DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mv and wdfy-3

DIOPT Version :10

Sequence 1:NP_647681.2 Gene:mv / 38259 FlyBaseID:FBgn0288310 Length:3535 Species:Drosophila melanogaster
Sequence 2:NP_001255658.1 Gene:wdfy-3 / 178220 WormBaseID:WBGene00007752 Length:3358 Species:Caenorhabditis elegans


Alignment Length:3791 Identity:726/3791 - (19%)
Similarity:1188/3791 - (31%) Gaps:1489/3791 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   509 LHYNVLHTIFVKRNPQGCPGCEDKLKSPVFHMDLLNIYKDNYKALLNTPAML-LFLKHLKHIAYL 572
            ||.....:.::|....|....:.....|:|| .::::|         ||..| ...|.:.|.|..
 Worm    12 LHLRKTFSEYLKIPVSGSRSNDPSRLLPLFH-KVMSMY---------TPQQLNAEFKEVVHFATF 66

  Fly   573 LPYDL---------------ASGILAEVALP--------IFRRYKELIESGESKRKISKVTPLQL 614
            |...|               |:..:||...|        |....:.|: |.|.:..|.....:.|
 Worm    67 LCSVLVKEVRQRAASTGTIEAAQSIAEFLRPGTELKGYTILEAIRFLL-SSEDEIMIDAACKVSL 130

  Fly   615 PSKLENYRALHECLSIFVMYLSDIRLVKAFYN-------------EENIRYMQDLLI-------- 658
            ||.|                   ::.:..|::             .||....:|.::        
 Worm   131 PSTL-------------------VKTIYLFFDLPAAATTVTVTDLTENATETEDEMLKNNEKLHD 176

  Fly   659 -IPELQRGVC-------DLIKVGIDNIAFLGENSQEQIT------LSRRLIQLQLNSSDRASQLF 709
             |.::..|:|       :|::.....:.|:|..||....      |..||:::..:.|...:.:.
 Worm   177 MIGQIMEGLCRFKCVSEELVRKDDLLLLFVGTTSQVAEANNCWRKLCARLLEVIADKSITNAVIK 241

  Fly   710 QALLYKCSKHSRAKFWLDESSTPAKLEGHKPADILYITALQWTLNFELLKTSQL---FYNEFAKI 771
            ..::.||.:    .|..:.||.|:............|..|...|......|.||   ||.  |..
 Worm   242 YVIVKKCVR----IFVKNLSSAPSNSHSDAQKTAESIICLSCFLKNSAYLTDQLLDEFYE--ADG 300

  Fly   772 YSIPVE-MLDDEDEDEVETPTSELLPGEKKLRHGDKNIFDILKLNYNALGCFLMLPKATMGPTTS 835
            |::..: :|..|.::|:.                 :||. ::.::....|.|.:.|:.|.|    
 Worm   301 YTVIKDFLLKSETDNEIV-----------------RNIL-LMAISLVNSGKFEITPQYTSG---- 343

  Fly   836 STATTPTAGICGSSSLETLVSQLPLAGSTSVSVTT-------------AASSDYADSTLD----- 882
                          .::....|||:.....:||..             :.|...:.:.:|     
 Worm   344 --------------LVQLPAFQLPIPAGNGLSVRNLNAFALLYHVFLESTSESTSCTVIDILHSI 394

  Fly   883 YASVIGNYDSYSRDMATPSFLQQLLACEPDESTV----LFDIRGSQSS----KDNPSNSLILPSE 939
            |.....||....::.....|:.| |..:|....|    |.:....|.|    ::..|..::|.:|
 Worm   395 YTCDPANYFILDKEYPLSIFIDQ-LERKPHAVRVKLLELIEFAVFQLSHIPCRELISLCVLLKTE 458

  Fly   940 -EEGATA---------------DGIINKLFSIVGSL----------------------FGGSPGS 966
             ..|.||               |.||...|..||.|                      |..:..|
 Worm   459 ISAGKTAMCTIIVQMCFKLITVDAIIKDAFREVGLLDALCFIIRRMFEMYEKNIQNASFTVTSTS 523

