DRSC/TRiP Functional Genomics Resources

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Protein Alignment mu2 and Mdc1

DIOPT Version :10

Sequence 1:NP_523887.2 Gene:mu2 / 38257 FlyBaseID:FBgn0002872 Length:1280 Species:Drosophila melanogaster
Sequence 2:NP_001010833.2 Gene:Mdc1 / 240087 MGIID:3525201 Length:1708 Species:Mus musculus


Alignment Length:1682 Identity:330/1682 - (19%)
Similarity:531/1682 - (31%) Gaps:623/1682 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    86 KLRFGNVEARLEFGEDHDEVHDSSGFGECLKNGLNNTTLDSMDVPETQPPSANTSVNTTADSLFI 150
            ::|..:..:|:....|.:|..|... |.|:.||..||...|    .|..|.::..|::.|.|:..
Mouse   152 RIRIESQNSRVLLAADSEEEGDFPS-GRCVANGQRNTASPS----ATVVPESDEEVSSPAPSVPG 211

  Fly   151 P--------ETQAVLCERPSTGQRVSLGD------DFMIPETQDMLADLPPEPPVFKPPVIPVVD 201
            |        :|.....::|.. :..||.|      :...||.....|.:..:|...|.....|..
Mouse   212 PSSPFGLGSDTDEEQGQQPGV-EESSLADSSGAAGEAEQPEANGTTAGIQAQPTEHKLKDTKVKK 275

  Fly   202 KPG-------------PTIDSDEESSQGSIIRMCTQDYNEDAIDDFDTSQVLCDV---LLPLPPP 250
            :.|             ||:..|.::           :.:||....|..|:.  ||   .:|:.||
Mouse   276 EAGRAGVSDGSVLERSPTLGEDSDT-----------EVDEDHKPGFADSET--DVEEERIPVTPP 327

  Fly   251 TAPIE----------------------------------------GLE--------NQDTKRDQL 267
            .||::                                        .||        |.||..::.
Mouse   328 VAPVKKNQVLLAVGIGDPEAPGVAHLQDCLAGSGTDVEDKTALDVPLERNHTPMVINSDTDEEEE 392

  Fly   268 DTTDMEMSALN-----------WS---------------ASNSKCC------------------- 287
            :..:...:||.           ||               ...|:..                   
Mouse   393 EEEEEVSAALTLAHLKERGIGLWSRDPGAEEVKSQPQVLVEQSQSASGRDSDTDVEEESSGRKRE 457

  Fly   288 -----------ALSSTKADDILPR--GDACITPDLTAP-------------------SVDRNICT 320
                       ||:.|:.:...||  .||....|:::|                   .|:..:..
Mouse   458 IIPDSPMDVDEALTVTQPESQPPRRPNDADEYMDMSSPGSHLVVNQASFAVVGKTRAQVEEEVPG 522

  Fly   321 PDLFDLIMGGDRR-----------------RDGSSSPD--PFVRPAD-------NTNTAT----- 354
            |   .:|:|...:                 ::|||||:  ..|||:.       .|..||     
Mouse   523 P---SVILGEKHQVPLEGAQPPEEAWETAVQEGSSSPEAAASVRPSQQPVAEDAGTECATAVSEQ 584

  Fly   355 -------PQFGG----VKQLVVATIETPTATPDTNSQEKNQDMIATQRFPRHKLLESDEEDNGQN 408
                   .|.|.    |:|:|:.|  ..:..|....:|..|.....:|.......:|.:|.....
Mouse   585 ESTLEVRSQSGSPAAPVEQVVIHT--DTSGDPTLPQREGAQTPTGREREAHVGRTKSAKECCDAE 647

  Fly   409 NQDFV--ATQAFNLGRPQAPQ-----ENEANQDLIATQAFNLAPPQKVDSPKPSTANDASNQDFI 466
            .:|..  |||.|..|..|.|:     |||      .||.|....||:   |.||..:       :
Mouse   648 PEDLCLPATQCFVEGESQHPEAVQSLENE------PTQLFPCTLPQE---PGPSHLS-------L 696

