DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5687 and Slc5a10

DIOPT Version :9

Sequence 1:	NP_001286910.1	Gene:	CG5687 / 38255	FlyBaseID:	FBgn0035293	Length:	683	Species:	Drosophila melanogaster
Sequence 2:	NP_001100477.1	Gene:	Slc5a10 / 303205	RGDID:	1305232	Length:	596	Species:	Rattus norvegicus

Alignment Length:	609	Identity:	135/609 - (22%)
Similarity:	249/609 - (40%)	Gaps:	126/609 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 APSHKATFSGYDYVILLGMLVISLGIGIFYGFFQKGGSSSNEFLLGSEMSIFPVTLSLTTS---- 149
            ||..:.:.|  |.:::.....:::.:|::........:.|..||.|.:|:.:|:..||..|
  Rat    11 APGSQLSTS--DIIVISLYFALNVAVGVWTACRANKNTVSGYFLAGRDMAWWPIGASLFASSEGS 73

  Fly   150 --FI--TAIELLGNPSEMYFQ-GTQFVLIVIPMVIVIPVAVKIFYPIYFKMELTSCYEYLGIRF- 208
              ||  ......|..:...|: ...:||:.:..|         |.|||...|:.:..||:..||
  Rat    74 GLFIGLAGSGAAGGLAVAGFEWNATYVLLALAWV---------FVPIYVSSEIVTLPEYIQKRFG 129

  Fly   209 GKEIRILGAVLYVIQMCFYTAVAV--LAPAIALSKATGLDTKIAVVLIYVVCVFYSSQGGMKAVV 271
            |:.||:..:||.:: :..:|.:::  .|.|:.:....|.:..::.:|...:...|:..||:..|:
  Rat   130 GQRIRMYLSVLSLL-LSVFTKISIDLYAGALFVHICLGWNFYLSTILTLAITALYTIAGGLATVI 193

  Fly   272 IADSFQAAVLAVSLVLI-------VG----LGCFYS-GNPIQVFQTASDH-NRLEFFNMDPDPTT 323
            ..|:.|.|::.|..|::       :|    |...|: ..|.:.....:.| .|.:..:|..||:|
  Rat   194 YTDALQTAIMVVGAVILAVKAFNQIGGYEQLEAAYAQATPSRTIPNTTCHLPRADAMHMFRDPST 258

  Fly   324 RHTVWS-----VVIGGFFYWTSLFCTNQASVQKCMSLKSLRLAK-----------IALGFAII-G 371
            ....|:     :.|...:||    ||:|..||:.:|.::|..||           :.:|..|: |
  Rat   259 GDLPWTGMTFGLTIMATWYW----CTDQVIVQRSLSARNLNHAKAGSILASYLKMLPMGLMIMPG 319

  Fly   372 LIVVFLLNFYTGLMVFTHYADCDPLTAGRISATDQLLPYYVINTYEHISSVAGIFVAGIFAASLG 436
            :|...|.....|.:|   .::|.......|..::...|..|:....  ..:.|:.:|.:.||.|.
  Rat   320 MISRVLFPDDVGCVV---PSECLRACGAEIGCSNIAYPKLVMELMP--IGLRGLMIAVMMAALLS 379

  Fly   437 TVASALNSLSAVTCED--------------LLVNGMNIKISPEKGATYAKWMSLGFGIASFGLVF 487
            ::.|..||.|.:...|              |||..:.|.:.  .|.:.| |:.:..|..|..|..
  Rat   380 SLTSIFNSSSTLFTMDIWRQFRPGAGERELLLVGRLVIVVL--VGVSVA-WIPVLQGSNSGQLFI 441

  Fly   488 IVEHLGGVLQATLTLNGLIGGVTLGLFVLGIACKQANTKGAFYG---GLLSLALVIFVGVVAQIV 549
            .::.:...|...:|          .:|:|||..::||.:|||:|   |||       ||.:..::
  Rat   442 YMQSVTSSLAPPVT----------AIFLLGIFWRRANEQGAFWGLMAGLL-------VGALRLVL 489

  Fly   550 SVEQPALPTSIDKCDCHVNMTNIIGSLLTEPLEVIEEGGFTSWPIFRLSYMWYSMIGCLLTVFLG 614
            ....|         :.|      .|.:.|.|           :|:..:.|:.:::....||..:.
  Rat   490 EFLYP---------EPH------CGQIDTRP-----------FPLGSIHYLHFAIALFFLTCAVM 528

  Fly   615 WFISLIIDFIQRRNVLKITGKDID 638
            ...||:....|:|.:..:|...:|
  Rat   529 AAGSLLSPPPQQRQIENLTWWTLD 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5687	NP_001286910.1	SLC5sbd_NIS-SMVT	99..620	CDD:271383	127/579 (22%)
Slc5a10	NP_001100477.1	SLC5-6-like_sbd	17..596	CDD:294310	133/603 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910