  Fly   967 GGSANSPTRANIDADFF-CLYEPNGECKKLLLKLFEATMAICIKGFQNEEVEKMQKHLRKLRAII 1030
            ..|.:....:.:..|.. .:.:.|.|..||..:.|.|.:.|.|....|||..  ...|:.::.::
 Worm   524 SRSQDQLKLSLLTTDLLTIIIKNNTENGKLFTECFGAKLLIEIVCEVNEEWR--SSLLQLVKQLL 586

  Fly  1031 LSHATDNWSEHGEQHARDNAVIQTLQTLLKIAELSSTHQEPTGVVNS------------------ 1077
            :...||.:..|.....:|...|:.|:.:..:.:..      .|||..                  
 Worm   587 IVAPTDQYIMHLVNTLQDRIPIENLEVMFSLLKAL------LGVVRESHKVRIQFRKSGGFLALS 645

  Fly  1078 --------------PSGDSQQPRPRARSFNSGSVELPRLQTVKLPAKNSLATPPTPRRRPNSSEA 1128
                          |:||.:.||.:.:......: :.::.|:.:            |..|:    
 Worm   646 ALLLGLEKRFTDLHPAGDGRIPREQCQMLEFVHI-IFKVFTLSM------------RFEPS---- 693

  Fly  1129 NAGVDADYFST-----------RASLSCAADSELELSENE----------------HEFYLTADE 1166
                :|.||||           |.:......:.:.:.|.|                ||.: ..|:
 Worm   694 ----NAKYFSTEITWDSITSLLRLTSIFNESTVISIEETEWKSLTHTDLASEIAACHEVF-RLDD 753

  Fly  1167 GYEADGEIA-------------------------DLSESECELNGGVLAANES--TWTPFQPSSR 1204
            ..|| |.:.                         :...|:...|....:..||  :||       
 Worm   754 NIEA-GNVPKGMPFNIYFGCYVCRLIFNMALDNYEKMTSDIRWNDDGASLEESIVSWT------- 810

  Fly  1205 YRSHIMHQGLSQLVVQMLAELSLLCI-----KQPNGWT--------------------------- 1237
                      |.|:|...|.:|:||:     .....||                           
 Worm   811 ----------SSLLVHPGAIISMLCLLPSISASSMKWTIAAQYYVSLLLKAILKSERNQQIMCQV 865

  Fly  1238 ---ESLTQLANRLFVIRDYLGGPLCLLKGFAPIL------SCSDPRLREL--------------- 1278
               :.|.::|.:||:..:::     ||:.|..:|      |.:..:||..               
 Worm   866 DMPKHLLRIAEKLFLTENHI-----LLQPFYYLLERLSYQSLTPNQLRSFLRLDSPLCCRSLDDD 925

  Fly  1279 ----QQSILELVTHLNTPEVLQCYYSILASKQPPVDLLMRHMHHISSGSLRKAQPCMELDFPIIT 1339
                ..|.:|:..:...|..|| ....|.|...|.|      .:|.:     |...:|.|..:..
 Worm   926 EDDDDDSKIEIADNEGGPVPLQ-RVKALVSMMTPRD------QYIGT-----APSFVEFDMSVEG 978

  Fly  1340 DGKIVVTS-EPLVSEQIERVRLHHQQCQTNTLFTRAACIFPVTQTRLWQPDGLTLSLWLELRGQQ 1403
            ...:.:.| .|:.|.                  |:|..|||..       :|.:...|:.|    
 Worm   979 FAALYLPSLAPMFST------------------TKAERIFPPL-------NGFSFCTWIYL---- 1014

  Fly  1404 MHRSSMQFNDDETRYSGEDLTKLHLLSLGTNQAMVSIYISNNMQLIFELVKPNEQLAPVRVEEQI 1468
                      |.......|...:.||::                        ...:||...:...
 Worm  1015 ----------DALSDKKADAHPIRLLTV------------------------TRAVAPPNSDPPS 1045

  Fly  1469 EANADTASVISANTQAANGGTIRQALKQTKLALLNSFGQMHLLNGHQASADSTGGYFESSAVQLQ 1533
            :..:.||.:.....|                  .::|.:..|::..:  :|..|...|.:| ..|
 Worm  1046 KKPSQTAHLACFQCQ------------------FSAFDRSLLISTEE--SDQPGADLEKTA-NFQ 1089

