Protein Alignment mv and Nsmaf

DIOPT Version :10

• Sequence 1: NP_647681.2
• Gene: mv / 38259
• FlyBaseID: FBgn0288310
• Length: 3535
• Species: Drosophila melanogaster
• Sequence 2: XP_006537725.1
• Gene: Nsmaf / 18201
• MGIID: 1341864
• Length: 956
• Species: Mus musculus
• Alignment Length: 977
• Identity: 243/977 - (24%)
• Similarity: 364/977 - (37%)
• Gaps: 264/977 - (27%)

  Fly  2503 EPIENLKPLCDALGIKENDSSWNLVHELDRLDQNRNNMAAKQK----TLLEKTVYRFEPLVQQCV 2563
            :||..: ||.|.|.|.::.            :...|...||.|    :|:...:|..:
Mouse   101 QPILKI-PLRDCLKIGKHG------------ENGANKHFAKAKSWGISLIFSQIYFIK------- 145

  Fly  2564 ESSMVTTRKVAELQNAERKALMCHMKVYDDTYTYTKWLEIIRRMTHEGAPWHSAERAECSWELDD 2628
            |.::|...|:      ||..:           .|...||:..::...........||.|..:|.|
Mouse   146 EHNIVAPYKI------ERGKM-----------EYVFELEVSGKVEDVVETLLQLHRASCLDKLGD 193

  Fly  2629 TEG--PSRVHTRLRRCHLDIDRRFFMNEYRPGQGHREDLEPYVRPLDYLIASYDQQLNISLNSQI 2691
            ...  .:.:.:||.|...|.:|                           ..|..::|::...:::
Mouse   194 QMAMITAILQSRLARTSFDKNR---------------------------FQSVSEKLHMECKAEM 231

  Fly  2692 LYNFAAKFLPVDGEIEGEIIITDLKLYFLATYRCRYFNVNCDIANITEIWLKRYQHQETAFEILL 2756
            :......        .|.:.|||..|||..........|...:.::..|:.:|:.......|:..
Mouse   232 VTPLVTN--------PGHVCITDTSLYFQPLNGYPKPVVQITLQDVRRIYKRRHGLMPLGLEVFC 288

  Fly  2757 DTNKSL-------FFSLQNADDWKIMREVFCDKIVATPDQSKVIAITQQWREGLLTNWEYLMTLN 2814
             |:..|       |:..|:.||.......:.:...|   :....:...||:.|.|:|::||:.||
Mouse   289 -TDDDLCSDIYLKFYEPQDRDDLYFYIATYLEHHAA---EHTAESYMLQWQRGHLSNYQYLLHLN 349

  Fly  2815 QISGRTYNDLMQYPVFPWVLANYNSEVLDLREGHNFRRLGRPIAVQVEENEKHYISNYTYIDSTN 2879
            .::.|:.|||.|||||||::::|:|..|||.....||.|.:|:.....|..:..::.|..:....
Mouse   350 NLADRSCNDLSQYPVFPWIISDYSSPELDLSNPATFRDLSKPVGALNAERLERLLTRYQEMPEPR 414

  Fly  2880 TTMGSLILKPYHYSSHYSNSGTVLHFLVRVPPFTSYFLRYQDNDFDLPDRTFHALNTTWLLASRD 2944
                      :.|.||||:.|.||.:|||:.|  .|.|..|:..||..||.|:::..|| ....|
Mouse   415 ----------FMYGSHYSSPGYVLFYLVRIAP--EYMLCLQNGRFDNADRMFNSIAETW-KNCLD 466

  Fly  2945 SPTDVKELIPEFFCLPEMF-ENFERFKFGCRQNGERVEDVSLPPW--SQRDSRLFVLIHRQALES 3006
            ..||.|||||||:.....| .|..:...|.||.|:.|:||.||.|  |.:|   |:..::.||||
Mouse   467 GATDFKELIPEFYDEDVSFLVNSLKLDLGKRQGGQMVDDVDLPAWASSPQD---FLQKNKDALES 528

