DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5687 and slc5a8l

DIOPT Version :9

Sequence 1:	NP_001286910.1	Gene:	CG5687 / 38255	FlyBaseID:	FBgn0035293	Length:	683	Species:	Drosophila melanogaster
Sequence 2:	NP_001030141.1	Gene:	slc5a8l / 556156	ZFINID:	ZDB-GENE-061110-98	Length:	610	Species:	Danio rerio

Alignment Length:	604	Identity:	202/604 - (33%)
Similarity:	339/604 - (56%)	Gaps:	34/604 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 ATFSGYDYVILLGMLVISLGIGIFYGFFQKGGSSSNEFLLGS-EMSIFPVTLSLTTSFITAIELL 157
            ||||.:|||:..|:::::.|||:|..|..:..:||:|||||. :|:..||.||||.||::.|.::
Zfish     9 ATFSVWDYVVFAGLILVAAGIGLFQSFRGRKEASSDEFLLGGRQMTAVPVALSLTASFMSGITVI 73

  Fly   158 GNPSEMYFQGTQFVLIVIPMVIVIPVAVKIFYPIYFKMELTSCYEYLGIRFGKEIRILGAVLYVI 222
            |.|:|.|..||.|.|..|...|:..::.:||.|:::::.:||.||||.:|:.|.||::|..:|:|
Zfish    74 GTPAEAYLYGTPFWLFFISYAIMSTISAEIFVPLFYRLNITSTYEYLEMRYNKLIRVIGTSMYII 138

  Fly   223 QMCFYTAVAVLAPAIALSKATGLDTKIAVVLIYVVCVFYSSQGGMKAVVIADSFQAAVLAVSLVL 287
            |...||.:.:.|||:||::.||||....:|....||:.|.:.||:|||:..|.||..::....|.
Zfish   139 QTALYTGMVIFAPALALNQITGLDLWGVLVATGAVCIIYCTLGGLKAVIWTDVFQMIIMLGGFVA 203

  Fly   288 IVGLGCFYSGNPIQVFQTASDHNRLEFFNMDPDPTTRHTVWSVVIGGFFYWTSLFCTNQASVQKC 352
            ::..|....|...:|:..:....|||.|:.||||..||:.|::|:||...|.|::..||:.||:.
Zfish   204 VIARGAVLQGGLGRVWNDSFYGGRLETFSFDPDPLRRHSFWTIVVGGSLMWASMYSINQSQVQRY 268

  Fly   353 MSLKSLRLAKIALGFAIIGLIVVFLLNFYTGLMVFTHYADCDPLTAGRISATDQLLPYYVINTYE 417
            :|.:::..||::|...::||.|...|...:||.:::.|.||||.|...:.||||||||.|::...
Zfish   269 ISCRTMTHAKLSLYVNMVGLWVTVSLAMMSGLTMYSIYKDCDPFTNKDVGATDQLLPYLVMDILA 333

  Fly   418 HISSVAGIFVAGIFAASLGTVASALNSLSAVTCEDLLVNGMNIKISPEKGATYAKWMSLG----F 478
            ....:.|:|||..::.:|.||:|::|:|.|||.||.:....     |........|:::|    :
Zfish   334 DFPGLPGLFVAAAYSGTLSTVSSSINALVAVTVEDFMKPAW-----PSLTERQLSWINMGMSVFY 393

  Fly   479 GIASFGLVFIVEHLGGVLQATLTLNGLIGGVTLGLFVLGIACKQANTKGAFYGGLLSLALVIFVG 543
            |....|:..:...:|.:|||.|::.|:|.|..|||::||:..:.||:.|...|....||:.::||
Zfish   394 GAVCIGMAGVASMMGNILQAALSIFGMISGPLLGLYMLGMFFRCANSTGGLAGLASGLAITLWVG 458

  Fly   544 VVAQI---VSVEQPALPTSIDKCDC-----HVNMT---NIIGSLLTEPLEVIEEGGFTSWPIFRL 597
            :.||:   :..:...||.|::.|..     ...||   .::.:...:|...:.:    :|  :.|
Zfish   459 IGAQLYPPLPEKTLRLPLSVEGCVALNTSETTTMTPFSTVLQTTTPQPRPALAD----NW--YSL 517

  Fly   598 SYMWYSMIGCLLTVFLGWFISLIIDFIQRRNV---LKITGKDIDNPAVSEEIFKSDSQVQYTTTT 659
            ||:::|.:|.::|:.:...:|.|....:::.|   |.|:..|:    :.....||||:|.....|
Zfish   518 SYLYFSPVGIVVTMIIALIVSAISGGCKQKKVRPELFISKSDL----ICFRCKKSDSEVSDLIET 578

  Fly   660 VIGDPRELTSDEGHVNHAI 678
            ...|.:.|.|...:.|..:
Zfish   579 KPKDNQGLDSPVFYDNEIV 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5687	NP_001286910.1	SLC5sbd_NIS-SMVT	99..620	CDD:271383	183/536 (34%)
slc5a8l	NP_001030141.1	SLC5sbd_SMCT1	8..547	CDD:271402	188/548 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.010