Protein Alignment mv and Nbeal2

DIOPT Version :10

• Sequence 1: NP_647681.2
• Gene: mv / 38259
• FlyBaseID: FBgn0288310
• Length: 3535
• Species: Drosophila melanogaster
• Sequence 2: NP_899099.2
• Gene: Nbeal2 / 235627
• MGIID: 2448554
• Length: 2750
• Species: Mus musculus
• Alignment Length: 3009
• Identity: 658/3009 - (21%)
• Similarity: 990/3009 - (32%)
• Gaps: 1080/3009 - (35%)

  Fly  1073 GVV----NSPSGDSQQPRPRARSFNSGSVEL----------PRLQTVKLPAKNSL-ATPPTPRRR 1122
            |||    ..|:.|.||. |.|.....|:|.:          |.|:|:.....:.| |..||   .
Mouse   230 GVVRGWGRGPAQDPQQV-PLALRALVGAVHVLHASRAPPRGPELRTLLEGYFHILNADWPT---S 290

  Fly  1123 PNSSEANAGVDADYFSTRAS--------LSCAADSELE---LSEN--EH--------EFYLTADE 1166
            |:||...|.|     :.|.|        |:|.....|:   ||.|  ||        :.||.|..
Mouse   291 PSSSPEEALV-----TLRVSMLDAIPMMLACEDRPVLQATFLSNNCFEHLIRLIQNSKLYLQARA 350

  Fly  1167 GYEADGEIAD--LSESE---------------------CELNGGVLAANESTWTPFQPSSR--YR 1206
            ..|.|.::|.  |:|.:                     |.::|             .||::  ::
Mouse   351 PPEGDSDLATWLLTEPDVQKVLDQDTDAIAVHVVRVLTCIMSG-------------SPSAKEVFK 402

  Fly  1207 SHIMHQGLSQLVV-------QMLAELSLLCI--------------KQP----NGWTESLTQ---- 1242
            ..|.:|.|.:::.       ::|.||..:.:              :||    ..|..:|..
Mouse   403 ERIGYQHLQEVLQSHGPPTHRLLQELLNMAVEGDHSMHPPPPIRNEQPVLVLMQWLPALPTAELR 467

  Fly  1243 --LANRLFVIRDYLGGPLCLLKGFAPILSCSDPRLRELQQSIL-ELVTHLNTPEVL--QCYYSIL 1302
              ||.||:.:.|                ||...|...:|..:: .|:..|||...|  :|...:|
Mouse   468 LFLAQRLWWLCD----------------SCPASRTTCVQAGLVGYLLETLNTGTALGARCQEQLL 516

  Fly  1303 ASKQPPVDLLMRHMHHISSGSL---RKAQPCMELDFPIITDGKIVVTSEPLVSEQIERVRLHHQQ 1364
            |        |::.:..:|...|   |..:|...||            ||   |...|..:..|..
Mouse   517 A--------LLQALGRVSLRPLELRRLLRPPPGLD------------SE---SSGNESQKARHAG 558

  Fly  1365 CQTNTLF--------TRAACIFPVTQT---------RLWQPDGLTLSLWLELRGQQMHRSSMQFN 1412
            .....|.        .||...|.:|.:         :.|...|.|...||.|:..:...:|.
Mouse   559 AVIRALSGMARHRGPARALRYFDLTPSMAGIMVPPVQRWPGAGFTFHAWLCLQSSEAVPTSA--- 620

  Fly  1413 DDETRYSGEDLTKLHLLSLGTNQAMVSIYISNNMQLIF----ELVKPNEQLAPVRVEEQIEAN-- 1471
                  ....|.:..|.|..|:.       .:..:..|    .||     :|....:|.:..|
Mouse   621 ------PSRPLQRKQLYSFFTSS-------GSGFEAFFTAAGTLV-----VAVCTRKEYVTVNLP 667

  Fly  1472 ----ADTASVISANTQAANGGTIRQALKQTKLALLNSFGQMHLLN-------------------- 1512
                ||:|....|......    |:...|.   |:|.|...||:.
Mouse   668 EVSFADSAWHCVAIVHVPG----RRPFSQN---LVNVFKDGHLVKTVPFRFPSLSEPFSSCCIGS 725