  Fly  3007 ELVRNQIHNWIDLIFGYKQSGESAVEAINVFHPATYAVFLD-SEISDPIEREAVKTMVKTYGQMP 3070
            ..|...:|.||||||||||.|..|:.|.|||||.||...:| :.|.||.|:.|:.|.:..:||.|
Mouse   529 GYVSEHLHEWIDLIFGYKQKGSEAIGAHNVFHPLTYEGGVDLNSIEDPDEKVAMLTQILEFGQTP 593

  Fly  3071 RQLFKSPHP---------ASKPLDY--SLVGKPI----------VSTVRGLRWGVYVGSPQLKAP 3114
            :|||.:|||         .|:...|  ||...|:          ....|.|.|.   ...:|:..
Mouse   594 KQLFVTPHPRRITPKFKSLSQASSYNASLTDSPVSPGEESFEDLTEESRTLAWS---NIAKLQLH 655

  Fly  3115 SWANIHKIPGTEHLVSFCNTNVVYA---------------------------------LPGRASV 3146
            ....|||...|...|| ||.:.|:.                                 |||..:|
Mouse   656 EQYKIHKEAVTGIAVS-CNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDTTV 719

  Fly  3147 MQ--------------GAEPDTYNVISWGYDDRIVRIQPLNK-----------------PQAKPK 3180
            :.              |...||.    .|:||.:.:|...|.                 |...|.
Mouse   720 ISSSWDNNVYFYSIAFGRRQDTL----MGHDDAVSKICWHNDRLYSGSWDSTVKVWSGVPAEMPG 780

  Fly  3181 NLLHNGTFDDITACGCDVN----------------SNQLWFGHKSGRISVY-----------KCT 3218
            ...|.  ||.:.....||:                |..|..|.|.|.::::           .|.
Mouse   781 TKRHQ--FDLLAELEHDVSMTYLLEKVNTINLNAVSTLLVSGTKEGMVNIWDLTTATLLHQTSCH 843

  Fly  3219 GGLDSQQRASAKSRQSYARGFSLSYNSAFRKMTNKGIGGGGSERVDEAGNLHPTSSASSV----- 3278
            .|.......|..||...:.|..                 |....:|....:..:|.||..
Mouse   844 SGTVCDAAFSPDSRHILSTGVD-----------------GCLNVIDVQTGMLISSMASEEPQRCF 891

  Fly  3279 --NSSSISSGGDAFQRDGADLNW--LGPTLLVR---HTDEITCITLSVEFKIAVTAGRDGIAVIW 3336
              :.:|:.||    .|.|..|.|  ||..:..|   ||..:||:.::.:....:|.|.|...:.|
Mouse   892 VWDGNSVLSG----SRSGELLVWDLLGAKVSERIQGHTGAVTCMWMNEQCSSIITGGEDRQIMFW 952

  Fly  3337 DL 3338
            .|
Mouse   953 KL 954

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mv	NP_647681.2	PH-like	2704..2785	CDD:473070	17/87 (20%)
		Beach	2796..3080	CDD:214982	120/296 (41%)
		WD40	<3302..>3518	CDD:441893	10/40 (25%)
Nsmaf	XP_006537725.1	PH_BEACH	221..314	CDD:275391	18/101 (18%)
		Beach	333..604	CDD:460459	120/286 (42%)
		WD40	<648..955	CDD:441893	64/335 (19%)
		WD40 repeat	665..702	CDD:293791	6/37 (16%)
		WD40 repeat	708..744	CDD:293791	7/39 (18%)
		WD40 repeat	749..793	CDD:293791	7/45 (16%)
		WD40 repeat	806..841	CDD:293791	5/34 (15%)
		WD40 repeat	847..884	CDD:293791	7/53 (13%)
		WD40 repeat	928..952	CDD:293791	5/23 (22%)