Protein Alignment mu2 and mdb1

DIOPT Version :10

• Sequence 1: NP_523887.2
• Gene: mu2 / 38257
• FlyBaseID: FBgn0002872
• Length: 1280
• Species: Drosophila melanogaster
• Sequence 2: NP_593964.2
• Gene: mdb1 / 2542517
• PomBaseID: SPACUNK4.14
• Length: 624
• Species: Schizosaccharomyces pombe
• Alignment Length: 614
• Identity: 123/614 - (20%)
• Similarity: 209/614 - (34%)
• Gaps: 186/614 - (30%)

  Fly   720 TPGSSSERNEVNAD--------VVDKPNEEPPTKNIRARKAK----KAEKADSSKDIPKPTTRTR 772
            ||...|:..|.||:        |:..|| .|...|::.:|.:    ..::.|.|.::.:......
pombe    85 TPVIFSKLEEDNANVNEGSKMGVMTVPN-TPQKPNLQQQKFEAINANEDQIDYSSNLEQNYNSLI 148

  Fly   773 RQTSDEDVRTPDLGKGRKAKNTASSKADTSKNIAKGSKRVTRQNSADDAELLEEDSSVQTE---- 833
            ||.||:.:         .....||.|:.........|:|:....||.:..|..|:|....:
pombe   149 RQGSDQVI---------PLSRFASEKSALELEKELFSERIPESQSAAEPVLKVENSENDLDEKLV 204

  Fly   834 -SGKRVKKVKSSKGETSKDIPKAKPRTRRQTADEDAMTPKAEKERQIQGEETKDMS--------- 888
             .|:.|:...||  :|.:::.....:...:|.||....  ...:..||| |||..|
pombe   205 LDGQHVEGDHSS--DTEEEVVSEDQKQLNKTDDESTFI--ESHQIYIQG-ETKSPSSVSQSLSGD 264

  Fly   889 ---KPAARTRRKASAEETESAAQAVKPKRGGKGKKNETTKAEATVEKPMVRTRRMTIAEDSSTLT 950
               |||....||.|||......:.|.|::.                           ..|||
pombe   265 PSLKPAEVFDRKQSAEINSPIEKDVNPQQN---------------------------ISDSS--- 299

  Fly   951 EVKTGGALIKRAVVRISRVSIEQLESSTSAGNNARVTGAAQSRSTTPSIEEPSSSSAAAKEPNVS 1015
                    ||...:....|:.|.....|.:..|      .:|:.:.|.|......|.:..|.|
pombe   300 --------IKNNSIHSDEVNPEVRPDLTPSNEN------EESKRSAPEIALKEKESTSQDESN-- 348

  Fly  1016 TATTRRRAKRL---TSGEEPTSS-SDVPTKKPKMSVDEEVLKNRSGATTT-RFSQPDADPLRAIN 1075
                 |.|:..   |:...|:|| .|.|.|..:.|..|...|:.:..|:: ..::|....:|...
pombe   349 -----REAEEAPISTNYSFPSSSLEDQPDKNVQSSAVENKNKHTNLVTSSFNLTKPMKSFIRRNG 408

  Fly  1076 LYVRKAKTTTGKIKVAFTMCNRPALETVLKSLKHVVEITEDPLQCDLLVMDKGERTYKFLTVIAS 1140
            |.|:::.|.    :..|.:...|.|                            .||:|||...:.
pombe   409 LRVQESVTD----ETDFVILGSPPL----------------------------RRTHKFLLATSL 441

  Fly  1141 NKPVLSTNWL-HSVKKTRSIDIKADHLFSDPTFEETYKFKPSSVLEHPRL--------------- 1189
            ..|::|:.:| ..:|..:.:|.:: :.:.|...|..:.|:...:  |.|.
pombe   442 GIPLVSSQYLTDCIKSGKVLDFRS-YKYKDEEAEAKWGFRLDDI--HRRTCFNGKRLYITKAIRD 503

  Fly  1190 ------LYGLHFML---GKDIV---PKANEMKVIIHSAGGKVHAQPPSLAISVDLYVVTTSKDTK 1242
                  ::||:.:|   |.:||   .:|.|...||       .|||                |..
pombe   504 SMVGDSIHGLYSILETSGAEIVGDIKRAQEKDTII-------LAQP----------------DND 545

  Fly  1243 SKRRLNNYEKVHFIKTEAVMQALVQHNIE 1271
            .:.|..:...::..|.|.|..::::..|:
pombe   546 QEGRNMSATGLNVYKIELVALSILRDRID 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mu2	NP_523887.2	MU2_FHA	5..98	CDD:375648
		BRCT_MDC1_rpt1	1088..1155	CDD:349375	11/67 (16%)
		BRCT_PAXIP1_rpt6_like	1189..1271	CDD:349385	18/108 (17%)
mdb1	NP_593964.2	BRCT_MDC1_rpt1	388..461	CDD:349375	18/104 (17%)