Protein Alignment mv and Nbea

DIOPT Version :10

• Sequence 1: NP_647681.2
• Gene: mv / 38259
• FlyBaseID: FBgn0288310
• Length: 3535
• Species: Drosophila melanogaster
• Sequence 2: XP_036019004.1
• Gene: Nbea / 26422
• MGIID: 1347075
• Length: 2968
• Species: Mus musculus
• Alignment Length: 3488
• Identity: 711/3488 - (20%)
• Similarity: 1167/3488 - (33%)
• Gaps: 1199/3488 - (34%)

  Fly   358 LNQIDV---RNFDACFEVLQEAAKSTNFSTAIFLHIYKMLLRLTDNLSSQEQHLQSLMESSASTA 419
            ||.|:|   :.:..||    ..:|...:|.    |.....|.:| :|.|:.:..|..:
Mouse   258 LNNINVDKDKPYLYCF----RTSKGVGYSA----HFVGNCLIVT-SLKSKGKGFQHCV------- 306

  Fly   420 MPKQQQHPR----------HKRQRSSQLHCLGATSLSCYFQGKLYHLLPSLEAELQEHSVRSLLR 474
              |....||          :.|.|:|::.        ||..|:                   |:.
Mouse   307 --KYDFQPRKWYMISIVHIYNRWRNSEIR--------CYVNGQ-------------------LVS 342

  Fly   475 TGSCCCHYNVRNYATCLQLATQLSSSYQKCAYKFLHYNVLHTIFVKRNPQGCPGCEDKLKSPVFH 539
            .|....|.|.             :.||.||   ||               |.....|  .:.||.
Mouse   343 YGDMAWHVNT-------------NDSYDKC---FL---------------GSSETAD--ANRVFC 374

  Fly   540 MDLLNIYKDNYKALLNTPAMLLFLKHLKHIAYLLPYDLASGILAEVALPIFRRYKELIESGESKR 604
            ..|..:|.  :...|| ||. :|..|.....|...:...|    |..:.:...:|:::..|:...
Mouse   375 GQLGAVYV--FSEALN-PAQ-IFAVHQLGPGYKSTFKFKS----ESDIHLAEHHKQVLYDGKLAS 431

  Fly   605 KI-----SKVTPLQL---PSKLENYRALHECLSIFV-----MYLSDIRLV------KAFYNEENI 650
            .|     :|.|..||   .|..||       .||||     :.|.|::.:      .|.::...|
Mouse   432 SIAFSYNAKATDAQLCLESSPKEN-------ASIFVHSPHALMLQDVKAIVTHSIHSAIHSIGGI 489

  Fly   651 RYMQDL--------LIIPELQRGVCDLIKVGIDNIAFLGENSQEQITLSRRLIQLQLNSSDRASQ 707
            :.:..|        |...:::..||..:      :|||.|..:..:.:..:::         ..:
Mouse   490 QVLFPLFAQLDNRQLNDSQVETTVCATL------LAFLVELLKSSVAMQEQML---------GGK 539

  Fly   708 LFQALLYKCSKHSRAKFWLDESSTPAKLEGHKPADILYITALQWTLNFELLKTSQLFYNEFAKIY 772
            .|..:.|...|.||...      |.|.||.                           :..|||
Mouse   540 GFLVIGYLLEKSSRVHI------TRAVLEQ---------------------------FLSFAK-- 569

  Fly   773 SIPVEMLDDEDEDEVETPTSELLPGEKKLRHGD---KNIFDILKLNYNALGCFLMLPKA---TMG 831
                                 .|.|   |.||.   |.:.|.:..|          |..   |..
Mouse   570 ---------------------YLDG---LSHGAPLLKQLCDHILFN----------PAIWIHTPA 600

  Fly   832 PTTSSTATTPTAGICGSSSLETLVSQ----LPLAGSTSV---SVTTAASSDYADSTLDYASVIGN 889
            ....|..|..:|...|::::.|.:.:    |.|..:...   .:..|.||..|...||     |.
Mouse   601 KVQLSLYTYLSAEFIGTATIYTTIRRVGTVLQLMHTLKYYYWVINPADSSGIAPKGLD-----GP 660

