DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cnb and Hmmr

DIOPT Version :9

Sequence 1:	NP_001261300.1	Gene:	Cnb / 38258	FlyBaseID:	FBgn0035295	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	NP_038580.2	Gene:	Hmmr / 15366	MGIID:	104667	Length:	794	Species:	Mus musculus

Alignment Length:	708	Identity:	135/708 - (19%)
Similarity:	269/708 - (37%)	Gaps:	208/708 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 NERAGKEGHPGTSSLPSMRLASSSSGAVSVEAA------RVDRSSLNENKIISL--SELWGKSSL 213
            |:.:|....||..   .::.:.::.|.||.:.:      |..:.:||.:|..:|  |....|.|:
Mouse    12 NDPSGCAPSPGAY---DVKTSEATKGPVSFQKSQRFKNQRESQQNLNIDKDTTLLASAKKAKKSV 73

  Fly   214 TKTVLDNNSPNRPLCSSSLKEEQLRRQHLEKMVHTLQSHLLEYQQRISVAIEVDRSKDAA----- 273
            :|.....|..:.......::.....|...:|.:..::|.|.:.:.:::.|:....|..|:
Mouse    74 SKKDSQKNDKDVKRLEKEIRALLQERGTQDKRIQDMESELEKTEAKLNAAVREKTSLSASNASLE 138

  Fly   274 -----LTEA-------------EQTVQSLNYEVQHLRD----AVHRLEADRGESQSRFDALQNEL 316
                 ||.|             ::.:::|:.|:..||:    .:..:...:...:.:..|.|.:|
Mouse   139 KRLTELTRANELLKAKFSEDGHQKNMRALSLELMKLRNKRETKMRSMMVKQEGMELKLQATQKDL 203

  Fly   317 SQAVNLATRFQEKNDKLERE------------------------LDHCRQDAKQWEERLEQ---- 353
            :::.....:.:.|...:|:|                        ::.|:.|..|.||.|::
Mouse   204 TESKGKIVQLEGKLVSIEKEKIDEKCETEKLLEYIQEISCASDQVEKCKVDIAQLEEDLKEKDRE 268

  Fly   354 -------LEMQLNSSKRAEELS------------------------HAELNKLRDKFA--KVDY- 384
                   ||..:..||:.|:|:                        .||:..|.::.|  :.:|
Mouse   269 ILSLKQSLEENITFSKQIEDLTVKCQLLETERDNLVSKDRERAETLSAEMQILTERLALERQEYE 333

  Fly   385 -------------QQEK-LKARI--------EELEKENNTLTNQKEM-------LQEYHQKQKAR 420
                         |||| |.||:        ||:..|.|....:.::       :|:..::.:..
Mouse   334 KLQQKELQSQSLLQQEKELSARLQQQLCSFQEEMTSEKNVFKEELKLALAELDAVQQKEEQSERL 398

  Fly   421 ADSLESHRKSLQETLAN----LTETETNLKKKLDIQQKSL---KQYYQQ----------QMENV- 467
            ...||...||..|.|..    |.|.|..|:|.:....:::   ::.|..          |:|:|
Mouse   399 VKQLEEETKSTAEQLTRLDNLLREKEVELEKHIAAHAQAILIAQEKYNDTAQSLRDVTAQLESVQ 463

  Fly   468 -----VAKKMQEFQDQLDKNEEHLKNEARERERLIAERAVKQLEMINEKNNQ----------ELN 517
                 .|:.:::...||:..:|...:.|:....:.|     |||...||.|.          :|.
Mouse   464 EKYNDTAQSLRDVTAQLESEQEKYNDTAQSLRDVTA-----QLESEQEKYNDTAQSLRDVTAQLE 523

  Fly   518 LIQEKHNE----------EVELYRLQLANASKKIDEMDLKLSCYKTKRADIAEKLHGVMEAQWQQ 572
            .:|||:|:          ::|.|:   ::..|:|:::.|:....:.|.| :|||  .|.:.|.|
Mouse   524 SVQEKYNDTAQSLRDVTAQLESYK---SSTLKEIEDLKLENLTLQEKVA-MAEK--SVEDVQQQ- 581

  Fly   573 ALAILTTPSQNS----IIQS----SDTEASESPELNNARMYPETPKSSKSQRSNNTEKNNLDVVG 629
               |||..|.|.    ::|.    |..:..|..|:.::.:...|...::.::.:...:..|:..|
Mouse   582 ---ILTAESTNQEYARMVQDLQNRSTLKEEEIKEITSSFLEKITDLKNQLRQQDEDFRKQLEEKG 643

  Fly   630 KR---------DPPSPMDKLQAYIELLLSKSPSDFDRLD----EILAMTSKQGSKQSK 674
            ||         :....::|.:...|.|..|:.....:||    |..|:.::.|:.|.:
Mouse   644 KRTAEKENVMTELTMEINKWRLLYEELYEKTKPFQQQLDAFEAEKQALLNEHGATQEQ 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cnb	NP_001261300.1	TPR_MLP1_2	291..408	CDD:285204	36/204 (18%)
		Tropomyosin	349..563	CDD:278679	67/323 (21%)
		Fib_alpha	<349..458	CDD:285864	36/182 (20%)
Hmmr	NP_038580.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..87		17/77 (22%)
		HMMR_N	16..338	CDD:292527	53/324 (16%)
		DUF342	<277..431	CDD:302792	33/153 (22%)
		5 X 21 AA tandem repeats	442..546		22/108 (20%)
		HMMR_C	636..789	CDD:292530	14/66 (21%)
		Hyaluronic acid-binding. /evidence=ECO:0000255	719..729
		Hyaluronic acid-binding. /evidence=ECO:0000255	741..750
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000