Protein Alignment mu2 and Ptip

DIOPT Version :10

• Sequence 1: NP_523887.2
• Gene: mu2 / 38257
• FlyBaseID: FBgn0002872
• Length: 1280
• Species: Drosophila melanogaster
• Sequence 2: XP_061503890.1
• Gene: Ptip / 5667791
• VectorBaseID: AGAMI1_009598
• Length: 2042
• Species: Anopheles gambiae
• Alignment Length: 1386
• Identity: 225/1386 - (16%)
• Similarity: 411/1386 - (29%)
• Gaps: 432/1386 - (31%)

  Fly   133 QPPSANTSVNTTADSLFIPETQAVLCERPSTGQRVSLGDDFMIPETQDMLADLPPEPPVFKPPVI 197
            |.|.....:.|:|...  |:|..|..::..:...|..|.....|:.|.::.:   :..:.:..|:
Mosquito   845 QQPMQQHIIQTSAGGQ--PQTIVVQQQQQPSSSIVQQGAMAQQPQQQQLIIN---QQQIIQQTVV 904

  Fly   198 P--VVDKPGPTIDSDEESSQGSIIRMCTQDYNEDAIDDFDTSQVLCDVLLPLPPPTAPIEGLENQ 260
            |  :..:........:...|..||        :..|....|.|:                 ::.|
Mosquito   905 PNQLQQQQSQQQQQQQHPQQQQII--------QQTIGPNGTQQM-----------------IQQQ 944

  Fly   261 DTKRDQLDTTDMEMSALNWS--ASN-------SKCCALSSTKADDILPRGDACITPDLTAPSVDR 316
            ..::.||.|..|:...:...  |||       .:...:.||....:||.|
Mosquito   945 QPQQQQLQTGGMQQPIMQQQIIASNGGGPPTQQQMMVVGSTGEQQMLPTG--------------- 994

  Fly   317 NICTPDLFDLIMGGDRRRDGSSSPDPFVRPADNTNTATPQFGGVKQLVVATIETPTATPDTNSQE 381
                       :||:........|....:|     ..|||              |..||.:..|:
Mosquito   995 -----------LGGNEMMQQQQQPQTPTQP-----PGTPQ--------------PQWTPQSPLQQ 1029

  Fly   382 KNQDMIATQ-RFPRHKLLESDEEDNGQNNQDFVATQAFNLGRP-------QAPQE-NEANQDLIA 437
            :.|..::.| :.|:.::.:|..:...|..|..........|..       |:||. ....|..|.
Mosquito  1030 QAQTGVSFQTQSPQTQMQQSPVQQQQQQQQQQQGGAMIPSGATIVQQTIVQSPQGLAPGQQQFIR 1094

  Fly   438 TQAFNLAPPQ-----KVDSPKPS---TANDASNQDFIETQAFNLGIPQANMAS-------PENNE 487
            |   .|.||.     ::|:....   ..:.|..|::|........:.|...|:       |..:.
Mosquito  1095 T---TLRPPMQRQLIQLDAQSREELMKLDPAGQQEYINRLQAKHTLMQRQQAAFQGRPGHPGAHP 1156

  Fly   488 ISNQDLIATQAFPAKINSSRCQDFVATQPFHVVNQHSVSLQDKEN-------------------- 532
            .:.|.::.....|..:|..:...::..|....:.|.....|..:|
Mosquito  1157 GARQQIVIRSPMPPGLNQQQQVRWLHHQQQQQIQQQQQQQQQLQNARQVVVRQPGAPGLSPITQQ 1221

  Fly   533 -----------IPLDDSVKVASDS-------KFFEATCGEIDAVLNEMISGTVATSPVSPNEESI 579
                       .|:|.:...|...       :..:..........|:..:...|.:..:....|.
Mosquito  1222 TVGPGPGMGTSYPIDPNATPAQQQQQRLQQHRLLQMQLQREQVQKNQQQAAAAAAAAAAQQAGSS 1286

  Fly   580 PF------------FEPCVIKDKNHYQKICQIE---------GVFSNVSNRSRGRTDGTGFGRLK 623
            |.            |.|.|:...:....:.|.:         |.....|:::.....|...|.|:
Mosquito  1287 PLQGQMMSPRAAGGFAPEVVVGADGSTMVVQQQTLVGPQQAAGAQHPPSSQASIDATGAAVGSLQ 1351

  Fly   624 RVAKS---ESPPETPIRK--DRRRSEGSERPGSNSRERLNNLVDKKS------------------ 665
            ...:.   :|..:|.:..  ..|...|...|...:    |.|||..|
Mosquito  1352 AAQQQQQMQSKTKTALANMLSSRLGNGGTVPAGGA----NTLVDGSSGQSGGSAEPSAAGTLRLM 1412

