Protein Alignment mv and sel-2

DIOPT Version :10

• Sequence 1: NP_647681.2
• Gene: mv / 38259
• FlyBaseID: FBgn0288310
• Length: 3535
• Species: Drosophila melanogaster
• Sequence 2: NP_001379017.1
• Gene: sel-2 / 175606
• WormBaseID: WBGene00004760
• Length: 2563
• Species: Caenorhabditis elegans
• Alignment Length: 2982
• Identity: 590/2982 - (19%)
• Similarity: 996/2982 - (33%)
• Gaps: 1000/2982 - (33%)

  Fly  1063 ELSSTHQEPTGVVNSPSGDSQQPRPRARSFNSGSVELPRLQTVKLPAKNSLATPPTPRRRPNSSE 1127
            |:|.|....:|.....:|..:.|.......|.   |...::||.|...:|.|...:|....|..:
 Worm     2 EISETSHNESGPPVQENGIVEIPVEEGEEVND---EESNMETVDLGLDDSAADASSPSVFKNIDD 63

  Fly  1128 ANAGVDADYF-------------------STRASLSCAADS--------ELELSENE---HEFYL 1162
            ...|..:|..                   |...|...|.:|        ||||...|   .:|::
 Worm    64 EAPGDPSDAAKKEEDSEEIVVPSVLAPTPSQEVSPPNAIESLPPLPEGKELELEPEELTPAQFFI 128

  Fly  1163 TAD-------------EGYEADGEIADLSESECELNGGVLAANESTWT---PFQ-------PSSR 1204
            ..|             :.|.|.|.|:         ..|.||:...::.   ||.       |...
 Worm   129 EYDLTQPSTPGTQSRRDSYSATGNIS---------RRGSLASFSKSFNISIPFSDDVTSSLPRLL 184

  Fly  1205 YRSHIMH---QGLSQLVVQMLAELSLLCIKQPN-GWTESLTQLANRL----------FVIRDYLG 1255
            .::.::|   :|..:.:.::   :::|....|| ..|:.:..|.|.|          |||.|...
 Worm   185 SKTTLIHSNEEGADETIQRL---VTVLHSNSPNTDRTQVVDNLFNLLVGGHFDQESKFVIEDAAN 246

  Fly  1256 GPLCLLKGFAPILSCSDPRLRELQQSILELVTHLNTPEVLQCYYSILASK-------QPPV--DL 1311
                 :.....:||..|..|:....|:...|...:...:..|....|.||       .||:  ||
 Worm   247 -----VDHMLTLLSHCDYDLQNEIWSLFLAVMKKSNRNLEACTRVGLISKVLDILPEAPPLLADL 306

  Fly  1312 LMRHMHHISSGSLRKAQPCMELDFPIITDGKIVVTSEPLVSEQ--IERVRLHH------QQCQTN 1368
            |::.:..:.:.|:...|.            |.::.:.....||  ...::|.|      |....:
 Worm   307 LVQIIAALVAYSINVKQT------------KHLLRALKSTKEQWPPNSLKLLHVLKEMPQHDSAD 359

  Fly  1369 TLFT-----RAACIFPVTQTRLWQPDGLTLSLWLELRGQQMHRSSMQFNDDETRYSGEDLTKLHL 1428
            ..|:     ::..|.|..:|..:| .|.|.:.||.:.    ..:|:.|..::.          .|
 Worm   360 VFFSFPGKDQSGIILPPIKTMPYQ-QGWTFATWLRME----PLNSVTFEKEQP----------VL 409

  Fly  1429 LSLGTNQAM-VSIYISNNMQLI-FELVKPNEQLAPVRVEEQIEANADTASVISANTQAANGGTIR 1491
            .|..|::.: .|.:.:.|..:: .|..|..||...||.|
 Worm   410 YSFRTSKGVGYSCHFTGNCLVVNVEKTKGKEQSRCVRAE-------------------------- 448

  Fly  1492 QALKQTKLALLNSFGQMHLLNGHQASADSTGGYFESSAVQLQHLRLPRHKWMHLVFG-LQQQADS 1555
                                                         |...||.|:... ...:...
 Worm   449 ---------------------------------------------LGARKWHHIAIAHCYSRWGR 468

