Protein Alignment mu2 and Paxip1

DIOPT Version :10

• Sequence 1: NP_523887.2
• Gene: mu2 / 38257
• FlyBaseID: FBgn0002872
• Length: 1280
• Species: Drosophila melanogaster
• Sequence 2: XP_063142007.1
• Gene: Paxip1 / 311944
• RGDID: 1307547
• Length: 1117
• Species: Rattus norvegicus
• Alignment Length: 1204
• Identity: 202/1204 - (16%)
• Similarity: 358/1204 - (29%)
• Gaps: 388/1204 - (32%)

  Fly   136 SANTSVNTTADSLFIPETQAVLCERPSTGQRVSLGDDFMIPETQDMLADLPPE-----PPVFKPP 195
            |...::|.....|.:||.:....||......:.:       .|.|.:.|...|     ...:.|.
  Rat   127 SCQLNLNKKCTHLIVPEPKGEKYERAVKRTSIKI-------VTPDWVLDCVSEKRRKDEASYHPR 184

  Fly   196 VIPVVDKPGPTIDSDEESSQGSIIRMCTQDYNEDAIDDFDTSQVLCDVLLPLPPPTAPIEGLENQ 260
            :|...:      :.:||..:|       .:..:|:.::..|.:..........|...|.......
  Rat   185 LIIYEE------EEEEEEEEG-------DNEEQDSQNEGSTDKSSAASSAEASPADQPCSPKARA 236

  Fly   261 DTKRDQL---DTTD----MEMSALNWSASNSKCCALSSTKADDILPRGDACITPDL-----TAPS 313
            :..:.:|   |::|    .:..:|||:.:.:.  .||:  |...||:|..   |.|     ..|.
  Rat   237 EVSKGELMFDDSSDSSPEKQERSLNWAPAEAP--PLST--AQHRLPQGKG---PGLINLCANVPP 294

  Fly   314 VDRNICTPDLFDLIMGGDRRRDGSSSPD------PFVRPADN-TNTATPQFGGVKQL-------- 363
            |..:|..||:...:|...:....|..|:      |.||...| ||.|     .::|:
  Rat   295 VPGDILPPDMRGNLMAAGQNLQSSERPEMLGTWSPAVRTLRNITNNA-----DIQQISRPSNVAH 354

  Fly   364 VVATIETPT--------------------------ATPDTNS-------QEKNQDMIATQRFPRH 395
            ::.::..||                          ..|:|::       |:..|...|....|:.
  Rat   355 ILQSLSAPTKNLEQQVAHVQQGHPSASAVLFGQAKGAPETHTLQQHHPPQQPQQQHPALHLQPQI 419

  Fly   396 KLLESDEEDNGQNNQDFVATQAFNLGRPQAPQENEANQDLIATQAFNLAPPQKVDSP----KPST 456
            ..|:..::...|..|.:....:...  ||...:::.:|..:......|.|.|::..|    :|..
  Rat   420 MQLQQQQQQQQQQPQPYPQPPSHQF--PQQVHQHQFSQQQLQFPQQPLHPQQQLHRPQQQLQPFQ 482

  Fly   457 ANDASNQDFIETQAFNLGIPQ-ANMASPENNEISNQDLIATQAFPAKINSSRCQDFVATQPFHVV 520
            ...|..|...:.|...|...| |.:...:..:...|..:..|....::.....|..:..|..|:.
  Rat   483 QQHALQQQLHQLQQQQLQQHQLAQLQQQQQQQQQQQHNLLQQQQQQQLQRLHQQQQMQNQAAHLS 547

  Fly   521 N-----QHSVSLQDKENIPL--------------------------DDSVKVASDSKFFEATCGE 554
            .     ||.|..|....:||                          |.:|::..:|
  Rat   548 QTSQALQHQVLPQQPLQLPLQPPPQQQQQQQQQQQQQQQQQQLFGHDPAVEIPEES--------- 603

  Fly   555 IDAVLNEMISGTVATSPVSPNEESIPFFEPCVIKDKN---HYQKICQIEGVFSNVSNRSRGRTDG 616
                   .:.|.|......|.:.|          ||.   .:::|.|..|          |..|.
  Rat   604 -------FLLGCVFAIADYPEQMS----------DKQLLATWKRIIQAHG----------GTVDP 641

