |:..||        |||...
  Fly  1752 FIERMVKP-----------------LYDRYQRD-------IELHLW--------EPINRF----- 1779

  Fly  2514 ALGIKENDSSWNLVHELDR-LDQNRNNMAAKQKTLLEKTVYRFEPLVQQCVESSMVTTRKVAELQ 2577
                      |...:|..: ..:.|....|:.:.|.::.:|.  |.          ..|:|.|:|
  Fly  1780 ----------WAECYEACKAASKQRATNQAENRRLFQQKIYM--PW----------KVRQVEEMQ 1822

  Fly  2578 NAERKALMCHMKVYDDTYTYTKWLEIIRRMTHEGAPWHSAERAECSWELDDTEGPSRVHTRLRRC 2642
            ..:..||. |..:  |::...:|....|.:.....||::.|..|..|:|..       |..:.|.
  Fly  1823 RLQAAALQ-HKTI--DSHIRKRWKTAKRFLYGPRGPWYTGEVDEEFWKLSQ-------HENVARM 1877

  Fly  2643 HLDIDRRFFMNEYRPGQGHREDL-----------------EPYVRPLDYLI----ASYDQQLNIS 2686
            .|.::.:.:.|::......|::.                 ...||  |:|.    :..:::|...
  Fly  1878 RLKLEPQLYPNKHENAANLRDNATSAYDTKEISEFDSTIKNAVVR--DFLADDESSQLEEELRQL 1940

  Fly  2687 LNSQILYNFAAKFLPVDGE---------IEGEIIITDLKLYFL---------ATYRCRYFNVNCD 2733
            :::|...:.|.:.|.:..:         ::|.|.:......|:         :.|..| |:.|
  Fly  1941 IDTQAQQDVALEKLVMSQDCELITLMTKVKGRIEVNQSVFTFVDLSPPTEDGSKYDFR-FSTN-- 2002

  Fly  2734 IANITEIWLKRYQHQETAFEILLDTNKSLFFSLQNADDWKIMREVFCDKIVATP----------- 2787
              .|.|:.|::|..:.:|.||.|....|.|.:...    |...:|| .|||..|
  Fly  2003 --KIREVHLRKYNLRRSALEIFLVDQTSYFLNFTT----KTRNKVF-TKIVGLPLPNILYGSGRS 2060

  Fly  2788 --DQSKVIAITQQWREGLLTNWEYLMTLNQISGRTYNDLMQYPVFPWVLANYNSEVLDLREGHNF 2850
              :..:...:||:|....::|:||||.||.|:||:||||.|||||||:||:|.|:||||.:..:|
  Fly  2061 PAELLRASGLTQRWINREISNFEYLMYLNTIAGRSYNDLSQYPVFPWILADYTSDVLDLTDPKSF 2125

  Fly  2851 RRLGRPIAVQVEENEKHYISNYTYIDSTNTTMGSLILKPYHYSSHYSNSGTVLHFLVRVPPFTSY 2915
            |.|.:||.....:||......|   ||.....|:  :..:||.:|||||..|||:|:||.||||.
  Fly  2126 RDLSKPIGCINPKNEAEVRGKY---DSFEDPSGA--IPKFHYGTHYSNSAGVLHYLLRVEPFTSL 2185

  Fly  2916 FLRYQDNDFDLPDRTFHALNTTWLLASRDSPTDVKELIPEFFCLPEMFENFERFKFGCRQ-NGER 2979
            .:..|...||:.||.||::..||.|. .|:|.||||||||||..||..:|..:|..|..| ..|:
  Fly  2186 HIDLQSGRFDVADRQFHSIPQTWKLL-MDNPNDVKELIPEFFYFPEFLKNMNKFDLGHLQITKEK 2249

  Fly  2980 VEDVSLPPWSQRDSRLFVLIHRQALESELVRNQIHNWIDLIFGYKQSGESAVEAINVFHPATY-- 3042
            |:||.||.|:..... |:.|||:|||||.|...:|:||||||||||.|..|.||:|||:..:|
  Fly  2250 VDDVILPAWATTPEE-FIAIHRRALESEYVSQHLHHWIDLIFGYKQKGPKAAEALNVFYYCSYEG 2313