  Fly  1556 VEISIFLDGLEQHTMRLPFRNLRQLTRVHSFQLLALGEGQPTGRSPGSSSSSRSTLDGSTPRYAL 1620
            .:|..|:||....|:.|.:    .:|...::...::|        ..:..::.|...|.     :
 Worm   469 SDIKCFIDGQLAETIELSW----VVTSATNWDRCSIG--------VSADGTANSAFCGQ-----M 516

  Fly  1621 SNVILFKRRLVDPLLMMN-LTAMGPDF-TEFTQCQVANWKPNYGFVSLGKLSSSNFGNHLDCMRQ 1683
            ..:.||...|.  |...| |..:||.: :.|......:....|        ....|..||
 Worm   517 GAMYLFAEALT--LQQANSLFCLGPVYQSTFKHDSETSLPEGY--------KKHLFDGHL----- 566

  Fly  1684 LRQARVLVYTAQQPDLVMSYDASQELDMACYGQ------------------PHGHMLYGELQQHQ 1730
                        ...||.:|....     |:||                  ||..|..| ::...
 Worm   567 ------------HSSLVFAYCPKN-----CHGQLCLYTPPKTAASTYFVQIPHAVMKEG-VEVIT 613

  Fly  1731 AQTLQAATSLSGGLSTLLYLFARIVELTGNASTQALALDLLLQVAHSDAQLYTEFQRQDYLSLIG 1795
            ..::..:....||:..||.|||:|...:.|.::             .|.::.     |..||||.
 Worm   614 THSIHKSLQSVGGIQILLPLFAQIDLPSSNDNS-------------IDGEVC-----QTLLSLIA 660

  Fly  1796 YVIKSEKCSKDVQLLRS---IVNNACSQVLITRKGDSINVNDNTMATLVYPRLMLTVLQRYSDWH 1857
            .::.|.:.|:. ||..|   ::.::|                               ||:.|..|
 Worm   661 LLLSSSQSSQQ-QLFHSKGFLIISSC-------------------------------LQKASPSH 693

  Fly  1858 RSGATHSDVLDMLFRCILALTRDKHPQRDFNMEQLQKCGLLGALLNLCKVYVIESPS-------P 1915
            .|    ..||:.|......|.|               |...|.||.....|::.:|.       .
 Worm   694 LS----MKVLEQLIHIAKFLLR---------------CPAGGPLLKHLFDYILFNPKLWIRARPE 739

  Fly  1916 VQISPYAAECFVQILAV-FSGSPPDSSMLDEIMKLLLLLHKPSDCYVTHDRTHFYFLLTAQQPT- 1978
            ||:..|      |.||. |..:...|.||..:         |:...:.|...|||:|...|..:
 Worm   740 VQVHLY------QYLATDFLANNNFSQMLRRV---------PTVIEMCHTLKHFYWLALPQTVSD 789

  Fly  1979 ---KER------SLVAANLSRVTTSLRRQL--HPQPQELDPERAERIKKLRRLHASTSGYRKAVN 2032
               :||      :.:.|..|.:.|.:.|.:  ...|:|.:..|.:.:..|..|.|:.   |:..|
 Worm   790 YTIEERPENFATADIVAIRSSILTFINRIIIASAGPEEEERVRDQEVHTLLNLLATV---REDDN 851

  Fly  2033 EFE----------EHLDQMADCSNLNKSALRLLSPVEATRWRLKFKRRHPTSANSPKRSP-LKIA 2086
            .::          ||...|....:.|| ||.::..:.|             :.|...|.| |||
 Worm   852 LYDVLALVTRLLAEHPAIMIPAIDKNK-ALGIIFNLLA-------------APNELIRIPALKI- 901

  Fly  2087 RRRIHPHLHLGKIWQPS--GHSTPSSGQSSLPNRKTDFYDQLGIIRLQQRLLILLKDFLCLLPDS 2149
                     ||.....|  ...|.|.|..:|       :..:|...|..:.::.|..:..|| :.
 Worm   902 ---------LGFFLSRSTLKRKTESMGNQNL-------FSLIGERLLSHKKVLSLPTYNVLL-EI 949