  Fly  1534 HLRLPR---------HKWMHL--VFGLQQQADSVEISIFLDGLEQHTMRLPF--RN----LRQLT 1581
            ..:|.|         .:|.||  ||. :....|.::|::|:|....|.:|.:  :|    ..||.
 Worm  1090 TDKLIRITLADQVRCGEWFHLAVVFN-RSVLKSSQVSLYLNGRHISTQKLMYVAQNAGGAATQLA 1153

  Fly  1582 RVHSFQLLALGEGQPTGRSPGSSSSSRSTLDGSTPRYALSNVILFKRRLVDPLLMMNLTAMGPDF 1646
            :.:|...:       .|..|.....||.       |:.|:::.|.:    :|:            
 Worm  1154 QTYSVNAV-------VGTLPALRRPSRL-------RFRLASIFLAE----EPM------------ 1188

  Fly  1647 TEFTQCQVANWKPNYGFVSLGKLSSSNFGNHLDCMRQLRQARVLVYTAQQPDLVMSYDASQELDM 1711
            |..|...|...:|:|    :|...:::       ...|.....:|::       :|..|:|||.:
 Worm  1189 TAETVRAVVQLQPHY----IGNYQTAS-------TAPLFHEEKIVFS-------LSAAATQELTL 1235

  Fly  1712 ACYGQPHGHMLYGELQQH--------------QAQTLQAATSLS---GGLSTLLYLFARIVELTG 1759
            |.....:|.|....|.||              ...|:..|....   ||:         ||...|
 Worm  1236 AKIRTMYGKMDAEILSQHLGISPNDHSTPLRVLCNTISHAPGAGRTFGGV---------IVGYLG 1291

  Fly  1760 NASTQALALDLLLQVAHSDAQLYTEFQRQDYLSLIGYVIKSEKCSKDVQLLRSIVNNACSQVLIT 1824
            ..:.....:..||......|.:|         .||...:.||.....   |:|:|:...||    
 Worm  1292 MRTFTPRPVPSLLDSIGGFASVY---------GLIAMAVDSEGLYAS---LKSLVSAIRSQ---- 1340

  Fly  1825 RKGDSINVNDNTMATLVYPRLMLTVLQRYSDWHRSGATHSDVLDMLFRCILALTRDKHPQRDFNM 1889
                              |||:.|       |:.:.:         ::.:..|..||        
 Worm  1341 ------------------PRLLAT-------WNNNRS---------YQILAVLLEDK-------- 1363

  Fly  1890 EQLQKCGLLGALLNLCKVYVI----------ESPSPVQISPYAAECFVQILAVFSGSPPDSSMLD 1944
                     ..:||...::::          ...:|...:|.|.|..:..|.|:.|:|      .
 Worm  1364 ---------AKMLNSHIMHMVFNVTGTADTSREHAPTISNPSAFEDLLCDLKVWKGAP------S 1413

  Fly  1945 EIMKLLLLLHKPSDCYVTHDRTHFYFLLTAQQPTKERSLVAANLSRVTTSLRRQLHPQPQELDPE 2009
            |:.|:||              .|||.|:|..|   ..:|.....|.:.:.:...:|.:|      
 Worm  1414 ELHKMLL--------------EHFYELITDHQ---LNNLQVVRKSSLLSRILLIIHDEP------ 1455

  Fly  2010 RAERIKKLRRLHASTSGYRKAVNEFEEHLDQMADCSNLNKSALRLLSPVEATRWRLKFKRRHPTS 2074
              ..||....:         ..|.....:....|    ::|.|::...:.||.         |||
 Worm  1456 --TMIKNTDEI---------IFNLISAIMQPQCD----SRSILKIGQSIAATL---------PTS 1496

  Fly  2075 AN---SPKRSPLKIARRRIHPHLHLGKIWQPSGHSTPSSGQSSLPNRKTDFYDQLGIIRLQQRLL 2136
            .:   .....|..|:        .:.|::..|....|               :.|..:.::.|||
 Worm  1497 ESECYEDSHLPFHIS--------EIQKLFIESSDPPP---------------EALHQVYIRNRLL 1538