  Fly  1513 -GHQASADSTGGYFESSAVQLQHLRLPRHKWMHLVFGLQQQADSVEISIFLDGLEQHTMRLPFRN 1576
             ||:.:..:||              ||              |.||..::      .||.
Mouse   726 AGHRTTTTTTG--------------LP--------------ASSVSTAL------AHTH------ 750

  Fly  1577 LRQLTRVHSFQL---LALGEGQPTGRSPGSSSS-----------SRSTLDGSTPRYALSNVILFK 1627
             ..|||..|...   |..|.|..|....||.||           |.::|:|.     |..|.:|.
Mouse   751 -PSLTRSQSVPASTGLGWGPGLGTPLQEGSVSSTLAGTQDTRWGSPTSLEGE-----LGAVAIFH 809

  Fly  1628 RRLVDPLLMMNLTAMGPDFTEFTQCQVANWKPNYGFVSLGKLSSSNFGNHLDCMRQLRQARVLVY 1692
            ..| .|..:..|.::||:       :.|.:||.      |:|  ..||.
Mouse   810 EAL-QPSALRVLCSLGPN-------EPAPFKPE------GEL--HEFGT---------------- 842

  Fly  1693 TAQQPDLVMSYDASQELDMACYGQPHGHMLYGELQQHQAQT--LQAATSLSGGLSTLLYLFARIV 1755
                 .|::.|......:..|.....||.|.|.|..|:.:|  ::...:..||:..||.|..|:.
Mouse   843 -----KLLLHYSPQACKNNICLDLSPGHGLDGRLTGHRVETWDVKDVVNCVGGMGVLLPLLERVA 902

  Fly  1756 -------------------ELTGNASTQALALDL---------------LLQVAHSDAQLYTEFQ 1786
                               |||...:||.|.|.|               .|.:..:..|.:|  .
Mouse   903 VQPQEAEAGPCETHDLVGPELTSGRNTQGLLLPLGKSSEDRMERNAVAAFLLMLRNFLQNHT--V 965

  Fly  1787 RQDYL------SLIGYVI-KSEKCSKDVQLLRSIVNNACSQVLITRKGDSINVNDNTMATLVYPR 1844
            .|:.|      ::||.:: |....:.|:.:|.|      :|:|:.:....   ....:..|:|..
Mouse   966 NQESLVQCQGPAIIGALLRKVPSSAMDMNVLMS------AQLLMEQAAAD---GGGPLLYLLYQH 1021

  Fly  1845 LMLTV-LQRYSDWH-RSGATHSDVLDMLFR--------------CILALTRDKHPQRDFNMEQLQ 1893
            |:... |...||:. |.|  |...:..:.|              .:.||.....|||:..:....
Mouse  1022 LLFNFHLWTLSDFAVRLG--HIQYMSSMVREHRQKLRKKYGVQFLLDALRTHYSPQRERPLAADD 1084

  Fly  1894 KCGLLGALLNLCKVYVIESPSPVQISPYAAECFVQILAVFSGSPPDSSMLDEIMKLLLLLHKPSD 1958
            ...:..:||.|.:.:::.:        ::.| .:|::..|..:..|...:...::|||.|.:.|
Mouse  1085 LRTVQTSLLGLVREFLVRN--------FSVE-DMQVVLNFLAATGDDGQVVGTLELLLTLLQGS- 1139

  Fly  1959 CYVTHDRTHFYFLLTAQQPTKERSLVAANL-----------------SRVTTSLRRQLHPQPQEL 2006
                          ..|.|.....|...||                 .||...|||.   |..|.
Mouse  1140 --------------PVQDPLAAFLLELGNLEVLLALLVRPKSTPLLTDRVCKILRRL---QQNER 1187

  Fly  2007 DPER-AERIKKLRRLH-ASTSGYRKAVNE--------------FEEHLDQMA--DCSNLN----- 2048
            .||| .:||    ||| ....|...:::|              |...:.|:.  ||.||:
Mouse  1188 LPERNRQRI----RLHDCGLQGLVASLSEESISPQLCQGLYKLFVGTVPQVVSPDCLNLSDLLAV 1248