  Fly   890 YDSYSRDMATPSFLQQLLACEPDESTVLFDIRGSQSSKDNPSNSLILPSEEEGATADGIINKLFS 954
            ..|....::..:|:...|     :..:|.|....:....:..|.|:...|:|.      |:.:..
Mouse   661 RPSQKEIISLRAFMLLFL-----KQLILKDRGVKEDELQSILNYLLTMHEDEN------IHDVLQ 714

  Fly   955 IVGSLFGGSPGSGGSANSPTRANIDADFFCLYEPNG--ECKKLLLKLFEA--TMAICIKGFQNEE 1015
            ::.:|....|.|...|              ..:.||  ...|||....|:  ..|:.:.|:
Mouse   715 LLVALMSEHPASMIPA--------------FDQRNGIRVIYKLLASKSESIWVQALKVLGY---- 761

  Fly  1016 VEKMQKHLRKLRAIILSHATDNWSEHGEQ---HARDNAVIQTLQTLLKIAELSSTHQEPTGVVNS 1077
               ..|||...|.:.:.|....::..||:   |. :...:.|..||.:|.    |.|..|.||:.
Mouse   762 ---FLKHLGHKRKVEIMHTHSLFTLLGERLMLHT-NTVTVTTYNTLYEIL----TEQVCTQVVHK 818

  Fly  1078 PSGDSQQPRPRARSFNSGSVELPRLQTVKLPA---KNSLATPPTPRRRPNSSEANAGVDADYFST 1139
            |     .|.|      ..:|::.....:|:.|   |||     ||             .|:....
Mouse   819 P-----HPEP------DSTVKIQNPMILKVVATLLKNS-----TP-------------SAELMEV 854

  Fly  1140 RASLSCAADSELELSENEHEFYLTADEGYEADGEIADLSESECELNGGVLAANESTWTPFQPSSR 1204
            |...   ....::|..|..|                   ...|.|..       |.|..:..|..
Mouse   855 RRLF---LSDMIKLFSNSRE-------------------NRRCLLQC-------SVWQDWMFSLG 890

  Fly  1205 Y--RSHIMHQGLSQLVVQMLAELSLLCIKQPNG----WTESLTQLANRLF--VIRDYLGGPLCLL 1261
            |  ......|.::::|..:...|....||...|    |.::|:...:::.  ..::||.
Mouse   891 YINPKSSEEQKITEMVYNIFRILLYHAIKYEWGGWRVWVDTLSIAHSKVTYEAHKEYLA------ 949

  Fly  1262 KGFAPILSCSDPRLRELQQSILELVTHLNTPEVLQCYYSILASKQPPVDLLMRHMHHISSGSLRK 1326
            |.:.......:..:::.::..:..::.|:         |..|..:..:::  |.:..:|    :.
Mouse   950 KMYEEYQRQEEENIKKGKKGNVSTISGLS---------SQTAGAKGGMEI--REIEDLS----QS 999

  Fly  1327 AQPCMELDFPIITDGKIVVTSEPLVSEQI----------ERVRLHHQQCQTNTLFTRAACIFPVT 1381
            ..|..|.|:|:.||.:.::.|.. ||:.|          ..|.:|
Mouse  1000 QSPESETDYPVSTDTRDLLMSTK-VSDDILGSSDRPGSGVHVEVH-------------------- 1043

  Fly  1382 QTRLWQPDGLTLSLWLELRGQQMHRSSMQFNDDETRYSGEDLTKLHLLSLGTNQAMVSIYISNNM 1446
                        .|.::::.:::..:.::.:|       .||:...|:. |.|.|:|.:
Mouse  1044 ------------DLLVDIKAEKVEATEVKLDD-------MDLSPETLVG-GENGALVEV------ 1082