  Fly  2137 ILLKDFLC----LLPDSSVDVVTR---------------H----YVKLELLLVLANQRSCAVRQA 2178
            .::.:||.    .:.....|.:.|               |    |:.|.:||::.||.|      
 Worm  1539 NIIANFLANSNTQVQQQMCDQLVRTLGFDWLFALMSPGVHSGTIYLALRILLLILNQPS------ 1597

  Fly  2179 IIQLVDVLTKRLPSG--------ELNAATKLMHPLHLANQLTIHGCDVGMFEACLAWINGMHCSL 2235
                   |..|...|        |.::..:....:.|...::.||..||              |.
 Worm  1598 -------LLARFKEGSANGGWLSEADSVVRNRAAVVLGFSVSAHGGAVG--------------SK 1641

  Fly  2236 TDI----QSCDAPVRIRQRFGLPSLLAIAEGTEPQWVFKALLRLYLQNP------DDQTCLIEAG 2290
            .||    .:|..       |.....|..|...:| :.:.|:|.|.:..|      .||   ....
 Worm  1642 IDINPELSNCGG-------FAALEHLMAAHADKP-YPYYAMLSLLVGQPISALRFCDQ---FNME 1695

  Fly  2291 LLQCSVKALYKIYSLRVGQSNAD---ESVVELLATIGERAMRSVGQINLVWDILN------LLSF 2346
            |:...|..|....|:....::|:   ::::.|.|.| ..::.....|:..|.:.|      :::|
 Worm  1696 LVWTHVFGLNSTSSVFEAINSANFCFDAIIPLFAMI-RTSIYHQSSIHQPWTVTNPSTVVQMITF 1759

  Fly  2347 YQDKQP---------QLIMRSFRT--------------AQAQLQ-------LEWLTKFFEPNSFR 2381
            .....|         :.|:..|.|              |..:.|       .|:...|....:.|
 Worm  1760 MYQNSPAFFNIAHTDEFILALFSTLIEDTNAMGVKSEVANRRSQDGGGSPDAEYFQAFLAQPNVR 1824

  Fly  2382 VAV-------TNDSSLSHSELRTRVELLID--------RCTQF------------FTVGVGQTTG 2419
            :.:       .::..::.|:..|.::.::|        |.||.            .|||.     
 Worm  1825 IVMDLLKKICCDNLQVNTSKNDTIIDAILDNISESGNTRKTQIACLTSLLHSVLEHTVGT----- 1884

  Fly  2420 PNYVASSQELALFQLLVSYGISSNQRCNNFIAWGLQPSRPRDLRSYIVDALW----------RSQ 2474
                         .||.|..:..|.:..|.:......|.   |.|..|||.|          |..
 Worm  1885 -------------DLLSSSALPPNTQAQNIVQIVANISL---LSSRAVDAFWNGLVFGSESMRML 1933

  Fly  2475 QDEFQRAIICDAKMIKAL--------LWLSLLEDMPEPIENLK---PLCDALG--------IKEN 2520
            ...:...:|...|:.||:        :....|..:..||:::.   .:.|||.        ...:
 Worm  1934 STLYHLQVIASKKVNKAVNAEPITGCIMRMTLFILSRPIDSVPVQLSVLDALSTLVSKRYLFLSS 1998

  Fly  2521 DSSW---NLVHEL-------DRLDQNRNN------------------------MAAKQKTLLEKT 2551
            :.:|   :|.|.:       |.|.|.::|                        :.||| .|:|:|
 Worm  1999 NEAWFFASLTHLIFMLSVTPDVLFQFQDNSSSSDLDRTSAQVAMCACRVWSDVICAKQ-ALIEET 2062

  Fly  2552 ---------------------VYRFEPLVQQCVES--------------SMVTTRKVAELQ---- 2577
                                 ||     .||.|:|              |.||.:.:.:.|    
 Worm  2063 FKKQSVTDINAARALLSHSAGVY-----WQQFVDSQLRAIQTGGSSAQGSAVTAKDIIQQQISSK 2122

