DRSC/TRiP Functional Genomics Resources

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Protein Alignment mv and WDR81

DIOPT Version :10

Sequence 1:NP_647681.2 Gene:mv / 38259 FlyBaseID:FBgn0288310 Length:3535 Species:Drosophila melanogaster
Sequence 2:NP_001157281.1 Gene:WDR81 / 124997 HGNCID:26600 Length:1941 Species:Homo sapiens


Alignment Length:463 Identity:117/463 - (25%)
Similarity:173/463 - (37%) Gaps:125/463 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly  2789 QSKVIAITQQWREGLLTNWEYLMTLNQISGRTYNDLMQYPVFPWVLANYNSEVLDLREGH-NFRR 2852
            |.::.::...|..|.::|:.|||.||:::||...|...:||.||        |:|....| .||.
Human   342 QEELRSLVLDWVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPW--------VVDFTTPHGRFRD 398

  Fly  2853 LGRPIAVQVEENEKHYISNYTYIDSTNTTMGSLILKPYHYSSHYSNSGTVLHFLV----RVP-PF 2912
            | |....::.:.:|.....|..........|:...:|.|...|.|:..:.:.:.|    |.| ..
Human   399 L-RKSKFRLNKGDKQLDFTYEMTRQAFVAGGAGGGEPPHVPHHISDVLSDITYYVYKARRTPRSV 462

  Fly  2913 TSYFLRYQDNDFDLPDRTFHALNTTWLLASRDSPTDVKELIPEFFCLPEMFENFERFKFGCRQNG 2977
            ....:|.|....:.|.......|.|           ..|.||||:..|.:|.:..          
Human   463 LCGHVRAQWEPHEYPASMERMQNWT-----------PDECIPEFYTDPSIFRSIH---------- 506

  Fly  2978 ERVEDVSLPPWSQRDSRLFVLIHRQALESELVRNQIHNWIDLIFGYKQSGESAVEAINV-FHPAT 3041
            ..:.|:.:|.|.. .|:.||..||..|||..|...:|:||||.||||..|:.||:..|| .|   
Human   507 PDMPDLDVPAWCS-SSQEFVAAHRALLESREVSRDLHHWIDLTFGYKLQGKEAVKEKNVCLH--- 567

  Fly  3042 YAVFLDSEISDPIEREAVKTMVKTYGQMPRQLFKSPHP---ASKPL---DYSLVGKPIVSTVR-- 3098
               .:|:.           |.:.:||.:  |||..|||   |..|.   :..|:.|.:|.|::  
Human   568 ---LVDAH-----------THLASYGVV--QLFDQPHPQRLAGAPALAPEPPLIPKLLVQTIQET 616

  Fly  3099 -----------GLRWGVYVGSPQLKA----PSWANIHKIPGTEH--------------------- 3127
                       .|..|  ||.|.|:|    .||.....:.|.:.                     
Human   617 TGREDFTENPGQLPNG--VGRPVLEATPCEASWTRDRPVAGEDDLEQATEALDSISLAGKAGDQL 679

  Fly  3128 ---------LVSFCNTNVVYALPGRASVMQGAEPDTYNVISWGYDDRIVRIQPLNKPQA-----K 3178
                     |:||...:.  :.|||.:...||:|..      |.:.||:..:..|..||     |
Human   680 GSSSQASPGLLSFSVASA--SRPGRRNKAAGADPGE------GEEGRILLPEGFNPMQALEELEK 736

  Fly  3179 PKNLLHNG 3186
            ..|.|..|
Human   737 TGNFLAKG 744

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mvNP_647681.2 PH-like 2704..2785 CDD:473070
Beach 2796..3080 CDD:214982 81/293 (28%)
WD40 <3302..>3518 CDD:441893
WDR81NP_001157281.1 Necessary and sufficient for the interaction with SQSTM1. /evidence=ECO:0000269|PubMed:28404643 1..650 97/359 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27
Beach 351..591 CDD:100117 81/289 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 618..637 4/20 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 694..718 7/31 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1022..1074
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1097..1217
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1523..1556
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1569..1602
WD 1 1639..1677
WD40 <1640..1939 CDD:441893
WD40 repeat 1652..1695 CDD:293791
WD 2 1686..1724
WD40 repeat 1700..1734 CDD:293791
WD 3 1729..1769
WD40 repeat 1743..1779 CDD:293791
WD 4 1777..1815
WD40 repeat 1789..1822 CDD:293791
WD 5 1819..1856
WD40 repeat 1831..1864 CDD:293791
WD 6 1860..1896
WD40 repeat 1871..1893 CDD:293791
WD 7 1902..1941
Blue background indicates that the domain is not in the aligned region.

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