  Fly  1447 QLIFELVKPNEQLAPVRVEEQIEANA-DTASVISANTQAANGGTIRQALKQTKLALLNSFGQMHL 1510
                |.:..|...|.|   |:::.|. .:..:|..|.:..||..|  .|...|..|.||
Mouse  1083 ----ESLLDNVYSAAV---EKLQNNVHGSVGIIKKNEEKDNGPLI--TLADEKEELPNS------ 1132

  Fly  1511 LNGHQASADSTGGYFESSAVQLQHLRLPRHKWMHLVFGLQQQADSVEISIFLDGLEQHTMRLPFR 1575
                     ||...|:....|.:.| ||.....|::..:|.....:.:|..|..|...|..:
Mouse  1133 ---------STPFLFDKIPRQEEKL-LPELSSNHIIPNIQDTQVHLGVSDDLGLLAHMTASV--- 1184

  Fly  1576 NLRQLT-----------RVHSFQLLALGEGQPTGRSPGSSSSSRSTLDGSTPRYALSNVILFKRR 1629
               :||           |:|:             .|.|.||.|...|..||
Mouse  1185 ---ELTCTSSIMEEKDFRIHT-------------TSDGVSSVSERELASST-------------- 1219

  Fly  1630 LVDPLLMMNLTAMGPDFTEFT----QCQVANWK--PNYGFVSLGKLSS----SNFGNHLDCMRQL 1684
                        .|.|:.|.|    :.:.:|.|  ||   |..|.:.|    |:.|.  :..:::
Mouse  1220 ------------KGLDYAEMTATTLETESSNSKAVPN---VDAGSIISDTERSDDGK--ESGKEI 1267

  Fly  1685 RQARVLVYT-AQQPDLVMSYDASQELDMACYGQPHGHMLYGELQQHQAQTLQAATSLSGGLSTLL 1748
            |:.:....| |.|.......|....:|:...|.|              .|.:.....|.|..|.:
Mouse  1268 RKIQTTATTQAVQGRSSTQQDRDLRVDLGFRGMP--------------MTEEQRRQFSPGPRTTM 1318

  Fly  1749 YLFARIVELTGNASTQALALDLLLQVAHSDAQLYTEFQRQDYLSLIGYVIKSEK---CSKDVQLL 1810
            :   ||.|...:...|.|..|||..: .:|..::.....:   |::.:|..:|.   ....:.|:
Mouse  1319 F---RIPEFKWSPMHQRLLTDLLFAL-ETDVHVWRSHSTK---SVMDFVNSNENIIFVHNTIHLI 1376

  Fly  1811 RSIVNN---ACSQVLITRKG-----------DSINVNDNTMA-TLV--YPRLMLTVLQRYSDWHR 1858
            ..:|:|   ||..:|.....           ::|.|.....| |.|  ..|||..|
Mouse  1377 SQMVDNIIIACGGILPLLSAATSPTGSKTELENIEVTQGMSAETAVTFLSRLMAMV--------- 1432

  Fly  1859 SGATHSDVLDMLFRCILALTRDKHPQRDFNMEQLQKCGLLGALLNLCKVYVIESPSPVQISPYAA 1923
                  |||  :|...|          :|:..:.:|....|.|:..|...|
Mouse  1433 ------DVL--VFASSL----------NFSEIEAEKNMSSGGLMRQCLRLV-------------- 1465

  Fly  1924 ECFVQILAVF----------SGSPPDSSMLDEIMKLLLLLHKPSDCYVTHDRTHFYFLLTAQQPT 1978
             |.|.:....          |.|...||             ||.:.      .|.....:|.:..
Mouse  1466 -CCVAVRNCLECRQRQRDRGSKSSHGSS-------------KPQEA------PHSVTAASASKTP 1510

  Fly  1979 KERSLVAANLSRVTTSLRRQLHPQPQELDPERAERIKKLRRLHASTSGYRKAVNEFEEHLDQMAD 2043
            .|.  |..|||.:.              ||:|..:...:.||.|..         |.: :|....
Mouse  1511 LEN--VPGNLSPIK--------------DPDRLLQDVDINRLRAVV---------FRD-VDDSKQ 1549