  Fly  3043 AVFLDSEISDPIEREAVKTMVKTYGQMPRQLFKSPHPASKPLDYSLVGKPIVSTVRGLRWGVYVG 3107
            ||.|| :|::|:|||||:.|:..:||:|.||.:.|||.....|     :..:..||.
  Fly  2314 AVDLD-KITNPVEREAVEGMINNFGQVPSQLLREPHPRRLTQD-----ETALKLVRA-------- 2364

  Fly  3108 SPQLKAPSWANIHKIPGTEHLVSFCNTNVVYALPGRASVMQGAEPDTYNVISWGYDDRIVRIQPL 3172
              :|:.|.            |..|.:..|.|                |..:|.. .|.||.:.|
  Fly  2365 --ELRRPD------------LTQFLDKVVQY----------------YCELSTP-KDPIVYLSP- 2397

  Fly  3173 NKPQAKPKNLLHNG-----TFDDITACGCDVNSNQLWFGHKSG-RISVYKCTGGLDSQQRASA-- 3229
              |::.|::.|...     :....|..||   ::.|.|....| .:.:...|..|.:::|...
  Fly  2398 --PRSPPRSFLQLSPDVLVSISKSTILGC---NSWLSFDKDQGFLLEIDATTANLKNRKRIFGPF 2457

  Fly  3230 -KSRQSYARGFSLS-----------YNSAFRKMT-NKGIGGGGSER---------VDEAGNLHPT 3272
             .|:|.:::.|::|           ::::.|... |||.......|         :|..|:...|
  Fly  2458 HSSQQPHSQLFAVSTDGKLLYAGGIWDNSLRVYNLNKGKAVASVTRHLDIITCIALDNCGSYLVT 2522

  Fly  3273 SSAS------SVNSSSISSG-----------GDAFQRDGADLNWLGP------TLLVRHTDEITC 3314
            .|..      |:.::....|           |.:..:....||....      |:|..|.|.|:.
  Fly  2523 GSRDCTCIVWSIQTNQQGGGSTNNIPVHALTGQSHLQAITQLNTQNSYSPKPLTVLYGHDDAISS 2587

  Fly  3315 ITLSVEFKIAVTAGRDGIAVIWDLNDWSYVRTIARPAEIHQSPIT----------HVAISPTLGD 3369
            :.:..|..:.|:...||...::.|.:..:|||: :|....:|.:.          |:|.|.....
  Fly  2588 VAIYTELDLVVSGSLDGTVNVYTLQEGQFVRTL-KPIGCTESCVQISFVTLSYHGHIAFSALDDT 2651

  Fly  3370 IVTVHTLP-QSCNTST---DPKPTAVATRPNSLNVADECFEVTEENL 3412
            ..:||... ..|:..:   ..:.|.:|:..:.|.|||:..::|...|
  Fly  2652 SHSVHVYSINGCSLGSKYVSGRVTGLASASDYLVVADDAGDITMSRL 2698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mv	NP_647681.2	PH-like	2704..2785	CDD:473070	22/98 (22%)
		Beach	2796..3080	CDD:214982	143/286 (50%)
		WD40	<3302..>3518	CDD:441893	29/131 (22%)
CG43367	NP_001189048.2	Laminin_G_3	644..752	CDD:463865	22/126 (17%)
		DUF4704	906..>1162	CDD:464870	50/283 (18%)
		DUF4800	1646..1899	CDD:464996	64/378 (17%)
		PH_BEACH	1952..2046	CDD:275391	22/103 (21%)
		Beach	2072..2351	CDD:460459	143/286 (50%)
		NBCH_WD40	2395..2742	CDD:466575	60/311 (19%)
		WD40 repeat	2465..2503	CDD:293791	6/37 (16%)
		WD40 repeat	2509..2580	CDD:293791	11/70 (16%)
		WD40 repeat	2585..2621	CDD:293791	9/36 (25%)