  Fly  2150 SVDVVTRHYV-----------KLE---LLLVLANQRS-CAVRQAIIQ-----LVDVLTKRLPSGE 2194
            .|:.:|..:.           |.|   ||.|:|:..| |...:.|:|     |:|::.....|.|
 Worm   950 LVEQMTPTFTYACHQPAQPEWKFENPHLLKVIAHVISQCEESENIVQIKKCFLIDIINLCRESKE 1014

  Fly  2195 LNAATKL---------------MHPLHLANQLT----------IHGCDVGMFEACLAWINGMHCS 2234
             |..|.|               .|.....|:::          :|......:.....|::.:..:
 Worm  1015 -NRRTILQMSVWQDWLIGLAYVFHTTESQNEVSELVWEAFSILLHHALRNEYGGWRVWVDTLAIA 1078

  Fly  2235 LTDI-------QSCDAPVRI-RQRFGLPSLLAIAEGTEPQWVFKALLRLYLQNPD----DQTCLI 2287
            .:.:       :..:|.::. |...|     ......||..:::|        |:    |....:
 Worm  1079 HSKVSFEKFKRKLAEAKIKAERSESG-----GEEAKMEPTPIYRA--------PEFAWSDVHVRL 1130

  Fly  2288 EAGLLQCSVKAL--YKIYSLRVG-QSNADE------SVVELLATIGERAMRSVGQINLVWDILNL 2343
            .|.||....:.:  :|:....:. |.||.|      :||.:::.:.:..:.:.|      .:|.|
 Worm  1131 LADLLSGIERVVDEWKVAECGISDQCNASENQVFVGNVVHVVSQLSDSLIMACG------GLLPL 1189

  Fly  2344 LSFYQDKQPQLIMRSFRTAQAQLQLE----WLTKFFE-PNSFRVAVTNDSSLSHSELR------- 2396
            |:  ....|...|......|.||.:.    :|.:|.. .::|.:|    |.:|.|||.
 Worm  1190 LA--SATAPNNDMEIVDPCQQQLPISVSAGFLMRFARLVDTFVLA----SGVSFSELEQEKNMPA 1248

  Fly  2397 ---TRVELLIDRCT---QFFTVGVGQTTGPNYVASSQELALFQLLVSYGISSNQRCNNFIAWGLQ 2455
               .|..|.|....   ......:.|...|.|..:|.:             .||....|:...|:
 Worm  1249 GGVLRQSLRISATVTVRHILASRIQQPDTPRYETNSTK-------------KNQCIMEFVREALE 1300

  Fly  2456 PSRPRDLRSY-----------IVDALWRSQQDEFQRA--IICDAKMIKALLWLSLLEDMPEPIEN 2507
            ...|..|.:.           |...::|...:|.::|  :......:.::|.:|...|:.||..:
 Worm  1301 KRSPDGLENVERLVQDSDITRIKGVVYRDMVEENRQAQFLALSVIYLVSVLMVSRYRDILEPPSS 1365

  Fly  2508 LKPLCDALGIK-------------ENDSSWNLVH------------------------------- 2528
            ..|..|:...|             ||.|:..|.:
 Worm  1366 PSPFFDSTTQKQENSENVNSETSPENGSNGKLANGGDNLSIKNGIESNGNDGEEEENGEEGQGDD 1430

  Fly  2529 -------------------------ELDRLDQN-----------------RNNMAAKQKTLLEKT 2551
                                     ||.::.|:                 |..:..|.:|.||..
 Worm  1431 GGRIAAIKVANADMKRGDGNEYDEEELSKMHQSNGRRPSTMMPVQQTAERRAYLTTKLQTALETC 1495

  Fly  2552 VYRFEPLVQQCV----------------ESSMVTTRKVAELQN-----AERKALMCHMKVYDDTY 2595
            .    ||:::.:                :..|..|:.:..|:|     .|...|:|..:......
 Worm  1496 A----PLLREMMSDFRGYLQKTLLGTHGQEIMNDTKVLETLRNRNASVIELVMLLCSQEWQTSLQ 1556