  Fly  2049 --------------------------KSALRLLSPVEATRWRLKFKRRHPTSANSPKRSPLKIAR 2087
                                      ...:|||:  ....|:....|.:...|.:....|
Mouse  1249 VQLSLQADLSVRLDICRQLFYLIYGQPDVVRLLA--RQAGWQDVLTRLYVLEAATDSSPP----- 1306

  Fly  2088 RRIHPHLHLGKIWQPSGHSTPSSGQSSLPNRKTDFYDQLGIIRLQQRLLILLKDFLCLLPDSSVD 2152
             |..|.|             |.|.:.:|....|:                        ||..|.|
Mouse  1307 -RFLPEL-------------PISSELALSPPPTE------------------------LPADSSD 1333

  Fly  2153 VVTRHYVKLELLLVLANQRSCAVRQAIIQLV-------DVLTKRLPSGELNAA------------ 2198
            |            .|.::..|..:.|..|.:       |:..:|...|..|.|
Mouse  1334 V------------FLPSESPCPDQDAFYQALSPFSTPFDLGLERASIGSGNTAGGGSSNGTVTPA 1386

  Fly  2199 -----------------TKLMHPLHLANQL--------TIHGCDVG------------------- 2219
                             .:..|...|:|.|        .|.|.|..
Mouse  1387 SQPGTPSPLDGPRPFPTAQGRHSSSLSNVLEDGSLLEPNISGDDTSNTSNPQQTPEEELCNLLTN 1451

  Fly  2220 -MFEACLAWINGMHCSLTDIQSCDAPVRIR-QRFGLPSLLAIAEGT---EPQWVFKALLRLYLQN 2279
             :|......:.|         |.:|..|.| |.|.:.:.|. |..|   .|..:.::||.:.|::
Mouse  1452 VLFSVTWRGVEG---------SAEAAWRERGQVFSVLTQLG-ASATLVRPPDCIKRSLLEMMLES 1506

  Fly  2280 PDDQTCLIEA---GLLQCSVKALYKIYSLR-----VGQSNAD-------ESVVELLATIGE---- 2325
            .  .|.:.||   ||...|.:||:.:..|:     .|..|.:       |.|..||..:|.
Mouse  1507 A--LTDIKEAPPGGLANLSQQALWLLRLLQDFLCAEGHGNQELWSEKLFEGVCNLLDRLGAWPHL 1569

  Fly  2326 -------RAMRSVGQINLVWDILNLLSFYQDKQPQLIMRSFRTAQAQLQLEWLTKFFEPNSFRVA 2383
                   |.|..:| :.||      |.:...:.|||      .|||.::|..|.:...|
Mouse  1570 ANSTADLREMAQIG-LRLV------LGYILLEDPQL------HAQAYVKLHTLLQTAVP------ 1615

  Fly  2384 VTNDSSLSHSELRTRVELLIDRCTQFFTVGVGQTTGPNYVASSQELALFQLL---------VSYG 2439
                         ||.|   :.|               ||.|..|.||.:.|         .|..
Mouse  1616 -------------TRRE---EAC---------------YVLSKLEAALSRALTTSSSETEHASTA 1649

  Fly  2440 ISSNQRCNNFI----------------AWGLQPSRP---------RDLRSYIVDALWRSQQDEFQ 2479
            :::::||:..:                .||| ||.|         .|.:::...|.||...|:..
Mouse  1650 VAASERCSWLVPLVRTLLDRAYGPLGLQWGL-PSLPPTNGSPTFFEDFQAFCATAEWRHFIDKQV 1713

  Fly  2480 RAIICDAKMIKALLWLSLLEDMPEPIENLKPLCDALGIKEND---SSWNLV----------HELD 2531
            :..:...:|                        |... |.:|   ..||..          |:.|
Mouse  1714 QPTMSKFEM------------------------DTYA-KSHDLMSGFWNACYDTLMSSGQRHQRD 1753

  Fly  2532 RLDQNRNNMAAKQKTLLEKTVYRFEPLVQQCVESSMVTTRKVAELQNAERKALMCHMKVYDDTYT 2596
            |:...|   |.|:..|        || .|:......:....|.:.|.|:....:.|
Mouse  1754 RIQSRR---AFKELVL--------EP-AQRRARVEGLRYASVLKQQAAQHSTALLH--------- 1797

