DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5687 and Slc5a6

DIOPT Version :9

Sequence 1:	NP_001286910.1	Gene:	CG5687 / 38255	FlyBaseID:	FBgn0035293	Length:	683	Species:	Drosophila melanogaster
Sequence 2:	NP_001171092.1	Gene:	Slc5a6 / 330064	MGIID:	2660847	Length:	634	Species:	Mus musculus

Alignment Length:	564	Identity:	189/564 - (33%)
Similarity:	306/564 - (54%)	Gaps:	37/564 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 SAPSHK--------ATFSGYDYVILLGMLVISLGIGIFYGFFQKGGSSSNEFLLGS-EMSIFPVT 143
            :||.|.        :|||..|||:...:||:||.||:::.....|..:..|.|:.. :|...||.
Mouse     7 AAPFHTTSGSSGAISTFSVVDYVVFGLLLVLSLVIGLYHACRGWGHHTVGELLMADRKMGCLPVA 71

  Fly   144 LSLTTSFITAIELLGNPSEMYFQGTQFVLIVIPMVIVIPVAVKIFYPIYFKMELTSCYEYLGIRF 208
            |||..:|.:|:.:||.|:|::..|||:..:.....:.:.:...||.|:::::.|||.||||.:||
Mouse    72 LSLLATFQSAVAILGAPAEIFRFGTQYWFLGCSYFLGLLIPAHIFIPVFYRLHLTSAYEYLELRF 136

  Fly   209 GKEIRILGAVLYVIQMCFYTAVAVLAPAIALSKATGLDTKIAVVLIYVVCVFYSSQGGMKAVVIA 273
            .|.:||.|.|.::.||..|..||:.||::||:..||.|..::|:.:.:||..|::.||:|||:..
Mouse   137 NKAVRICGTVTFIFQMVIYMGVALYAPSLALNAVTGFDLWLSVLALGIVCNIYTALGGLKAVIWT 201

  Fly   274 DSFQAAVLAVSLVLIVGLGCFYSGNPIQVFQTASDHNRLEFFNMDPDPTTRHTVWSVVIGGFFYW 338
            |.||..|:.:..::::.:|....|....|:...|.|..:...|:||||..|||.|::..||.|..
Mouse   202 DVFQTLVMFLGQLVVIIVGAARVGGLGHVWNVTSQHGLISGINLDPDPFVRHTFWTLAFGGVFMM 266

  Fly   339 TSLFCTNQASVQKCMSLKSLRLAKIALGFAIIGLIVVFL-LNFYTGLMVFTHYADCDPLTAGRIS 402
            .||:..|||.||:.:|..|.|.|.::. :|:.....|.| ::...||::|.:|.........:.:
Mouse   267 LSLYGVNQAQVQRYLSSHSERAAVLSC-YAVFPCQQVALCMSCLIGLVMFAYYNMYSMSPELKQA 330

  Fly   403 ATDQLLPYYVINTYEHISSVAGIFVAGIFAASLGTVASALNSLSAVTCEDLLVNGMNIKISPEKG 467
            |.|||:.|:|::..:.:..:.|:|||.:|:.||.|::||.|||:.||.|||:....     |:..
Mouse   331 APDQLVLYFVMDLLKDMPGLPGLFVACLFSGSLSTISSAFNSLATVTMEDLIQPWF-----PQLT 390

  Fly   468 ATYAKWMSLG----FGIASFGLVFIVEHLGGVLQATLTLNGLIGGVTLGLFVLGIACKQANTKGA 528
            .|.|..:|.|    :|:...|:.:|..|||.||||.|::.|::||..||||.||:....||..||
Mouse   391 ETRAIMLSRGLAFAYGLVCLGMAYISSHLGSVLQAALSIFGMVGGPLLGLFCLGLFFPCANPLGA 455

  Fly   529 FYGGLLSLALVIFVGVVAQIVS-----VEQPALPTSIDKCDCHVN---MTNIIGSLLTEPLEVIE 585
            ..|.|..|.:..::| :..|||     |..|.|..|......:|.   :|.::.|.|::|..:..
Mouse   456 IVGLLTGLTMAFWIG-IGSIVSRMSSAVAPPPLNGSSSFLPANVTVAAVTTVMPSTLSKPTGLQH 519

  Fly   586 EGGFTSWPIFRLSYMWYSMIGCLLTVFLGWFISLIIDFIQRRNV 629
                    .:.|||:|||.......:.:|..:||:...::.|::
Mouse   520 --------FYSLSYLWYSAHNSTTVIVVGLIVSLLTGGMRGRSL 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5687	NP_001286910.1	SLC5sbd_NIS-SMVT	99..620	CDD:271383	181/534 (34%)
Slc5a6	NP_001171092.1	SLC5-6-like_sbd	23..548	CDD:320982	184/539 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.780