  Fly   666 EALNKSVIREHGIDSIPEEITKEDKSDSEEKGDCFNNVVNQWRSRKRR----------------- 713
            .|.:.:.:::..:...|:|:....:...::     :.|..|.:.::::
Mosquito  1413 TAQHNAALQQQTMGRSPQELLALQQQQQQQ-----HQVQQQQQQQQQQQQQALQQQQLQQHQQQV 1472

  Fly   714 -------------------------------IQSRPGTPGSSSERNEVNADVVDKPNEEP--PTK 745
                                           :|:..|.||           ::..|...|  |..
Mosquito  1473 VRRTLGNITNSGMPVGAGPMVVGPPGGGPVVVQTAGGGPG-----------IIPIPPGAPGGPGV 1526

  Fly   746 NIRARKAKKAEKADSSKDIPKPTTRTRRQTSDEDVRT-PDLGKGRKAKNTASSKADTSKNIAKGS 809
            .:::..|.|...|..|...|.|..|.:....:.:::. |:|                   ...|.
Mosquito  1527 MMQSAAAMKGGPAQFSPGRPTPLPRPQYYGHNPNLKLHPEL-------------------FLLGC 1572

  Fly   810 KRVTRQNSADDAELLEED---SSVQTESGKRVKKVKSSKGETSKDI-PKAKP---RTRR----QT 863
                      ...::|.|   |:.:.|..|.:  :|...||..... ||...   ||:|    ..
Mosquito  1573 ----------TFHIIEYDELHSAAEIEEWKTI--IKKHGGEIESHYGPKVTHVLCRTQRHGVVMQ 1625

  Fly   864 ADEDA--------MTPKAEKERQIQGEETKDMSKPAARTRRKASAEETESAAQAVKPKRGGKGKK 920
            |..||        :.....|.:.:...:...:..||....:|.:.:...|..       |.:|::
Mosquito  1626 AIRDAKRCITTYWLNDIVLKRQLLPPWQALHLPTPAIFGNQKPATKHNMSIT-------GFEGEE 1683

  Fly   921 NETTKAEATVEKPMVRTRRMTIAEDSSTLTEVKTGGALIKRAVVRISRVSIEQLESSTSAGNNAR 985
            .             :|.::| |.|..:.:|..     ..|...|.|.|.:..|........|...
Mosquito  1684 R-------------LRIKQM-IEESGARMTPY-----FSKSNTVLICRQNENQKYKFAKEWNIPA 1729

  Fly   986 VTGA-----------AQSRSTTPSIEEPSSS-------------SAAAKEPNVSTATTRRRAKR- 1025
            |...           |..:...|..::.:.|             ..|.|.|...|..:..|.||
Mosquito  1730 VNTVWLSDILLGNLNAMQQCDAPKYQQFTLSCHFRVDYNLVMHLMTAWKSPINLTQESHERVKRT 1794

  Fly  1026 LTSGEEPTSSSDVPTKKPKMS-VDEEVLKNRSGATTTRFSQPDADPLRAINLYVRKAKTTTGKIK 1089
            |:....|.|.:..|...|.|. :..|::..|..|       |||.|                  .
Mosquito  1795 LSELPPPVSGAKKPRTLPPMEPIPAEIVCQRQPA-------PDAIP------------------H 1834

  Fly  1090 VAFTMCNRPALETVLKSLKHVV------EITEDPLQCDLLVMDKGERTYKFLTVIASNKPVLSTN 1148
            |.|:..:..      :.|.|.|      ::|.:..:...|||.:..||.|.:..:|:.:.::|:.
Mosquito  1835 VLFSQVDNS------EGLAHAVTRTLGGKVTNNATEATHLVMTRVARTVKLILALATVRHLVSSK 1893

  Fly  1149 WLHSVKKTRSIDIKADHLFSD-PTFEETYKFKPSSVLEHP---RLLYGLHFMLGKDIVPKANEMK 1209
            |: |........:..|:...| ....|.:|.....|||.|   :|..|..|.:...:.|...:::
Mosquito  1894 WV-SDSAVAGQFLPLDNYRLDVGELNEQFKCDLHQVLEAPGRAKLFEGKVFFVTPQVKPACKDVR 1957

  Fly  1210 VIIHSAGGKVHAQPPSL-------AISVDLYVVTTSKD---------TKSKRRLNNYEKVHFIKT 1258
            .:|...||.|...|.::       |.....||:.:..:         .|:|..:     .....|
Mosquito  1958 QMIELGGGVVEKNPRTIKRIREANAEKPGSYVIVSCPEDRIIIQPFIQKAKHAV-----CQICTT 2017

  Fly  1259 EAVMQALVQHNIEMLQEHTLK 1279
            |.|||:::|..: .::.|.:|
Mosquito  2018 EYVMQSIMQQRL-CIEPHIIK 2037

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mu2	NP_523887.2	MU2_FHA	5..98	CDD:375648
		BRCT_MDC1_rpt1	1088..1155	CDD:349375	16/72 (22%)
		BRCT_PAXIP1_rpt6_like	1189..1271	CDD:349385	20/97 (21%)
Ptip	XP_061503890.1	None