  Fly  2578 -----------NAERK-----------ALMCHMKVYDDTYTYTKWL--------EIIRRMTHEGA 2612
                       .|:|.           ::........|......||        |::|..:....
 Worm  2123 FNRVASGITRFAAKRSMSTTTALPSSGSVAAWKSTSTDKQVIFMWLRVHVSLIKELVRAQSTRYT 2187

  Fly  2613 PWHSAERAEC-----SWE----------------------LDDTEGPSRVHTRLRRCHLDIDRRF 2650
            .||:..|..|     .||                      ||.||||:   ||:|| .|..:|.|
 Worm  2188 EWHAHVRKWCLHDWHQWEAELTRERGIWGPERASKLEKFKLDLTEGPT---TRMRR-KLIPNRNF 2248

  Fly  2651 F-MNEYRPGQGHRE---------------DLEPYV--------RPLDYLI--------ASYDQ-- 2681
            : :..:||   |.|               |.:||.        |.||..|        ||.:.  
 Worm  2249 YHIYPFRP---HLEAPSAKAQRAKVAISFDSKPYYETCLRHRRRTLDTRIIDSSNVSTASPEDGS 2310

  Fly  2682 -----------QLNIS-LNSQILYNFA-------------------------------------- 2696
                       .|::| :||.::...:                                      
 Worm  2311 GSSNLLGYSFTDLSLSEINSSLIRRLSTTAPATSNVSGTSLELNEEECETSERKEDDESISSISE 2375

  Fly  2697 ---------------------AK------------------------------------------ 2698
                                 ||                                          
 Worm  2376 KTDSNGVQSSGPSTSSNTTKEAKKEEKKEEKKAGPDNQTLLRLLEQGEQLHSMFRCARIQGLETA 2440

  Fly  2699 ----------FLPVDGEIEGEIIITDLK------LYFL---------------------ATYRCR 2726
                      |..|||       .|.||      |.||                     ::..|.
 Worm  2441 EGLLLFGRDHFYVVDG-------FTLLKTKEIRDLDFLSQEMHDPIVPYPATGATQPPKSSRLCS 2498

  Fly  2727 YFNVNCDIANITEIWLKRYQHQETAFEILLDTNKSLFFSLQNADDWKIMREVFCDKIVATP---- 2787
            .|:.|.    |.|:..:||..|..|.|:.....::...:...    ||...|| ||:.:..    
 Worm  2499 KFSYNM----IREVHKRRYLLQPIALEVFSSDGRNYLLAFPK----KIRDRVF-DKLTSMAINLS 2554

  Fly  2788 --------DQSKVIAI-------------------TQQWREGLLTNWEYLMTLNQISGRTYNDLM 2825
                    .|...:||                   ||:|..|.::|::|||.||.::||.||||.
 Worm  2555 SGGSDSLGGQKANVAIETTGRGASLLSSLIGQQSVTQRWLSGNISNFQYLMHLNTLAGRCYNDLS 2619

  Fly  2826 QYPVFPWVLANYNSEVLDLREGHNFRRLGRPIAVQVEENEKHYISNY-TYIDSTNTTMGSLILKP 2889
            |||:||||||:|.|..||......||...:|:..|..:..:.::..: .:.|.:..|      .|
 Worm  2620 QYPIFPWVLADYTSSQLDFNNISTFRDFSKPMGAQSPDRLEQFLKRFREWDDPSGET------PP 2678

  Fly  2890 YHYSSHYSNSGTVLHFLVRVPPFTSYFLRYQDNDFDLPDRTFHALNTTWLLASRDSPTDVKELIP 2954
            |.|.:|||::..|:.:|||:.|||..||..|...|||.||.||::...|..|||::..|||||||
 Worm  2679 YMYGTHYSSAMIVVSYLVRLEPFTQQFLSLQGGHFDLADRMFHSVGDAWTSASRNNMADVKELIP 2743