  Fly  2044 CSNLNKSALRLLSPVEATRWR--LKFKRRHPTSANSPKRSPLKIARRRI--------------HP 2092
            ...|..:.:..:|.:..:::|  |:.:|....:.:.|.|:    .|:.|              ||
Mouse  1550 AQFLALAVVYFISVLMVSKYRDILEPQRETARTGSQPGRN----IRQEINSPTSTVVVIPSIPHP 1610

  Fly  2093 HLH---LGKIW--QPSGHS-----------------TPSSG-----QSSLPNRKTDFYDQLGIIR 2130
            .|:   |.|:.  |...||                 ||:.|     :||:|:  ||  ..:|
Mouse  1611 SLNHGLLAKLMPEQSFAHSFYKETPATFPDTVKEKETPTPGEDIQLESSVPH--TD--SGMG--- 1668

  Fly  2131 LQQRLLILLKDFLCLLPDSSVDVVTRHYVKLELLLVLANQRSCAVRQAIIQLVDVLTKRLPSGEL 2195
             ::::..:| |...|.|.:..|.::      |||..|:::...: ::::.:....:.|..||...
Mouse  1669 -EEQVASIL-DGAELEPAAGPDAMS------ELLSTLSSEVKKS-QESLTEHPSEMLKPAPSISS 1724

  Fly  2196 NAATKLMHPLHLANQLTIHGCDVGMFEAC---------LAWINGMHCSL-TDIQSCDAPVRIRQR 2250
            .:.||.::...:...|.....::.   .|         .|.....|..| ....|.|..|.:..:
Mouse  1725 ISQTKGINVKEILKSLVAAPVEIA---ECGPEPIPYPDPALKREAHAILPMQFHSFDRSVVVPVK 1786

  Fly  2251 FGLPSLLAI----------------------AEGTEPQWVFKALLRLYLQNPDDQTCLIEAGLLQ 2293
            ...|..||:                      |.|..|    |:::        :.|..:::|...
Mouse  1787 KPPPGSLAVTTVGATAAGSGLPTGSTSSIFAAPGATP----KSMI--------NTTGAVDSGSSS 1839

  Fly  2294 CSVKALYKIYSLRVGQSNADESVVELLATIG-------------ERAMRSVGQINLVWDILNLLS 2345
            .|..:     |...|.::.:...|:.:|.:.             |||:..|..:        |..
Mouse  1840 SSSSS-----SFVNGATSKNLPAVQTVAPMPEDSAENMSITAKLERALEKVAPL--------LRE 1891

  Fly  2346 FYQDKQPQLIMRSFRTAQAQLQLEWLTKFFEPNSFRVAVTNDSSLSHSELRTRVELLIDRCTQFF 2410
            .:.|..|.|......:...:|.:|.|          |.:.:.:|:        |||::..|:|.:
Mouse  1892 IFVDFAPFLSRTLLGSHGQELLIEGL----------VCMKSSTSV--------VELVMLLCSQEW 1938

  Fly  2411 TVGVGQTTGPNYVASSQELALFQL-----LVSYGISSN-QRCNNFIAWGLQPSRPRDLRSYIVDA 2469
            ...:.:..|         ||..:|     |:.:.:..: .|..|...:.|...|..|:..:   |
Mouse  1939 QNSIQKNAG---------LAFIELINEGRLLCHAMKDHIVRVANEAEFILNRQRAEDVHKH---A 1991

  Fly  2470 LWRSQQDEFQRAIICDAKMIKALLWLSLLED------MPEPIENLKPLCDALGIKENDSSWNLV- 2527
            .:.||..::......:.||...|:..:...|      :.:.|.|:        :.....:|..|
Mouse  1992 EFESQCAQYAADRREEEKMCDHLISAAKHRDHVTANQLKQKILNI--------LTNKHGAWGAVS 2048