  Fly   467 ETQ-AFNLGIPQANMASPENNEISNQDLIATQAFPAKINSSRC-------------------QDF 511
            :|. |..|.:|              .:::|||.|..:..|...                   |..
Mouse   697 QTPGADTLDVP--------------WEVLATQPFCLREQSETSELHEAHGSQPSLPREPPGHQHL 747

  Fly   512 VATQPFHV----VNQHSVSLQDK--------------ENIPLDDSVKVASDSKFFEATCGEIDAV 558
            |.|.|.|.    :....:...:|              |..||:..::..:::       .|.|.:
Mouse   748 VHTSPVHTELLRIEGREIQTVEKAMGIPKEMADRMTPEREPLEREIRGRTEN-------SERDVI 805

  Fly   559 LNEMISGTVATSPV------SPNEESIPFFEPCVIKDKNHYQKICQIEGVFSNVSNRSRGRTDGT 617
            ..|:|.||....|.      |..:|:        .||....::..::|...|..|.:        
Mouse   806 GEELIQGTKDREPKKVLARDSQRKEA--------DKDLEGNRESLEVEIEMSKDSQK-------- 854

  Fly   618 GFGRLKRVAKSE-----SPPETPIRKDRRRSEGSERPGSNSRERLNNLVDKKSEALNKSV----- 672
               |.::|.|.|     .|.:..:..||    |....||:         |:|.:..:.::     
Mouse   855 ---RERKVEKPEPKREWEPADLEVTPDR----GVTEEGSH---------DQKGQIASLTLKPGVG 903

  Fly   673 IRE-HGIDSIPEEITKEDKSDSEEKGDCFNNVVNQWRSRKRRIQSRPGTPGSSSERNEVNADVVD 736
            ::: .|:.|.|  |....::|. .|||    .::..|.::.|:..:. ||...:.|.:       
Mouse   904 VKDLEGLASAP--IITGSQADG-GKGD----PLSPGRQQRGRLSCQT-TPAGKASRGD------- 953

  Fly   737 KPNEEPP------------TKNIRARKAKKAEK-----ADSSKDIP-------KPTTRTRRQTSD 777
               .|||            |:::...:::|...     :.||.:||       ||..|.||  |.
Mouse   954 ---PEPPDHCLFSSVPEASTQSLLTSQSQKQSTPQPLFSTSSSEIPLPESLHTKPNVRPRR--SS 1013

  Fly   778 EDVRTPDLGKGRKAKNTA-SSKADTSKNIAKGSKRVTRQNSADDAELL-----EEDSSVQTESGK 836
            ....:|......|...|. :::...|:..::.::....::|....||:     |...|..||. .
Mouse  1014 RMTPSPHSSAALKPNTTCPTNQPAASRPTSRPTRGRANRSSTRTPELIVPVDPELQPSTSTEQ-P 1077

  Fly   837 RVKKVKSSKGETSKDIPK---AKPRTRRQTADEDAMTPKAEKERQIQGEETKD------------ 886
            .:.|:.|...|....:|:   ..|..:..|:.|.::||. .|.|..:|..:|.            
Mouse  1078 VIPKLTSQVTEGRVQMPEPLLTGPEIQSPTSTEQSVTPD-RKPRATRGRPSKSPNKTPEPLISTG 1141

  Fly   887 -------------MSKPAAR-TR---RKASAEETE------------------------------ 904
                         :.||.:| ||   ||:|....|                              
Mouse  1142 PELQPPTSIEQPVIPKPTSRVTRGRPRKSSVRTPESVVSTGPELQPLTSIEQPVIPEPRATRGRP 1206

  Fly   905 ----------------------SAAQAVKPKRGGKGKKNETTKAEATVEKPMVRT----RRMTIA 943
                                  ||.|.|.|....:..:..::|:..|.| |:|:|    ...|..
Mouse  1207 SKSSIKTPESVVPTGPELQPLTSAKQPVTPNLTSRASRGRSSKSIRTPE-PVVQTGPEFHPSTST 1270

