DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cnb and SHTN1

DIOPT Version :9

Sequence 1:	NP_001261300.1	Gene:	Cnb / 38258	FlyBaseID:	FBgn0035295	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	NP_001120683.1	Gene:	SHTN1 / 57698	HGNCID:	29319	Length:	631	Species:	Homo sapiens

Alignment Length:	612	Identity:	122/612 - (19%)
Similarity:	221/612 - (36%)	Gaps:	177/612 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 SSLNENKIISLSELWGKSSLTKTVLDNNSPNRPLCSSSLKEEQLRRQHLEKMVHTLQSHLLEYQ- 257
            :||.|..|....:|..::..||...|.....|......|:|.|.....:.:.|:.:|:| ||.:
Human    14 TSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNH-LEIEK 77

  Fly   258 --------------------QRISV-------------AIEVDRSKDAALTE-AEQTVQSL--NY 286
                                :|||:             .|.:|.......|: |.:|..|:  ..
Human    78 TCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQK 142

  Fly   287 EVQHLRDAVHRLEADRGESQSRFDALQNELSQAVNLATRFQEKNDKLERE-------LDHCRQ-- 342
            :::.|||.:..::.::.......:.|:::|.:.:....:.:::...|..|       |:.|.:
Human   143 QIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVS 207

  Fly   343 --DAKQWEERLEQLEMQLNSSKRAEELSH---AELNKLR--------------------DKFAKV 382
              ..:::||....||::.:..|:||..:.   .|.|||:                    |:.||:
Human   208 MLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKL 272

  Fly   383 DYQQEKLK----ARIEELEK--ENNTLTNQKEMLQEYHQKQKARADSLESHRKSLQETLANLTET 441
            ..|.|:.:    .:::|||:  ||.||  .||:     ...|.:.:.||..:|.|:....|..|.
Human   273 TQQLEEERIQHQQKVKELEEQLENETL--HKEI-----HNLKQQLELLEEDKKELELKYQNSEEK 330

  Fly   442 ETNLKKKLDIQQKSLKQYYQQQMENVV-----------------------------------AKK 471
            ..|||..:|..||.:     .|.||.|                                   |||
Human   331 ARNLKHSVDELQKRV-----NQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSGSGAKK 390

  Fly   472 MQEFQDQLDKNEEHLKNEARERERLIAERAVK--QLEMINE----KNNQELNLIQEKHNEEVE-- 528
            .:..|.:..:....||.:|.|.   :.:|..|  .|..:|:    |...|.:...|...:|::
Human   391 EKATQPETTEEVTDLKRQAVEE---MMDRIKKGVHLRPVNQTARPKTKPESSKGCESAVDELKGI 452

  Fly   529 LYRLQLANASKKIDEMDLKLSCYKTKRADIAEKLHGVMEAQWQQALAILTTP---------SQNS 584
            |..|..:.:|:.:..:|.:.|  :|:...|..:.....||.......||.|.         |.:|
Human   453 LGTLNKSTSSRSLKSLDPENS--ETELERILRRRKVTAEADSSSPTGILATSESKSMPVLGSVSS 515

  Fly   585 IIQSSDTEASESPELNNARMYPETPKSSKSQRS-NNTEKNNLDVVGKRDPPSPMDKLQAYIELLL 648
            :.:::..:.:...|.|:..  |.||:..:..|. .....:.:..    .|||.:...:.||:
Human   516 VTKTALNKKTLEAEFNSPS--PPTPEPGEGPRKLEGCTSSKVTF----QPPSSIGCRKKYID--- 571

  Fly   649 SKSPSDFDRLDEILAMTSKQGSKQSKP 675
                                |.||::|
Human   572 --------------------GEKQAEP 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cnb	NP_001261300.1	TPR_MLP1_2	291..408	CDD:285204	32/156 (21%)
		Tropomyosin	349..563	CDD:278679	64/285 (22%)
		Fib_alpha	<349..458	CDD:285864	37/137 (27%)
SHTN1	NP_001120683.1	DUF972	141..>189	CDD:283750	5/47 (11%)
		Tmemb_cc2	<268..350	CDD:287269	27/93 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	343..511		33/177 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..566		9/47 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	579..631		122/612 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000