  Fly  2528 ----HELDRLDQNRNNMAAKQK------------TLLEKTV-YRFEPLVQQCVESSMVTTRKVAE 2575
                |:..|||...:::..:::            .||:..| |..|   :..|:|......:...
Mouse  2049 HSQLHDFWRLDYWEDDLRRRRRFVRNAFGSTHAEALLKSAVEYGTE---EDVVKSKKAFRSQAIV 2110

  Fly  2576 LQNAERKALMCHMKVYDDTYTYTKWLEIIRRMTHEGAPWHSAERAECSWELDDTEGPSRVHTRLR 2640
            .||:|.:.::                                            ||
Mouse  2111 NQNSETELML--------------------------------------------EG--------- 2122

  Fly  2641 RCHLDIDRRFFMNEYRPGQGHREDLEPYVRPLDYLIASYDQQLNISLNSQILYNFAAKFLPVDGE 2705
                |.|....:.|               :.:|.|..|:..:|.||....:|...|....|| ..
Mouse  2123 ----DDDAVSLLQE---------------KEIDNLAVSFLPKLFISRGPVVLSTPAQLIAPV-VV 2167

  Fly  2706 IEGEIIITDLKLYFL-----ATYRCRYFNVNCDIANITE-------------IWLKRYQHQETAF 2752
            .:|.:.||..::||.     |.::    .::..:...||             ::.:||..|.||.
Mouse  2168 AKGTLSITTTEIYFEVDEDDAAFK----KIDTKVLAYTEGLHGKWMFSEIRAVFSRRYLLQNTAL 2228

  Fly  2753 EILLDTNKSLFFSLQNADDWKIMREVF---------------CDKI-VATPDQ-SKVIAITQQWR 2800
            |:.:....|:.|:.  .|...:.:.|:               ..:| :|||.| .|...:||:|:
Mouse  2229 EVFMANRTSVMFNF--PDQATVKKVVYSLPRVGVGTSYGLPQARRISLATPRQLYKSSNMTQRWQ 2291

  Fly  2801 EGLLTNWEYLMTLNQISGRTYNDLMQYPVFPWVLANYNSEVLDLREGHNFRRLGRPIAVQVEENE 2865
            ...::|:||||.||.|:|||||||.|||||||||.||.||.|||....|||.|.:||.....:..
Mouse  2292 RREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLTLPGNFRDLSKPIGALNPKRA 2356

  Fly  2866 KHYISNYTYIDSTNTTMGSLILKPYHYSSHYSNSGTVLHFLVRVPPFTSYFLRYQDNDFDLPDRT 2930
            ..|...|...:...:       .|:||::|||.:.:.|.:|||:.|||::||...|..||.||||
Mouse  2357 VFYAERYETWEEDQS-------PPFHYNTHYSTATSALSWLVRIEPFTTFFLNANDGKFDHPDRT 2414

  Fly  2931 FHALNTTWLLASRDSPTDVKELIPEFFCLPEMFENFERFKFGCRQNGERVEDVSLPPWSQRDSRL 2995
            |.::..:|..:.||: :|||||||||:.|||||.|...:..|.|::...|.||.||||:::...
Mouse  2415 FSSIARSWRTSQRDT-SDVKELIPEFYYLPEMFVNSNGYHLGVREDEVVVNDVDLPPWAKKPED- 2477

  Fly  2996 FVLIHRQALESELVRNQIHNWIDLIFGYKQSGESAVEAINVFHPATY--AVFLDSEISDPIERE- 3057
            ||.|:|.|||||.|..|:|.||||||||||.|..||.|:||||..||  :|.||| |:||:.||
Mouse  2478 FVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAVRALNVFHYLTYEGSVNLDS-ITDPVLREI 2541

  Fly  3058 --------------------AVKTMVKTYGQMPRQLFKSPHP-----------ASKPLDYSLVGK 3091
                                |::..::.:||.|.||...|||           ...||.:....:
Mouse  2542 PEAYFIRDPHTFLLTKDFIKAMEAQIQNFGQTPSQLLIEPHPPRSSAMHLCFLPQSPLMFKDQMQ 2606

