DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cnb and Cntrob

DIOPT Version :9

Sequence 1:	NP_001261300.1	Gene:	Cnb / 38258	FlyBaseID:	FBgn0035295	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	NP_001128117.1	Gene:	Cntrob / 303240	RGDID:	1307488	Length:	897	Species:	Rattus norvegicus

Alignment Length:	721	Identity:	155/721 - (21%)
Similarity:	293/721 - (40%)	Gaps:	157/721 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 PSKKSELNSINSRLQNIALDAEEPP------SDIST---ISTNTVRNAGRPSR-ELHGMVHSTPK 108
            ||..|.|     |.:::..|:.|||      |::::   .|.:..|.|...:| :|:....|:|.
  Rat     6 PSPNSPL-----RPEDLLTDSSEPPGLNQVSSEVTSQLYTSLHLSRQAEATARAQLYLASTSSPP 65

  Fly   109 SGSVEPLRHRPLDDNILLEIDHYL--DDNNAHRWQRHDHH------LHHRSDDHLR--NERAGKE 163
            :..::.|. :.|..::.:.:::.|  .|.:.|.::.....      ||...|...|  :||..::
  Rat    66 NEGIDSLA-QELSRSLSVGLENNLKKKDGSKHIFEMESVRGQLQTMLHTSRDMAYRTGSERREED 129

  Fly   164 GHPGTSSL------PSMRLASSSSGAVSVEAARVDRSSLNENKIISLSELWGKSSLTKTVLDNNS 222
            .....|:.      |...|:.|||..                   :|.||:.:.:..:.....|.
  Rat   130 SFDSDSTATLLNTRPLQDLSPSSSAQ-------------------ALEELFPRYTSLRPGPPTNP 175

  Fly   223 PNRPLCSSSLKEEQLRRQHLEKMVHTLQSHLLEYQQRISVAIEVDRSKDAALTEAEQT----VQS 283
            |:......:|..|..||:|.|:.:.:||:.:||.||:::||:..|..||..:.:.::|    |:.
  Rat   176 PDCQGLRDALDSELTRRKHCERHIQSLQTRVLELQQQLAVAVAADHKKDLMIEQLDKTLARVVEG 240

  Fly   284 LN-YEVQH------LRDAVHRLEADRGESQSRFDALQNELSQAVNLATRFQEKNDKLERELDHCR 341
            .| :|.:.      |::.....|..|.:.|.....|:..||:|:....|.||.....:||.:...
  Rat   241 WNRHEAERTEVLRGLQEERQAAELTRSKQQETVTRLEQSLSEAMEALNREQESTRLQQREREALE 305

  Fly   342 QDAKQWEERLE---------QLEM------QLNSSKRAEELSHAELNKLRDKFAKVDYQQEKLKA 391
            ::.:....|||         |.|.      ||:..:|.|.|..| |.:.|..:.|   |:::||.
  Rat   306 EERQALAMRLEVEQQQCQALQQERDEAKAGQLSEHRRLEALQVA-LQEERQAWVK---QEQQLKE 366

  Fly   392 RIEELEKENNTL------TNQKE------------MLQEYHQKQKARADSLESHRKSLQETLANL 438
            |::.|::|....      |:|:|            :||...::.:...|::...|.:||
  Rat   367 RLQALQEEGQAQLEREKGTSQREAQAAREAQQQLALLQSEVRRLEGDLDTVRRERDALQ------ 425

  Fly   439 TETETNL-KKKLDIQQKSLKQYYQQQMENVVAKKMQEFQDQLDKNEEHLKNEARERERLIAERAV 502
              .|.:| :.:.:.|:..::.....|:|..|.:::.|.|:...:....|::..|
  Rat   426 --LEMSLVQARYESQRIQMESELAVQLEQRVTERLAEVQENSLRQAASLRDHHR----------- 477

  Fly   503 KQLEMINEKNNQEL--NLIQ---------EKHNEEVELYRLQLANASKKIDEMDLKLSCYKTKRA 556
            |||:.::.::.|||  .|.|         |:..:..:.|.|:||....::.::.......:.:|.
  Rat   478 KQLQELSGQHQQELAAQLAQFKVEMAEREERQQQVAQDYELRLAREQARVRDLKSGNQQLEEQRV 542

  Fly   557 DIAEKLHGVMEAQWQQALAILTT----PSQNSIIQSSDTEASESPELNNARMY--PETPKSSKSQ 615
            ::.|:|..:::|.|.:|..:|:|    |:..:.:....:.....||....|::  |....:.|..
  Rat   543 ELVERLQAMLQAHWDEANQLLSTTLLPPNPQAPLAEPSSPGPLEPEKGERRIWAMPPMAVALKPV 607

  Fly   616 RSNNTEKNNLDVVGKRD-PPSPMDKLQAYIELLLSKSPSDFDRLDEILAMTSKQGSKQSKPKSGS 679
            .....|       |:.| |.:|        .:|.|.|| |.    .:|...|.|.....:|....
  Rat   608 LQQGRE-------GRADLPGAP--------SVLCSTSP-DL----SLLLGPSFQSQNSFQPLEPK 652

  Fly   680 GNSKPP 685
            .:..||
  Rat   653 PDVAPP 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cnb	NP_001261300.1	TPR_MLP1_2	291..408	CDD:285204	35/137 (26%)
		Tropomyosin	349..563	CDD:278679	54/258 (21%)
		Fib_alpha	<349..458	CDD:285864	32/142 (23%)
Cntrob	NP_001128117.1	Smc	<179..551	CDD:224117	89/394 (23%)
Cntrob	NP_001128117.1	PHA03247	<568..766	CDD:223021	22/111 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0009853
OrthoInspector	1	1.000	-	-		oto95665
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR34439
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.010