DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mfap1 and Mfap1a

DIOPT Version :9

Sequence 1:	NP_647679.1	Gene:	Mfap1 / 38256	FlyBaseID:	FBgn0035294	Length:	478	Species:	Drosophila melanogaster
Sequence 2:	NP_080496.1	Gene:	Mfap1a / 67532	MGIID:	1914782	Length:	439	Species:	Mus musculus

Alignment Length:	478	Identity:	268/478 - (56%)
Similarity:	339/478 - (70%)	Gaps:	44/478 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAATAAAAASGIQSTAGAIPMRNEKGELSMQKVKVQRYISGKRPDYARADSSSEESDDDDFIDT 65
            ||..:|......|||||||:|:||||||:||:||||:||:||||||||..:||.||.::..||..
Mouse     1 MSVPSALMKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKK 65

  Fly    66 RKRLERHKAERHKLELSRQGGSAEGEERAAGEGQEEDDAEVDDPRLRRLRQRPVDMEDMERERRE 130
            .|                       |:.|..|.||||.:  .|||||||:.|  ..||:| ||..
Mouse    66 AK-----------------------EQEAEPEEQEEDSS--SDPRLRRLQNR--ISEDVE-ERLA 102

  Fly   131 RHRHIHEPEIM-ESDSEDEEEDEGAQGAIQRGTNKITLASESDTDAELSDTELENRRTKLRSRML 194
            |||.|.|||:: ||||    |.||....::|..      |..:.:.|:.|.|:|.||..:|.|..
Mouse   103 RHRKIVEPEVVGESDS----EVEGDAWRLERED------SSEEEEEEIDDEEIERRRGMMRQRAQ 157

  Fly   195 QQQREE-EVLQKEDEKQS-ESSESESSEYEEETESEEDNEPRLKPLFVRKRDRATIQEKEREAQK 257
            :::.|| ||::.|||.:| |.|||| |||||.|:||::.||||||:|:||:||.|:||:|.||.|
Mouse   158 ERKNEEMEVMEVEDEGRSGEESESE-SEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALK 221

  Fly   258 QKQLEAEAKRAAKERRRATLRMVEESVKKDLEKTKPETNEACIEDVCTDDENDEVEYEAWKLREL 322
            ||:||.||||.|:|||:.||::|||..||:||:.|  .:.|.::.:.|||||||.||||||:|||
Mouse   222 QKELEQEAKRMAEERRKYTLKIVEEETKKELEENK--RSLAALDALNTDDENDEEEYEAWKVREL 284

  Fly   323 KRMKRDREERDNVEREKLDIDRMRNMTEEERRQELRQNPKVVTNKATKGKYKFLQKYYHRGAFYL 387
            ||:||:||:|:.:|:||.:|:||||:||||||.|||.|.||:||||.||||||||||||||||::
Mouse   285 KRIKREREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGKYKFLQKYYHRGAFFM 349

  Fly   388 DEENDVLKRDFAQATLEDHFDKTILPKVMQVKNFGRCGRTKYTHLVDQDTTKFDSPWYAESSSNI 452
            ||:.:|.||||:..||||||:|||||||||||||||.||||||||||||||.|||.|..||:.|.
Mouse   350 DEDEEVYKRDFSAPTLEDHFNKTILPKVMQVKNFGRSGRTKYTHLVDQDTTSFDSAWGQESAQNT 414

  Fly   453 KFHNEHAGGMRQQFDKPTGSKRK 475
            ||..:.|.|:|..|::|:..|||
Mouse   415 KFFKQKAAGVRDVFERPSAKKRK 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mfap1	NP_647679.1	MFAP1	233..437	CDD:284422	142/203 (70%)
Mfap1a	NP_080496.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..200		108/237 (46%)
Mfap1a	NP_080496.1	MFAP1	190..399	CDD:399759	145/210 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833841
Domainoid	1	1.000	306	1.000	Domainoid score	I1353
eggNOG	1	0.900	-	-		E1_KOG1425
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4332
Inparanoid	1	1.050	484	1.000	Inparanoid score	I1428
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54781
OrthoDB	1	1.010	-	-		D1535406at2759
OrthoFinder	1	1.000	-	-		FOG0004655
OrthoInspector	1	1.000	-	-		otm42481
orthoMCL	1	0.900	-	-		OOG6_103001
Panther	1	1.100	-	-	LDO	PTHR15327
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3269
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770