  Fly  3092 PIVSTVRGLRWGVYVGSPQLKAPSWANIHKIPGTEHLVSFCNTNVVYALPGRASVMQGAEPDTYN 3156
            ..|..|             ||.||     ..|.| |:.:  ||.....:|...:|....   .:.
Mouse  2607 QDVIMV-------------LKFPS-----NSPVT-HVAA--NTLPHLTIPAVVTVTCSR---LFA 2647

  Fly  3157 VISW----------GYDDRIVRIQPLNKPQAKPKNLLHNGTFDDITACGCDVNSNQLWFGHKSGR 3211
            |..|          ||.        |::....|..:      |.:.|....||..|:
Mouse  2648 VNRWHNTVGLRGAPGYS--------LDQAHHLPIEM------DPLIANNSGVNKRQI-------- 2690

  Fly  3212 ISVYKCTGGLDSQQR-------ASAKSRQSYARGFSLSYNSAFRKMTNKGIGGGGSERVDEAGNL 3269
                  |..:|...:       .:|.:|.....||   ::.:||..:.            |.|.|
Mouse  2691 ------TDLVDQSIQINAHCFVVTADNRYILICGF---WDKSFRVYST------------ETGKL 2734

  Fly  3270 ------HPTSSASSVNSSSISSGGDAF----QRDGADLNW--------LGP-----------TLL 3305
                  |.........|.|. .|||.:    .||...|.|        :|.           .:|
Mouse  2735 TQIVFGHWDVVTCLARSESY-IGGDCYIVSGSRDATLLLWYWSGRHHIIGDNPNSSDYPAPRAVL 2798

  Fly  3306 VRHTDEITCITLSVEFKIAVTAGRDGIAVIWDLNDWSYVRTIARPAEIHQSPITHVAISPTLGDI 3370
            ..|..|:.|:::..|..:.::..::|                  |..:|  .||        ||:
Mouse  2799 TGHDHEVVCVSVCAELGLVISGAKEG------------------PCLVH--TIT--------GDL 2835

  Fly  3371 VTVHTLPQSCNTSTDPKPTAVATRPNSLNVADECFEVTEENLDDFVNVNVNPNGKSILRLHSVNA 3435
            :.....|::|            ..|..::|:.|...:.......|.|.::  |||.:.:: .:|
Mouse  2836 LRALEGPENC------------LFPRLISVSSEGHCIIYYERGRFSNFSI--NGKLLAQM-EIN- 2884

  Fly  3436 RYVQHLVHEDRILAVCYSYIKEGVGVNVIATAVEGGFVRFWSS 3478
                     |...|:..|    ..|.|:: |..:.|.|..|.:
Mouse  2885 ---------DSTRAILLS----SDGQNLV-TGGDNGVVEVWQA 2913

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mv	NP_647681.2	PH-like	2704..2785	CDD:473070	19/114 (17%)
		Beach	2796..3080	CDD:214982	142/317 (45%)
		WD40	<3302..>3518	CDD:441893	32/188 (17%)
Nbea	XP_036019004.1	Laminin_G_3	245..392	CDD:463865	43/215 (20%)
		DUF4704	457..937	CDD:464870	121/663 (18%)
		DUF1088	1956..2122	CDD:461925	31/223 (14%)
		PH_BEACH	2159..2256	CDD:434260	21/103 (20%)
		Beach	2288..2585	CDD:460459	141/306 (46%)
		NBCH_WD40	2685..2957	CDD:466575	57/317 (18%)
		WD40 repeat	2746..2800	CDD:293791	11/54 (20%)
		WD40 repeat	2805..2840	CDD:293791	9/62 (15%)
		WD40 repeat	2845..2874	CDD:293791	6/42 (14%)
		WD40 repeat	2883..2921	CDD:293791	10/46 (22%)
		WD40 repeat	2929..2955	CDD:293791