  Fly  2597 YTKWLEIIRRMTHEGAPWHSAERAECSWELDDTEGPSRVHTRLRRCHLDIDRRFFMNEYRPGQGH 2661
               |..:.|:::.....|.........|:|...|..||:..:|...| ..|.....:..|...|.
Mouse  1798 ---WGALWRQLSSPCGAWALRIPPAPHWKLSSAETYSRMRLKLVPNH-HFDPHLEASALRDNLGE 1858

  Fly  2662 R------------------------EDL------EPYVRPLDYLI---ASYDQQLNISLNSQILY 2693
            .                        |:|      |..:..|:.|:   |..|::     ..:::.
Mouse  1859 APMTPTEETSLPLAVTKEAKISAPPEELPEEQLGEEDLAALESLMEEAAELDEK-----REKLVL 1918

  Fly  2694 NFAAKFLPVDGEIEGEIIITDLKLYFL--ATYRCRY-----FNVNCDIANITEIWLKRYQHQETA 2751
            :...:.:.|...:.|.:.||...:||.  :|.|...     .:....:|.:.|:.|:|:..:.:|
Mouse  1919 SAECQLVTVVAVVPGLLEITTQHVYFYDGSTERVETEEGIGHDFRRPLAQLREVHLRRFNLRRSA 1983

  Fly  2752 FEILLDTNKSLFFSLQN---------------------ADDWKIMREVFCDKIVATP-------- 2787
            .|:......:.|.:..:                     ....::..:|:...:...|
Mouse  1984 LELFFIDQSNYFLNFPHKVAASSASSPCQAPRPQLYPIPSHTQLRNQVYSLLLRLRPPTQGYLSS 2048

  Fly  2788 ----DQSKVIAITQQWREGLLTNWEYLMTLNQISGRTYNDLMQYPVFPWVLANYNSEVLDLREGH 2848
                :..:...:||:|.:..::|:||||.||.|:|||||||.|||||||||.:|.|.||||....
Mouse  2049 RSPLEMLRASGLTQKWVQREISNFEYLMQLNTIAGRTYNDLSQYPVFPWVLQDYVSPVLDLSNPA 2113

  Fly  2849 NFRRLGRPIAVQVEENEKHYISNYTYIDSTNTTMGSLILKPYHYSSHYSNSGTVLHFLVRVPPFT 2913
            .||.|.:||.|   .|.||........:|.....|:  :..:||.:||||:..|:|:|:||.|||
Mouse  2114 VFRDLSKPIGV---VNPKHAQLVREKYESFEDPAGT--IDKFHYGTHYSNAAGVMHYLIRVEPFT 2173

  Fly  2914 SYFLRYQDNDFDLPDRTFHALNTTWLLASRDSPTDVKELIPEFFCLPEMFENFERFKFGCRQ-NG 2977
            |..::.|...||..||.||::...| .|..:||.||||||||||..|:..||...|..||.| ..
Mouse  2174 SLHVQLQSGRFDCSDRQFHSVAAAW-QARLESPADVKELIPEFFYFPDFLENQNGFDLGCLQLTN 2237

  Fly  2978 ERVEDVSLPPW--SQRDSRLFVLIHRQALESELVRNQIHNWIDLIFGYKQSGESAVEAINVFHPA 3040
            |:|.||.||||  |..|   |:..||||||||.|...:|.||||||||||.|.:|.||:|||:..
Mouse  2238 EKVGDVVLPPWAGSPED---FIQKHRQALESEYVSTHLHEWIDLIFGYKQRGPAAEEALNVFYYC 2299

  Fly  3041 TY--AVFLDSEISDPIEREAVKTMVKTYGQMPRQLFKSPHPASKPLDYSLVGKPIVSTVRGLRWG 3103
            ||  ||.|| .::|..||:|::.::..:||.|.||.|.|||
Mouse  2300 TYEGAVDLD-HVADERERKALEGIISNFGQTPCQLLKEPHP------------------------ 2339

  Fly  3104 VYVGSPQLKAPSWANIHKIPGTEHLVSFCNTNVVYALPGRASVMQGAEP---------DTYNVIS 3159
                 |:|.|...||......|.....|.|.|.:.|.  .|.|:..|.|         .:::.|:
Mouse  2340 -----PRLSAEEAANRLARLDTNSPSIFQNLNQLKAF--FAEVVSEAVPLVLALVPHRQSHSFIT 2397

