Protein Alignment CG5687 and SLC5A7

DIOPT Version :10

• Sequence 1: NP_647678.3
• Gene: CG5687 / 38255
• FlyBaseID: FBgn0035293
• Length: 683
• Species: Drosophila melanogaster
• Sequence 2: NP_068587.1
• Gene: SLC5A7 / 60482
• HGNCID: 14025
• Length: 580
• Species: Homo sapiens
• Alignment Length: 537
• Identity: 107/537 - (19%)
• Similarity: 197/537 - (36%)
• Gaps: 94/537 - (17%)

  Fly   103 ILLGMLVISLGIGIFYGFFQKGGSSSNE-----FLLGSEMSIFPVTLSLTTSFITAIELLGNPSE 162
            |::..|:|.| :||:..:..|...|:.|     .:.|.::.:.....::|.:::....:.|....
Human    11 IIVFYLLILL-VGIWAAWRTKNSGSAEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEA 74

  Fly   163 MYFQGTQFVLIVIPMVIVIPVAV-KIFY--PIYFKMELTSCYEYLGIRFGKEIRILGAVLYVIQM 224
            :|..|........|:...:.:.: .:|:  |:..|..:|....:..| :||.   :|.:|::..:
Human    75 VYVPGYGLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQI-YGKR---MGGLLFIPAL 135

  Fly   225 ---CFYTAVAVLAPAIALSKATGLDTKIAVVLIYVVCVFYSSQGGMKAVVIADSFQAAVLAVSLV 286
               .|:.|....|....:|....:|..|:|::..::...|:..||:.:|...|
Human   136 MGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTD------------ 188

  Fly   287 LIVGLGCFYSGNPIQVFQTASDHNRLEFFNMDPDPTTRHTVW--SVVIGGFFYWTSLFCTN---- 345
             :|.|.|.:.|..|.| ..|..|..:...............|  :|.....:.|...|...
Human   189 -VVQLFCIFVGLWISV-PFALSHPAVADIGFTAVHAKYQKPWLGTVDSSEVYSWLDSFLLLMLGG 251

  Fly   346 ---QASVQKCMSLKSLRLAKIALGFAIIGLIVVFLLNFYTGLMVF------THYADCDPLTAGRI 401
               ||..|:.:|..|...|::....|..|.:|:.:.....|.:..      |.|...||.|.
Human   252 IPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAYGLPDPKTT--- 313

  Fly   402 SATDQLLP---YYVINTYEHISSVAGIFVAGIFAASLGTVASALNSLSAVTCEDLLVNGMNIKIS 463
            ...|.:||   .|:...|     ::...:..:.||.:.:..|::.|.|::...::.........|
Human   314 EEADMILPIVLQYLCPVY-----ISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNAS 373

  Fly   464 PEKGATYAKWMSLGFGIASFGLVFIVEHLGGV--LQATLTLNGLIGGVTLGLFVLGIACKQANTK 526
            .::.....:.....||.::..:..:.:.:.|:  |.:.|....:...:...|||.|     .||.
Human   374 DKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIVIFPQLLCVLFVKG-----TNTY 433

  Fly   527 GAFYG---GL----------LSLALVIFV--------GVVAQIVSVEQPALPTSIDKCDCHVNMT 570
            ||..|   ||          |.|..:||.        |:..|....:..|:.||.        :|
Human   434 GAVAGYVSGLFLRITGGEPYLYLQPLIFYPGYYPDDNGIYNQKFPFKTLAMVTSF--------LT 490

  Fly   571 NIIGSLLTEPLEVIEEG 587
            ||..|.|.:.|  .|.|
Human   491 NICISYLAKYL--FESG 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5687	NP_647678.3	SLC5sbd_NIS-SMVT	99..620	CDD:271383	107/537 (20%)
SLC5A7	NP_068587.1	SLC5sbd_CHT	8..495	CDD:271368	102/523 (20%)
		Mediates interaction with SEC14L1. /evidence=ECO:0000250|UniProtKB:Q9JMD7	502..580		2/4 (50%)
		Dileucine-like motif. /evidence=ECO:0000269|PubMed:15953352	527..532