  Fly  2596 TYT--KWLEII---RRMTH----------------------EGAPWHSAERAE------------ 2621
            .:.  .::|::   |.|.|                      |....|:...||
 Worm  1557 KHAGLAFIELVNEGRLMAHATRDHVLRVANEADFILNRLRAEDVSKHAQFEAESREQLAARHEEY 1621

  Fly  2622 --CS-------------------------------------WELDDTEGPSRVHTRLRRCHLDID 2647
              |.                                     |:||..|..||     ||
 Worm  1622 GRCDLLIASGRLRDSINATRLLEKMSAILSDQDDSKSGTQFWKLDVWEDDSR-----RR------ 1675

  Fly  2648 RRFFMNEYRPGQGHRE--------DLEPYVRPLDYL-------------------------IASY 2679
            :||..|.|  |..|.|        :.||.:...:.:                         |..:
 Worm  1676 KRFVPNAY--GSRHEEANLPEGEKNEEPEISEQEKIRKVLKGLFSKRQNSSGSHELVDESDIDKW 1738

  Fly  2680 DQQLNISLNSQ-ILYNFAAKFLPVDGEIEGEIIITDLKLYFLA-----TYR---------CRYFN 2729
            .|:::.:.:|| ..::..||.:.....:.|.:.:|...|:|.|     .|:         |...:
 Worm  1739 AQEVDPTPSSQSACFSTTAKLIAPGVVVPGTLSVTANDLFFDANESDPNYKKQCAQVLRYCEALH 1803

  Fly  2730 VNCDIANITEIWLKRYQHQETAFEILLDTNKSLFFSLQNADDWKIMREVFCDKIV---------- 2784
            ...::..|..|:|:||..|.||.|:.|.:..::.|:..:.|..|        |:|
 Worm  1804 ARWNLQEIRAIFLRRYLLQNTALELFLASRTAIMFAFDSEDAVK--------KVVYQLPRVGVGV 1860

  Fly  2785 --ATPDQSKVIAIT-----------QQWREGLLTNWEYLMTLNQISGRTYNDLMQYPVFPWVLAN 2836
              ..|...|...:|           .:|::..::|::|||.||.::|||:|||.|||||||:|.|
 Worm  1861 KYGLPQSRKTSLMTPRQLFKHSDMCAKWQKREISNFDYLMFLNTVAGRTFNDLSQYPVFPWILTN 1925

  Fly  2837 YNSEVLDLREGHNFRRLGRPIAVQVEENEKHYISNYTYIDSTNTTMGSLILKPYHYSSHYSNSGT 2901
            |.|:.|||....|||.|.:||....|...|.:...||..|...       :..:||.:|||....
 Worm  1926 YTSDTLDLSVASNFRDLSKPIGALSEARRKFFNDRYTSWDDDQ-------VPAFHYGTHYSTPAF 1983

  Fly  2902 VLHFLVRVPPFTSYFLRYQDNDFDLPDRTFHALNTTWLLASRDSPTDVKELIPEFFCLPEMFENF 2966
            .|::|:||.||.|.|:...|..||.|||..|::..:|....||| .||||||||.|.|||||.|.
 Worm  1984 TLNWLLRVEPFASMFINLHDGKFDHPDRITHSIKDSWDRCQRDS-HDVKELIPELFYLPEMFRNS 2047

  Fly  2967 ERFKFGCRQNGERVEDVSLPPWSQRDSRLFVLIHRQALESELVRNQIHNWIDLIFGYKQSGESAV 3031
            .:|..|.|.:|..|:||.||||::.... |||:|||||||:||..|::.||||||||||.|..||
 Worm  2048 SKFNLGRRADGTPVDDVVLPPWAESPEH-FVLMHRQALESDLVSCQLNQWIDLIFGYKQRGAEAV 2111

  Fly  3032 EAINVFHPATYAVFLDSEISD-PIEREAVKTMVKTYGQMPRQLFKSPHP------ASKPLDYSLV 3089
            .|.|||:..||...:..:::: |.:..|::..:.::||.|.||....||      :..|..:...
 Worm  2112 RATNVFYHLTYEGTVTPKMAETPGQVAAIEQQILSFGQTPSQLLTEAHPPRHSIMSMAPTMFRRH 2176