  Fly  3160 WGYDDRIVRIQPLNKPQAKPKNLLHNGTFDDITACGCDVNSNQLWFGHKS---GRISVYK-CTGG 3220
            ....|.:|.:..             :|.....|....|.|.|..:...|.   |...|.| .:|.
Mouse  2398 QSSSDMLVTVSA-------------SGLLGTHTWLPYDRNINNYFTFSKDPTMGSPKVQKLLSGP 2449

  Fly  3221 LDSQQRASAKSRQSYARGFSLSYNSAFRKMTNKGIGGGGSERVDE--AGNL------H---PTSS 3274
            ..|....||::......|          |:...|....||.||..  .|.|      |   .|..
Mouse  2450 WVSDSGVSAQALAVAPDG----------KLLFSGGHWDGSLRVTSLPRGRLLNQLSRHLDIVTCL 2504

  Fly  3275 ASSVNSSSISSGGDAFQRDGADLNW-----------LGP---TLLVRHTDEITCITLSVEFKIAV 3325
            |.......:.||    .||...:.|           |.|   .:|..|...::|:.:|.|..:||
Mouse  2505 ALDTCGIYLISG----SRDTTCMVWRLLQQSGLSAGLAPKPVQVLYGHVAAVSCVAISTELDMAV 2565

  Fly  3326 TAGRDGIAVIWDLNDWSYVRTIARPAEIHQSPITHVAISPTLGDIVTVHTLPQSCNTSTDPKPTA 3390
            :...||..:|..:....:|..:..|......||:|:|:... |.||.        .:|...:|.|
Mouse  2566 SGSEDGTVIIHTVRRGQFVAALRPPGATLPGPISHLALGAE-GQIVV--------QSSACERPGA 2621

  Fly  3391 VAT--------------------RPNSLNVADECFEVTEENLDDFVNVNVNPNGKSILRL----- 3430
            ..|                    :|.:|.||           :|||.:........||.|
Mouse  2622 QVTYSLHLYSVNGRLRASVTLTEQPTALTVA-----------EDFVLLGTAQCSLHILHLNKLRP 2675

  Fly  3431 -----------HSVNARYVQHLVHEDRILAVCYSYIKEGV--GVNVIATAVEGGFV-------RF 3475
                       |||:       |.::|      |::..|:  |..::..|.:...|       |.
Mouse  2676 AVPPLPMKVPVHSVS-------VTKER------SHVLVGLEDGKLIVVGAGQPSEVRSSQFARRL 2727

  Fly  3476 W-SSWNLSFVSELTTGTSP 3493
            | ||..:|.||...|..:|
Mouse  2728 WRSSRRISQVSSGETEYNP 2746

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mv	NP_647681.2	PH-like	2704..2785	CDD:473070	15/108 (14%)
		Beach	2796..3080	CDD:214982	143/288 (50%)
		WD40	<3302..>3518	CDD:441893	53/241 (22%)
Nbeal2	NP_899099.2	Neurobeachin	<297..498	CDD:466574	43/234 (18%)
		DUF4704	876..>1125	CDD:464870	50/270 (19%)
		PRK12323	<1248..>1405	CDD:481241	28/213 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1319..1340		8/56 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1363..1441		11/77 (14%)
		DUF4800	1590..1856	CDD:464996	66/359 (18%)
		PH_BEACH	1914..2039	CDD:275391	16/124 (13%)
		Beach	2061..2341	CDD:214982	144/318 (45%)
		WD 1	2382..2420		5/50 (10%)
		NBCH_WD40	2404..2709	CDD:466575	74/364 (20%)
		WD 2	2444..2487		12/52 (23%)
		WD40 repeat	2459..2496	CDD:293791	9/46 (20%)
		WD 3	2490..2527		9/40 (23%)
		WD40 repeat	2502..2547	CDD:293791	10/48 (21%)
		WD 4	2540..2578		10/37 (27%)
		WD40 repeat	2552..2588	CDD:293791	9/35 (26%)
		WD 5	2585..2627		12/50 (24%)
		WD40 repeat	2627..2666	CDD:293791	7/49 (14%)
		WD 6	2635..2670		9/45 (20%)
		WD 7	2678..2713		8/47 (17%)