  Fly  2955 EFFCLPEMFENFERFKFGCRQNGERVEDVSLPPWSQRDSRLFVLIHRQALESELVRNQIHNWIDL 3019
            |||.|||||.|...|..|.:|||..|.||.||.|...|.|.|:.:|||||||:.|.:.:|.||||
 Worm  2744 EFFTLPEMFTNTNHFDLGVKQNGIHVNDVLLPAWCHGDPREFIRLHRQALESDYVSSHLHEWIDL 2808

  Fly  3020 IFGYKQSGESAVEAINVFHPATYAVFLDSE-ISDPIEREAVKTMVKTYGQMPRQLFKSPHPASK- 3082
            ||||||:||.||:..|:||...|...:|.| |.||:.|.|....|..:||:|.||||.|||..| 
 Worm  2809 IFGYKQNGEEAVKNSNLFHHLFYEGSVDFERIDDPLTRNATIGFVNNFGQIPTQLFKKPHPQKKV 2873

  Fly  3083 PLDYSLVGKPIVSTVRGLRWGVY-VGSPQ-----LKAPSWANIHK-----IPGTEHLVSFCNTNV 3136
            .:.......|.|:|.|.....:: :.:||     |:: :..:||:     :...|....|..|| 
 Worm  2874 NILEGFSNTPGVTTSRLFYHAIHNMSAPQTPFKELRS-AIGSIHQNDKIGVVALEQNKVFIGTN- 2936

  Fly  3137 VYALPGRASVMQGAEPDTYNVISWGYDDRIVRIQPLNKPQAKPKNLLHNGTFDDITACGCDVNSN 3201
                               ..|:||..||.||:..::..::.   .:|.....|...|....:..
 Worm  2937 -------------------RYITWGLPDRSVRMGQIDNDKSV---CVHEMCEVDEMTCAAAGDET 2979

  Fly  3202 QLWFGHKSGRISVYKCTGGLDSQQRASAKSRQSYARGFSLSYNSAFRKMTNKGIGGGGSERVDEA 3266
            .|:.|:.||.|:|:                                 |:.||.:           
 Worm  2980 TLFCGNTSGCITVW---------------------------------KVNNKPL----------- 3000

  Fly  3267 GNLHPTSSASSVNSSSISSGGDAFQRDGADLNWLGPTLLVRHTDEITCITLSVEFKIAVTAGRDG 3331
                      |:...|:.:|                     |:|.|||:.......:.|:|.||.
 Worm  3001 ----------SMKKLSVLNG---------------------HSDAITCLVSCQSHAVLVSASRDL 3034

  Fly  3332 IAVIWDLNDWSYVRTIARPAEIHQSPITHVAISPTLGDIVTVHTLPQSCNT-----STDPKPTAV 3391
            ..::|.|::...:|.:.:    |...:..||::...|||.|      :|:|     :.:.:..||
 Worm  3035 TVLVWHLSEMFLIRQLPK----HPHAVLAVAVNDATGDIAT------ACSTLLHVWTLNGELLAV 3089

  Fly  3392 ATRPNSLNVADECFEVTEENLDDFVNVNVNPNGKSILRLHSVNARYVQHLVHEDRILAVCYSYIK 3456
                  ||..|             |...::|                     :..|:::.:|.:.
 Worm  3090 ------LNTCD-------------VAPAIDP---------------------QQMIISLAFSTMN 3114

  Fly  3457 EGVGVNVIATAVEGGFVRFWS 3477
            |....|||......|.|:.:|
 Worm  3115 EWDNDNVIMCGTSDGIVKIYS 3135

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mvNP_647681.2 PH-like 2704..2785 CDD:473070 23/107 (21%)
Beach 2796..3080 CDD:214982 136/285 (48%)
WD40 <3302..>3518 CDD:441893 37/181 (20%)
wdfy-3NP_001255658.1 PH_BEACH 2423..2550 CDD:275391 26/142 (18%)
Beach 2591..2871 CDD:460459 136/285 (48%)
WD40 <2945..3150 CDD:475233 56/319 (18%)
WD40 repeat 2971..3010 CDD:293791 12/92 (13%)
WD40 repeat 3016..3052 CDD:293791 9/35 (26%)
WD40 repeat 3057..3091 CDD:293791 10/45 (22%)
FYVE_WDFY3 3285..3349 CDD:277259
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.