DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5687 and Slc5a12

DIOPT Version :9

Sequence 1:	NP_001286910.1	Gene:	CG5687 / 38255	FlyBaseID:	FBgn0035293	Length:	683	Species:	Drosophila melanogaster
Sequence 2:	NP_001003915.1	Gene:	Slc5a12 / 241612	MGIID:	2138890	Length:	623	Species:	Mus musculus

Alignment Length:	567	Identity:	194/567 - (34%)
Similarity:	318/567 - (56%)	Gaps:	57/567 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 FSGYDYVILLGMLVISLGIGIFYGFFQKGGSSSNEFLLGS-EMSIFPVTLSLTTSFITAIELLGN 159
            |..:|||:..|:.|||.|||:|:...::..::|.|||:|. :||..||.||||.||::|:.:||.
Mouse     6 FEAWDYVVFAGLFVISSGIGVFFAIKERKKTTSREFLVGGRQMSFGPVALSLTASFMSAVTVLGT 70

  Fly   160 PSEMYFQGTQFVLIVIPMVIVIPVAVKIFYPIYFKMELTSCYEYLGIRFGKEIRILGAVLYVIQM 224
            |:|:|..|..|.|.:|..|.|:....::|.|::::..:||.||||.:||.|.:|....::|::|.
Mouse    71 PAEVYRFGASFFLFLISYVFVVFFTSELFLPVFYRSGITSTYEYLQLRFNKPVRYAATIIYIVQT 135

  Fly   225 CFYTAVAVLAPAIALSKATGLDTKIAVVLIYVVCVFYSSQGGMKAVVIADSFQAAVLAVSLVLIV 289
            ..||.|.|.|||:||::.||.:...:|....:||.||.|.||:||||..|:||..|:.|..:.::
Mouse   136 ILYTGVVVYAPALALNQVTGFNLWASVFATGIVCTFYCSLGGLKAVVWTDAFQMVVMIVGFLTVL 200

  Fly   290 GLGCFYSGNPIQVFQTASDHNRLEFFNMDPDPTTRHTVWSVVIGGFFYWTSLFCTNQASVQKCMS 354
            ..|..:.|....|.:.|.:.:||...:.|.||..|||.|::.|||.|.|..::..||:::|:|:|
Mouse   201 IQGSNHVGGFNNVLEKAGNGSRLHIVDFDVDPLRRHTFWTITIGGTFTWLGVYGVNQSTIQRCIS 265

  Fly   355 LKSLRLAKIALGFAIIGLIVVFLLNFYTGLMVFTHYADCDPLTAGRISATDQLLPYYVINTYEHI 419
            .|:.:.||:||.|.::||.::.....::||::::|:.||||.|:|.|||.|||:||:|:..:..:
Mouse   266 CKTEKHAKLALYFNLLGLWIIVACAVFSGLIMYSHFKDCDPWTSGVISAPDQLMPYFVMEIFATM 330

  Fly   420 SSVAGIFVAGIFAASLGTVASALNSLSAVTCEDLLVNGMNIKISPEKGATYAKWMSLG----FGI 480
            ..:.|:|||..|:.:|.|||:::|:|:.||.||.:.:     ..|......:.|:|.|    |||
Mouse   331 PGLPGLFVACAFSGTLSTVAASINALATVTFEDFVKS-----CFPHLSDKLSTWISKGLCILFGI 390

  Fly   481 ASFGLVFIVEHLGGVLQA--------TLT------LNGLIGGVTLGLFVLGIACKQANTKGAFYG 531
            ....:..:...:|.|:||        .:|      |..:..||::...::|.           .|
Mouse   391 MCTSMAVVASLMGSVVQAPGIVSQERAITGSFQRNLASVCYGVSIWKLIMGA-----------LG 444

  Fly   532 GLLS-LALVIFVGVVAQIVSVEQP---ALPTSIDKCDCHVNMTNIIG-SLLTEPLEVIEEGGFTS 591
            |||: :.|..:|.:.:.|....:.   .||.|.:.| ..:|:|..:. .:.:.|  |:.:    :
Mouse   445 GLLTGITLSFWVAIGSFIYPAPESKTLPLPLSTEHC-VELNITTTVAPQISSRP--VLAD----T 502

  Fly   592 WPIFRLSYMWYSMIGCLLTVFLGWFISLIIDFIQRRNVLKITGKDID 638
            |  :.|||:::|.:|||..:..|    :||.|:..    |..|||||
Mouse   503 W--YSLSYLYFSAVGCLGCIAAG----IIISFLTG----KQRGKDID 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5687	NP_001286910.1	SLC5sbd_NIS-SMVT	99..620	CDD:271383	184/544 (34%)
Slc5a12	NP_001003915.1	SLC5-6-like_sbd	3..531	CDD:294310	188/553 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.910