Protein Alignment mu2 and RTT107

DIOPT Version :10

• Sequence 1: NP_523887.2
• Gene: mu2 / 38257
• FlyBaseID: FBgn0002872
• Length: 1280
• Species: Drosophila melanogaster
• Sequence 2: NP_012024.1
• Gene: RTT107 / 856559
• SGDID: S000001197
• Length: 1070
• Species: Saccharomyces cerevisiae
• Alignment Length: 711
• Identity: 146/711 - (20%)
• Similarity: 244/711 - (34%)
• Gaps: 185/711 - (26%)

  Fly   246 PLPPPTAPIEGLENQDTKRDQLDTTDMEMSALNWSASNSKCCALSSTKADDILPRGDACITPDLT 310
            ||....|.:..|:.|||..:||.....|:  :....::|....|...|.  :.......|:|||
Yeast   218 PLKGELATLCELDMQDTSEEQLFAKWEEV--IGDKQTSSSQLTLHPNKT--LFKNHHFAISPDL- 277

  Fly   311 APSVDRNICTPDLFDLIMGGDRRRDGSSSPDPFVRPADNTNTATPQFGGVKQLVVATIETPTATP 375
                  |..|| |:..:.|.....||..:|..|   :|:..:....|..:...:..:..:|..
Yeast   278 ------NFFTP-LYWFLKGFIEDLDGKVTPLSF---SDDLKSVYQAFPDIDCYIGHSANSPIL-- 330

  Fly   376 DTNSQEKNQD---------------MIATQRF-----------PRH-KLLESDEEDNGQNNQDFV 413
                 ||.:.               |.|.|:|           |.| ||..|.|......|  :.
Yeast   331 -----EKTKSIKPEIHVGNVSWLFYMFALQKFTPVSQCKLIHQPFHAKLFTSKELTVAYTN--YF 388

  Fly   414 ATQAFN-------LGRPQAPQENEANQDLIAT----QAFNLAPPQKVD----------------- 450
            .:|.|.       ||....|:....|..||..    :.|.:|....:|
Yeast   389 GSQRFYIQRLVEILGGLSTPELTRKNTHLITKSTIGKKFKVAKKWSLDPQNAIIVTNHMWLEQCY 453

  Fly   451 ------SPKPSTANDASNQDFIETQAFNLGIPQANMASPENNEISNQDLIATQAFPAKINSSRCQ 509
                  :||.|...:....|.:......:|:..:::.:|:|..:...|..:....|...|....|
Yeast   454 MNNSKLNPKDSRFQNFKLDDNMGWNIGQIGMDHSSLPTPKNLSMVTYDTQSISEKPPPTNDQMDQ 518

  Fly   510 DFVATQPFHVVNQHSVSLQDKENIPLDDSVKVASDSKF--FEATCGEIDAVLNEMISGTVATSPV 572
                      :|.::..|..|:..|: .|.:.:.|.|.  .:...||: ||.:   ||.:..|.|
Yeast   519 ----------INDNTNVLSKKDGTPI-SSFENSIDEKIDKLQKISGEV-AVTH---SGDLERSFV 568

  Fly   573 S-PNEESIPFFEPCVIKDKNHYQK------ICQIEGVFSNVSNRSRGRTDGTGFGRLKRVAKSES 630
            | |:..|.    |.|...|::.||      |.....||.. .:..|...:.|     |.:.:.::
Yeast   569 SRPSRASF----PVVDSKKSNLQKKDSNSDISMETEVFCE-GHEKREEKEFT-----KPITEYDA 623

  Fly   631 PPETPIRKDRRRSEGSERPGSNSRERLNNLVDKKSEALNKSVIREHGIDSIPEEITKEDKSDSEE 695
            |.:..||:..|:               .|.:|.|.|.....:..:.| .....||....|::.|:
Yeast   624 PKKQEIREQSRK---------------KNDIDYKKEEEETELQVQLG-QRTKREIKTSKKNEKEK 672

  Fly   696 KGDCFNNVVNQWRSRKRRIQSRP---GTPGSSSERN--------EVNADVVDKPNEEPPTKNIRA 749
            :.:..:..|:|..:.|:..:|..   .|...:|:::        |..:|..|..|:|.|..|.:.
Yeast   673 ETNECHIEVDQMTNEKQGEESTGKLISTEDVTSKKDTDKFSHLFEGLSDNDDHINDEKPAVNSKY 737

  Fly   750 RKAKKAEKADSSKDIPKPTTRTRRQTSDEDVRTPDLGKGRKAKNTASSKADTSKNIAKGSKRVTR 814
            ...|.::...|..|.|        .|:...|..|..|..|.||..|:.:..|
Yeast   738 TTPKTSQNITSGVDTP--------TTAQTQVFMPSSGNSRLAKTQAAKRLHT------------- 781

  Fly   815 QNSADDAELLEEDSSVQTESGKRVKKVKSSKGETSKDIPKAKPRTRRQTADEDAMTPKAEK 875
                 |.|.|.|..    ::.|| |::.|.:...|:|:.::.        :...:..||||
Yeast   782 -----DIESLNEFQ----KNFKR-KRIDSEEISLSQDVERSN--------NNKELATKAEK 824

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mu2	NP_523887.2	MU2_FHA	5..98	CDD:375648
		BRCT_MDC1_rpt1	1088..1155	CDD:349375
		BRCT_PAXIP1_rpt6_like	1189..1271	CDD:349385
RTT107	NP_012024.1	BRCT	117..213	CDD:425736
		BRCT	265..349	CDD:214602	18/101 (18%)
		BRCT	382..456	CDD:469589	12/75 (16%)
		PTZ00121	<580..824	CDD:173412	60/304 (20%)
		RTT107_BRCT_5	830..914	CDD:465266
		RTT107_BRCT_6	948..1054	CDD:435575