  Fly   617 TGFGRLKRVAKSESPPETPIRKDRRRSEGSERPGSNSRERLNNLVDKKSEALNKSVIREHGIDSI 681
            |...|...:.              ..|:.|.......|||             |..:..|.::::
  Rat   642 TFTSRCTHLL--------------CESQVSSMYAQALRER-------------KRCVTAHWLNTV 679

  Fly   682 PEEITKEDKSDSEEKGDCFNNVVNQWRSRKRRIQSRPGTPGSSSERNEVNADVVDKPNEEPPTKN 746
                                       .:|:::.         .....::..|...|..:|.:::
  Rat   680 ---------------------------LKKKKLM---------PPHRALHFPVAFPPGGKPCSQH 708

  Fly   747 IRARKAKKAEKADSSKDIPKPTTRTRRQTSDEDVRTPDLGKGRKAKNTASSKADTSKNIAKGSKR 811
            |    .......|:.:|               |::......|                 ||.:..
  Rat   709 I----ISVTGFVDNDRD---------------DLKLMAYLAG-----------------AKYTGY 737

  Fly   812 VTRQNSADDAELLEEDSSVQTESGKRVKKVKSSKGETSKDIPKAKPRTRRQTADEDAMTPKAEKE 876
            :.|.|:   ..:.:|.|.::.|..|..:            ||....:..     .|.:....|..
  Rat   738 LCRSNT---VLICKEPSGLKYEKAKEWR------------IPCVNAQWL-----GDILLGNFEAL 782

  Fly   877 RQIQGEETKDMSKPAARTRRKASAEETESAAQAVKPKRGGKGKKNETTKAEATVEKPMVRTRRMT 941
            ||:|.......:.|                                         .|.|.|..:.
  Rat   783 RQVQYSRYTAFNLP-----------------------------------------DPFVPTPHLV 806

  Fly   942 IAEDSSTLTEVKTGGALIK--RAVVRISRVSIEQLESSTSAGNNARVTGAAQSRSTTPSIEEPSS 1004
            ::...:..|.||....|:.  |...::....:..::.|..|.....|.     :||..|...|..
  Rat   807 LSLLDAWRTPVKVTAELLMSIRLPPKLKPNEVANIQPSKRARGWRDVI-----KSTDYSCRGPGF 866

  Fly  1005 SSAAAKEPN---VSTATTRRRAKRLTSGEEPTSSSDV--PTKKPKMSVDEEVLKNRSGATTTRFS 1064
            ||....:.:   |::...|..|..:.. .......|:  ||||....:...||       .|.|
  Rat   867 SSQHPHDSSQLPVTSVLCRHWAMHMVH-RHTCRIEDLPPPTKKLTPELTPYVL-------FTGF- 922

  Fly  1065 QPDADPLRAINLYVRKAKTTTGKIKVAFTMCNRPALETVLKSLKHVVEITEDPLQCDLLVMDKGE 1129
                :|:: :..|::|.....|                         |:.|...:|..|:..|..
  Rat   923 ----EPVQ-VQQYIKKLYILGG-------------------------EVAESTKKCTHLIASKVT 957

  Fly  1130 RTYKFLTVIASNKPVLSTNWLHSVKKTRSIDIKADHLFSDPTFEETYKFKPSSVLEHPR---LLY 1191
            ||.||||.|:..|.:::.:||....|.:....:.:::..|...|..:.|.....|:...   |..
  Rat   958 RTVKFLTAISVVKHIVTPDWLEECFKRQMFIDEQNYILRDAEAEVLFSFSLEESLKRAHVSPLFK 1022

  Fly  1192 GLHFMLGKDIVPKANEMKVIIHSAGGKVHAQPPS 1225
            ..:|.:...|.|....||.|:..|||||.|:.||
  Rat  1023 TKYFYITPGICPSLATMKAIVECAGGKVLAKQPS 1056

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mu2	NP_523887.2	MU2_FHA	5..98	CDD:375648
		BRCT_MDC1_rpt1	1088..1155	CDD:349375	15/66 (23%)
		BRCT_PAXIP1_rpt6_like	1189..1271	CDD:349385	15/37 (41%)
Paxip1	XP_063142007.1	None