  Fly   944 EDSSTLTEVKTGGALIKRAVVRISRVSI---EQLESSTSAGNNARVTGA--AQSRSTTPSIEEPS 1003
            |...  |...:..|..:|:.|:....|:   .:|:..||....|....|  .|.|:..||.|:..
Mouse  1271 EQPD--TREPSSQARTRRSAVKTPEASVPTTPELQPFTSKKQPAPKPTALVTQGRTYKPSTEDCE 1333

  Fly  1004 SSSAAAK--EPNVST---ATTRRRAKRLTSGEEPTSSSDV---PTKKPKMSVDEEVL-------- 1052
            |....|.  ||:.||   .|.:...:.||....|.|:|.|   |..||.:.:.:.|.        
Mouse  1334 SVGPVAPDFEPSTSTDHLVTPKVTDQSLTLQSSPLSASPVSSTPDLKPPVPIAQPVTPEPIPQAN 1398

  Fly  1053 ---KNRS----GATT--------TRFSQP-------------DAD------PLRAINLYVRKAKT 1083
               |.|:    |:.|        :..|:|             :||      |.|..:     .||
Mouse  1399 HQRKRRAAGKQGSRTVPLGHKSYSALSEPEPQSSASQSSGASEADSPRQKRPRRQAS-----QKT 1458

  Fly  1084 TTGKIKVAFTMCNRPALETVL-----KSLKHVVEITE---------DPLQ--------------- 1119
            ...|.:...|.......||.:     :...|..|:|:         .|.|               
Mouse  1459 VVIKEEPVETEVKEEPQETAIPTPEKRKRDHAEEVTQGKPTRSRRTKPNQETAPKVLFTGVMDSR 1523

  Fly  1120 ------------------CDLLVMDKGERTYKFLTVIASNKPVLSTNWLHSVKKTRSIDIKADHL 1166
                              ...||.|:..||.|||..:....|:||.|||:..:|........|:|
Mouse  1524 GERAVLALGGSLASSVNEASHLVTDRIRRTVKFLCALGKGIPILSLNWLYQSRKAGCFLPPDDYL 1588

  Fly  1167 FSDPTFEETYKFKPSSVL---EHPRLL--YGLHFMLGKDIVPKANEMKVIIHSAGGKVHAQPPSL 1226
            .:||..|:.:.|.....|   ...|||  |.:|...|  :.|...:|..||...||..   .||:
Mouse  1589 VTDPEQEKNFSFSLRDSLCRARERRLLEDYEIHVTPG--VQPPPPQMGEIISCCGGTF---LPSM 1648

  Fly  1227 AISVDLY--VVTTSKDTKS---KRRLN------NYEKVHFIKTEAVMQALVQHNIEM 1272
            ..|..|:  ::|.::|...   ..||.      .:.....:|.||..:|.|..|:||
Mouse  1649 PHSYKLHRVIITCTEDLPRCAIPSRLGLPLLSPEFLLTGVLKQEATPEAFVLSNLEM 1705

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mu2NP_523887.2 MU2_FHA 5..98 CDD:375648 2/11 (18%)
BRCT_MDC1_rpt1 1088..1155 CDD:349375 22/113 (19%)
BRCT_PAXIP1_rpt6_like 1189..1271 CDD:349385 25/94 (27%)
Mdc1NP_001010833.2 Interaction with CHEK2. /evidence=ECO:0000250 1..150
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Interaction with the MRN complex. /evidence=ECO:0000250 2..222 18/74 (24%)
FHA_MDC1 32..131 CDD:438717
COG3456 55..>238 CDD:442679 21/91 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 166..328 39/180 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 418..498 10/79 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 521..643 25/126 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 680..700 7/29 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 719..747 2/27 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 779..900 29/159 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 915..1511 124/623 (20%)
PHA03247 <952..1429 CDD:223021 99/493 (20%)
BRCT_MDC1_rpt1 1512..1582 CDD:349375 15/69 (22%)
BRCT_MDC1_rpt2 1614..1693 CDD:349394 20/83 (24%)
Blue background indicates that the domain is not in the aligned region.

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