  Fly  3090 GKPIVSTVRGLRWGVYVGSPQLKAPSWANIHKIPGTEHLVSFCNTNVVYALPGRASVMQGAEPDT 3154
            .:.:...::      |:.:..:...:....|::|  :..|.....|:|::|           ...
 Worm  2177 DEDLCMMMK------YISNSPVVYLAANTFHQLP--QPTVVGVAQNLVFSL-----------NKW 2222

  Fly  3155 YNVISWGYDDR-IVRIQPLNKPQAKPKNLLHNGTFDDITACGCDVNSNQLWFGHKSGRISVYKCT 3218
            .|..|:|...| .:.:.|.|                                  ..|::|:....
 Worm  2223 DNSYSYGASQRSALSMDPSN----------------------------------AEGQVSLPLTA 2253

  Fly  3219 GGLDSQQRASAKSRQSYARGFSLSYNSAFRKMTNKGIGGGGSERVDEAGNLHPTSSASSVNSSSI 3283
               |:|..::|.:.....|....:::.......:..:....|:.:...|  :|..|...|::.|
 Worm  2254 ---DAQLASAASTTPVARRHLGDAFDQRLTVQCSNFVTTTDSKFIFACG--YPDYSFRIVDTDS- 2312

  Fly  3284 SSGGDAFQRDGADLNWLGPTLLVRHTDEITCITLSVEFKI-----AVTAGRDGIAVIWDLN---- 3339
               |...|            .:..|.|.:|||..| |..:     .||...|...|:|..|
 Worm  2313 ---GRVRQ------------AVYGHGDVVTCIARS-ETSLFSDCYVVTGSMDCTVVLWHWNGTTG 2361

  Fly  3340 ----DWSYVRTIARPAEI---HQSPITHVAISPTLG--------DIVTVHTLPQSCNTSTD---- 3385
                :::....:..|..|   |::.|:.:.:|...|        .::.:||      ||:|
 Worm  2362 FIAGEYNQPGEVPSPRSILTGHEASISALCVSAEHGLVVSGCEDGVILIHT------TSSDLLRR 2420

  Fly  3386 PKPTAVATRPNSLNVADECFEVTEENLDDFVNVNVNPNGKSILRLHSVNARYVQHLVHEDRILAV 3450
            .:...:.|:   |:::.||..::..:....|.             :|..|:.:..::.:|:|  .
 Worm  2421 IRGHGIVTQ---LSMSRECILLSLFDSKRMVT-------------YSATAKKLDEVLVDDKI--E 2467

  Fly  3451 CYSYIKEGVGVNVIATAVEGGFVRFWSSWNLSFVSELTTGTSPIRSIC-YSTHQHLV 3506
            |.:..::|   ....|....|.:..|..:.|:.:.......|.:||:. .::|:.::
 Worm  2468 CVTVTRDG---EFAVTGAVNGRINIWRMFPLTKLYTYQPLNSAVRSVAVVASHRFIL 2521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mv	NP_647681.2	PH-like	2704..2785	CDD:473070	22/106 (21%)
		Beach	2796..3080	CDD:214982	130/301 (43%)
		WD40	<3302..>3518	CDD:441893	43/234 (18%)
sel-2	NP_001379017.1	Laminin_G_3	384..530	CDD:463865	36/249 (14%)
		DUF4704	595..1080	CDD:464870	121/605 (20%)
		DUF1088	1569..1733	CDD:461925	25/176 (14%)
		PH_BEACH	1757..1854	CDD:434260	24/104 (23%)
		Beach	1887..2162	CDD:460459	129/283 (46%)
		NBCH_WD40	2187..2532	CDD:466575	69/431 (16%)
		WD40 repeat	2283..2321	CDD:293791	8/55 (15%)
		WD40 repeat	2327..2382	CDD:293791	13/55 (24%)
		WD40 repeat	2387..2422	CDD:293791	8/40 (20%)
		WD40 repeat	2430..2462	CDD:293791	6/44 (14%)
		WD40 repeat	2466..2502	CDD:293791	7/40 (18%)