Protein Alignment CG5687 and SLC5A2

DIOPT Version :10

• Sequence 1: NP_647678.3
• Gene: CG5687 / 38255
• FlyBaseID: FBgn0035293
• Length: 683
• Species: Drosophila melanogaster
• Sequence 2: XP_006721135.3
• Gene: SLC5A2 / 6524
• HGNCID: 11037
• Length: 698
• Species: Homo sapiens
• Alignment Length: 667
• Identity: 140/667 - (20%)
• Similarity: 249/667 - (37%)
• Gaps: 190/667 - (28%)

  Fly    32 TPGGSAPLDSSHKYLIVRGESPSESQEHVEFDNAATLLLRAFKNQQIPASAELEECSAPSHKATF 96
            |..||||...:.|.||               ||.|
Human     5 TEAGSAPEMGAQKALI---------------DNPA------------------------------ 24

  Fly    97 SGYDYVILLGMLVISLGIGIFYGFFQKGGSSSNEFLLGSEMSIFPVTLSLTTSFI-----TAIEL 156
               |.:::....::.:|:|::.......|:....||.|..|..:||..||..|.|     ..:..
Human    25 ---DILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAG 86

  Fly   157 LGNPSEMYFQGTQ----FVLIVIPMVIVIPVAVKIFYPIYFKMELTSCYEYLGIRF-GKEIR--- 213
            .|..|.:...|.:    ||::::..         :|.|:|....:.:..:||..|| |:.||
Human    87 TGAASGLAVAGFEWNALFVVLLLGW---------LFAPVYLTAGVITMPQYLRKRFGGRRIRLYL 142

  Fly   214 -ILGAVLYVIQMCFYTAVAV--LAPAIALSKATGLDTKIAVVLIYVVCVFYSSQGGMKAVVIADS 275
             :|...||:     :|.::|  .:.|:.:.:|.|.:...:|:.:..:.:.|:..||:.|::..|:
Human   143 SVLSLFLYI-----FTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDT 202

  Fly   276 FQAAVLAVSLVLIVGLGCF----YSG---------NPIQVFQTASDHNRLEF-FNMDPD------ 320
            .|..|:.....:::|....    |||         ..:.|.:..:..|...| :...||
Human   203 VQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSLTVSEDPAVGNISSFCYRPRPDSYHLLR 267

  Fly   321 -PTTRHTVWSVVIGGF-----FYWTSLFCTNQASVQKCMSLKSLRLAK---IALGFAIIGLIVVF 376
             |.|....|..::.|.     :||    |::|..||:|::.|||...|   |..|:  :.|..:|
Human   268 HPVTGDLPWPALLLGLTIVSGWYW----CSDQVIVQRCLAGKSLTHIKAGCILCGY--LKLTPMF 326

  Fly   377 LLNFYTGLMVFTHYAD---------CDPLTAGRISATDQLLPYYVINTYEHISSVAGIFVAGIFA 432
            |: ...|::....|.|         |..:....:..::...|..|:....  :.:.|:.:|.:.|
Human   327 LM-VMPGMISRILYPDEVACVVPEVCRRVCGTEVGCSNIAYPRLVVKLMP--NGLRGLMLAVMLA 388

  Fly   433 ASLGTVASALNSLSAVTCEDLLVNGMNIKISPEKG----------------ATYAKWMSLGFGIA 481
            |.:.::||..||.|.:...|:..     ::.|..|                .....|:.: ...|
Human   389 ALMSSLASIFNSSSTLFTMDIYT-----RLRPRAGDRELLLVGRLWVVFIVVVSVAWLPV-VQAA 447

  Fly   482 SFGLVF-----IVEHLGGVLQATLTLN-------------GLIGGVTLGL------FVLGI-ACK 521
            ..|.:|     :..:|...:.|...|.             |||||:.:||      |..|. :|.
Human   448 QGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRVNEQGAFWGLIGGLLMGLARLIPEFSFGSGSCV 512

  Fly   522 QANTKGAFYGGL--LSLALVIFV--GVVAQIVSVEQPALPTSIDKCDCHVNMTNIIGSLL----- 577
            |.:...||..|:  |..|:|:|.  |::...||:....:|..        ::..::.||.
Human   513 QPSACPAFLCGVHYLYFAIVLFFCSGLLTLTVSLCTAPIPRK--------HLHRLVFSLRHSKEE 569

  Fly   578 TEPLEVIEEGGFTSWPI 594
            .|.|:..|:.| :|.|:
Human   570 REDLDADEQQG-SSLPV 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5687	NP_647678.3	SLC5sbd_NIS-SMVT	99..620	CDD:271383	129/600 (22%)
SLC5A2	XP_006721135.3	SLC5sbd_SGLT2	24..698	CDD:212056	130/633 (21%)